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Genomes and Genes | G J HankeySummaryAffiliation: University of Western Australia Country: Australia Publications
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Publications
Clinical update: management of strokeGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
Lancet 369:1330-2. 2007
Homocysteine and depression in later lifeOsvaldo P Almeida
FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
Arch Gen Psychiatry 65:1286-94. 2008..Genetic association studies are not prone to the same sources of error and offer an opportunity to explore the consistency and external validity of this association...- Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational studyGraeme J Hankey
Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, 6001, Australia
J Neurol Neurosurg Psychiatry 84:281-7. 2013..We determined the rates and predictors of risk of stroke and its subtypes in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial... 
Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruitedPeter Sandercock
The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Trials 12:252. 2011..IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit...- Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trialGraeme J Hankey
FRACP, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia 6001
Stroke 43:1572-7. 2012..To determine the effect of B vitamin treatment on the incidence of cancer among patients with stroke or transient ischemic attack... - Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trialGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
Lancet Neurol 11:512-20. 2012.... - Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AFGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Lancet Neurol 11:315-22. 2012..We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA)... - Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic strokeChristopher Beer
Western Australian Centre for Health and Ageing, University of Western Australia, Australia
J Neuroinflammation 7:71. 2010..We aimed to determine if systemic markers of vascular dysfunction and inflammation are independently associated with concentrations of the astroglial protein S100B, a marker of brain injury, in participants with acute ischaemic stroke... - Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control studyChristopher D Beer
Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Australia
Cardiovasc Ultrasound 8:46. 2010..We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function... - Ultrasound settings significantly alter arterial lumen and wall thickness measurementsKathleen Potter
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Cardiovasc Ultrasound 6:6. 2008..We aimed to quantify the effect that commonly adjusted ultrasound settings have on arterial lumen and wall thickness measurements made with CIMT measurement software... 
Carotid intima-medial thickness measured on multiple ultrasound frames: evaluation of a DICOM-based software systemKathleen Potter
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Cardiovasc Ultrasound 5:29. 2007....- The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysisKathleen Potter
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
BMC Cardiovasc Disord 8:24. 2008..B-vitamin supplements reduce tHcy and improve endothelial function in short term trials, but the long-term effects of the treatment on vascular structure and function are unknown... - Preventable stroke and stroke preventionG J Hankey
Department of Neurology, Royal Perth Hospital, Perth, Australia
J Thromb Haemost 3:1638-45. 2005.... - Vascular disease of the heart, brain and limbs: new insights into a looming epidemicGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
Lancet 366:1753-4. 2005 - Potential new risk factors for ischemic stroke: what is their potential?Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia, 6001
Stroke 37:2181-8. 2006..The aim of this review was to examine the potential role of other risk factors in the etiology of ischemic stroke... - Is plasma homocysteine a modifiable risk factor for stroke?Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
Nat Clin Pract Neurol 2:26-33. 2006.... - Clinical usefulness of plasma homocysteine in vascular diseaseGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Wellington Street, Perth, Western Australia, 6001
Med J Aust 181:314-8. 2004..There is currently insufficient evidence to recommend routine screening and treatment of high tHcy concentrations with folic acid and other vitamins to prevent atherothrombotic vascular disease... - Redefining risks after TIA and minor ischaemic strokeGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Lancet 365:2065-6. 2005 - Is clopidogrel the antiplatelet drug of choice for high-risk patients with stroke/TIA?: NoG J Hankey
Stroke Unit, Royal Perth Hospital, Perth, Australia
J Thromb Haemost 3:1137-40. 2005 - Adding aspirin to clopidogrel after TIA and ischemic stroke: benefits do not match risksGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Neurology 64:1117-21. 2005.... - Homocysteine and strokeGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia 6001, Australia
Lancet 365:194-6. 2005 - Secondary prevention of recurrent strokeGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Stroke 36:218-21. 2005 - Sustained homocysteine-lowering effect over time of folic acid-based multivitamin therapy in stroke patients despite increasing folate status in the populationG J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Cerebrovasc Dis 19:110-6. 2005.... - Time frame and predictors of recovery from disability following recurrent ischemic strokeG J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia, 6000
