John A Hamilton

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts
    Caryn L Elsegood
    Department of Molecular Endocrinology and Bone Biology, Merck Research Laboratories, West Point, PA 19486, USA
    Int J Biochem Cell Biol 38:1518-29. 2006
  2. ncbi Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    R Tedjo Sasmono
    CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    J Leukoc Biol 82:111-23. 2007
  3. ncbi Colony stimulating factors and myeloid cell biology in health and disease
    John A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne Department of Medicine, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia Electronic address
    Trends Immunol 34:81-9. 2013
  4. ncbi Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF
    John A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne Department of Medicine, The Royal Melbourne Hospital Parkville, Victoria, Australia
    PLoS ONE 7:e45853. 2012
  5. ncbi GM-CSF is not essential for optimal fertility or for weight control
    John A Hamilton
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Victoria 3050, Australia
    Cytokine 57:30-1. 2012
  6. ncbi Inflammatory microcrystals induce murine macrophage survival and DNA synthesis
    J A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Arthritis Res 3:242-6. 2001
  7. ncbi Colony-stimulating factors in inflammation and autoimmunity
    John A Hamilton
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 8:533-44. 2008
  8. ncbi Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)
    John A Hamilton
    Arthritis and Inflammation Research Centre, The University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Clinical Sciences Building, Royal Parade, Victoria 3050, Parkville, Australia
    Brain Res 940:49-54. 2002
  9. ncbi Comparison of macrophage responses to oxidized low-density lipoprotein and macrophage colony-stimulating factor (M-CSF or CSF-1)
    J A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Clinical Sciences Building, Royal Parade, Parkville, VIC 3050, Australia
    Biochem J 354:179-87. 2001
  10. ncbi GM-CSF in inflammation and autoimmunity
    John A Hamilton
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria 3050, Parkville, Australia
    Trends Immunol 23:403-8. 2002

Detail Information

Publications96

  1. ncbi M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts
    Caryn L Elsegood
    Department of Molecular Endocrinology and Bone Biology, Merck Research Laboratories, West Point, PA 19486, USA
    Int J Biochem Cell Biol 38:1518-29. 2006
    ....
  2. ncbi Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    R Tedjo Sasmono
    CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    J Leukoc Biol 82:111-23. 2007
    ..In keeping with this hypothesis, we showed that purified Ly-6G-positive granulocytes express CSF-1R after overnight culture and can subsequently differentiate to form F4/80-positive macrophages in response to CSF-1...
  3. ncbi Colony stimulating factors and myeloid cell biology in health and disease
    John A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne Department of Medicine, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia Electronic address
    Trends Immunol 34:81-9. 2013
    ..We discuss controversies regarding the role of CSFs in controlling specific myeloid cell populations and highlight how the newly identified M-CSF receptor ligand, interleukin (IL)-34, is necessitating a reassessment of the field...
  4. ncbi Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF
    John A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne Department of Medicine, The Royal Melbourne Hospital Parkville, Victoria, Australia
    PLoS ONE 7:e45853. 2012
    ..The enhanced hypoxia-dependent survival and/or proliferation of macrophages in the presence of CSF-1 or TNF may contribute to their elevated numbers at a site of chronic inflammation...
  5. ncbi GM-CSF is not essential for optimal fertility or for weight control
    John A Hamilton
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Victoria 3050, Australia
    Cytokine 57:30-1. 2012
    ..It is concluded that GM-CSF is not necessary for an optimal fertility outcome or for normal weight maintenance during development...
  6. ncbi Inflammatory microcrystals induce murine macrophage survival and DNA synthesis
    J A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Arthritis Res 3:242-6. 2001
    ..The crystals studied join the list of particulates having these effects on macrophages, indicating the generality of this type of response...
  7. ncbi Colony-stimulating factors in inflammation and autoimmunity
    John A Hamilton
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 8:533-44. 2008
    ..Here, I describe these biological features, discuss the probable specific outcomes of targeting CSFs in vivo and highlight outstanding questions that need to be addressed...
  8. ncbi Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)
    John A Hamilton
    Arthritis and Inflammation Research Centre, The University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Clinical Sciences Building, Royal Parade, Victoria 3050, Parkville, Australia
    Brain Res 940:49-54. 2002
    ..These fibrillogenic peptides join the list of aggregates having these effects on macrophages, indicating the generality of this type of response...
