M D Grounds

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Anti-TNFalpha (Remicade) therapy protects dystrophic skeletal muscle from necrosis
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, Australia 6009
    FASEB J 18:676-82. 2004
  2. ncbi request reprint Muscle regeneration: molecular aspects and therapeutic implications
    M D Grounds
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Australia
    Curr Opin Neurol 12:535-43. 1999
  3. ncbi request reprint Absence of desmin slightly prolongs myoblast proliferation and delays fusion in vivo in regenerating grafts of skeletal muscle
    G M Smythe
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Perth
    Cell Tissue Res 304:287-94. 2001
  4. ncbi request reprint The absence of MyoD in regenerating skeletal muscle affects the expression pattern of basement membrane, interstitial matrix and integrin molecules that is consistent with delayed myotube formation
    J Huijbregts
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
    Acta Histochem 103:379-96. 2001
  5. ncbi request reprint Why do cultured transplanted myoblasts die in vivo? DNA quantification shows enhanced survival of donor male myoblasts in host mice depleted of CD4+ and CD8+ cells or Nk1.1+ cells
    S I Hodgetts
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Perth
    Cell Transplant 9:489-502. 2000
  6. ncbi request reprint The exogenous administration of basic fibroblast growth factor to regenerating skeletal muscle in mice does not enhance the process of regeneration
    C A Mitchell
    Department of Pathology, University of Western Australia, Nedlands, Australia
    Growth Factors 13:37-55. 1996
  7. ncbi request reprint Myotube formation is delayed but not prevented in MyoD-deficient skeletal muscle: studies in regenerating whole muscle grafts of adult mice
    J D White
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Western Australia
    J Histochem Cytochem 48:1531-44. 2000
  8. ncbi request reprint Immunobiology and the future of myoblast transfer therapy
    G M Smythe
    Department of Anatomy and Human Biology, University of Western Australia, Perth, Australia
    Mol Ther 1:304-13. 2000
  9. ncbi request reprint Exposure to tissue culture conditions can adversely affect myoblast behavior in vivo in whole muscle grafts: implications for myoblast transfer therapy
    G M Smythe
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Australia
    Cell Transplant 9:379-93. 2000
  10. pmc The timing between skeletal muscle myoblast replication and fusion into myotubes, and the stability of regenerated dystrophic myofibres: an autoradiographic study in mdx mice
    J K McGeachie
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands Perth, Australia
    J Anat 194:287-95. 1999

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Anti-TNFalpha (Remicade) therapy protects dystrophic skeletal muscle from necrosis
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, Australia 6009
    FASEB J 18:676-82. 2004
    ..Remicade is a highly specific anti-inflammatory intervention, and clinical application to muscular dystrophies is suggested by this marked protective effect against skeletal muscle breakdown...
  2. ncbi request reprint Muscle regeneration: molecular aspects and therapeutic implications
    M D Grounds
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Australia
    Curr Opin Neurol 12:535-43. 1999
    ....
  3. ncbi request reprint Absence of desmin slightly prolongs myoblast proliferation and delays fusion in vivo in regenerating grafts of skeletal muscle
    G M Smythe
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Perth
    Cell Tissue Res 304:287-94. 2001
    ..These results indicate a slightly extended phase of myoblast proliferation with delayed fusion in vivo in mature regenerating desmin (-/-) skeletal muscle...
  4. ncbi request reprint The absence of MyoD in regenerating skeletal muscle affects the expression pattern of basement membrane, interstitial matrix and integrin molecules that is consistent with delayed myotube formation
    J Huijbregts
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
    Acta Histochem 103:379-96. 2001
    ....
  5. ncbi request reprint Why do cultured transplanted myoblasts die in vivo? DNA quantification shows enhanced survival of donor male myoblasts in host mice depleted of CD4+ and CD8+ cells or Nk1.1+ cells
    S I Hodgetts
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Perth
    Cell Transplant 9:489-502. 2000
    ..These results provide a strategic approach to enhance donor myoblast survival in clinical trials of MTT...
  6. ncbi request reprint The exogenous administration of basic fibroblast growth factor to regenerating skeletal muscle in mice does not enhance the process of regeneration
    C A Mitchell
    Department of Pathology, University of Western Australia, Nedlands, Australia
    Growth Factors 13:37-55. 1996
    ....
  7. ncbi request reprint Myotube formation is delayed but not prevented in MyoD-deficient skeletal muscle: studies in regenerating whole muscle grafts of adult mice
    J D White
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Western Australia
    J Histochem Cytochem 48:1531-44. 2000
    ..Overall, although muscle regeneration was delayed it was not impaired in MyoD(-/-) mice in this model...
