G J Hankey

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Clinical update: management of stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
    Lancet 369:1330-2. 2007
  2. doi request reprint Homocysteine and depression in later life
    Osvaldo P Almeida
    FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Arch Gen Psychiatry 65:1286-94. 2008
  3. doi request reprint Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Lancet Neurol 11:315-22. 2012
  4. pmc Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts
    Annette Dobson
    The University of Queensland, School of Population Health, Herston, Australia
    BMC Public Health 12:669. 2012
  5. doi request reprint Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Australia
    J Neurol Neurosurg Psychiatry 84:281-7. 2013
  6. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
  7. doi request reprint Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial
    Graeme J Hankey
    FRACP, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia 6001
    Stroke 43:1572-7. 2012
  8. pmc Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Lancet Neurol 11:512-20. 2012
  9. pmc Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke
    Christopher Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Australia
    J Neuroinflammation 7:71. 2010
  10. pmc Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study
    Christopher D Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 8:46. 2010

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Clinical update: management of stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
    Lancet 369:1330-2. 2007
  2. doi request reprint Homocysteine and depression in later life
    Osvaldo P Almeida
    FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Arch Gen Psychiatry 65:1286-94. 2008
    ..Genetic association studies are not prone to the same sources of error and offer an opportunity to explore the consistency and external validity of this association...
  3. doi request reprint Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Lancet Neurol 11:315-22. 2012
    ..We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA)...
  4. pmc Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts
    Annette Dobson
    The University of Queensland, School of Population Health, Herston, Australia
    BMC Public Health 12:669. 2012
    ..The aim of this paper is to calculate population based estimates and display them using simple charts that may be useful communication tools for public health authorities, health care providers and policy makers...
  5. doi request reprint Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Australia
    J Neurol Neurosurg Psychiatry 84:281-7. 2013
    ..We determined the rates and predictors of risk of stroke and its subtypes in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial...
  6. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
    ..IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit...
  7. doi request reprint Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial
    Graeme J Hankey
    FRACP, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia 6001
    Stroke 43:1572-7. 2012
    ..To determine the effect of B vitamin treatment on the incidence of cancer among patients with stroke or transient ischemic attack...
  8. pmc Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Lancet Neurol 11:512-20. 2012
    ....
  9. pmc Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke
    Christopher Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Australia
    J Neuroinflammation 7:71. 2010
    ..We aimed to determine if systemic markers of vascular dysfunction and inflammation are independently associated with concentrations of the astroglial protein S100B, a marker of brain injury, in participants with acute ischaemic stroke...
  10. pmc Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study
    Christopher D Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 8:46. 2010
    ..We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function...
  11. pmc Ultrasound settings significantly alter arterial lumen and wall thickness measurements
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 6:6. 2008
    ..We aimed to quantify the effect that commonly adjusted ultrasound settings have on arterial lumen and wall thickness measurements made with CIMT measurement software...
  12. pmc Carotid intima-medial thickness measured on multiple ultrasound frames: evaluation of a DICOM-based software system
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Cardiovasc Ultrasound 5:29. 2007
    ....
  13. pmc The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    BMC Cardiovasc Disord 8:24. 2008
    ..B-vitamin supplements reduce tHcy and improve endothelial function in short term trials, but the long-term effects of the treatment on vascular structure and function are unknown...
  14. doi request reprint Management of cholesterol to reduce the burden of stroke in Asia: consensus statement
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Int J Stroke 5:209-16. 2010
    ..Further trials of statins in Asian patients are also needed, particularly in those with intracranial stenosis...
  15. doi request reprint Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial
    Graeme J Hankey
    Neurology Department, Royal Perth Hospital, Perth, Australia
    Stroke 41:1679-83. 2010
    ....
  16. ncbi request reprint Secondary prevention of recurrent stroke
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Stroke 36:218-21. 2005
  17. ncbi request reprint Sustained homocysteine-lowering effect over time of folic acid-based multivitamin therapy in stroke patients despite increasing folate status in the population
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Cerebrovasc Dis 19:110-6. 2005
    ....
  18. doi request reprint Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Australia
    Lancet Neurol 9:273-84. 2010
    ..Other new anticoagulants, including the oral factor Xa inhibitors, rivaroxaban, apixaban, and edoxaban, the parenteral factor Xa inhibitor, idrabiotaparinux, and the novel VKA, tecarfarin, are currently being assessed...