  9. ncbi Comparison of macrophage responses to oxidized low-density lipoprotein and macrophage colony-stimulating factor (M-CSF or CSF-1)
    J A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Clinical Sciences Building, Royal Parade, Parkville, VIC 3050, Australia
    Biochem J 354:179-87. 2001
    ..LDL-mediated macrophage survival and, in contrast with the literature, ox.LDL-induced macrophage DNA synthesis...
  10. ncbi GM-CSF in inflammation and autoimmunity
    John A Hamilton
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria 3050, Parkville, Australia
    Trends Immunol 23:403-8. 2002
    ....
  11. ncbi The critical role of the colony-stimulating factor-1 receptor in the differentiation of myeloblastic leukemia cells
    John A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Mol Cancer Res 6:458-67. 2008
    ..We also propose that expression and activation of the CSF-1R explain much prior literature on macrophage lineage commitment in M1 leukemic cells and may be important in controlling the progression of certain myeloid leukemias...
  12. ncbi Nondisposable materials, chronic inflammation, and adjuvant action
    John A Hamilton
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Australia
    J Leukoc Biol 73:702-12. 2003
    ..Thus, there would be more cells in an inflammatory lesion or at a site of adjuvant action with the potential, following activation and/or differentiation, to perpetuate inflammatory or antigen-specific, immune responses, respectively...
  13. ncbi GM-CSF Biology
    John A Hamilton
    Department of Medicine, Arthritis and Inflammation Research Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville 3010 Vic, Australia
    Growth Factors 22:225-31. 2004
    ..g. as an adjuvant, and also includes those observed in depletion studies, e.g. during inflammatory reactions where GM-CSF can be shown to have a proinflammatory action...
  14. ncbi Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Victoria, Australia
    J Immunol 173:4643-51. 2004
    ..Of general significance, the findings also indicate that the nature of the stimulus is quite critical in determining whether a particular inflammatory mediator, such as GM-CSF, plays a role in an ensuing inflammatory reaction...
  15. ncbi Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages
    Dominic De Nardo
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 183:8110-8. 2009
    ..In summary, our findings highlight the importance of signaling crosstalk between TLRs, as well as between TLRs and c-Fms, in regulating the inflammatory reaction to pathogens...
  16. ncbi Regulation of WAVE1 expression in macrophages at multiple levels
    Hang Dinh
    Arthritis and Inflammation Research Centre and CRC for Chronic Inflammatory Diseases, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Leukoc Biol 84:1483-91. 2008
    ..We suggest that WAVE1 is also important for macrophage biology and that it could have separate functions to those of WAVE2...
  17. ncbi Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R37. 2010
    ..The aim of the current study is to determine how u-PA might be acting in systemic arthritis models...
  18. ncbi A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor
    Gael A Manes
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    FEBS J 273:1791-804. 2006
    ..Taken together, our results suggest that SLAP-2 could potentially be involved in signaling by the CSF-1 receptor...
  19. ncbi Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models
    Derek C Lacey
    Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol 188:5752-65. 2012
    ..Care needs to be exercised when drawing definitive conclusions from a particular in vitro system about the roles of GM-CSF and M-CSF in macrophage lineage biology...
  20. ncbi Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages
    Adrian Achuthan
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mol Cell Biol 28:6149-59. 2008
    ..Thus, CSF-1 is a key regulator of Stx7 expression and function in macrophages. Furthermore, the effects of CSF-1 on Stx7 may provide a mechanism for the regulation of macrophage effector functions by CSF-1...
  21. ncbi Glycolytic control of adjuvant-induced macrophage survival: role of PI3K, MEK1/2, and Bcl-2
    Margaret Chang
    The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Leukoc Biol 85:947-56. 2009
    ..Enhanced glucose uptake by macrophages may therefore be critical to the action of particulate adjuvants...
  22. ncbi GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling
    Andrew J Fleetwood
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 86:411-21. 2009
    ..Collectively, these findings demonstrate that constitutive and LPS-induced type I IFN play significant roles in regulating the differences in phenotype and function between BMM and GM-BMM...
  23. ncbi Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    Andrew J Fleetwood
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 178:5245-52. 2007
    ....
  24. ncbi Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions
    John Roiniotis
    Department of Medicine, Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 182:7974-81. 2009
    ....
