Graeme J Hankey

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Unanswered questions and research priorities to optimise stroke prevention in atrial fibrillation with the new oral anticoagulants
    Graeme J Hankey
    Prof Graeme J Hankey, MD, FRACP, FRCP, School of Medicine and Pharmacology, The University of Western Australia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, 6009 Australia, Tel 61 8 9346 3292, E mail
    Thromb Haemost 111:808-16. 2014
  2. doi request reprint Intracranial hemorrhage and novel anticoagulants for atrial fibrillation: what have we learned?
    Graeme J Hankey
    School of Medicine and Pharmacology, The University of Western Australia, Room 222, Harry Perkins Institute of Medical Research QQ block, QE II Medical Centre, 6 Verdun Street, Nedlands, 6009, Australia
    Curr Cardiol Rep 16:480. 2014
  3. doi request reprint Secondary stroke prevention
    Graeme J Hankey
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia Department of Neurology, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia Electronic address
    Lancet Neurol 13:178-94. 2014
  4. doi request reprint Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis
    Graeme J Hankey
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Stroke 44:2232-9. 2013
  5. doi request reprint Novel oral anticoagulants for atrial fibrillation
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia
    Curr Atheroscler Rep 15:344. 2013
  6. doi request reprint Anticoagulant therapy for patients with ischaemic stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, WA 6001, Australia
    Nat Rev Neurol 8:319-28. 2012
  7. doi request reprint Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 169:401-8. 2013
  8. doi request reprint Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    J Vasc Surg 58:364-70. 2013
  9. doi request reprint Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trial
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, W A, Australia
    Cerebrovasc Dis 27:259-65. 2009
  10. doi request reprint Temporal trends in the incidence and recurrence of hospitalised atherothrombotic disease in an Australian population, 2000-07: data linkage study
    Lee Nedkoff
    School of Population Health, M431, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Heart 98:1449-56. 2012

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Unanswered questions and research priorities to optimise stroke prevention in atrial fibrillation with the new oral anticoagulants
    Graeme J Hankey
    Prof Graeme J Hankey, MD, FRACP, FRCP, School of Medicine and Pharmacology, The University of Western Australia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, 6009 Australia, Tel 61 8 9346 3292, E mail
    Thromb Haemost 111:808-16. 2014
    ..Is there a dose or dosing regimen for each NOAC that is as effective and safe as adjusted-dose warfarin for patients with atrial fibrillation who have mechanical prosthetic heart valves? 9. What is the long-term safety of the NOACs? ..
  2. doi request reprint Intracranial hemorrhage and novel anticoagulants for atrial fibrillation: what have we learned?
    Graeme J Hankey
    School of Medicine and Pharmacology, The University of Western Australia, Room 222, Harry Perkins Institute of Medical Research QQ block, QE II Medical Centre, 6 Verdun Street, Nedlands, 6009, Australia
    Curr Cardiol Rep 16:480. 2014
    ..Future treatments for NOAC-associated ICH promise to include specific antidotes to dabigatran (e.g., aDabi-Fab, PER977) and factor Xa inhibitors (e.g., r-Antidote PRT064445, PER977)...
  3. doi request reprint Secondary stroke prevention
    Graeme J Hankey
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia Department of Neurology, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia Electronic address
    Lancet Neurol 13:178-94. 2014
    ..Immediate and sustained implementation of effective and appropriate secondary prevention strategies in patients with first-ever stroke or transient ischaemic attack has the potential to reduce the burden of stroke by up to a quarter. ..
  4. doi request reprint Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis
    Graeme J Hankey
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Stroke 44:2232-9. 2013
    ..We aimed to determine whether B-vitamin supplementation would reduce tHcy and the incidence of new cognitive impairment among individuals with stroke or transient ischemic attack≥6 months previously...
  5. doi request reprint Novel oral anticoagulants for atrial fibrillation
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia
    Curr Atheroscler Rep 15:344. 2013
    ..Multiple guidelines for the management of AF now recommend the NOACs for stroke prevention among atrial fibrillation (AF) patients at risk for stroke...