Neurology 68:202-5. 2007..To assess the rate, degree, and predictors of recovery from a disabled to nondisabled state in patients disabled after recurrent ischemic stroke... - Nutrition and the risk of strokeGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Western Australia
Lancet Neurol 11:66-81. 2012..Future challenges include the need to improve the quality of evidence linking many nutrients, foods, and dietary patterns to the risk of stroke... - Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trialGraeme J Hankey
Neurology Department, Stroke Unit, Royal Perth Hospital, Perth, Australia
Int J Stroke 6:3-9. 2011.... - Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trialGraeme J Hankey
Neurology Department, Royal Perth Hospital, Perth, Australia
Stroke 41:1679-83. 2010.... - Management of cholesterol to reduce the burden of stroke in Asia: consensus statementGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Int J Stroke 5:209-16. 2010..Further trials of statins in Asian patients are also needed, particularly in those with intracranial stenosis... - Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular eventsGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Australia
Lancet Neurol 9:273-84. 2010..Other new anticoagulants, including the oral factor Xa inhibitors, rivaroxaban, apixaban, and edoxaban, the parenteral factor Xa inhibitor, idrabiotaparinux, and the novel VKA, tecarfarin, are currently being assessed... - Replacing aspirin and warfarin for secondary stroke prevention: is it worth the costs?Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia, Australia
Curr Opin Neurol 23:65-72. 2010..This review aims to determine whether it is cost-effective to replace aspirin and warfarin with more effective, yet more costly, treatments for secondary stroke prevention... - How I interpreted the randomised trials of carotid angioplasty/stenting versus endarterectomyGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Eur J Vasc Endovasc Surg 36:34-40. 2008..More importantly, it will be possible to determine which patients should be treated preferentially with CAS, which patients with CEA, and which patients should not undergo either revascularisation procedure... - When the patient fails to respond to treatment: TIAs that go on, and onG J Hankey
Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Australia
Pract Neurol 8:103-11. 2008.... - Antiplatelet therapy for stroke preventionGraeme J Hankey
Consultant Neurologist and Head of Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington Street, Perth, Western Australia 6001, Australia
Curr Atheroscler Rep 9:312-8. 2007..A large trial comparing clopidogrel with the combination of aspirin and extended-release dipyridamole in more than 20,000 patients with recent (< 120 days) atherothrombotic ischemic stroke is expected to report in 2008... - Antiplatelet therapy for the prevention of recurrent stroke and other serious vascular events: a review of the clinical trial data and guidelinesGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA 6000, Australia
Curr Med Res Opin 23:1453-62. 2007..One strategy of reducing the burden of stroke is the prevention of recurrent stroke, following an initial ischaemic stroke or transient ischaemic attack (TIA) of arterial origin, by means of antiplatelet therapy... - Rate, degree, and predictors of recovery from disability following ischemic strokeG J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Neurology 68:1583-7. 2007..To determine the rate, degree, and predictors of recovery from disabling ischemic stroke... - Folic acid-based multivitamin therapy to prevent stroke: the jury is still outGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, 197 Wellington St, Perth, Australia 6001
Stroke 35:1995-8. 2004 - Management of the first-time transient ischaemic attackG J Hankey
Department of Neurology, Royal Perth Hospital, University of Western Australia, Perth, Australia
Emerg Med (Fremantle) 13:70-81. 2001..g. migraine aura, partial seizures, benign paroxysmal positional vertigo, hysteria). This comprehensive review outlines an approach to the management of this complex and challenging problem... - Treatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populationsG J Hankey
Royal Perth Hospital, and Department of Medicine, University of Western Australia
Lancet 354:1457-63. 1999.... - Antiplatelet drugsGraeme J Hankey
Royal Perth Hospital, 197 Wellington Street, Perth, WA 6001, Australia
Med J Aust 178:568-74. 2003.... - Stroke prediction and prevention by carotid endarterectomy: keep an eye on the doughnut and not just the holeG J Hankey
Stroke Unit, Royal Perth Hospital and University of Western Australia, Perth, W A, Australia
Cerebrovasc Dis 9:345-50. 1999.... - Transient ischaemic attacks and strokeG J Hankey
Royal Perth Hospital, WA
Med J Aust 172:394-400. 2000..They should undergo immediate computed tomography brain scan and, if intracranial haemorrhage is excluded, be given aspirin (160-300 mg). Rehabilitation and secondary prevention of recurrent stroke should begin on day one after stroke... - Five-year survival after first-ever stroke and related prognostic factors in the Perth Community Stroke StudyG J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital Western Australia
Stroke 31:2080-6. 2000.... - Homocysteine and strokeG J Hankey