  25. ncbi A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors
    Dominic De Nardo
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Biol Chem 280:9813-22. 2005
    ....
  26. ncbi The generation and properties of human macrophage populations from hemopoietic stem cells
    Kerrie J Way
    Department of Medicine and CRC for Chronic Inflammatory Diseases, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 85:766-78. 2009
    ..In addition to the large numbers of macrophage lineage cells able to be produced, this replicating system may be suitable for the molecular analysis of macrophage lineage commitment and progression and for gene targeting and delivery...
  27. ncbi Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation
    Jason C Lenzo
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 90:429-40. 2012
    ..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed...
  28. ncbi Phosphatidylinostitol-3 kinase and phospholipase C enhance CSF-1-dependent macrophage survival by controlling glucose uptake
    Margaret Chang
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Victoria, Australia
    Cell Signal 21:1361-9. 2009
    ..Taken together, these results suggest that CSF-1 regulates macrophage survival, in part, by stimulating glucose uptake via Glut1, and PI3K and PLC signalling pathways...
  29. ncbi CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin
    Adrian Achuthan
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Victoria 3050, Australia
    Cell Signal 18:2252-61. 2006
    ..We propose that the formation of paxillin-Crk complexes may mediate the cytoskeletal changes that underlie the increased cell spreading of macrophages following their activation by CpG DNA...
  30. ncbi The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
    I K Campbell
    Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 68:144-50. 2000
    ..Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA...
  31. ncbi The proliferative human monocyte subpopulation contains osteoclast precursors
    Roya Lari
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Arthritis Res Ther 11:R23. 2009
    ..The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyte subpopulations may have special or restricted functions, including as osteoclast precursors...
  32. ncbi Macrophage lineage phenotypes and osteoclastogenesis--complexity in the control by GM-CSF and TGF-beta
    Roya Lari
    Department of Medicine and CRC for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Bone 40:323-36. 2007
    ..It is proposed that the findings have particular relevance for the control of bone resorption in pathology, for example, in inflammatory lesions...
  33. ncbi CSF-1 signal transduction
    J A Hamilton
    University of Melbourne Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
    J Leukoc Biol 62:145-55. 1997
    ..The relevance of any potentially important molecular signaling pathway activated by CSF-1 in cells in vitro will ultimately have to be related to the functions of monocytes/macrophages in vivo...
  34. ncbi cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation
    Nicholas J Wilson
    Arthritis and Inflammation Research Centre, Department of Medicine RMH WH, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    FEBS J 272:4141-52. 2005
    ..It appears that there are at least two CSF-1-dependent pathway(s), one MEK/ERK dependent pathway and another controlling the bulk of the tyrosine phosphorylation, and that cAMP can modulate signalling through both of these pathways...
  35. ncbi Regulation of IRAK-1 activation by its C-terminal domain
    Thao Nguyen
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Cell Signal 21:719-26. 2009
    ..Phosphorylation of IRAK-1 by IRAK-4 in response to TLR activation may then release IRAK-1 from the inhibitory constraint exerted by its C-terminal domain...
  36. ncbi Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages
    Dominic De Nardo
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Signal 21:246-52. 2009
    ..Furthermore, differences in the kinetics and extent of IRAK-4 down-regulation by TLR ligands may provide a mechanism whereby macrophages can tailor their inflammatory response according to the location and/or type of pathogen detected...
  37. ncbi Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity
    K A McMahon
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Biochem J 358:431-6. 2001
    ..These data suggest that PP2A and ERK form part of the Src-dependent signal-transduction cascade governing CSF-1-mediated macrophage differentiation in M1 cells...
  38. ncbi Functions of granulocyte-macrophage colony-stimulating factor
    Andrew J Fleetwood
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville 3010, Victoria, Australia
    Crit Rev Immunol 25:405-28. 2005
    ..This review summarizes the evidence supporting a major role for GM-CSF in inflammation and autoimmunity and its functions as major regulator governing granulocyte and macrophage lineage populations at all stages of maturation...
  39. ncbi A proteomics strategy for the enrichment of receptor-associated complexes
    Maddalena Cross
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Proteomics 5:4754-63. 2005
    ..This affinity matrix method, using an entire cytoplasmic region, may have relevance for other growth factor receptors...