  8. ncbi request reprint Immunobiology and the future of myoblast transfer therapy
    G M Smythe
    Department of Anatomy and Human Biology, University of Western Australia, Perth, Australia
    Mol Ther 1:304-13. 2000
    ....
  9. ncbi request reprint Exposure to tissue culture conditions can adversely affect myoblast behavior in vivo in whole muscle grafts: implications for myoblast transfer therapy
    G M Smythe
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Australia
    Cell Transplant 9:379-93. 2000
    ..The use of whole-muscle grafts provides an alternative and sensitive model to analyze the crucial effects of various tissue culture components on the subsequent survival and proliferation of myogenic cells in vivo...
  10. pmc The timing between skeletal muscle myoblast replication and fusion into myotubes, and the stability of regenerated dystrophic myofibres: an autoradiographic study in mdx mice
    J K McGeachie
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands Perth, Australia
    J Anat 194:287-95. 1999
    ..These results have implications for understanding the cellular biology and pathology of dystrophic muscle, particularly in relation to myoblast transfer therapy as a potential treatment of Duchenne muscular dystrophy...
  11. ncbi request reprint Rskalpha-actin/hIGF-1 transgenic mice with increased IGF-I in skeletal muscle and blood: impact on regeneration, denervation and muscular dystrophy
    T Shavlakadze
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth
    Growth Horm IGF Res 16:157-73. 2006
    ..No beneficial effect of muscle specific over-expression of Rskalpha-actin/hIGF-I transgene was seen in these three experimental models...
  12. ncbi request reprint Enhanced migration and fusion of donor myoblasts in dystrophic and normal host muscle
    G M Smythe
    Department of Anatomy, The University of Western Australia, Nedlands, Perth, Western Australia, 6907
    Muscle Nerve 23:560-74. 2000
    ..These data endorse the use of host T-cell depletion as a promising long-term strategy to improve myoblast transfer therapy (MTT) in the clinical situation...
  13. ncbi request reprint Leukaemia inhibitory factor increases myoblast replication and survival and affects extracellular matrix production: combined in vivo and in vitro studies in post-natal skeletal muscle
    J D White
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
    Cell Tissue Res 306:129-41. 2001
    ..These combined in vitro and in vivo studies show an effect of LIF on ECM production in vitro, on myoblast survival and on in vivo myoblast replication...
  14. ncbi request reprint The role of tumor necrosis factor-alpha (TNF-alpha) in skeletal muscle regeneration. Studies in TNF-alpha(-/-) and TNF-alpha(-/-)/LT-alpha(-/-) mice
    R A Collins
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Western Australia
    J Histochem Cytochem 49:989-1001. 2001
    ....
  15. ncbi request reprint Absence of MyoD increases donor myoblast migration into host muscle
    G M Smythe
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, 6009, Western Australia
    Exp Cell Res 267:267-74. 2001
    ....
  16. ncbi request reprint Complement and myoblast transfer therapy: donor myoblast survival is enhanced following depletion of host complement C3 using cobra venom factor, but not in the absence of C5
    S I Hodgetts
    Department of Anatomy and Human Biology, University of Western Australia, Crawley, Western Australia, Australia
    Immunol Cell Biol 79:231-9. 2001
    ..The observation that myoblast survival was increased in all mice treated with CVF suggests that CVF may indirectly enhance donor myoblast survival by a mechanism possibly involving activated C3 fragments...
  17. pmc Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability
    P W Hamer
    Department of Human Movement and Exercise Science, The University of Western Australia, Crawley, Australia
    J Anat 200:69-79. 2002
    ..This simple and inexpensive technique has sensitivity for the detection of increased myofibre permeability and/or sublethal damage that has advantages over other traditional histological techniques at the light microscopy level...
  18. doi request reprint Reduced muscle necrosis and long-term benefits in dystrophic mdx mice after cV1q (blockade of TNF) treatment
    Hannah G Radley
    School of Anatomy and Human Biology, The University of Western Australia, Anatomy and Human Biology, Perth, WA 6009, Australia
    Neuromuscul Disord 18:227-38. 2008
    ..An additional measure of well-being in the cV1q treated mice was that they ran significantly more than control mdx mice...
  19. doi request reprint Impact of fasting on the rhythmic expression of myogenic and metabolic factors in skeletal muscle of adult mice
    T Shavlakadze
    School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
    Am J Physiol Cell Physiol 305:C26-35. 2013
    ..This in vivo circadian study addresses for the first time the signaling activities of key molecules related to protein turnover and their possible cross-regulation of expression of genes related to protein degradation. ..