Stroke Unit, Royal Perth Hospital, Western Australia and Department of Medicine, University of Western Australia
Curr Opin Neurol 14:95-102. 2001..The results of ongoing clinical trials in stroke patients to determine the impact of multivitamin therapy on recurrent stroke and other serious vascular events are awaited... - Current oral antiplatelet agents to prevent atherothrombosisG J Hankey
Stroke Unit, Royal Perth Hospital, Perth, Australia
Cerebrovasc Dis 11:11-7. 2001.... - Evacuation of intracerebral hematoma is likely to be beneficial--againstGraeme J Hankey
Department of Medicine, University of Western Australia, Perth, Western Australia
Stroke 34:1568-9. 2003 - Homocysteine levels in patients with stroke: clinical relevance and therapeutic implicationsG J Hankey
Royal Perth Hospital, and Department of Medicine, University of Western Australia, Perth, Western Australia, Australia
CNS Drugs 15:437-43. 2001.... - Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
Stroke 33:1034-40. 2002..This population-based study aimed to describe disability, dependency, and related independent prognostic factors at 5 years after a first-ever stroke in patients in Perth, Western Australia... - Long-term outcome after ischaemic stroke/transient ischaemic attackGraeme J Hankey
Stroke Unit, Royal Perth Hospital and Department of Medicine, University of Western Australia, Perth, WA, Australia
Cerebrovasc Dis 16:14-9. 2003.... - Warfarin-Aspirin Recurrent Stroke Study (WARSS) trial: is warfarin really a reasonable therapeutic alternative to aspirin for preventing recurrent noncardioembolic ischemic stroke?Graeme J Hankey
Department of Neurology, Royal Perth Hospital, Perth, Western Australia
Stroke 33:1723-6. 2002 - Angiotensin-converting enzyme inhibitors for stroke prevention: is there HOPE for PROGRESS After LIFE?Graeme J Hankey
Department of Neurology, Royal Perth Hospital, University of Western Australia, Perth, Australia
Stroke 34:354-6. 2003 - Smoking and risk of strokeG J Hankey
Department of Neurology, Royal Perth Hospital, University of Western Australia, Australia
J Cardiovasc Risk 6:207-11. 1999..The mechanisms by which smoking causes stroke remain uncertain, but are probably multifactorial and primarily atherogenic... - Role of lipid-modifying therapy in the prevention of initial and recurrent strokeGraeme J Hankey
Department of Neurology, Royal Perth Hospital, Western Australia
Curr Opin Lipidol 13:645-51. 2002..To establish the role of cholesterol-modifying therapy in stroke prevention... - Long-term risk of first recurrent stroke in the Perth Community Stroke StudyG J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
Stroke 29:2491-500. 1998..BACKGROUND and.. - Ongoing and planned trials of antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes: setting a new standard of careGraeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, WA, Australia
Cerebrovasc Dis 17:11-6. 2004..These ongoing and planned clinical trials of antiplatelet therapy promise to further define the role of combination antiplatelet therapy in the acute and long-term management of patients with ischaemic brain syndromes... - Cyclooxygenase-2 inhibitors: are they really atherothrombotic, and if not, why not?Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
Stroke 34:2736-40. 2003.... - One year after CAPRIE, IST and ESPS 2. Any changes in concepts?G J Hankey
Royal Perth Hospital, and University of Western Australia, Perth, Western Australia
Cerebrovasc Dis 8:1-7. 1998.... - Heparin in acute ischaemic stroke. The T wave is negative and it's time to stopG J Hankey
Stroke Unit, Royal Perth Hospital, WA
Med J Aust 169:534-6. 1998.... - Surgery for primary intracerebral hemorrhage: is it safe and effective? A systematic review of case series and randomized trialsG J Hankey
Department of Neurology, Royal Perth Hospital, Western Australia, Australia
Stroke 28:2126-32. 1997..This study compares the outcome of patients with PICH who are treated surgically with those who are not... - Homocysteine and vascular diseaseG J Hankey
Department of Neurology, Royal Perth Hospital, Western Australia
Lancet 354:407-13. 1999.... - Ximelagatran or warfarin for stroke prevention in patients with atrial fibrillation?Graeme J Hankey
Stroke Unit, Royal Perth Hospital, 197 Wellington Street Perth, Australia 6001
Stroke 35:389-91. 2004 - Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy oP Dusitanond
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Stroke 36:144-6. 2005.... - Association between phosphodiesterase 4D gene and ischaemic strokeJ M Staton
Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia
J Neurol Neurosurg Psychiatry 77:1067-9. 2006..An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group... - Inherited thrombophilia in ischemic stroke and its pathogenic subtypesG J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia
Stroke 32:1793-9. 2001..Whether the thrombophilias may still be important in younger patients with ischemic stroke or in predicting complications (eg, venous thrombosis) and stroke outcome remains uncertain... - Ten-year risk of first recurrent stroke and disability after first-ever stroke in the Perth Community Stroke StudyKate Hardie
School of Population Health, University of Western Australia, Perth, Australia
Stroke 35:731-5. 2004..Effective strategies for prevention of stroke need to be implemented early, monitored frequently, and maintained long term after first-ever stroke... - The risks and benefits of antithrombotic therapy in chronic atrial fibrillationG J Hankey
