B R Henderson

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage
    Kirsty M Brodie
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, NSW, Australia
    Cell Signal 22:291-302. 2010
  2. ncbi request reprint Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales, Australia
    Bioessays 27:884-93. 2005
  3. pmc The ins and outs of APC and beta-catenin nuclear transport
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute, NSW, Australia
    EMBO Rep 3:834-9. 2002
  4. ncbi request reprint Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales 2145, Australia
    J Biol Chem 277:24258-64. 2002
  5. ncbi request reprint Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
    B R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millenium Institute, Westmead NSW 2145, Australia
    Nat Cell Biol 2:653-60. 2000
  6. ncbi request reprint Identification of a functional nuclear export sequence in BRCA1
    J A Rodriguez
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute, Westmead, 2145 New South Wales, Australia
    J Biol Chem 275:38589-96. 2000
  7. ncbi request reprint Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor
    A Eleftheriou
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales 2145, Australia
    J Biol Chem 276:25883-8. 2001
  8. ncbi request reprint BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export
    Megan Fabbro
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, 2145, New South Wales, Australia
    J Biol Chem 277:21315-24. 2002
  9. ncbi request reprint Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1
    Jose Antonio Rodriguez
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead NSW 2145, Australia
    Oncogene 23:1809-20. 2004
  10. ncbi request reprint The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
    Wendy W Y Au
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 280:6993-7001. 2005

Collaborators

  • Myth T S Mok
  • M Yoshida
  • Gopala Rangan
  • Guoping Zheng
  • I S Nathke
  • Yiping Wang
  • Jose A Rodriguez
  • S S Taylor
  • Thian Kui Tan
  • Richard Baer
  • B Falini
  • Rebecca A Keough
  • Mariana Brocardo
  • Manisha Sharma
  • Megan Fabbro
  • Varsha Tembe
  • Wendy W Y Au
  • Cameron P Flegg
  • Kirsty M Brodie
  • Cara Jamieson
  • Michael Johnson
  • Niccolò Bolli
  • Fabian Zanella
  • A Eleftheriou
  • Stefan Schüchner
  • M A Galea
  • Melanie Galea
  • Cahora Medina-Palazon
  • Mariana G Brocardo
  • Kate Mills
  • Linda Bendall
  • Jasmine M Henderson
  • Ying Lei
  • Anthony Tighe
  • M Felicetta De Marco
  • Arcangelo Liso
  • Massimo F Martelli
  • Fernando Blanco
  • Aranzazu Rosado
  • Alessandra Pucciarini
  • Barbara Bigerna
  • Amancio Carnero
  • Roberta Mannucci
  • Ildo Nicoletti
  • Francesco Fabbiano
  • Cristina Mecucci
  • Wolfgang Link
  • Maria Paola Martelli
  • Louie Leung
  • Cameron Flegg
  • Jasmine Henderson
  • Stefan Schuechner

