Adam J Guastella

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, Australia
    Biol Psychiatry 63:544-9. 2008
  2. doi request reprint Does oxytocin influence the early detection of angry and happy faces?
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Psychoneuroendocrinology 34:220-5. 2009
  3. doi request reprint A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychoneuroendocrinology 34:917-23. 2009
  4. doi request reprint Oxytocin enhances the encoding of positive social memories in humans
    Adam J Guastella
    Brain and Mind Research Institute, University of New South Wales, Sydney, Australia
    Biol Psychiatry 64:256-8. 2008
  5. doi request reprint Cognitive-behavioural emotion writing tasks: a controlled trial of multiple processes
    Adam J Guastella
    University of New South Wales, School of Psychology, Sydney 2052 NSW, Australia
    J Behav Ther Exp Psychiatry 39:558-66. 2008
  6. doi request reprint Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Biol Psychiatry 67:692-4. 2010
  7. doi request reprint Social cognitive performance as a marker of positive psychotic symptoms in young people seeking help for mental health problems
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Schizophr Res 149:77-82. 2013
  8. pmc Social cognition deficits and psychopathic traits in young people seeking mental health treatment
    Anita van Zwieten
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    PLoS ONE 8:e67753. 2013
  9. pmc Reduced heart rate variability in social anxiety disorder: associations with gender and symptom severity
    Gail A Alvares
    Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e70468. 2013
  10. pmc Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health care
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 12:234. 2012

Detail Information

Publications53

  1. doi request reprint A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, Australia
    Biol Psychiatry 63:544-9. 2008
    ..The aim of this study was to determine whether 50 mg of DCS enhances ET for social anxiety disorder (SAD) according to a comprehensive set of symptom and life impairment measures...
  2. doi request reprint Does oxytocin influence the early detection of angry and happy faces?
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Psychoneuroendocrinology 34:220-5. 2009
    ..Oxytocin may have greater influence in altering the cognitive processing of social valence at more conceptual and elaborate levels of processing...
  3. doi request reprint A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychoneuroendocrinology 34:917-23. 2009
    ....
  4. doi request reprint Oxytocin enhances the encoding of positive social memories in humans
    Adam J Guastella
    Brain and Mind Research Institute, University of New South Wales, Sydney, Australia
    Biol Psychiatry 64:256-8. 2008
    ..In nonhuman mammals, oxytocin has a critical role in social recognition and the development of long-term bonds. There has been limited research evaluating effects of oxytocin on the encoding and recognition of faces in humans...
  5. doi request reprint Cognitive-behavioural emotion writing tasks: a controlled trial of multiple processes
    Adam J Guastella
    University of New South Wales, School of Psychology, Sydney 2052 NSW, Australia
    J Behav Ther Exp Psychiatry 39:558-66. 2008
    ..Results suggest the use of these paradigms to study emotion-processing mechanisms and, potentially, in practice to enhance coping in process-specific ways...
  6. doi request reprint Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Biol Psychiatry 67:692-4. 2010
    ..Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems...
  7. doi request reprint Social cognitive performance as a marker of positive psychotic symptoms in young people seeking help for mental health problems
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Schizophr Res 149:77-82. 2013
    ..Research is also needed to investigate whether targeted social cognition treatments reduce risk for the development of positive psychotic symptoms. ..
  8. pmc Social cognition deficits and psychopathic traits in young people seeking mental health treatment
    Anita van Zwieten
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    PLoS ONE 8:e67753. 2013
    ..Research is needed to establish the directionality of this relationship and to determine whether social cognition training is an effective treatment amongst young people with psychopathic tendencies. ..
  9. pmc Reduced heart rate variability in social anxiety disorder: associations with gender and symptom severity
    Gail A Alvares
    Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e70468. 2013
    ..The purpose of this study was to examine whether heart rate variability was reduced in treatment-seeking patients diagnosed with social anxiety disorder, a disorder characterized by social fear and avoidance...
  10. pmc Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health care
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 12:234. 2012
    ..This study determines the socio-demographic, psychopathological and illness-stage correlates of suicidal ideation in young persons attending headspace services...
  11. doi request reprint Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
    Gail A Alvares
    Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia
    Psychoneuroendocrinology 37:2022-31. 2012
    ..It adds to a growing body of evidence that oxytocin seems to attenuate negative cognitive responses to stress in anxious individuals...