  40. ncbi The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation
    Andrew D Cook
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, 3010, Victoria, Australia
    Thromb Haemost 95:659-67. 2006
    ..Peritoneal inflammation in t-PA-/- mice represents a useful model to study the progression of intra-abdominal adhesions during surgery and clinical peritonitis...
  41. ncbi The role of the RgpA-Kgp proteinase-adhesin complexes in the adherence of Porphyromonas gingivalis to fibroblasts
    Rishi D Pathirana
    Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 720 Swanston Street, Victoria 3010, Australia
    Microbiology 154:2904-11. 2008
    ..P. gingivalis W50 mutant cells lacking Kgp exhibited the lowest binding to MRC-5 cells, suggesting an important role for this proteinase and its associated adhesins in binding to fibroblasts...
  42. ncbi Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts
    U Novak
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
    Blood 86:2948-56. 1995
    ..Furthermore, we propose that kinases other than JAK kinase may be involved in the phosphorylation of the STAT proteins in response to CSF-1...
  43. ncbi Low dose metal particles can induce monocyte/macrophage survival
    Derek C Lacey
    The University of Melbourne, Cooperative Research Centre for Chronic Inflammatory Disease, Royal Melbourne Hospital, Parkville, VIC 3050 Australia
    J Orthop Res 27:1481-6. 2009
    ..If this phenomenon occurs in vivo, it could mean that increased numbers of macrophages (and osteoclasts) would be found at a site of joint implant failure, which could contribute to the local inflammatory reaction and osteolysis...
  44. ncbi Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4
    Steven Bozinovski
    Lung Disease Research Group, Dept of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, Univ of Melbourne, Parkville 3010, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 286:L877-85. 2004
    ..These data expand the understanding of the contribution of GM-CSF to innate immune responses in lung and suggest that blocking GM-CSF might benefit some lung diseases where LPS has been implicated in etiology...
  45. ncbi Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models
    Christine M De Nardo
    Department of Medicine, Arthritis and Inflammation Research Centre, The University of Melbourne, Royal Parade, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R199. 2010
    ....
  46. ncbi Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis
    Andrew D Cook
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Rheum 63:2340-51. 2011
    ....
  47. ncbi Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages
    V Kanagasundaram
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Biochem J 320:69-77. 1996
    ..The possible significance of these findings for CSF-1-regulated macrophage functions is discussed...
  48. ncbi Phospholipase D is activated by phorbol ester but not CSF-1 in murine bone marrow-derived macrophages
    A Jaworowski
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Biochem Biophys Res Commun 201:733-9. 1994
    ..These results show that stimulation of protein kinase C and the activation of phospholipase D are not involved in the early events of CSF-1-stimulated signal transduction pathways in BMM...
  49. ncbi A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling
    Maddalena Cross
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050, Australia
    Biochem J 380:243-53. 2004
    ..The phosphorylation of p110 myosin XVIIIA by CSF-1 may alter its cellular localization or target its association with other proteins...
  50. ncbi Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation
    Ross Vlahos
    Department of Pharmacology, The University of Melbourne, VIC 3010, Australia
    Am J Respir Crit Care Med 182:34-40. 2010
    ..We have previously shown that granulocyte/macrophage colony-stimulating factor (GM-CSF) regulates lung innate immunity to LPS through Akt/Erk activation of nuclear factor-kappaB and activator protein (AP)-1...
  51. ncbi Glucose metabolism is required for oxidized LDL-induced macrophage survival: role of PI3K and Bcl-2 family proteins
    Caryn L Elsegood
    Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Australia
    Arterioscler Thromb Vasc Biol 29:1283-9. 2009
    ..Because atherosclerotic lesion-associated macrophages take up large amounts of glucose, we investigated whether, and how, oxLDL promotes glucose uptake and how glucose metabolism regulates oxLDL-induced macrophage survival...
  52. ncbi Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    Steven Bozinovski
    Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Chem 277:42808-14. 2002
    ..Inhibition of GM-CSF may be of therapeutic benefit in inflammatory diseases in which LPS contributes to lung damage...
  53. ncbi Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock
    Kellie Cartledge
    Ludwig Institute for Cancer Research, Parkville, Victoria 3050, Australia
    Biochemistry 46:15144-52. 2007
    ..Together, these findings indicate that the C-terminal domain of Harc is a key determinant of its cochaperone functions...