Detail Information

Publications35

  1. doi request reprint Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage
    Kirsty M Brodie
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, NSW, Australia
    Cell Signal 22:291-302. 2010
    ....
  2. ncbi request reprint Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales, Australia
    Bioessays 27:884-93. 2005
    ..This review discusses BRCA1, BRCA2 and BARD1 subcellular localization with emphasis on regulation of transport by protein dimerization and its functional implications...
  3. pmc The ins and outs of APC and beta-catenin nuclear transport
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute, NSW, Australia
    EMBO Rep 3:834-9. 2002
    ..Models that link APC and beta-catenin transport to function are discussed...
  4. ncbi request reprint Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1
    Beric R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales 2145, Australia
    J Biol Chem 277:24258-64. 2002
    ....
  5. ncbi request reprint Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
    B R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millenium Institute, Westmead NSW 2145, Australia
    Nat Cell Biol 2:653-60. 2000
    ..These findings suggest that wild-type APC controls the nuclear accumulation of beta-catenin by a combination of nuclear export and cytoplasmic degradation...
  6. ncbi request reprint Identification of a functional nuclear export sequence in BRCA1
    J A Rodriguez
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute, Westmead, 2145 New South Wales, Australia
    J Biol Chem 275:38589-96. 2000
    ..The unexpected ability of BRCA1 to shuttle between nucleus and cytoplasm may have implications for the regulation and function of this tumor suppressor...
  7. ncbi request reprint Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor
    A Eleftheriou
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales 2145, Australia
    J Biol Chem 276:25883-8. 2001
    ..The shuttling ability of tumor cell beta-catenin has implications for its regulation and its role in transferring signals between the nucleus and plasma membrane...
  8. ncbi request reprint BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export
    Megan Fabbro
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, 2145, New South Wales, Australia
    J Biol Chem 277:21315-24. 2002
    ..Our identification of BARD1 as a BRCA1 nuclear chaperone has regulatory implications for its reported effects on BRCA1 protein stability, ubiquitin ligase activity, and DNA repair...
  9. ncbi request reprint Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1
    Jose Antonio Rodriguez
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead NSW 2145, Australia
    Oncogene 23:1809-20. 2004
    ..Our findings suggest that BRCA1/BARD1 heterodimer formation is important for optimal nuclear targeting of BARD1 and its role in DNA repair and cell survival...
  10. ncbi request reprint The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
    Wendy W Y Au
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 280:6993-7001. 2005
    ..We propose that both RING and BRCT domains together target BRCA1 to large focal assemblies at DNA double-stranded breaks...
  11. ncbi request reprint ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A
    M A Galea
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales 2145, Australia
    J Biol Chem 276:45833-9. 2001
    ..We conclude that APC nuclear import is regulated by the ARM domain through its interaction with B56 alpha and postulate that APC/B56 alpha complexes target the dephosphorylation of specific proteins within the nucleus...
  12. ncbi request reprint BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
    Megan Fabbro
    Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, University of Sydney, Westmead, 2145 New South Wales, Australia
    Exp Cell Res 298:661-73. 2004
    ..Our findings identify a novel apoptosis inhibitory function of BARD1 and suggest that nuclear retention of BRCA1-BARD1 complexes contributes to both DNA repair and cell survival...
  13. ncbi request reprint BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis
    Varsha Tembe
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:20513-22. 2007
    ..We propose that BARD1 has two main sites of action in its cellular response to DNA damage, the nucleus, where it promotes cell survival through DNA repair, and the mitochondria, where BARD1 regulates apoptosis...
  14. ncbi request reprint Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage
    Wendy W Y Au
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead NSW 2145, Australia
    Cell Signal 19:1879-92. 2007
    ..Our results indicate that BRCA1 requires BARD1 for targeting to different types of DNA lesion, and that distinct C-terminal sequences mediate selective recruitment to sites of double- or single-strand DNA damage...
  15. ncbi request reprint Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain
    Jose Antonio Rodriguez
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, NSW 2145, Australia
    Exp Cell Res 293:14-21. 2004
    ..We propose that BRCT mutations alter nuclear targeting of BRCA1, and that this may contribute to the inhibition of nuclear DNA repair and transcription function...
  16. pmc Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells
    Guoping Zheng
    Centre for Transplantation and Renal Research, The University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia
    Am J Pathol 175:580-91. 2009
    ..Specific inhibition rather than activation of matrix metalloproteinases may offer a novel approach for treatment of fibrotic disease...
  17. ncbi request reprint Nuclear targeting and cell cycle regulatory function of human BARD1
    Stefan Schüchner
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Darcy Road, PO Box 412, Westmead, Sydney, New South Wales 2145, Australia
    J Biol Chem 280:8855-61. 2005
    ..Thus, BARD1 regulation of the cell cycle is a nuclear event and may be linked to its induced expression during mitosis and its possible involvement in the DNA damage checkpoint...
  18. pmc Expression of the nm23-2/NDP kinase alpha gene in rat mammary and oral carcinoma cells of varying metastatic potential
    B R Henderson
    Department of Medical Oncology, University of Sydney, Westmead Centre, NSW, Australia
    Br J Cancer 68:874-8. 1993
    ..The data do not suggest a correlation between nm23-2 gene expression and metastasis-suppression in these tumours...