  12. doi request reprint Biased attentional processing of positive stimuli in social anxiety disorder: an eye movement study
    Nigel T M Chen
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Cogn Behav Ther 41:96-107. 2012
    ..No differential pattern of engagement was evident between groups. We conclude that social anxiety is maintained in part by the aberrant processing of positive social stimuli...
  13. ncbi request reprint Oxytocin increases gaze to the eye region of human faces
    Adam J Guastella
    School of Psychology, University of New South Wales, Kensington, Sydney, Australia
    Biol Psychiatry 63:3-5. 2008
    ..In humans, oxytocin has been found to enhance trust and the ability to interpret the emotions of others. It has been suggested that oxytocin may enhance facial processing by increasing focus on the eye region of human faces...
  14. doi request reprint Functional impairment in adolescents and young adults with emerging mood disorders
    Jan Scott
    Jan Scott, MBBS, MD, FRCPsych, Academic Psychiatry, Institute of Neuroscience, Newcastle University, Newcastle and Centre for Affective Disorders, Institute of Psychiatry, London, UK Elizabeth M Scott, MBChB, FRANZCP, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney and School of Medicine, University of Notre Dame, Sydney, Australia Daniel F Hermens, GradDipSci, PhD, Sharon L Naismith, MClinPsych, DPsych, Adam J Guastella, PhD, Django White, Bradley Whitwell, DipAppSci, Jim Lagopoulos, MBiomedE, PhD, FAINM, Ian B Hickie, MD, FRANZCP, Clinical Research Unit, France
    Br J Psychiatry 205:362-8. 2014
    ..Between 30 and 60% of adults with unipolar or bipolar disorders exhibit impairments across multiple domains. However, little is known about impaired functioning in youth with mood disorders...
  15. doi request reprint Applying clinical staging to young people who present for mental health care
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales
    Early Interv Psychiatry 7:31-43. 2013
    ....
  16. doi request reprint Heart rate variability is associated with emotion recognition: direct evidence for a relationship between the autonomic nervous system and social cognition
    Daniel S Quintana
    SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia
    Int J Psychophysiol 86:168-72. 2012
    ..Our data suggests that increased HRV may provide a novel marker of one's ability to recognize emotions in humans. Implications for understanding the biological basis of emotion recognition, and social impairment in humans are discussed...
  17. doi request reprint Effects of oxytocin on human social approach measured using intimacy equilibriums
    Jean C J Liu
    School of Psychology, University of New South Wales, Sydney, Australia
    Horm Behav 62:585-91. 2012
    ..Based on this notion, our results suggest that oxytocin does not facilitate social approach by increasing the intimacy equilibrium between two strangers...
  18. doi request reprint Reduced eye gaze explains "fear blindness" in childhood psychopathic traits
    Mark R Dadds
    School of Psychology, University of New South Wales, Sydney, Australia
    J Am Acad Child Adolesc Psychiatry 47:455-63. 2008
    ..This study tested whether psychopathic traits are associated with reduced attention to the eye region of other people's faces...
  19. doi request reprint The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial
    Adam J Guastella
    Autism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    J Child Psychol Psychiatry 56:444-52. 2015
    ..The aim of this study was to investigate the efficacy of a course of oxytocin nasal spray to improve social behavior in youth with ASD...
  20. doi request reprint Heart rate variability predicts alcohol craving in alcohol dependent outpatients: further evidence for HRV as a psychophysiological marker of self-regulation
    Daniel S Quintana
    SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia
    Drug Alcohol Depend 132:395-8. 2013
    ..Thus, the aim of the present study was to determine whether HRV predicts alcohol craving in dependent individuals in the community...
  21. doi request reprint Assessing the role of spatial engagement and disengagement of attention in anxiety-linked attentional bias: a critique of current paradigms and suggestions for future research directions
    Patrick J F Clarke
    School of Psychology, The University of Western Australia, Crawley, WA 6009, Australia
    Anxiety Stress Coping 26:1-19. 2013
    ....
  22. doi request reprint Arginine Vasopressin selectively enhances recognition of sexual cues in male humans
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, NSW, Australia
    Psychoneuroendocrinology 36:294-7. 2011
    ..They further extend animal and human genetic studies linking Arginine Vasopressin to sexual behavior in males. Findings suggest an important cognitive mechanism that could enhance sexual behaviors in humans...