  20. ncbi request reprint Strength at the extracellular matrix-muscle interface
    M D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Perth, WA, Australia
    Scand J Med Sci Sports 15:381-91. 2005
    ..Novel interventions to potentially increase muscle strength and reduce myofiber damage are mentioned, and these are also highly relevant to muscle diseases and aging muscle...
  21. ncbi request reprint A novel role for non-muscle gamma-actin in skeletal muscle sarcomere assembly
    C M Lloyd
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia
    Exp Cell Res 297:82-96. 2004
    ..Consequently, a modified model is proposed which describes the role of gamma-actin in skeletal sarcomere assembly...
  22. ncbi request reprint Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNFalpha function with Etanercept in mdx mice
    Stuart Hodgetts
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Neuromuscul Disord 16:591-602. 2006
    ..Etanercept is a highly specific anti-inflammatory drug, widely used clinically, and potential application to muscular dystrophies is suggested by this reduced breakdown of mdx skeletal muscle...
  23. ncbi request reprint Duchenne muscular dystrophy: focus on pharmaceutical and nutritional interventions
    H G Radley
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia
    Int J Biochem Cell Biol 39:469-77. 2007
    ....
  24. doi request reprint Blockade of TNF in vivo using cV1q antibody reduces contractile dysfunction of skeletal muscle in response to eccentric exercise in dystrophic mdx and normal mice
    A T Piers
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia
    Neuromuscul Disord 21:132-41. 2011
    ..This in vivo evidence that cV1q reduces the TNF-mediated adverse response to exercise-induced muscle damage supports the use of targeted anti-TNF treatments to reduce the severity of the functional deficit and dystropathology in DMD...
  25. ncbi request reprint Age-associated changes in the response of skeletal muscle cells to exercise and regeneration
    M D Grounds
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Western Australia
    Ann N Y Acad Sci 854:78-91. 1998
    ..Emphasis is placed on the important role of the host environment, inflammatory cells, growth factors and their receptors (particularly for FGF-2), and the extracellular matrix...
  26. ncbi request reprint In vitro assessment of the biological activity of basic fibroblast growth factor released from various polymers and biomatrices
    M J Davies
    Department of Pathology, University of Western Australia, Nedlands
    J Biomater Appl 12:31-56. 1997
    ..These studies emphasise the importance of in vitro analysis of release kinetics of growth factors from a range of materials as a basis for potential in vivo applications...
  27. ncbi request reprint Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice
    Thea Shavlakadze
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
    Mol Ther 10:829-43. 2004
    ..This mechanism of action can account for the long-term reduced severity of the dystropathology in mdx mice that overexpress mIGF-1 and provides promising opportunities for therapeutic strategies...
  28. ncbi request reprint Macrophages and dendritic cells in normal and regenerating murine skeletal muscle
    A Pimorady-Esfahani
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Australia
    Muscle Nerve 20:158-66. 1997
    ....
  29. ncbi request reprint Studies on the structure of complement C3 and the stability of C3 derived phagocytic ligands C3b/iC3b in SJL/J and BALB/c mice
    D M Lynch
    Department of Pathology, University of Western Australia, Nedlands
    Eur J Immunogenet 20:1-9. 1993
    ....
  30. doi request reprint Two-tiered hypotheses for Duchenne muscular dystrophy
    M D Grounds
    School of Anatomy and Human Biology, University of Western Australia, Crawley, WA, Australia
    Cell Mol Life Sci 65:1621-5. 2008
    ..A deeper understanding of the events arising as an early consequence of dystrophin deficiency in these two situations may strengthen approaches to therapy for DMD designed to improve muscle function and the quality of life...
  31. ncbi request reprint Intrinsic differences in MyoD and myogenin expression between primary cultures of SJL/J and BALB/C skeletal muscle
    M A Maley
    Department of Pathology, University of Western Australia, Nedlands
    Exp Cell Res 211:99-107. 1994
    ..The observed strain-specific difference infers a greater intrinsic myogenicity of cells in SJL/J muscle in vitro and reflects the superior capacity for new muscle formation previously reported in SJL/J mice in vivo...
  32. ncbi request reprint Silencing TNFalpha activity by using Remicade or Enbrel blocks inflammation in whole muscle grafts: an in vivo bioassay to assess the efficacy of anti-cytokine drugs in mice
    Miranda D Grounds
    School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009, Australia
    Cell Tissue Res 320:509-15. 2005
    ..This simple reproducible in vivo assay model in mice can be used to evaluate the efficacy of many novel anti-cytokine interventions designed to block inflammation...