  6. doi request reprint Anticoagulant therapy for patients with ischaemic stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, WA 6001, Australia
    Nat Rev Neurol 8:319-28. 2012
    ..Ongoing research aims to resolve these limitations, examine whether the promising results of clinical trials can be translated into clinical practice, and monitor the long-term safety of anticoagulant therapies...
  7. doi request reprint Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 169:401-8. 2013
    ..In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in older men without thyroid disease...
  8. doi request reprint Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    J Vasc Surg 58:364-70. 2013
    ..This study was conducted to determine whether plasma total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are associated with abdominal aortic aneurysm (AAA) and aortic diameter...
  9. doi request reprint Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trial
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, W A, Australia
    Cerebrovasc Dis 27:259-65. 2009
    ..We used (18)F-fluorodeoxygluose positron emission tomography ((18)F-FDG PET) to investigate whether long-term homocysteine-lowering treatment alters arterial wall inflammation in patients with a history of ischemic stroke...
  10. doi request reprint Temporal trends in the incidence and recurrence of hospitalised atherothrombotic disease in an Australian population, 2000-07: data linkage study
    Lee Nedkoff
    School of Population Health, M431, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Heart 98:1449-56. 2012
    ....
  11. pmc Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Lancet Neurol 11:512-20. 2012
    ....
  12. doi request reprint Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:E2230-7. 2012
    ..Both hypothyroidism and subclinical hyperthyroidism hinder cognitive function...
  13. pmc The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    BMC Cardiovasc Disord 8:24. 2008
    ..B-vitamin supplements reduce tHcy and improve endothelial function in short term trials, but the long-term effects of the treatment on vascular structure and function are unknown...
  14. ncbi request reprint Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stro
    Matthew W Sherwood
    Division of Cardiovascular Medicine, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC M W S, M R P, J P P, A S H, Y L, R M C, R C B Department of Medicine, Division of Hematology and Thromboembolism, McMaster University, Hamilton, Ontario, Canada J D D Department of Medicine, Division of Hematology, Hofstra North Shore LIJ School of Medicine, Lenox Hill Hospital, New York, NY A C S School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia G J H Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA D E S Johnson and Johnson Pharmaceutical Research and Development, Raritan, NJ C C N Department of Medicine, Stanford University Medical Center, Palo Alto, CA K W M and Department of Medicine, University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, United Kingdom K A A F
    Circulation 129:1850-9. 2014
    ..We sought to determine reasons for TI, the characteristics of patients undergoing TI, and the relationship between anticoagulant and outcomes among patients with TI...
  15. ncbi request reprint Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in at
    Graeme J Hankey
    From the School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia G J H Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia G J H Duke Clinical Research Institute S R S, J P P, Y L, M R P and Duke Translational Medicine Institute R M C, Duke University Medical Center, Durham, NC Department of Medicine, Stanford University, CA K W M Cardiovascular Institute, Mount Sinai Medical Center, New York J L H Department of Cardiovascular Medicine, Hospital of the University of Münster, Munster, Germany G B Massachusetts General Hospital and Harvard Medical School, Boston D E S University of Cincinnati College of Medicine, OH R C B Department of Global Clinical Development, Bayer HealthCare Pharmaceuticals, Whippany, NJ S D B Cerenis Therapeutics, Labege, France J F P Janssen Research and Development, Raritan, NJ C C N Ruprecht Karls University, Heidelberg, Germany W H and University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, United Kingdom K A A F
    Stroke 45:1304-12. 2014
    ..Intracranial hemorrhage (ICH) is a life-threatening complication of anticoagulation...
  16. doi request reprint Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 161:591-8. 2009
    ..We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity...
  17. pmc Older men who use computers have lower risk of dementia
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e44239. 2012
    ..To determine if older men who use computers have lower risk of developing dementia...