  19. ncbi request reprint Folic acid-based multivitamin therapy to prevent stroke: the jury is still out
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia 6001
    Stroke 35:1995-8. 2004
  20. ncbi request reprint Clinical usefulness of plasma homocysteine in vascular disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Wellington Street, Perth, Western Australia, 6001
    Med J Aust 181:314-8. 2004
    ..There is currently insufficient evidence to recommend routine screening and treatment of high tHcy concentrations with folic acid and other vitamins to prevent atherothrombotic vascular disease...
  21. ncbi request reprint Homocysteine and stroke
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
    Lancet 365:194-6. 2005
  22. ncbi request reprint Adding aspirin to clopidogrel after TIA and ischemic stroke: benefits do not match risks
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Neurology 64:1117-21. 2005
    ....
  23. ncbi request reprint Time frame and predictors of recovery from disability following recurrent ischemic stroke
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia, 6000
    Neurology 68:202-5. 2007
    ..To assess the rate, degree, and predictors of recovery from a disabled to nondisabled state in patients disabled after recurrent ischemic stroke...
  24. ncbi request reprint Rate, degree, and predictors of recovery from disability following ischemic stroke
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Neurology 68:1583-7. 2007
    ..To determine the rate, degree, and predictors of recovery from disabling ischemic stroke...
  25. ncbi request reprint Antiplatelet therapy for the prevention of recurrent stroke and other serious vascular events: a review of the clinical trial data and guidelines
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA 6000, Australia
    Curr Med Res Opin 23:1453-62. 2007
    ..One strategy of reducing the burden of stroke is the prevention of recurrent stroke, following an initial ischaemic stroke or transient ischaemic attack (TIA) of arterial origin, by means of antiplatelet therapy...
  26. ncbi request reprint Is plasma homocysteine a modifiable risk factor for stroke?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Nat Clin Pract Neurol 2:26-33. 2006
    ....
  27. ncbi request reprint Potential new risk factors for ischemic stroke: what is their potential?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia, 6001
    Stroke 37:2181-8. 2006
    ..The aim of this review was to examine the potential role of other risk factors in the etiology of ischemic stroke...
  28. ncbi request reprint Antiplatelet therapy for stroke prevention
    Graeme J Hankey
    Consultant Neurologist and Head of Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Western Australia 6001, Australia
    Curr Atheroscler Rep 9:312-8. 2007
    ..A large trial comparing clopidogrel with the combination of aspirin and extended-release dipyridamole in more than 20,000 patients with recent (< 120 days) atherothrombotic ischemic stroke is expected to report in 2008...
  29. doi request reprint When the patient fails to respond to treatment: TIAs that go on, and on
    G J Hankey
    Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia
    Pract Neurol 8:103-11. 2008
    ....
  30. doi request reprint How I interpreted the randomised trials of carotid angioplasty/stenting versus endarterectomy
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Eur J Vasc Endovasc Surg 36:34-40. 2008
    ..More importantly, it will be possible to determine which patients should be treated preferentially with CAS, which patients with CEA, and which patients should not undergo either revascularisation procedure...
  31. ncbi request reprint Vascular disease of the heart, brain and limbs: new insights into a looming epidemic
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
    Lancet 366:1753-4. 2005
  32. ncbi request reprint Preventable stroke and stroke prevention
    G J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Australia
    J Thromb Haemost 3:1638-45. 2005
    ....
  33. ncbi request reprint Redefining risks after TIA and minor ischaemic stroke
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Lancet 365:2065-6. 2005
  34. ncbi request reprint Is clopidogrel the antiplatelet drug of choice for high-risk patients with stroke/TIA?: No
    G J Hankey
    Stroke Unit, Royal Perth Hospital, Perth, Australia
    J Thromb Haemost 3:1137-40. 2005
  35. doi request reprint Replacing aspirin and warfarin for secondary stroke prevention: is it worth the costs?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia, Australia
    Curr Opin Neurol 23:65-72. 2010
    ..This review aims to determine whether it is cost-effective to replace aspirin and warfarin with more effective, yet more costly, treatments for secondary stroke prevention...
  36. doi request reprint Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial
    Graeme J Hankey
    Neurology Department, Stroke Unit, Royal Perth Hospital, Perth, Australia
    Int J Stroke 6:3-9. 2011
    ....