Quality Improvement Unit, Royal Perth Hospital, Perth, WA
Med J Aust 164:624-6. 1996..Clearer guidelines are emerging to identify those patients and to standardise current prescribing practices... - Protein Z gene polymorphisms, protein Z concentrations, and ischemic strokeJ Staton
Department of Hematology, Royal Perth Hospital, Perth, Australia
Stroke 36:1123-7. 2005.... - Protein Z in ischemic stroke and its etiologic subtypesAndrew M McQuillan
Department of Hematology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6897, Australia
Stroke 34:2415-9. 2003..The objectives of this study were to determine the association between protein Z, ischemic stroke, and etiologic subtypes of ischemic stroke... - Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men studyA H Ford
WA Centre for Health and Ageing, Centre for Medical Research and School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
Mol Psychiatry 17:559-66. 2012..46, 95% CI 1.01-2.11, P=0.043). The results of this study are consistent with, but do not prove the hypothesis that high tHcy causes cognitive impairment in later life... - Trends in five-year survival and risk of recurrent stroke after first-ever stroke in the Perth Community Stroke StudyKate Hardie
School of Population Health, University of Western Australia, Perth, Australia
Cerebrovasc Dis 19:179-85. 2005..Serial community-based studies of the incidence and outcome of stroke are an important means of monitoring the translation of proven preventive interventions to improvements in population health... - Prevention of coronary heart disease with aspirin and clopidogrel: efficacy, safety, costs and cost-effectivenessWai Khoon Ho
Department of Haematology, Royal Perth Hospital, Perth, Australia
Expert Opin Pharmacother 5:493-503. 2004..g., > 20%/year). The combination of clopidogrel and aspirin should be considered in patients with non-ST-segment elevation acute coronary syndrome or undergoing percutaneous coronary intervention... - Endothelial and platelet activation in acute ischemic stroke and its etiological subtypesPaul Cherian
Department of Medicine, University of Western Australia, Perth, Australia
Stroke 34:2132-7. 2003..Persistent elevated blood concentrations of PDM may be a marker of increased risk of ischemic stroke... - Thrombolytic therapy in acute ischaemic stroke: the jury needs more evidenceG J Hankey
Department of Neurology, Royal Perth Hospital, Perth, WA
Med J Aust 166:419-22. 1997..More research is needed to determine which stroke patients will benefit from thrombolysis and the best regimen to use... - The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS)Osvaldo P Almeida
WA Centre for Health and Ageing, University of Western Australia, Australia
Psychol Med 37:1775-86. 2007..This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account... - Population-based observational study of claudication in older men: the Health in Men StudyRahul Lakshmanan
University of Western Australia, Fremantle Hospital, Fremantle, WA, Australia
Med J Aust 192:641-5. 2010..To assess the prevalence of and risk factors for claudication and its association with subsequent cardiovascular events... - Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trialKathleen Potter
School of Medicine and Pharmacology, University of Western Australia, W A, Australia
Cerebrovasc Dis 27:259-65. 2009..We used (18)F-fluorodeoxygluose positron emission tomography ((18)F-FDG PET) to investigate whether long-term homocysteine-lowering treatment alters arterial wall inflammation in patients with a history of ischemic stroke... - Medical treatment of peripheral arterial diseaseGraeme J Hankey
Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
JAMA 295:547-53. 2006.... - Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men StudyOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Perth, WA, Australia
Int J Epidemiol 38:1049-59. 2009..The aim of this study is to determine if polymorphisms of SNPs rs1130864 and rs1205 are associated with prevalent depression... - Premorbid personality traits are associated with post-stroke behavioral and psychological symptoms: a three-month follow-up study in Perth, Western AustraliaKathryn R Greenop
WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
Int Psychogeriatr 21:1063-71. 2009..This study sought to investigate further the relationship between premorbid personality and a number of common post-stroke behavioral and psychological symptoms in a three-month follow-up study... - Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
Eur J Endocrinol 161:591-8. 2009..We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity... - Low free testosterone predicts frailty in older men: the health in men studyZoe Hyde
Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
J Clin Endocrinol Metab 95:3165-72. 2010..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome... - Body mass index and survival in men and women aged 70 to 75Leon Flicker
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
J Am Geriatr Soc 58:234-41. 2010..To examine in an older population all-cause and cause-specific mortality associated with underweight (body mass index (BMI)<18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25.0-29.9), and obesity (BMI> or =30.0)... - Higher luteinizing hormone is associated with poor memory recall: the health in men studyZoe Hyde
Western Australian Institute for Medical Research, Australia