  23. doi request reprint Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus
    Dean S Carson
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Addict Biol 15:448-63. 2010
    ..Overall, these results give further insight into the way in which oxytocin might moderate compulsive behaviors and demonstrate the capacity of peripherally administered oxytocin to induce widespread central effects...
  24. pmc Evaluating differential developmental trajectories to adolescent-onset mood and psychotic disorders
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 13:303. 2013
    ....
  25. pmc Clinical classification in mental health at the cross-roads: which direction next?
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown 2050, Australia
    BMC Med 11:125. 2013
    ..Although this enhanced epidemiology and health services planning, it failed to link broad diagnostic groupings to underlying pathophysiology or specific treatment response...
  26. doi request reprint Distinguishing young people with emerging bipolar disorders from those with unipolar depression
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    J Affect Disord 144:208-15. 2013
    ..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders...
  27. doi request reprint Intranasal arginine vasopressin enhances the encoding of happy and angry faces in humans
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Biol Psychiatry 67:1220-2. 2010
    ..There has been little research in humans exploring its effect on social cognition, including the encoding of social memories...
  28. ncbi request reprint A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia
    Behav Res Ther 45:663-72. 2007
    ..Further experimental research is needed to better understand the mechanisms underlying the therapeutic effects of DCS...
  29. pmc A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis
    Cristina Cacciotti-Saija
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Schizophr Bull 41:483-93. 2015
    ..Although results suggest no benefit of oxytocin treatment, results also highlight an urgent need to consider nasal spray delivery and dose-related variables for future clinical trials. ..
  30. pmc The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis
    Sara Shahrestani
    Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    Neuropsychopharmacology 38:1929-36. 2013
    ....
  31. doi request reprint Exploring the role of intra-nasal oxytocin on the partner preference effect in humans
    Jean C J Liu
    School of Psychology, University of New South Wales, Sydney, New South Wales, Australia
    Psychoneuroendocrinology 38:587-91. 2013
    ..Taken together, our findings suggest that oxytocin might not promote human bond formation in ways analogous to prairie voles - that is, by inducing a partner preference effect...
  32. doi request reprint Clinical staging model applied to young people presenting with social anxiety
    Patrick J F Clarke
    Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Early Interv Psychiatry 6:256-64. 2012
    ..The goal was to provide a detailed description of common clinical stage of those presenting for treatment of social anxiety, and to delineate the associations between symptom type, severity and clinical stage...
  33. doi request reprint A critical review of the influence of oxytocin nasal spray on social cognition in humans: evidence and future directions
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, 2050, Australia
    Horm Behav 61:410-8. 2012
    ..This should now be a major focus for future research. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
  34. pmc A cross-sectional exploration of the clinical characteristics of disengaged (NEET) young people in primary mental healthcare
    Bridianne O'Dea
    Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    BMJ Open 4:e006378. 2014
    ..This study aimed to examine NEET status and its correlates in a sample of such youth...
  35. pmc Ambulatory sleep-wake patterns and variability in young people with emerging mental disorders
    Rébecca Robillard
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Brain and Mind Research Institute, Camperdown NSW, Australia
    J Psychiatry Neurosci 40:28-37. 2015
    ..The present study aimed to examine the differences in objective ambulatory measures of the sleep-wake and activity cycles across young people with anxiety, mood or psychotic disorders...
  36. doi request reprint Heart rate variability during adolescent and adult social interactions: a meta-analysis
    Sara Shahrestani
    Autism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Australia
    Biol Psychol 105:43-50. 2015
    ..The role of age, gender and HRV index were also examined as potential moderators of HRV. Implications for health and wellbeing resulting from exposure to negative social interactions are discussed. ..
  37. doi request reprint Attentional bias modification facilitates attentional control mechanisms: evidence from eye tracking
    Nigel T M Chen
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia Centre for the Advancement of Research on Emotion, School of Psychology, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia Electronic address
    Biol Psychol 104:139-46. 2015
    ..Mediational analysis revealed that the shift in attentional bias following ABM was independent to the change in attentional control. The findings suggest that the mechanisms of ABM are multifaceted. ..
  38. doi request reprint Moderate alcohol intake is related to increased heart rate variability in young adults: implications for health and well-being
    Daniel S Quintana
    SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Sydney, Australia Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Psychophysiology 50:1202-8. 2013
    ..Regardless, results highlight HRV as a candidate mechanism for the findings reported in the epidemiological literature. ..