  18. doi request reprint In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality
    Bu B Yeap
    School of Medicine and Pharmacology B B Y, S A P C, G J H, L F, University of Western Australia, Perth, Western Australia 6009, Australia Department of Endocrinology and Diabetes B B Y, Fremantle Hospital, Fremantle, Western Australia 6160, Australia Western Australian Centre for Health and Ageing H A, O P A, L F, Centre for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australia PathWest Laboratory Medicine S A P C, Fremantle and Royal Perth Hospitals, Perth, Western Australia 6009, Australia ANZAC Research Institute D J H, University of Sydney, Sydney, New South Wales 2139, Australia School of Psychiatry and Clinical Neurosciences O P A, University of Western Australia, Perth, Western Australia 6009, Australia Vascular Biology Unit J G, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine, James Cook University, Townsville, Queensland 4811, Australia and School of Surgery P E N, University of Western Australia, Perth, Western Australia 6009, Australia
    J Clin Endocrinol Metab 99:E9-18. 2014
    ..Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined...
  19. doi request reprint Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 166:191-7. 2012
    ..However, the relationship of the IGF1 system with aortic dilation and AAA is unclear. We tested the hypothesis that circulating IGF1 and IGFBPs are associated with AAA and aortic diameter in older men...
  20. ncbi request reprint Lower plasma testosterone or dihydrotestosterone, but not estradiol, is associated with symptoms of intermittent claudication in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia Department of Endocrinology and Diabetes, Fremantle Hospital, Fremantle, WA, Australia
    Clin Endocrinol (Oxf) 79:725-32. 2013
    ..We assessed associations of T, DHT and E2 with lower limb intermittent claudication in older men...
  21. doi request reprint Falls, injuries from falls, health related quality of life and mortality in older adults with vision and hearing impairment--is there a gender difference?
    Derrick Lopez
    Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
    Maturitas 69:359-64. 2011
    ..Our objective was to determine if there are gender differences in the associations between visual and hearing impairment and these outcomes...
  22. doi request reprint Lower testosterone levels predict incident stroke and transient ischemic attack in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
    J Clin Endocrinol Metab 94:2353-9. 2009
    ..However, it is unclear whether lower testosterone levels predict major cardiovascular events...
  23. ncbi request reprint Trends in five-year survival and risk of recurrent stroke after first-ever stroke in the Perth Community Stroke Study
    Kate Hardie
    School of Population Health, University of Western Australia, Perth, Australia
    Cerebrovasc Dis 19:179-85. 2005
    ..We aimed to determine trends in survival and recurrent stroke, over 5 years after first-ever stroke, for 2 cohorts of patients enrolled in the Perth Community Stroke Study in 1989-90 and 1995-96...
  24. doi request reprint Homocysteine, frailty, and all-cause mortality in older men: the health in men study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Perth, Australia
    J Gerontol A Biol Sci Med Sci 68:590-8. 2013
    ..Frailty and hyperhomocysteinemia are common in the older population. The researchers' objectives were to determine whether elevated homocysteine (tHcy) is associated with frailty and mortality...
  25. ncbi request reprint Protein Z in ischemic stroke and its etiologic subtypes
    Andrew M McQuillan
    Department of Hematology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6897, Australia
    Stroke 34:2415-9. 2003
    ..The objectives of this study were to determine the association between protein Z, ischemic stroke, and etiologic subtypes of ischemic stroke...
  26. doi request reprint Traditional risk factors for incident cardiovascular events have limited importance in later life compared with the health in men study cardiovascular risk score
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
    Stroke 42:952-9. 2011
    ..This study aimed to determine, among older men, the risk and independent significant baseline prognostic factors for first-ever stroke and MI...
  27. ncbi request reprint Adding aspirin to clopidogrel after TIA and ischemic stroke: benefits do not match risks
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Neurology 64:1117-21. 2005
    ....
  28. doi request reprint Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial
    Graeme J Hankey
    Neurology Department, Stroke Unit, Royal Perth Hospital, Perth, Australia
    Int J Stroke 6:3-9. 2011
    ....
  29. doi request reprint 24-month effect of smoking cessation on cognitive function and brain structure in later life
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Crawley, Perth, WA, Australia
    Neuroimage 55:1480-9. 2011
    ..We completed this trial to determine if smoking cessation decreases the progression of cognitive decline in later life...
  30. doi request reprint Prevalence of sexual activity and associated factors in men aged 75 to 95 years: a cohort study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, School of Medicine and Pharmacology, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
    Ann Intern Med 153:693-702. 2010
    ..Knowledge about sexuality in elderly persons is limited, and normative data are lacking...
