Keith Grimwood

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Trials 14:53. 2013
  2. pmc Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Trials 13:156. 2012
  3. pmc Azithromycin for Indigenous children with bronchiectasis: study protocol for a multi-centre randomized controlled trial
    Patricia C Valery
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    BMC Pediatr 12:122. 2012
  4. pmc Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocol
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trials 12:94. 2011
  5. doi request reprint Airway microbiology and host defences in paediatric non-CF bronchiectasis
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Brisbane, Queensland, Australia
    Paediatr Respir Rev 12:111-8. 2011
  6. doi request reprint Rotavirus infections and vaccines: burden of illness and potential impact of vaccination
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Herston Road, Herston, QLD 4029, Australia
    Paediatr Drugs 12:235-56. 2010
  7. doi request reprint Shared Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres
    Timothy J Kidd
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, Royal Children s Hospital, The University of Queensland, Brisbane, Australia
    Eur Respir J 41:1091-100. 2013
  8. doi request reprint High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform
    Melanie W Syrmis
    Queensland Paediatric Infectious Diseases Laboratory, Royal Children s Hospital, Brisbane, Queensland, Australia
    J Med Microbiol 62:734-40. 2013
  9. doi request reprint Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial
    Claire E Wainwright
    Queensland Children s Medical Research Institute, and Queensland Children s Respiratory Centre, Royal Children s Hospital, University of Queensland, Brisbane, Australia
    JAMA 306:163-71. 2011
  10. doi request reprint Clonal complex Pseudomonas aeruginosa in horses
    Timothy J Kidd
    Department of Infectious Diseases, Royal Children s Hospital, Queensland Children s Medical Research Institute, The University of Queensland, Brisbane, Australia
    Vet Microbiol 149:508-12. 2011

