P J Henry

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Typical endothelin ETA receptors mediate atypical endothelin-1-induced contractions in sheep isolated tracheal smooth muscle
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    J Pharmacol Exp Ther 289:1385-90. 1999
  2. ncbi request reprint Endothelin receptor distribution and function in the airways
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Clin Exp Pharmacol Physiol 26:162-7. 1999
  3. ncbi request reprint A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice
    Peter J Henry
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Australia
    Pulm Pharmacol Ther 18:67-74. 2005
  4. ncbi request reprint An endothelin receptor antagonist, SB-217242, inhibits airway hyperresponsiveness in allergic mice
    Peter J Henry
    Department of Pharmacology, University of Western Australia, Crawley 6009, Australia
    Am J Physiol Lung Cell Mol Physiol 283:L1072-8. 2002
  5. ncbi request reprint Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea
    Peter J Henry
    School of Medicine and Pharmacology, University of Western Australia, Nedlands
    J Pharmacol Exp Ther 314:995-1001. 2005
  6. ncbi request reprint The protease-activated receptor2 (PAR2)-prostaglandin E2-prostanoid EP receptor axis: a potential bronchoprotective unit in the respiratory tract?
    Peter J Henry
    School of Medicine and Pharmacology, University of Western Australia, Stirling Highway, Nedlands, Western Australia, 6009, Australia
    Eur J Pharmacol 533:156-70. 2006
  7. pmc Effect of respiratory tract viral infection on murine airway beta-adrenoceptor function, distribution and density
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 104:914-21. 1991
  8. pmc Predominance of endothelinA (ETA) receptors in ovine airway smooth muscle and their mediation of ET-1-induced contraction
    R G Goldie
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 112:749-56. 1994
  9. ncbi request reprint A protective role for protease-activated receptors in the airways
    T M Cocks
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
    Nature 398:156-60. 1999
  10. pmc Endothelin-1 (ET-1)-induced contraction in rat isolated trachea: involvement of ETA and ETB receptors and multiple signal transduction systems
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 110:435-41. 1993

Collaborators

  • P J Rigby
  • Roy G Goldie
  • T M Cocks
  • J D Moffatt
  • Peter Mirtschin
  • D A Knight
  • Rommel S Lan
  • Roopwant K Judge
  • Benjamin A De Campo
  • Sham Mohd Saleh
  • B A De Campo
  • Jacqueline A Wilce
  • Chen Fuh Lam
  • Geoffrey A Stewart
  • R S Lan
  • Terence Peters
  • Richard J Betts
  • Tracy S Mann
  • George Jelinek
  • Peter V van Heerden
  • Kenneth F Ilett
  • Angela C D'Aprile
  • Matthew C J Wilce
  • George A Jelinek
  • Arco Y Jeng
  • Dania Lynch
  • G A Stewart