  31. doi request reprint Elevated homocysteine is associated with poorer self-perceived physical health in older men: the Health in Men Study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, Perth, WA, Australia
    Maturitas 73:158-63. 2012
    ....
  32. doi request reprint Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial
    Graeme J Hankey
    FRACP, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia 6001
    Stroke 43:1572-7. 2012
    ..To determine the effect of B vitamin treatment on the incidence of cancer among patients with stroke or transient ischemic attack...
  33. ncbi request reprint Thromboprophylaxis practice patterns in two Western Australian teaching hospitals
    John W Eikelboom
    Department of Hematology, Royal Perth Hospital, Wellington Street, Perth, WA, 6001 Australia
    Haematologica 89:586-93. 2004
    ..Our objective was to determine what proportion of patients undergoing elective hip or knee arthroplasty actually receive recommended thromboprophylaxis according to international guidelines...
  34. pmc Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational study
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, WA, Australia
    Br J Clin Pharmacol 71:592-9. 2011
    ..To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes...
  35. pmc Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Perth, WA, Australia
    Int J Epidemiol 38:1049-59. 2009
    ..The aim of this study is to determine if polymorphisms of SNPs rs1130864 and rs1205 are associated with prevalent depression...
  36. doi request reprint Body mass index and survival in men and women aged 70 to 75
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
    J Am Geriatr Soc 58:234-41. 2010
    ..To examine in an older population all-cause and cause-specific mortality associated with underweight (body mass index (BMI)<18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25.0-29.9), and obesity (BMI> or =30.0)...
  37. ncbi request reprint Association of cardiovascular risk factors and disease with depression in later life
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
    Am J Geriatr Psychiatry 15:506-13. 2007
    ..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men...
  38. pmc Body adiposity in later life and the incidence of dementia: the health in men study
    Brian D Power
    Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia
    PLoS ONE 6:e17902. 2011
    ..To determine if adiposity in later life increases dementia hazard...
  39. ncbi request reprint Secondary prevention of recurrent stroke
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Stroke 36:218-21. 2005
  40. ncbi request reprint Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Stroke 37:547-9. 2006
    ..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels...
  41. doi request reprint Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
    J Clin Endocrinol Metab 97:4030-9. 2012
    ..Objective: We assessed the associations of T, DHT, and E2 in men aged 70 yr or older and established reference ranges for these in healthy older men...
  42. doi request reprint Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 164:715-23. 2011
    ..We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular mortality in older men...
  43. ncbi request reprint Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Clin Endocrinol (Oxf) 68:404-12. 2008
    ..To determine the relationship of total and free serum testosterone to cognitive performance in older men...
  44. doi request reprint B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
    Ann Neurol 68:503-10. 2010
    ..The purpose of this research was to determine if treatment with B-vitamins reduces the hazard of poststroke depression compared with placebo...
  45. doi request reprint A randomized placebo controlled trial of early treatment of acute ischemic stroke with atorvastatin and irbesartan
    Christopher Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, WA, Australia
    Int J Stroke 7:104-11. 2012
    ..Cholesterol and blood pressure lowering therapies are effective in the secondary prevention of ischemic stroke...
  46. ncbi request reprint Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Clin Endocrinol (Oxf) 70:455-63. 2009
    ..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men...
  47. ncbi request reprint Is there a role for laboratory testing to identify patients at risk of aspirin treatment failure?
    Wai Khoon Ho
    Centre for Clinical Research Excellence, Department of Neurology and Department of Haematology, Royal Perth Hospital, Australia and School of Medicine and Pharmacology, University of Western Australia, Australia
    Blood Coagul Fibrinolysis 15:129-30. 2004
  48. doi request reprint Replacing aspirin and warfarin for secondary stroke prevention: is it worth the costs?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia, Australia
    Curr Opin Neurol 23:65-72. 2010
    ..This review aims to determine whether it is cost-effective to replace aspirin and warfarin with more effective, yet more costly, treatments for secondary stroke prevention...
  49. ncbi request reprint Venous thromboembolism: diagnosis and management of pulmonary embolism
    Cindy H Lee
    Department of Haematology, Royal Perth Hospital, Perth, WA, Australia
    Med J Aust 182:569-74. 2005
    ....