  54. ncbi Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha
    J A Hamilton
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
    J Immunol 156:2553-7. 1996
    ..it is proposed that the type I IFN receptor (IFNAR 1) "knockout" mice may be useful in delineating some of the in vivo actions of CSF-1, LPS, TNF-alpha, and possibly other agents...
  55. ncbi CSF-1 and cell cycle control in macrophages
    J A Hamilton
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mol Reprod Dev 46:19-23. 1997
    ..CSF-1-mediated effects on the following signal transduction molecules in these systems will be described: PI3-kinase, myelin basic protein kinases, Erks, and STAT transcription factors...
  56. ncbi Extracellular proteomes of M-CSF (CSF-1) and GM-CSF-dependent macrophages
    Mark J Bailey
    Department of Medicine, CRC for Chronic Inflammatory Diseases, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Immunol Cell Biol 89:283-93. 2011
    ..The uncharacterized protein C19orf10, a protein found at high levels in the synovial fluid of arthritis patients, was also differentially regulated; its extracellular levels were upregulated in the presence of GM-CSF...
  57. ncbi Direct comparison of the effects of CSF-1 (M-CSF) and GM-CSF on human monocyte DNA synthesis and CSF receptor expression
    M Finnin
    Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
    J Interferon Cytokine Res 19:417-23. 1999
    ..The information obtained in this study will be useful for the design of strategies to enrich for the subpopulation in question based on CSF receptor expression...
  58. ncbi Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL
    J A Hamilton
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Clinical Sciences Building, Royal Parade, Parkville, VIC 3050, Australia
    Biochem J 355:207-14. 2001
    ..We found that aggregation of lightly oxidized LDL potentiated dramatically its ability to stimulate macrophage DNA synthesis, indicating that extensive oxidation of LDL is not required for this response in vitro and perhaps in vivo...
  59. ncbi Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor
    Y H Yang
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Arthritis Rheum 44:111-9. 2001
    ..These studies provide the first in vivo evidence for a role of GM-CSF, and possibly M-CSF, in the proinflammatory actions of IL-1...
  60. ncbi Proliferation-independent induction of macrophage cyclin D2, and repression of cyclin D1, by lipopolysaccharide
    P K Vadiveloo
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia 3050
    J Biol Chem 273:23104-9. 1998
    ....
  61. ncbi Detection and properties of the human proliferative monocyte subpopulation
    Felix I L Clanchy
    Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
    J Leukoc Biol 79:757-66. 2006
    ..The phenotype and properties of the PM subpopulation were examined as a prelude to determining its role in disease using methods that can be applied to clarify human monocyte heterogeneity...
  62. ncbi HUVEC co-culture and haematopoietic growth factors modulate human proliferative monocyte activity
    Felix I L Clanchy
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Cytokine 59:31-4. 2012
    ..The inhibition of M-CSFR kinase activity by GW2580 indicated that the ligand(s) for this receptor was a potent inducer of proliferation of this subset; inhibitors of intracellular signalling pathways also reduced PM proliferation...
  63. ncbi Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis
    Andrew D Cook
    Arthritis and Inflammation Research Center, University of Melbourne, Department of Medicine, Victoria, Australia
    Am J Pathol 160:917-26. 2002
    ..Our data highlight the complexities of PA function, and suggest that approaches either to target u-PA or to enhance local t-PA activity in joints may be of therapeutic benefit in rheumatoid arthritis...
  64. ncbi Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis
    I K Campbell
    Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, Australia
    Eur J Immunol 30:1568-75. 2000
    ..This model may lead to improved understanding of autoimmunity in CIA and RA and may provide a platform for analysis of the contribution of non-MHC genes to CIA...
  65. ncbi Proliferation of a subpopulation of human peripheral blood monocytes in the presence of colony stimulating factors may contribute to the inflammatory process in diseases such as rheumatoid arthritis
    S T Moss
    Department of Medicine, Inflammation Research Centre, University of Melbourne, Royal Melbourne Hospital, Australia
    Immunobiology 202:18-25. 2000
    ....
  66. ncbi Protein phosphatase 2A is expressed in response to colony-stimulating factor 1 in macrophages and is required for cell cycle progression independently of extracellular signal-regulated protein kinase activity
    N J Wilson
    Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville 3050, Australia
    Biochem J 339:517-24. 1999
    ..Two-dimensional SDS/PAGE analysis of lysates of 32P-labelled BMM, which had been treated with CSF-1 in the presence or absence of OA, identified candidate substrates for PP2A...