J Alzheimers Dis 19:943-51. 2010..These findings suggest a role for both androgens and gonadotropins in differing cognitive domains, and that gonadotropins may influence cognition independent of sex steroids... - Depression, antidepressant use and mortality in later life: the Health In Men StudyOsvaldo P Almeida
Western Australia Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
PLoS ONE 5:e11266. 2010..Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants... - Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
Clin Endocrinol (Oxf) 70:455-63. 2009..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men... - B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trialOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
Ann Neurol 68:503-10. 2010..The purpose of this research was to determine if treatment with B-vitamins reduces the hazard of poststroke depression compared with placebo... - Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Australia
Clin Endocrinol (Oxf) 68:404-12. 2008..To determine the relationship of total and free serum testosterone to cognitive performance in older men... - Aspirin resistance: a new independent predictor of vascular events?John W Eikelboom
Department of Haematology, Royal Perth Hospital, Wellington Street, Perth, WA 6001, Australia
J Am Coll Cardiol 41:966-8. 2003 - Thromboprophylaxis practice patterns in two Western Australian teaching hospitalsJohn W Eikelboom
Department of Hematology, Royal Perth Hospital, Wellington Street, Perth, WA, 6001 Australia
Haematologica 89:586-93. 2004..Our objective was to determine what proportion of patients undergoing elective hip or knee arthroplasty actually receive recommended thromboprophylaxis according to international guidelines... - Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men studyOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
Am J Geriatr Psychiatry 17:889-98. 2009.... - Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older menOsvaldo P Almeida
WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
Arch Gen Psychiatry 65:283-9. 2008..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity... - Preventing depression after stroke: Results from a randomized placebo-controlled trialOsvaldo P Almeida
Unit of Geriatric Psychiatry, Royal Perth Hospital and University of Western Australia, Perth, Australia
J Clin Psychiatry 67:1104-9. 2006..We designed this study to determine whether the daily treatment of nondepressed acute stroke patients with sertraline reduced the incidence of depression at follow-up... - Homocysteine or renal impairment: which is the real cardiovascular risk factor?Kathleen Potter
Department of Cardiology, Level 4, A Block, Royal Perth Hospital, Perth WA6847, Australia
Arterioscler Thromb Vasc Biol 28:1158-64. 2008.... - Traditional risk factors for incident cardiovascular events have limited importance in later life compared with the health in men study cardiovascular risk scoreChristopher Beer
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
Stroke 42:952-9. 2011..This study aimed to determine, among older men, the risk and independent significant baseline prognostic factors for first-ever stroke and MI... - Lower testosterone levels predict incident stroke and transient ischemic attack in older menBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
J Clin Endocrinol Metab 94:2353-9. 2009..However, it is unclear whether lower testosterone levels predict major cardiovascular events... - Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemiaLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Stroke 37:547-9. 2006..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels... - Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational studyChristopher Beer
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, WA, Australia
Br J Clin Pharmacol 71:592-9. 2011..To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes... - Peripheral arterial disease: prognostic significance and prevention of atherothrombotic complicationsPaul E Norman
School of Surgery and Pathology, Fremantle Hospital, PO Box 480, Fremantle, WA 6959, Australia
Med J Aust 181:150-4. 2004..Patients with PAD require medical management to prevent future coronary and cerebral vascular events. There are currently insufficient data to recommend routine population screening for asymptomatic PAD using the ABPI... - Association of cardiovascular risk factors and disease with depression in later lifeOsvaldo P Almeida
Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
Am J Geriatr Psychiatry 15:506-13. 2007..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men... - Aspirin decreases the risk of depression in older men with high plasma homocysteineO P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
Transl Psychiatry 2:e151. 2012..Randomized trials are required to confirm the antidepressant effect of aspirin in people with high tHcy... - Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic strokeV J Cole
Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
J Thromb Haemost 1:963-70. 2003..Our results do not support a role for the integrin alpha2 C807T and GPVI Q317L polymorphisms in the development of first-ever ischemic stroke. However, larger studies are required to confirm this... - Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men StudyB B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Osteoporos Int 23:599-606. 2012..Differences in osteocalcin levels might influence glucose metabolism and thereby cardiovascular risk, or reflect changes in bone turnover thus representing a marker for poorer health outcomes...