  50. doi request reprint Homocysteine or renal impairment: which is the real cardiovascular risk factor?
    Kathleen Potter
    Department of Cardiology, Level 4, A Block, Royal Perth Hospital, Perth WA6847, Australia
    Arterioscler Thromb Vasc Biol 28:1158-64. 2008
    ....
  51. pmc Alcohol consumption and cognitive impairment in older men: a mendelian randomization study
    Osvaldo P Almeida
    From the School of Psychiatry and Clinical Neurosciences O P A, and School of Medicine and Pharmacology G J H, B B Y, L F, University of Western Australia, Perth WA Centre for Health and Ageing O P A, L F, Centre for Medical Research, Perth Departments of Psychiatry O P A and Geriatric Medicine L F, Royal Perth Hospital Department of Neurology G J H, Sir Charles Gairdner Hospital, Perth Department of Endocrinology B B Y, Fremantle Hospital, Fremantle Queensland Research Centre for Peripheral Vascular Disease J G, School of Medicine and Dentistry, James Cook University, Townsville and Department of Vascular and Endovascular Surgery J G, The Townsville Hospital, Townsville, Australia
    Neurology 82:1038-44. 2014
    ..To determine whether alcohol consumption is causally associated with cognitive impairment in older men as predicted by mendelian randomization...
  52. doi request reprint Higher free thyroxine levels are associated with frailty in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
    Clin Endocrinol (Oxf) 76:741-8. 2012
    ..Some symptoms of frailty overlap those of thyroid dysfunction, but it is unclear whether differences in thyroid status influence risk of frailty. We evaluated associations between thyroid status and frailty in older men...
  53. ncbi request reprint Antiplatelet therapy for stroke prevention
    Graeme J Hankey
    Consultant Neurologist and Head of Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Western Australia 6001, Australia
    Curr Atheroscler Rep 9:312-8. 2007
    ..A large trial comparing clopidogrel with the combination of aspirin and extended-release dipyridamole in more than 20,000 patients with recent (< 120 days) atherothrombotic ischemic stroke is expected to report in 2008...
  54. ncbi request reprint Antiplatelet therapy for the prevention of recurrent stroke and other serious vascular events: a review of the clinical trial data and guidelines
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA 6000, Australia
    Curr Med Res Opin 23:1453-62. 2007
    ..One strategy of reducing the burden of stroke is the prevention of recurrent stroke, following an initial ischaemic stroke or transient ischaemic attack (TIA) of arterial origin, by means of antiplatelet therapy...
  55. ncbi request reprint The tissue factor pathway in ischemic stroke
    Murray J Adams
    Western Australian Biomedical Research Institute, School of Biomedical Sciences, Curtin University, Perth, Australia
    Blood Coagul Fibrinolysis 17:527-32. 2006
    ....
  56. ncbi request reprint Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial
    Graeme J Hankey
    Neurology Department, Royal Perth Hospital, Perth, Australia
    Stroke 41:1679-83. 2010
    ....
  57. ncbi request reprint Clinical usefulness of plasma homocysteine in vascular disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Wellington Street, Perth, Western Australia, 6001
    Med J Aust 181:314-8. 2004
    ..There is currently insufficient evidence to recommend routine screening and treatment of high tHcy concentrations with folic acid and other vitamins to prevent atherothrombotic vascular disease...
  58. pmc In older men, lower plasma 25-hydroxyvitamin d is associated with reduced incidence of prostate, but not colorectal or lung cancer
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    PLoS ONE 9:e99954. 2014
    ..Prostate, colorectal and lung cancers are common in men. In this study, we aimed to determine whether vitamin D status is associated with the incidence of these cancers in older men...
  59. ncbi request reprint Ximelagatran or warfarin for stroke prevention in patients with atrial fibrillation?
    Graeme J Hankey
    Stroke Unit, Royal Perth Hospital, 197 Wellington Street Perth, Australia 6001
    Stroke 35:389-91. 2004
  60. doi request reprint Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis
    Edith Kohler
    Royal Perth Hospital, Perth, Australia
    Stroke 44:2493-9. 2013
    ..Minocycline, in animal models and 2 small randomized controlled human trials, is a promising neuroprotective agent in acute stroke. We analyzed the efficacy and safety of intravenous minocycline in acute ischemic and hemorrhagic stroke...