  33. ncbi request reprint Measurement of sub-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18
    Renzhi Han
    School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cell Calcium 40:299-307. 2006
    ..This study suggests that the sub-sarcolemmal Ca(2+) homeostasis is well maintained in isolated adult mdx myofibers and also further supports the hypothesis that cytosolic Ca(2+) handling is compromised in mdx myotubes...
  34. doi request reprint The physiological effects of IGF-1 (class 1:Ea transgene) over-expression on exercise-induced damage and adaptation in dystrophic muscles of mdx mice
    James A Ridgley
    The University of Western Australia, Crawley, Australia
    Pflugers Arch 457:1121-32. 2009
    ....
  35. doi request reprint Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
    Clin Exp Pharmacol Physiol 35:846-51. 2008
    ....
  36. pmc Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia, Australia
    Neurobiol Dis 31:1-19. 2008
    ....
  37. ncbi request reprint Skeletal muscle regeneration after crush injury in dystrophic mdx mice: an autoradiographic study
    M D Grounds
    Department of Pathology, University of Western Australia, Nedlands
    Muscle Nerve 15:580-6. 1992
    ..Little difference in the regenerative capacity, either histologically or with respect to the timing of muscle precursor replication, was found between mdx mice and C57Bl/10Sn or other nondystrophic strains of mice...
  38. ncbi request reprint A comparison between real-time quantitative PCR and DNA hybridization for quantitation of male DNA following myoblast transplantation
    Erika Bosio
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Perth, WA, Australia
    Cell Transplant 13:817-21. 2004
    ..5 times higher than the maximum possible with slot-blot. In conclusion, Q-PCR has a higher dynamic range and is more efficient than slot-blot analysis for the detection of donor cell engraftment in a transsexual transplantation model...
  39. ncbi request reprint The role of p53 in vivo during skeletal muscle post-natal development and regeneration: studies in p53 knockout mice
    Jason D White
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
    Int J Dev Biol 46:577-82. 2002
    ..These data indicate that p53 is not required for the regulation of myoblast proliferation, differentiation and myotube formation in vivo during myogenesis of adult skeletal muscle...
  40. ncbi request reprint Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice
    Hannah G Radley
    School of Anatomy and Human Biology, M309, University of Western Australia, Crawley, Australia
    Neurobiol Dis 23:387-97. 2006
    ....
  41. doi request reprint Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice
    Felicity J Waters
    School of Anatomy and Human Biology, University of Western Australia, Crawley, WA, Australia
    Mol Cell Biochem 337:119-31. 2010
    ..These results support the hypothesis that p53 plays some role in TNF-mediated necrosis of dystrophic muscle and present a potential new target for therapeutic interventions...
  42. ncbi request reprint Superior survival and proliferation after transplantation of myoblasts obtained from adult mice compared with neonatal mice
    Tracey F Lee-Pullen
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, QEII Medical Centre, Nedlands, Perth, WA 6009, Australia
    Transplantation 78:1172-6. 2004
    ....
  43. doi request reprint A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo
    Thea Shavlakadze
    School of Anatomy and Human Biology, The University of Western Australia, Perth 6009, WA, Australia
    J Cell Sci 123:960-71. 2010
    ..These data demonstrate that elevated IGF-1 has a hypertrophic effect on skeletal muscle only in growth situations...
  44. doi request reprint Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice
    Thea Shavlakadze
    M309, School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia
    Biogerontology 11:363-76. 2010
    ..This delay is transient. Once inflammation occurs, myogenesis can proceed. The presence of well developed myotubes in old muscle autografts at 10 days confirms a very good inherent myogenic response of geriatric skeletal muscle...
  45. ncbi request reprint The role of stem cells in skeletal and cardiac muscle repair
    Miranda D Grounds
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia
    J Histochem Cytochem 50:589-610. 2002
    ..For heart muscle, experiments showing the participation of bone marrow-derived stem cells and endothelial cells in the repair of damaged cardiac muscle are encouraging...
  46. ncbi request reprint Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions
    Peter G Arthur
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
    Curr Opin Clin Nutr Metab Care 11:408-16. 2008
    ..Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting...
  47. ncbi request reprint Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling
    Miranda D Grounds
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Australia
    Biogerontology 3:19-24. 2002
    ..The possible clinical prevention of age-related muscle wasting (and associated motorneurone loss) by the locally acting muscle isoform of IGF-I is discussed...