  37. ncbi request reprint Management of the first-time transient ischaemic attack
    G J Hankey
    Department of Neurology, Royal Perth Hospital, University of Western Australia, Perth, Australia
    Emerg Med (Fremantle) 13:70-81. 2001
    ..g. migraine aura, partial seizures, benign paroxysmal positional vertigo, hysteria). This comprehensive review outlines an approach to the management of this complex and challenging problem...
  38. ncbi request reprint Surgery for primary intracerebral hemorrhage: is it safe and effective? A systematic review of case series and randomized trials
    G J Hankey
    Department of Neurology, Royal Perth Hospital, Western Australia, Australia
    Stroke 28:2126-32. 1997
    ..This study compares the outcome of patients with PICH who are treated surgically with those who are not...
  39. ncbi request reprint Current oral antiplatelet agents to prevent atherothrombosis
    G J Hankey
    Stroke Unit, Royal Perth Hospital, Perth, Australia
    Cerebrovasc Dis 11:11-7. 2001
    ....
  40. ncbi request reprint Homocysteine and stroke
    G J Hankey
    Stroke Unit, Royal Perth Hospital, Western Australia and Department of Medicine, University of Western Australia
    Curr Opin Neurol 14:95-102. 2001
    ..The results of ongoing clinical trials in stroke patients to determine the impact of multivitamin therapy on recurrent stroke and other serious vascular events are awaited...
  41. ncbi request reprint Five-year survival after first-ever stroke and related prognostic factors in the Perth Community Stroke Study
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital Western Australia
    Stroke 31:2080-6. 2000
    ....
  42. ncbi request reprint Transient ischaemic attacks and stroke
    G J Hankey
    Royal Perth Hospital, WA
    Med J Aust 172:394-400. 2000
    ..They should undergo immediate computed tomography brain scan and, if intracranial haemorrhage is excluded, be given aspirin (160-300 mg). Rehabilitation and secondary prevention of recurrent stroke should begin on day one after stroke...
  43. ncbi request reprint Stroke prediction and prevention by carotid endarterectomy: keep an eye on the doughnut and not just the hole
    G J Hankey
    Stroke Unit, Royal Perth Hospital and University of Western Australia, Perth, W A, Australia
    Cerebrovasc Dis 9:345-50. 1999
    ....
  44. ncbi request reprint Treatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populations
    G J Hankey
    Royal Perth Hospital, and Department of Medicine, University of Western Australia
    Lancet 354:1457-63. 1999
    ....
  45. ncbi request reprint Smoking and risk of stroke
    G J Hankey
    Department of Neurology, Royal Perth Hospital, University of Western Australia, Australia
    J Cardiovasc Risk 6:207-11. 1999
    ..The mechanisms by which smoking causes stroke remain uncertain, but are probably multifactorial and primarily atherogenic...
  46. ncbi request reprint Homocysteine and vascular disease
    G J Hankey
    Department of Neurology, Royal Perth Hospital, Western Australia
    Lancet 354:407-13. 1999
    ....
  47. ncbi request reprint Heparin in acute ischaemic stroke. The T wave is negative and it's time to stop
    G J Hankey
    Stroke Unit, Royal Perth Hospital, WA
    Med J Aust 169:534-6. 1998
    ....
  48. ncbi request reprint Long-term risk of first recurrent stroke in the Perth Community Stroke Study
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
    Stroke 29:2491-500. 1998
    ..BACKGROUND and..
  49. ncbi request reprint Homocysteine levels in patients with stroke: clinical relevance and therapeutic implications
    G J Hankey
    Royal Perth Hospital, and Department of Medicine, University of Western Australia, Perth, Western Australia, Australia
    CNS Drugs 15:437-43. 2001
    ....
  50. ncbi request reprint Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
    Stroke 33:1034-40. 2002
    ..This population-based study aimed to describe disability, dependency, and related independent prognostic factors at 5 years after a first-ever stroke in patients in Perth, Western Australia...
  51. ncbi request reprint Warfarin-Aspirin Recurrent Stroke Study (WARSS) trial: is warfarin really a reasonable therapeutic alternative to aspirin for preventing recurrent noncardioembolic ischemic stroke?
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, Western Australia
    Stroke 33:1723-6. 2002
  52. ncbi request reprint Ximelagatran or warfarin for stroke prevention in patients with atrial fibrillation?