  61. ncbi request reprint Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes
    Paul Cherian
    Department of Medicine, University of Western Australia, Perth, Australia
    Stroke 34:2132-7. 2003
    ..We also hypothesized that these markers would be differentially elevated in ischemic stroke caused by large- and small-artery atherothrombosis compared with cardiogenic embolism...
  62. pmc Management of peripheral arterial disease in the elderly: focus on cilostazol
    Travis M Falconer
    School of Surgery, University of Western Australia, Fremantle Hospital, Western Australia, Australia
    Clin Interv Aging 3:17-23. 2008
    ..In addition to risk factor management, treatment with cilostazol should be considered in patients with disabling IC...
  63. ncbi request reprint Ongoing and planned trials of antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes: setting a new standard of care
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Cerebrovasc Dis 17:11-6. 2004
    ..These ongoing and planned clinical trials of antiplatelet therapy promise to further define the role of combination antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes...
  64. ncbi request reprint Prevention of coronary heart disease with aspirin and clopidogrel: efficacy, safety, costs and cost-effectiveness
    Wai Khoon Ho
    Department of Haematology, Royal Perth Hospital, Perth, Australia
    Expert Opin Pharmacother 5:493-503. 2004
    ..g., > 20%/year). The combination of clopidogrel and aspirin should be considered in patients with non-ST-segment elevation acute coronary syndrome or undergoing percutaneous coronary intervention...
  65. ncbi request reprint Venous thromboembolism: diagnosis and management of deep venous thrombosis
    Wai Khoon Ho
    Royal Perth Hospital, Perth, WA
    Med J Aust 182:476-81. 2005
    ..The risk of recurrence is highest in people with recurrent unprovoked DVT or chronic predisposing factors (eg, cancer) who require indefinite anticoagulant treatment...
  66. ncbi request reprint Aspirin resistance
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Lancet 367:606-17. 2006
    ..Potential mechanisms of aspirin resistance can then be explored and treatments assessed...
  67. ncbi request reprint Is plasma homocysteine a modifiable risk factor for stroke?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Nat Clin Pract Neurol 2:26-33. 2006
    ....
  68. doi request reprint Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Australia
    Lancet Neurol 9:273-84. 2010
    ..Other new anticoagulants, including the oral factor Xa inhibitors, rivaroxaban, apixaban, and edoxaban, the parenteral factor Xa inhibitor, idrabiotaparinux, and the novel VKA, tecarfarin, are currently being assessed...
  69. ncbi request reprint Ten-year risk of first recurrent stroke and disability after first-ever stroke in the Perth Community Stroke Study
    Kate Hardie
    School of Population Health, University of Western Australia, Perth, Australia
    Stroke 35:731-5. 2004
    ..We aimed to determine the absolute frequency of first recurrent stroke and disability and the relative frequency of recurrent stroke over 10 years after first-ever stroke in Perth, Western Australia...
  70. ncbi request reprint Management of cholesterol to reduce the burden of stroke in Asia: consensus statement
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Int J Stroke 5:209-16. 2010
    ..Further trials of statins in Asian patients are also needed, particularly in those with intracranial stenosis...
  71. doi request reprint Systemic arterial inflammation, measured with 18FDG-PET, is common amongst subjects with both recent and prior cerebrovascular disease
    Christopher D Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Australia
    Clin Neurol Neurosurg 114:613-6. 2012
    ..To compare systemic arterial inflammation in subjects with recent ischaemic stroke or TIA and controls with prior cerebrovascular disease...
  72. ncbi request reprint Preventing depression after stroke: Results from a randomized placebo-controlled trial
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, Royal Perth Hospital and University of Western Australia, Perth, Australia
    J Clin Psychiatry 67:1104-9. 2006
    ..We designed this study to determine whether the daily treatment of nondepressed acute stroke patients with sertraline reduced the incidence of depression at follow-up...