Detail Information

Publications29

  1. ncbi request reprint Typical endothelin ETA receptors mediate atypical endothelin-1-induced contractions in sheep isolated tracheal smooth muscle
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    J Pharmacol Exp Ther 289:1385-90. 1999
    ....
  2. ncbi request reprint Endothelin receptor distribution and function in the airways
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Clin Exp Pharmacol Physiol 26:162-7. 1999
    ..4. Evidence to date suggests that changes in the endothelin content within the airway wall, conceivably associated with lung pathology, are likely to have profound effects on the function of many cells within the lung...
  3. ncbi request reprint A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice
    Peter J Henry
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Australia
    Pulm Pharmacol Ther 18:67-74. 2005
    ....
  4. ncbi request reprint An endothelin receptor antagonist, SB-217242, inhibits airway hyperresponsiveness in allergic mice
    Peter J Henry
    Department of Pharmacology, University of Western Australia, Crawley 6009, Australia
    Am J Physiol Lung Cell Mol Physiol 283:L1072-8. 2002
    ..These findings provide direct evidence for a mediator role for ET-1 in development of airway hyperresponsiveness and airway eosinophilia in Der P1-sensitized mice after antigen challenge...
  5. ncbi request reprint Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea
    Peter J Henry
    School of Medicine and Pharmacology, University of Western Australia, Nedlands
    J Pharmacol Exp Ther 314:995-1001. 2005
    ..In summary, inhibitors of PGE(2) reuptake and metabolism significantly potentiate PAR(2)-mediated increases in PGE(2) levels and smooth muscle relaxation in murine-isolated airways...
  6. ncbi request reprint The protease-activated receptor2 (PAR2)-prostaglandin E2-prostanoid EP receptor axis: a potential bronchoprotective unit in the respiratory tract?
    Peter J Henry
    School of Medicine and Pharmacology, University of Western Australia, Stirling Highway, Nedlands, Western Australia, 6009, Australia
    Eur J Pharmacol 533:156-70. 2006
    ..This article reviews the PAR2-prostaglandin E2-prostanoid EP receptor axis and discusses approaches through which its activation may provide beneficial effects in respiratory disease...
  7. pmc Effect of respiratory tract viral infection on murine airway beta-adrenoceptor function, distribution and density
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 104:914-21. 1991
    ....
  8. pmc Predominance of endothelinA (ETA) receptors in ovine airway smooth muscle and their mediation of ET-1-induced contraction
    R G Goldie
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 112:749-56. 1994
    ..ETB receptors also exist in the lamina propria of ovine trachea and in peripheral alveoli, perhaps residing in vascular endothelial cells...
  9. ncbi request reprint A protective role for protease-activated receptors in the airways
    T M Cocks
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
    Nature 398:156-60. 1999
    ..Our results indicate that trypsin released from the epithelium can initiate powerful bronchoprotection in the airways by activation of epithelial PAR2...
  10. pmc Endothelin-1 (ET-1)-induced contraction in rat isolated trachea: involvement of ETA and ETB receptors and multiple signal transduction systems
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 110:435-41. 1993
    ....
  11. pmc Potentiation by endothelin-1 of cholinergic nerve-mediated contractions in mouse trachea via activation of ETB receptors
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 114:563-9. 1995
    ..This neuronal pathway offers an additional mechanism through which endothelin-1 may elevate bronchomotor tone...
  12. pmc Distribution of beta 1- and beta 2-adrenoceptors in mouse trachea and lung: a quantitative autoradiographic study
    P J Henry
    Department of Pharmacology, University of Western Australia, Perth, Nedlands
    Br J Pharmacol 99:136-44. 1990
    ..Conversely, beta l-adrenoceptors which mediate relaxant responses of mouse trachea to beta,-adrenoceptor agonists (Henry & Goldie, 1990), accounted for 69% of all beta-adrenoceptors in the airway smooth muscle...
  13. pmc Endothelin-1-induced [3H]-inositol phosphate accumulation in rat trachea
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 105:135-41. 1992
    ..20 miicroM, 0.17-0.24 microM, n = 12).6. It seems likely that ET-1 has a direct effect on InsP generation in rat tracheal smooth muscle and that this is largely responsible for the spasmogenic actions of this peptide...
  14. pmc Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea
    R S Lan
    Department of Pharmacology, The University of Western Australia, Nedlands, Western Australia, 6907 Australia
    Br J Pharmacol 132:93-100. 2001
    ..PAR-stimulated PGE(2) release appears to be generated preferentially by COX-2 rather than COX-1, and induces relaxation via activation of the EP(2) receptor...
  15. pmc ETB but not ETA receptor-mediated contractions to endothelin-1 attenuated by respiratory tract viral infection in mouse airways
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 112:1188-94. 1994
    ..Thus, virus infection in murine airways produced profound alterations in endothelin receptor density, some of which were associated with changes in receptor-mediated contractile activity...
  16. ncbi request reprint The endothelins in the pulmonary system