    Graeme J Hankey
    Stroke Unit, Royal Perth Hospital, 197 Wellington Street Perth, Australia 6001
    Stroke 35:389-91. 2004
  53. ncbi request reprint Ongoing and planned trials of antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes: setting a new standard of care
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
    Cerebrovasc Dis 17:11-6. 2004
    ..These ongoing and planned clinical trials of antiplatelet therapy promise to further define the role of combination antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes...
  54. ncbi request reprint Cyclooxygenase-2 inhibitors: are they really atherothrombotic, and if not, why not?
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
    Stroke 34:2736-40. 2003
    ....
  55. doi request reprint Nutrition and the risk of stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Western Australia
    Lancet Neurol 11:66-81. 2012
    ..Future challenges include the need to improve the quality of evidence linking many nutrients, foods, and dietary patterns to the risk of stroke...
  56. ncbi request reprint Antiplatelet drugs
    Graeme J Hankey
    Royal Perth Hospital, 197 Wellington Street, Perth, WA 6001, Australia
    Med J Aust 178:568-74. 2003
    ....
  57. ncbi request reprint One year after CAPRIE, IST and ESPS 2. Any changes in concepts?
    G J Hankey
    Royal Perth Hospital, and University of Western Australia, Perth, Western Australia
    Cerebrovasc Dis 8:1-7. 1998
    ....
  58. ncbi request reprint Evacuation of intracerebral hematoma is likely to be beneficial--against
    Graeme J Hankey
    Department of Medicine, University of Western Australia, Perth, Western Australia
    Stroke 34:1568-9. 2003
  59. ncbi request reprint Long-term outcome after ischaemic stroke/transient ischaemic attack
    Graeme J Hankey
    Stroke Unit, Royal Perth Hospital and Department of Medicine, University of Western Australia, Perth, WA, Australia
    Cerebrovasc Dis 16:14-9. 2003
    ....
  60. ncbi request reprint Angiotensin-converting enzyme inhibitors for stroke prevention: is there HOPE for PROGRESS After LIFE?
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, University of Western Australia, Perth, Australia
    Stroke 34:354-6. 2003
  61. ncbi request reprint Role of lipid-modifying therapy in the prevention of initial and recurrent stroke
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital, Western Australia
    Curr Opin Lipidol 13:645-51. 2002
    ..To establish the role of cholesterol-modifying therapy in stroke prevention...
  62. ncbi request reprint Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy o
    P Dusitanond
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Stroke 36:144-6. 2005
    ....
  63. doi request reprint Is hypovitaminosis D associated with abdominal aortic aneurysm, and is there a dose-response relationship?
    Y Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
    Eur J Vasc Endovasc Surg 45:657-64. 2013
    ..This study aims to investigate the association between plasma 25-hydroxyvitamin D (25(OH)D) concentrations with the presence of abdominal aortic aneurysm (AAA) and aortic diameter...
  64. pmc Association between phosphodiesterase 4D gene and ischaemic stroke
    J M Staton
    Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia
    J Neurol Neurosurg Psychiatry 77:1067-9. 2006
    ..An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group...
  65. pmc Aspirin decreases the risk of depression in older men with high plasma homocysteine
    O P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Transl Psychiatry 2:e151. 2012
    ..Randomized trials are required to confirm the antidepressant effect of aspirin in people with high tHcy...
  66. ncbi request reprint Inherited thrombophilia in ischemic stroke and its pathogenic subtypes
    G J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
    Stroke 32:1793-9. 2001
    ..Whether the thrombophilias may still be important in younger patients with ischemic stroke or in predicting complications (eg, venous thrombosis) and stroke outcome remains uncertain...
  67. ncbi request reprint Ten-year risk of first recurrent stroke and disability after first-ever stroke in the Perth Community Stroke Study
    Kate Hardie
    School of Population Health, University of Western Australia, Perth, Australia
    Stroke 35:731-5. 2004
    ..We aimed to determine the absolute frequency of first recurrent stroke and disability and the relative frequency of recurrent stroke over 10 years after first-ever stroke in Perth, Western Australia...
  68. ncbi request reprint The risks and benefits of antithrombotic therapy in chronic atrial fibrillation
    G J Hankey
    Quality Improvement Unit, Royal Perth Hospital, Perth, WA
    Med J Aust 164:624-6. 1996
    ..Clearer guidelines are emerging to identify those patients and to standardise current prescribing practices...