  67. ncbi Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1
    J A Hamilton
    Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 67:226-32. 2000
    ....
  68. ncbi Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation
    R J Bischof
    Inflammation Research Centre, The University of Melbourne, Department of Medicine at The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Clin Exp Immunol 119:361-7. 2000
    ....
  69. ncbi Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice
    I K Campbell
    Department of Medicine, Inflammation Research Center, University of Melbourne, Victoria, Australia
    J Immunol 161:3639-44. 1998
    ..These findings suggest that GM-CSF is required for CIA development in mice and support the idea that GM-CSF is a key cytokine in inflammatory joint disease...
  70. ncbi Proteomic analysis of macrophage differentiation. p46/52(Shc) Tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation
    X F Csar
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia 3050
    J Biol Chem 276:26211-7. 2001
    ..This group of molecules may contain novel signaling molecules important in macrophage differentiation...
  71. ncbi Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation
    D C Lacey
    The University of Melbourne, Department of Medicine, and Cooperative Research Centre for Chronic Inflammatory Diseases, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Osteoarthritis Cartilage 17:735-42. 2009
    ..The aim of this study was to develop a MSC isolation method and to determine the in vitro effects of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) on their osteogenic differentiation...
  72. ncbi Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation
    D C Marks
    Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Mol Cell Biol Res Commun 1:144-52. 1999
    ..These data suggest that the reduced Src binding observed in the M1/Y559F cells may contribute to their reduced ability to differentiate...
  73. ncbi Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF)
    R Vlahos
    Lung Disease Research Laboratories, Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Pharmacol Ther 112:106-15. 2006
    ..As such, GM-CSF represents an attractive therapeutic target for the treatment of COPD...
  74. ncbi Signalling through CSF receptors
    G Vairo
    University of Melbourne, Dept of Medicine, Royal Melbourne Hospital, Parkville, Australia
    Immunol Today 12:362-9. 1991
    ..In this review, Gino Vairo and John Hamilton discuss the biochemistry of CSF action and its relevance to growth control, and examine the possibility that different CSFs may use common control pathways within the one cell type...
  75. ncbi Deregulated c-myc expression overrides IFN gamma-induced macrophage growth arrest
    G Vairo
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
    Oncogene 10:1969-76. 1995
    ..These results show that inhibition of c-myc expression is an essential component in IFN gamma-mediated cell cycle arrest and demonstrates that distinct mechanisms contribute to IFN gamma- and cAMP-mediated growth arrest in macrophages...
  76. ncbi Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages
    V Kanagasundaram
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Mol Cell Biol 19:4079-92. 1999
    ..Specific structural proteins associated with the separate CSF-1R multimeric complexes upon CSF-1 stimulation and the presence of the distinct pools of the CSF-1R were dependent on the integrity of the microtubular network...
  77. ncbi Effects of wortmannin and rapamycin on CSF-1-mediated responses in macrophages
    J A Hamilton
    Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Vic, Australia
    Int J Biochem Cell Biol 30:271-83. 1998
    ..The findings reinforce the need to study the signal transduction cascades relevant to each individual growth factor and preferably not in cell lines...
  78. ncbi Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF
    J A Hamilton
    Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia
    Arterioscler Thromb Vasc Biol 19:98-105. 1999
    ....
  79. ncbi The generation of highly enriched osteoclast-lineage cell populations
    J M W Quinn
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Bone 30:164-70. 2002
    ..These can be employed to generate osteoclast populations of high purity and in large numbers when stimulated by TGFbeta, which greatly augments the osteoclastogenic effects of RANKL...
  80. ncbi Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cells
    X F Csar
    University of Melbourne, Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
    Proteomics 1:435-43. 2001
    ..This new protocol combining 2-D SDS-PAGE and HTP-chromatography allows the characterization of low abundance phosphoproteins involved in the cellular responses to G-CSF and presumably to other cytokines/growth factors...
  81. ncbi Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
    A D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Res 3:293-8. 2001
    ..The results also highlight the essential role of GM-CSF in the ongoing development of inflammation and arthritis in CIA, with possible therapeutic implications for rheumatoid arthritis...
  82. ncbi Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain
    Andrew D Cook
    Correspondence to Dr Andrew D Cook, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, VC 3010, Australia
    Ann Rheum Dis 72:265-70. 2013
    ..However, its contribution to inflammatory and arthritic pain is unknown. The aims of this study were to determine whether GM-CSF controls inflammatory and/or arthritic pain...