  73. doi request reprint Premorbid personality traits are associated with post-stroke behavioral and psychological symptoms: a three-month follow-up study in Perth, Western Australia
    Kathryn R Greenop
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Int Psychogeriatr 21:1063-71. 2009
    ..This study sought to investigate further the relationship between premorbid personality and a number of common post-stroke behavioral and psychological symptoms in a three-month follow-up study...
  74. pmc Depression, antidepressant use and mortality in later life: the Health In Men Study
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 5:e11266. 2010
    ..Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants...
  75. doi request reprint Which dietary and lifestyle behaviours may be important in the aetiology (and prevention) of stroke?
    W Y Yau
    School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia
    J Clin Neurosci 18:76-80. 2011
    ..However, these associations need confirmation from larger randomised trials given the small sample size of the current study...
  76. doi request reprint Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Lancet Neurol 11:315-22. 2012
    ..We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA)...
  77. ncbi request reprint Antiplatelet drugs
    Graeme J Hankey
    Royal Perth Hospital, 197 Wellington Street, Perth, WA 6001, Australia
    Med J Aust 178:568-74. 2003
    ....
  78. doi request reprint How I interpreted the randomised trials of carotid angioplasty/stenting versus endarterectomy
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Eur J Vasc Endovasc Surg 36:34-40. 2008
    ..More importantly, it will be possible to determine which patients should be treated preferentially with CAS, which patients with CEA, and which patients should not undergo either revascularisation procedure...
  79. ncbi request reprint Failure of aspirin to prevent atherothrombosis: potential mechanisms and implications for clinical practice
    John W Eikelboom
    Department of Haematology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
    Am J Cardiovasc Drugs 4:57-67. 2004
    ....
  80. doi request reprint Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Arch Gen Psychiatry 65:283-9. 2008
    ..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity...
  81. ncbi request reprint Medical treatment of peripheral arterial disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
    JAMA 295:547-53. 2006
    ..The goals of treatment are to prevent future major coronary and cerebrovascular events and improve leg symptoms...
  82. ncbi request reprint Clinical update: management of stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
    Lancet 369:1330-2. 2007
  83. ncbi request reprint Management of acute ischaemic stroke: new guidelines from the American Stroke Association and European Stroke Initiative
    Catharina J M Klijn
    Stroke Unit, Department of Neurolgoy, Royal Perth Hospital, Perth, Western Australia, Australia
    Lancet Neurol 2:698-701. 2003
    ..And finally, to improve the uptake of effective therapies into clinical practice (eg, by widely disseminating the ASA and EUSI guidelines)...
  84. ncbi request reprint Cyclooxygenase-2 inhibitors: are they really atherothrombotic, and if not, why not?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
    Stroke 34:2736-40. 2003
    ....
  85. ncbi request reprint Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, and Stroke Unit, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Clin Sci (Lond) 121:501-7. 2011
    ..Further investigation of the effect this has on long-term clinical outcome or whether this can be modified by treatment is warranted...
  86. ncbi request reprint Potential new risk factors for ischemic stroke: what is their potential?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia, 6001
    Stroke 37:2181-8. 2006
    ..The aim of this review was to examine the potential role of other risk factors in the etiology of ischemic stroke...
  87. pmc Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study
    Christopher D Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 8:46. 2010
    ..We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function...
  88. ncbi request reprint Vascular disease of the heart, brain and limbs: new insights into a looming epidemic
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
    Lancet 366:1753-4. 2005
  89. ncbi request reprint Aspirin resistance: a new independent predictor of vascular events?
    John W Eikelboom
    Department of Haematology, Royal Perth Hospital, Wellington Street, Perth, WA 6001, Australia
    J Am Coll Cardiol 41:966-8. 2003
  90. ncbi request reprint Folic acid-based multivitamin therapy to prevent stroke: the jury is still out
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia 6001
    Stroke 35:1995-8. 2004
  91. ncbi request reprint Long-term outcome after ischaemic stroke/transient ischaemic attack
    Graeme J Hankey
    Stroke Unit, Royal Perth Hospital and Department of Medicine, University of Western Australia, Perth, WA, Australia
    Cerebrovasc Dis 16:14-9. 2003
    ....