  69. ncbi request reprint Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke
    J Staton
    Department of Hematology, Royal Perth Hospital, Perth, Australia
    Stroke 36:1123-7. 2005
    ....
  70. ncbi request reprint Protein Z in ischemic stroke and its etiologic subtypes
    Andrew M McQuillan
    Department of Hematology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6897, Australia
    Stroke 34:2415-9. 2003
    ..The objectives of this study were to determine the association between protein Z, ischemic stroke, and etiologic subtypes of ischemic stroke...
  71. pmc Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study
    A H Ford
    WA Centre for Health and Ageing, Centre for Medical Research and School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Mol Psychiatry 17:559-66. 2012
    ..46, 95% CI 1.01-2.11, P=0.043). The results of this study are consistent with, but do not prove the hypothesis that high tHcy causes cognitive impairment in later life...
  72. ncbi request reprint Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes
    Paul Cherian
    Department of Medicine, University of Western Australia, Perth, Australia
    Stroke 34:2132-7. 2003
    ..We also hypothesized that these markers would be differentially elevated in ischemic stroke caused by large- and small-artery atherothrombosis compared with cardiogenic embolism...
  73. ncbi request reprint Prevention of coronary heart disease with aspirin and clopidogrel: efficacy, safety, costs and cost-effectiveness
    Wai Khoon Ho
    Department of Haematology, Royal Perth Hospital, Perth, Australia
    Expert Opin Pharmacother 5:493-503. 2004
    ..g., > 20%/year). The combination of clopidogrel and aspirin should be considered in patients with non-ST-segment elevation acute coronary syndrome or undergoing percutaneous coronary intervention...
  74. ncbi request reprint Trends in five-year survival and risk of recurrent stroke after first-ever stroke in the Perth Community Stroke Study
    Kate Hardie
    School of Population Health, University of Western Australia, Perth, Australia
    Cerebrovasc Dis 19:179-85. 2005
    ..We aimed to determine trends in survival and recurrent stroke, over 5 years after first-ever stroke, for 2 cohorts of patients enrolled in the Perth Community Stroke Study in 1989-90 and 1995-96...
  75. ncbi request reprint Thrombolytic therapy in acute ischaemic stroke: the jury needs more evidence
    G J Hankey
    Department of Neurology, Royal Perth Hospital, Perth, WA
    Med J Aust 166:419-22. 1997
    ..More research is needed to determine which stroke patients will benefit from thrombolysis and the best regimen to use...
  76. doi request reprint Higher luteinizing hormone is associated with poor memory recall: the health in men study
    Zoe Hyde
    Western Australian Institute for Medical Research, Australia
    J Alzheimers Dis 19:943-51. 2010
    ..These findings suggest a role for both androgens and gonadotropins in differing cognitive domains, and that gonadotropins may influence cognition independent of sex steroids...
  77. doi request reprint Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
    Am J Geriatr Psychiatry 17:889-98. 2009
    ....
  78. doi request reprint Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 161:591-8. 2009
    ..We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity...
  79. pmc Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Perth, WA, Australia
    Int J Epidemiol 38:1049-59. 2009
    ..The aim of this study is to determine if polymorphisms of SNPs rs1130864 and rs1205 are associated with prevalent depression...
  80. doi request reprint Body mass index and survival in men and women aged 70 to 75
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
    J Am Geriatr Soc 58:234-41. 2010
    ..To examine in an older population all-cause and cause-specific mortality associated with underweight (body mass index (BMI)<18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25.0-29.9), and obesity (BMI> or =30.0)...
  81. doi request reprint Low free testosterone predicts frailty in older men: the health in men study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 95:3165-72. 2010
    ..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome...
  82. ncbi request reprint Population-based observational study of claudication in older men: the Health in Men Study
    Rahul Lakshmanan
    University of Western Australia, Fremantle Hospital, Fremantle, WA, Australia
    Med J Aust 192:641-5. 2010
    ..To assess the prevalence of and risk factors for claudication and its association with subsequent cardiovascular events...
  83. pmc Depression, antidepressant use and mortality in later life: the Health In Men Study
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 5:e11266. 2010
    ..Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants...