  83. ncbi CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages
    Jennifer Huynh
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Cell Signal 24:1753-61. 2012
    ..Together, our data argue that key signalling responses to CSF-1 depend on the ability of the CSF-1R to signal from endosomes following its internalisation, thus adding an important spatiotemporal aspect to CSF-1R signalling...
  84. ncbi Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal
    A Jaworowski
    Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Biol Chem 274:15127-33. 1999
    ..We were not able to show that CSF-1 enhanced BMM JNK-1 activity to a significant extent; again, no role could be found for JNK-1 activity in the BMM apoptosis occurring after CSF-1 removal...
  85. ncbi Tissue-type plasminogen activator deficiency exacerbates arthritis
    Y H Yang
    Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol 167:1047-52. 2001
    ..Fibrin deposition appeared to parallel disease severity under the various conditions, suggesting that PA-mediated fibrinolysis may be normally playing a protective role in inflammatory joint disease...
  86. ncbi The phenotype of inflammatory macrophages is stimulus dependent: implications for the nature of the inflammatory response
    Andrew D Cook
    Arthritis and Inflammation Research Center, Department of Medicine, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 171:4816-23. 2003
    ..The inflammatory response elicited using the Ag mBSA may be more relevant for studying the inflammatory responses in many diseases, such as those of autoimmune origin and those involving an acquired immune response...
  87. ncbi Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells
    Rishi D Pathirana
    Cooperative Centre for Oral Health Science, School of Dental Science, The University of Melbourne, 720 Swanston Street, Melbourne, Victoria 3010, Australia
    Infect Immun 75:2484-92. 2007
    ..gingivalis W50 cells to KB cells. Furthermore, isogenic mutants of P. gingivalis W50 lacking the kgp gene product, but not the rgpA or rgpB gene products, exhibited significantly decreased adherence to KB cells compared to the wild type...
  88. ncbi Tissue plasminogen activator does not alter development of acquired epilepsy
    Mei Lyn Tan
    Department of Medicine Royal Melbourne Hospital, University of Melbourne, Melbourne Brain Centre, Parkville, Victoria 3052, Australia
    Epilepsia 53:1998-2004. 2012
    ..Therefore, the increased use of t-PA to treat stroke may have important implications for the development of poststroke epilepsy. Using experimental and clinical approaches, we investigated the role of t-PA in the development of epilepsy...
  89. ncbi The development of macrophages from human CD34+ haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF
    Felix I L Clanchy
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Cytokine 61:33-7. 2013
    ..This study refines the means by which large numbers of macrophages are obtained under serum-free conditions from haematopoietic precursors...
  90. ncbi Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain
    A J Fosang
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Biochem J 295:273-6. 1993
    ....
  91. ncbi Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
    A J Fosang
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
    J Biol Chem 266:15579-82. 1991
    ..The specific cleavage site was between an asparagine and a pair of phenylalanine residues, where the asparagine corresponds to residue 341 in human and rat mature core protein sequence...
  92. ncbi Plasminogen activator/plasmin system in arthritis and inflammation: friend or foe?
    John A Hamilton
    Arthritis Rheum 58:645-8. 2008
  93. ncbi S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo
    Steven Bozinovski
    Lung Disease Research Group, Departments of Pharmacology and Medicine, The University of Melbourne, Parkville 3010 VIC Australia
    J Proteome Res 4:136-45. 2005
    ....
  94. ncbi Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis
    Stephen M Riordan
    Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
    Hepatology 37:1154-64. 2003
    ..TLR2 likely contributes to increased circulating TNF-alpha and sTNFR levels in cirrhosis...
  95. ncbi The interferon in TLR signaling: more than just antiviral
    Paul J Hertzog
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Trends Immunol 24:534-9. 2003
    ..Should we be surprised? Has the inflammatory response unexpectedly highjacked the body's antiviral system? Or are we too easily blinkered by preconceptions from how a compound was discovered?..
  96. ncbi Extravascular coagulation and the plasminogen activator/plasmin system in rheumatoid arthritis
    Nathalie Busso
    Centre Hospitalier Universitaire Vaudois University Hospital, Lausanne, Switzerland
    Arthritis Rheum 46:2268-79. 2002