    R G Goldie
    Department of Pharmacology, University of Western Australia, Perth, Nedlands, Australia
    Pulm Pharmacol 9:69-93. 1996
    ..Additionally, ECE-1 and ECE-2 present as potentially important targets for therapeutic intervention, although the development of selective nonpeptide inhibitors may be some years away...
  17. pmc Inhibitory effects of nordihydroguaiaretic acid on ETA-receptor-mediated contractions to endothelin-1 in rat trachea
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 111:561-9. 1994
    ....
  18. ncbi request reprint The impact of inflammation on bronchial neuronal networks
    R G Goldie
    Department of Pharmacology, The University of Western Australia, Western Australian Institute for Medical Research, Nedlands, Perth, WA, 6907, Australia
    Pulm Pharmacol Ther 14:177-82. 2001
    ..The concept of neuronal plasticity and phenotype switching induced by inflammation is also examined, with particular emphasis on sensory airway nerves...
  19. ncbi request reprint Influence of endothelin-1(1-31) on smooth muscle tone and cholinergic nerve-mediated contraction in rat isolated trachea
    R G Goldie
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    J Cardiovasc Pharmacol 36:S228-31. 2000
    ..These data are consistent with the idea that ET-1(1-31) could play a significant mediator role in obstructive airway diseases such as asthma...
  20. ncbi request reprint Endothelins and asthma
    R G Goldie
    Department of Pharmacology, University of Western Australia, Perth, Nedlands, Australia
    Life Sci 65:1-15. 1999
    ..Despite this profile, a causal link between ET-1 and asthma has not been definitively established. This review attempts to bring together some of the evidence suggesting the potential mediator roles for ET-1 in this disease...
  21. ncbi request reprint Protease-activated receptors (PARs) are partly pro-inflammatory and partly anti-inflammatory: will PAR agonists or antagonists participate in future drug therapies?
    B A De Campo
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Curr Drug Targets 7:629-37. 2006
    ....
  22. pmc Stimulation of protease-activated receptor-2 inhibits airway eosinophilia, hyperresponsiveness and bronchoconstriction in a murine model of allergic inflammation
    Benjamin A De Campo
    Respiratory Pharmacology Group, School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Hwy, Nedlands, Australia
    Br J Pharmacol 144:1100-8. 2005
    ..SLIGRL also displayed bronchodilator activity in allergic mice. These studies support the concept that PAR(2) exerts predominantly bronchoprotective actions within allergic murine airways...
  23. ncbi request reprint Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice
    Rommel S Lan
    School of Medicine and Pharmacology, Faculty of Medicine and Dentistry, University of Western Australia, Perth, 6009 W A, Australia
    Am J Physiol Lung Cell Mol Physiol 286:L388-98. 2004
    ..These findings suggest that during viral infection, the upregulation of PARs in the airways is coupled to increased activation of COX and enhanced generation of bronchodilatory prostanoids...
  24. ncbi request reprint Diethylenetriamine nitric oxide adduct relaxes precontracted mouse tracheal smooth muscle
    Chen Fuh Lam
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Clin Exp Pharmacol Physiol 30:709-11. 2003
    ..4. We conclude that DETA/NO induces a concentration-dependent relaxation of mouse carbachol-contracted isolated tracheal smooth muscle that is mediated by NO released from DETA/NO via the activation of sGC...
  25. ncbi request reprint Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice
    Benjamin A De Campo
    Department of Pharmacology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Clin Sci (Lond) 103:353S-356S. 2002
    ..If endogenous ET-1(1-31) is formed within allergic airways, it is likely to undergo further conversion by NEP to more active products...
  26. ncbi request reprint Influence of dexamethasone on protease-activated receptor 2-mediated responses in the airways
    Sham Mohd Saleh
    School of Medicine and Pharmacology, University of Western Australia, Stirling Highway, Nedlands, Australia
    J Pharmacol Exp Ther 324:622-30. 2008
    ....
  27. ncbi request reprint Role of protease-activated receptors in airway function: a target for therapeutic intervention?
    Rommel S Lan
    Department of Pharmacology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia 6009, Perth, Australia
    Pharmacol Ther 95:239-57. 2002
    ....
  28. ncbi request reprint Toxins not neutralized by brown snake antivenom
    Roopwant K Judge
    Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, Canberra 2601, ACT, Australia
    Toxicol Appl Pharmacol 213:117-25. 2006
    ..These results represent the first proteomic investigation of the venoms from the snakes of the genus Pseudonaja, revealing a possible limitation of the brown snake antivenom in binding to the low MW protein components...
  29. ncbi request reprint Identification of PLA(2) and alpha-neurotoxin proteins in the venom of Pseudonaja affinis (dugite)
    Roopwant K Judge
    Department of Biochemistry, University of Western Australia, Perth, Australia
    Toxicol Appl Pharmacol 181:184-91. 2002
    ..The crude venom was found to temporarily inhibit the beating of the cardiac myocytes, after which the beating resumed erratically. Cortical neurons, however, were irreversibly affected, showing concentration-dependent cell death...