  84. ncbi request reprint Thromboprophylaxis practice patterns in two Western Australian teaching hospitals
    John W Eikelboom
    Department of Hematology, Royal Perth Hospital, Wellington Street, Perth, WA, 6001 Australia
    Haematologica 89:586-93. 2004
    ..Our objective was to determine what proportion of patients undergoing elective hip or knee arthroplasty actually receive recommended thromboprophylaxis according to international guidelines...
  85. doi request reprint B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
    Ann Neurol 68:503-10. 2010
    ..The purpose of this research was to determine if treatment with B-vitamins reduces the hazard of poststroke depression compared with placebo...
  86. doi request reprint Traditional risk factors for incident cardiovascular events have limited importance in later life compared with the health in men study cardiovascular risk score
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
    Stroke 42:952-9. 2011
    ..This study aimed to determine, among older men, the risk and independent significant baseline prognostic factors for first-ever stroke and MI...
  87. ncbi request reprint Aspirin resistance: a new independent predictor of vascular events?
    John W Eikelboom
    Department of Haematology, Royal Perth Hospital, Wellington Street, Perth, WA 6001, Australia
    J Am Coll Cardiol 41:966-8. 2003
  88. doi request reprint Lower testosterone levels predict incident stroke and transient ischemic attack in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
    J Clin Endocrinol Metab 94:2353-9. 2009
    ..However, it is unclear whether lower testosterone levels predict major cardiovascular events...
  89. doi request reprint Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trial
    Kathleen Potter
    School of Medicine and Pharmacology, University of Western Australia, W A, Australia
    Cerebrovasc Dis 27:259-65. 2009
    ..We used (18)F-fluorodeoxygluose positron emission tomography ((18)F-FDG PET) to investigate whether long-term homocysteine-lowering treatment alters arterial wall inflammation in patients with a history of ischemic stroke...
  90. ncbi request reprint The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS)
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Australia
    Psychol Med 37:1775-86. 2007
    ..This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account...
  91. ncbi request reprint Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Clin Endocrinol (Oxf) 68:404-12. 2008
    ..To determine the relationship of total and free serum testosterone to cognitive performance in older men...
  92. doi request reprint Premorbid personality traits are associated with post-stroke behavioral and psychological symptoms: a three-month follow-up study in Perth, Western Australia
    Kathryn R Greenop
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Int Psychogeriatr 21:1063-71. 2009
    ..This study sought to investigate further the relationship between premorbid personality and a number of common post-stroke behavioral and psychological symptoms in a three-month follow-up study...
  93. ncbi request reprint Preventing depression after stroke: Results from a randomized placebo-controlled trial
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, Royal Perth Hospital and University of Western Australia, Perth, Australia
    J Clin Psychiatry 67:1104-9. 2006
    ..We designed this study to determine whether the daily treatment of nondepressed acute stroke patients with sertraline reduced the incidence of depression at follow-up...
  94. doi request reprint Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Arch Gen Psychiatry 65:283-9. 2008
    ..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity...
  95. ncbi request reprint Medical treatment of peripheral arterial disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
    JAMA 295:547-53. 2006
    ..The goals of treatment are to prevent future major coronary and cerebrovascular events and improve leg symptoms...
  96. doi request reprint Homocysteine or renal impairment: which is the real cardiovascular risk factor?
    Kathleen Potter
    Department of Cardiology, Level 4, A Block, Royal Perth Hospital, Perth WA6847, Australia
    Arterioscler Thromb Vasc Biol 28:1158-64. 2008
    ....
  97. ncbi request reprint Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Stroke 37:547-9. 2006
    ..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels...
  98. doi request reprint Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Clin Endocrinol (Oxf) 70:455-63. 2009
    ..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men...
  99. pmc Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational study
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, WA, Australia
    Br J Clin Pharmacol 71:592-9. 2011
    ..To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes...
  100. ncbi request reprint Peripheral arterial disease: prognostic significance and prevention of atherothrombotic complications
    Paul E Norman
    School of Surgery and Pathology, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia
    Med J Aust 181:150-4. 2004
    ..Patients with PAD require medical management to prevent future coronary and cerebral vascular events. There are currently insufficient data to recommend routine population screening for asymptomatic PAD using the ABPI...
  101. ncbi request reprint Association of cardiovascular risk factors and disease with depression in later life
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
    Am J Geriatr Psychiatry 15:506-13. 2007
    ..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men...