  19. doi request reprint BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters
    Megan Fabbro
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Darcy Road, P O Box 412, Westmead, NSW 2145, Australia
    Cancer Lett 263:189-96. 2008
    ..We propose that BARD1 reduces BRCA1 transcriptional activity, and that this at least partly involves BRCA1/BARD1 E3 ubiquitin ligase activity, which is disrupted by the C61G mutation...
  20. ncbi request reprint Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 281:17140-9. 2006
    ..Our findings identify beta-catenin as a regulator of APC targeting to membrane clusters and link these two proteins to cell migration...
  21. pmc Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit
    Cameron P Flegg
    From the Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, University of Sydney, Westmead New South Wales 2145, Australia
    J Biol Chem 285:18144-54. 2010
    ..We propose that B56alpha can act as a PP2A C-subunit chaperone and regulates PP2A activity at diverse subcellular locations...
  22. ncbi request reprint Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
    Megan Fabbro
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, New South Wales, Australia
    Exp Cell Res 282:59-69. 2003
    ..Here, we review the pathways by which tumor suppressors such as APC, p53, VHL, and BRCA1 cross the nuclear envelope and the impact of regulated nuclear import/export on protein function...
  23. doi request reprint APC shuttling to the membrane, nucleus and beyond
    Mariana Brocardo
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, NSW 2145, Australia
    Trends Cell Biol 18:587-96. 2008
    ..The transport routes of APC overlap that of other tumor suppressors, including BRCA1 and p53, pin-pointing common destinations and functions for these cancer regulators...
  24. doi request reprint Detection of cytoplasmic and nuclear localization of adenomatous polyposis coli (APC) protein in cells
    Mariana Brocardo
    Westmead Millennium Institute, The University of Sydney, NSW, Australia
    Methods Mol Biol 468:77-89. 2008
    ..Antibody specificity is an important factor in the determination of APC localization, and in this chapter we outline a strategy for the unambiguous detection of APC using a combination of biochemical and cell biology approaches...
  25. doi request reprint Methods to measure nuclear export of beta-catenin using fixed and live cell assays
    Manisha Sharma
    Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, The University of Sydney, Westmead, NSW, Australia
    Methods Mol Biol 647:187-97. 2010
    ..In this chapter, we outline a number of assays to measure the nuclear export of beta-catenin in fixed and live cells...
  26. ncbi request reprint IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
    ....
  27. pmc Dexamethasone decreases urokinase plasminogen activator mRNA stability in MAT 13762 rat mammary carcinoma cells
    B R Henderson
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    Br J Cancer 67:99-101. 1993
    ..Based on these results, we propose that dexamethasone induces a short-lived protein(s) which down-regulates uPA RNA levels post-transcriptionally in these metastatic tumour cells...
  28. doi request reprint A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci
    Myth T S Mok
    Westmead Institute for Cancer Research, The University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, NSW 2145, Australia
    Cell Signal 22:47-56. 2010
    ..Our findings indicate that BRCA1-BARD1 and 53BP1 are proximal but not overlapping at DNA break sites and are consistent with recent evidence for distinct roles of these proteins in the DNA damage response pathway...
  29. ncbi request reprint Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival
    Mariana Brocardo
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 283:5950-9. 2008
    ..We propose that a subset of cancer mutations induce APC mitochondrial localization and that APC regulation of Bcl-2 at mitochondria may contribute to tumor cell survival...
  30. doi request reprint Regulation of beta-catenin trafficking to the membrane in living cells
    Michael Johnson
    Westmead Institute for Cancer Research, The University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, NSW 2145, Australia
    Cell Signal 21:339-48. 2009
    ..In summary, beta-catenin displays a high turnover rate at membrane ruffles consistent with its dynamic internalization and recycling at these sites by macropinocytosis...
  31. ncbi request reprint Protein trafficking in response to DNA damage
    Varsha Tembe
    Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, University of Sydney, NSW 2145, Australia
    Cell Signal 19:1113-20. 2007
    ..The extent of intracellular transport suggests a dynamic and possibly co-ordinated role for protein trafficking in the DNA damage response...
  32. pmc Redefining the subcellular location and transport of APC: new insights using a panel of antibodies
    Mariana Brocardo
    Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, University of Sydney, Darcy Road PO Box 412, Westmead, New South Wales 2145, Australia
    EMBO Rep 6:184-90. 2005
    ..These results verify that the bulk of APC resides in the cytoplasm and indicate the need for caution when evaluating the nuclear accumulation of APC...
  33. ncbi request reprint Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways
    Rebecca A Keough
    Hanson Institute, Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia
    Exp Cell Res 289:108-23. 2003
    ..Deletion analysis and in vivo export studies using a heterologous assay system identified several nuclear export sequences which facilitate Mybbp1a nuclear export of Mybbp1a by CRM1-dependent and -independent pathways...
  34. ncbi request reprint Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants
    Niccolò Bolli
    Section of Hematology and Immunology, University of Perugia, Perugia, Italy
    Cancer Res 67:6230-7. 2007
    ..The fact that W288-retaining mutants always combine with the strongest NES reveals mutational selective pressure toward efficient export into cytoplasm, pointing to this event as critical for leukemogenesis...
  35. ncbi request reprint An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays
    Fabian Zanella
    Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Assay Drug Dev Technol 5:333-41. 2007
    ..76. In summary, U2nesRELOC is a cell-based nuclear export assay suitable for high throughput screening, providing counterscreens for pathway deconvolution...