  48. doi request reprint Three-dimensional optical coherence tomography of whole-muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice
    Blake R Klyen
    The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Biomed Opt 13:011003. 2008
    ..These preliminary findings suggest that, with further development, 3D-OCT could be used as a tool for the evaluation of small-animal muscle morphology and pathology, in particular, for analysis of mouse models of muscular dystrophy...
  49. ncbi request reprint Adeno-associated virus-mediated vascular endothelial growth factor gene therapy in skeletal muscle before transplantation promotes revascularization of regenerating muscle
    Gayle M Smythe
    Department of Anatomy and Human Biology, University of Western Australia, Crawley, Perth, Australia 6009
    Tissue Eng 8:879-91. 2002
    ....
  50. ncbi request reprint An evaluation of leukaemia inhibitory factor as a potential therapeutic agent in the treatment of muscle disease
    Jason D White
    Department of Anatomy and Human Biology, University of Western Australia, Stirling Hwy, Western Australia, 6009, Crawley, Australia
    Neuromuscul Disord 12:909-16. 2002
    ....
  51. ncbi request reprint Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy
    Thea Shavlakadze
    School of Anatomy and Human Biology, The University of Western Australia, 35, Stirling Highway, Crawley, Perth, WA 6009, Australia
    Neuromuscul Disord 15:139-46. 2005
    ..It is proposed that the protective effect of mIGF-1 on denervated myofibres might be due to reduced protein breakdown...
  52. ncbi request reprint Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle
    Thea Shavlakadze
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
    Growth Horm IGF Res 15:4-18. 2005
    ..Full understanding of these complex in vivo issues is essential, not only for skeletal muscle but for many other tissues, in order to effectively extend observations derived from transgenic studies into potential clinical situations...
  53. ncbi request reprint Early regeneration of whole skeletal muscle grafts is unaffected by overexpression of IGF-1 in MLC/mIGF-1 transgenic mice
    Thea Shavlakadze
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Western Australia 6009
    J Histochem Cytochem 52:873-83. 2004
    ..Skeletal muscle-specific overexpression of mIGF-1 does not appear to stimulate the early events associated with myogenesis during regeneration of whole muscle grafts...
  54. ncbi request reprint Myoblast structure affects subsequent skeletal myotube morphology and sarcomere assembly
    Monique Berendse
    School of Anatomy and Human Biology, University of Western Australia, Mail Delivery Point M309, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Exp Cell Res 291:435-50. 2003
    ....
  55. ncbi request reprint Irradiation of dystrophic host tissue prior to myoblast transfer therapy enhances initial (but not long-term) survival of donor myoblasts
    Stuart I Hodgetts
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    J Cell Sci 116:4131-46. 2003
    ..Serum protein levels of TNFalpha, IL-1beta, IL-6 and IL-12 fluctuated following irradiation treatments. These combined results strongly reinforce a major role for host immune cells in the rapid death of injected cultured donor myoblasts...
  56. ncbi request reprint Effect of indomethacin on force responses and sarcoplasmic reticulum function in skinned skeletal muscle fibers and cytosolic [Ca2+] in myotubes
    Renzhi Han
    School of Biomedical and Chemical Studies, The University of Western Australia, Crawley, Australia
    Am J Physiol Cell Physiol 285:C881-90. 2003
    ..These data suggest that intracellular PLA2 may be an important modulator of ECC in skeletal muscle...
  57. ncbi request reprint A role for natural killer cells in the rapid death of cultured donor myoblasts after transplantation
    Stuart I Hodgetts
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia
    Transplantation 75:863-71. 2003
    ..This study shows blood-borne factors are responsible and that ablating the host natural killer (NK) cell response greatly enhances the survival of such donor myoblasts...
  58. ncbi request reprint The allure of stem cell therapy for muscular dystrophy
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Australia
    Neuromuscul Disord 17:206-8. 2007
    ..However, the authors' interpretation of the results did not consider that benefits might arise from the concomitant use of immunosuppressive drugs alone...
  59. ncbi request reprint Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice
    Jonathan D Schertzer
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Cell Physiol 294:C161-8. 2008
    ..The results demonstrate that IGF-I can ameliorate fundamental aspects of E-C coupling failure in dystrophic muscle fibers and that these effects are important for the improvements in cellular function induced by this growth factor...
  60. ncbi request reprint Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells
    Jason D White
    School of Veterinary Science, The University of Melbourne, Parkville, VIC 3010, Australia
    Differentiation 76:283-98. 2008
    ..We postulate that Dlk1 is implicated in the commitment and/or proliferation of fetal myoblasts as well as in the maintenance of hypertrophy in fully differentiated myofibers...