  39. doi request reprint A meta-analysis on the impact of alcohol dependence on short-term resting-state heart rate variability: implications for cardiovascular risk
    Daniel S Quintana
    School of Psychology, University of Sydney, Sydney, NSW, Australia
    Alcohol Clin Exp Res 37:E23-9. 2013
    ..However, prior studies on the impact of alcohol dependence on HRV have reported contradictory findings highlighting the need for a meta-analysis...
  40. doi request reprint Prepared for the best: readiness to modify attentional processing and reduction in anxiety vulnerability in response to therapy
    Patrick J F Clarke
    Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Emotion 12:487-94. 2012
    ....
  41. doi request reprint Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats
    Dean S Carson
    Brain and Mind Research Institute, University of Sydney, Australia
    Neuropharmacology 58:38-43. 2010
    ..These results point to the potential utility of human trials of oxytocin as a therapeutic treatment for methamphetamine addiction...
  42. ncbi request reprint A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear
    Adam J Guastella
    School of Psychology, University of New South Wales, Kensington, Sydney, NSW 2052, Australia
    J Psychiatr Res 41:466-71. 2007
    ..DCS did not enhance the reduction of spider fears or the generalisation of treatment of a single session of exposure-based therapy. These results suggest that DCS may not enhance loss of non-clinical levels of fear in human populations...
  43. doi request reprint Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection
    Gail A Alvares
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Exp Clin Psychopharmacol 18:316-21. 2010
    ..The results suggest that in an explicitly aversive context, oxytocin does not buffer against the immediate impact of blunt social rejection...
  44. doi request reprint Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model
    Daniel S Quintana
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2050, Australia Electronic address
    Neurosci Biobehav Rev 49:182-92. 2015
    ..We propose a two-level model involving three pathways to account for responses observed in both social cognition and behavior after intranasal OT administration and suggest avenues for future research to advance this research field. ..
  45. doi request reprint Heart rate variability during social interactions in children with and without psychopathology: a meta-analysis
    Sara Shahrestani
    Autism Clinic for Translational Research, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    J Child Psychol Psychiatry 55:981-9. 2014
    ..Research has employed heart rate variability (HRV) during both socially engaging and socially disengaging dyadic tasks between children and adults to assess this...
  46. pmc Biased saccadic responses to emotional stimuli in anxiety: an antisaccade study
    Nigel T M Chen
    Brain and Mind Research Institute, University of Sydney, Camperdown NSW, Australia
    PLoS ONE 9:e86474. 2014
    ..The findings further highlight the relevance of considering saccade peak velocity in the assessment of anxiety-linked attentional processing. ..
  47. pmc A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
    Daniel S Quintana
    SCAN Research and Teaching Unit, School of Psychology, The University of Sydney Sydney, NSW, Australia Brain and Mind Research Institute, The University of Sydney Sydney, NSW, Australia
    Front Neurosci 7:48. 2013
    ....
  48. pmc Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e44014. 2012
    ..Furthermore, no studies have examined the impact of OT on HRV under resting conditions, which provides an index of maximal capacity for social engagement...
  49. doi request reprint A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome
    Stewart L Einfeld
    Centre for Disability Research and Policy, University of Sydney, Sydney, New South Wales, Australia Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Am J Med Genet A 164:2232-9. 2014
    ..023) with higher dose oxytocin. The lack of effect of oxytocin nasal spray may reflect the importance of endogenous release of oxytocin in response to exogenous oxytocin...
  50. pmc Impairments in goal-directed actions predict treatment response to cognitive-behavioral therapy in social anxiety disorder
    Gail A Alvares
    Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 9:e94778. 2014
    ..These findings indicate that variations in goal-directed control in social anxiety may represent both a behavioral endophenotype and may be used to predict individuals who will respond to learning-based therapies. ..
  51. doi request reprint Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney 2006, Australia
    Psychoneuroendocrinology 38:612-25. 2013
    ..We hope that these recommendations assist in establishing a scientific standard that can improve the rigor and subsequent reliability of reported effects of oxytocin nasal spray in humans...
  52. doi request reprint Oxytocin as a moderator of hypnotizability
    Richard A Bryant
    School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia
    Psychoneuroendocrinology 37:162-6. 2012
    ..This is the first demonstration of a neurochemical basis for hypnotic responding, and points to a potential neural mechanism to explain hypnotizability...
  53. ncbi request reprint Targeted primary care-based mental health services for young Australians
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, Sydney, NSW
    Med J Aust 196:136-40. 2012
    ....