Collaborators

Detail Information

Publications30

  1. pmc Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Trials 14:53. 2013
    ....
  2. pmc Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Trials 13:156. 2012
    ....
  3. pmc Azithromycin for Indigenous children with bronchiectasis: study protocol for a multi-centre randomized controlled trial
    Patricia C Valery
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    BMC Pediatr 12:122. 2012
    ..This study tests the hypothesis that azithromycin administered once a week as maintenance antibiotic treatment will reduce the rate of pulmonary exacerbations in Indigenous children with bronchiectasis...
  4. pmc Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocol
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trials 12:94. 2011
    ..Our study tests the hypothesis that the anti-microbial and anti-inflammatory properties of azithromycin, improve the clinical outcomes of Indigenous Australian infants hospitalised with bronchiolitis...
  5. doi request reprint Airway microbiology and host defences in paediatric non-CF bronchiectasis
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Brisbane, Queensland, Australia
    Paediatr Respir Rev 12:111-8. 2011
    ..Airway inflammatory responses are excessive and persist, even once infection is cleared. Improved specimen collection, molecular techniques and biomarkers are needed to enhance management...
  6. doi request reprint Rotavirus infections and vaccines: burden of illness and potential impact of vaccination
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Herston Road, Herston, QLD 4029, Australia
    Paediatr Drugs 12:235-56. 2010
    ..Nonetheless, cost effectiveness in each country still depends largely on the local rotavirus mortality rate and the price of the vaccine in relation to the per capita gross domestic product...
  7. doi request reprint Shared Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres
    Timothy J Kidd
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, Royal Children s Hospital, The University of Queensland, Brisbane, Australia
    Eur Respir J 41:1091-100. 2013
    ..At least one of the predominant and widespread genotypes is associated with increased healthcare utilisation. Longitudinal studies are now needed to determine the infection control implications of these findings...
  8. doi request reprint High-throughput single-nucleotide polymorphism-based typing of shared Pseudomonas aeruginosa strains in cystic fibrosis patients using the Sequenom iPLEX platform
    Melanie W Syrmis
    Queensland Paediatric Infectious Diseases Laboratory, Royal Children s Hospital, Brisbane, Queensland, Australia
    J Med Microbiol 62:734-40. 2013
    ..SNP results for the 56 non-CF isolates were consistent with previous MLST data. Thus, the PA iPLEX format provides an attractive high-throughput alternative to ERIC-PCR for large-scale investigations of shared P. aeruginosa strains...
  9. doi request reprint Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial
    Claire E Wainwright
    Queensland Children s Medical Research Institute, and Queensland Children s Respiratory Centre, Royal Children s Hospital, University of Queensland, Brisbane, Australia
    JAMA 306:163-71. 2011
    ..While bronchoalveolar lavage (BAL) is an alternative diagnostic tool, evidence for its clinical benefit is lacking...
  10. doi request reprint Clonal complex Pseudomonas aeruginosa in horses
    Timothy J Kidd
    Department of Infectious Diseases, Royal Children s Hospital, Queensland Children s Medical Research Institute, The University of Queensland, Brisbane, Australia
    Vet Microbiol 149:508-12. 2011
    ..Instead, other potential acquisition pathways, as well as strain specific adaptation to the equine genital tract, should be investigated...
  11. pmc Comparison of three molecular techniques for typing Pseudomonas aeruginosa isolates in sputum samples from patients with cystic fibrosis
    Timothy J Kidd
    Queensland Paediatric Infectious Diseases Laboratory, Department of Infectious Diseases, Royal Children s Hospital, Queensland Children s Medical Research Institute, The University of Queensland, Brisbane, QLD, Australia
    J Clin Microbiol 49:263-8. 2011
    ..aeruginosa. Its focus on highly conserved housekeeping genes is particularly suited for long-term clinical monitoring and detecting novel strains...
  12. pmc Pseudomonas aeruginosa exhibits frequent recombination, but only a limited association between genotype and ecological setting
    Timothy J Kidd
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, Royal Children s Hospital, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e44199. 2012
    ..aeruginosa population. The increased abundance of some CF strains in different geographical regions is a likely product of chance colonisation events followed by adaptation to the CF lung and horizontal transmission among patients...
  13. ncbi request reprint Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand
    Anne B Chang
    Royal Children s Hospital and Queensland Children s Medical Research Institute, Brisbane, QLD, Australia
    Med J Aust 193:356-65. 2010
    ..Individualised long-term use of oral or nebulised antibiotics, corticosteroids, bronchodilators and mucoactive agents may provide a benefit, but are not recommended routinely...
  14. doi request reprint Acute and persistent diarrhea
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, Royal Children s Hospital, Herston Road, Herston, Brisbane, Queensland 4029, Australia
    Pediatr Clin North Am 56:1343-61. 2009
    ....
  15. doi request reprint Lower airway microbiology and cellularity in children with newly diagnosed non-CF bronchiectasis
    Nitin Kapur
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland, Australia
    Pediatr Pulmonol 47:300-7. 2012
    ..Infection and inflammation are important in the pathogenesis of bronchiectasis. However, there are few published data describing the lower airway microbiology and cellularity in children...
  16. doi request reprint Pentavalent rotavirus vaccine and prevention of gastroenteritis hospitalizations in Australia
    Emma J Field
    Communicable Diseases Branch, Queensland Health, Brisbane, Queensland, Australia
    Pediatrics 126:e506-12. 2010
    ..We sought to assess vaccine effectiveness (VE) of 3 doses of RV5 at preventing rotavirus and nonrotavirus acute gastroenteritis (AGE) hospitalizations in the first birth cohort and impact on hospitalizations in all age groups...
  17. ncbi request reprint Rotavirus vaccines: opportunities and challenges
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, University of Queensland, Brisbane, Australia
    Hum Vaccin 5:57-69. 2009
    ..Nevertheless, if these challenges are met, rotavirus vaccines should help reduce the 5% of all childhood deaths attributable to rotavirus gastroenteritis...
  18. doi request reprint Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control
    Asma N Alsaleh
    Queensland Children s Medical Research Institute, The University of Queensland, Brisbane Queensland 4029, Australia
    BMC Infect Dis 14:15. 2014
    ..We therefore investigated the impact of sample collection quality and the presence of visible mould in samples upon respiratory virus detection by real-time polymerase chain reaction (PCR) assays...
  19. doi request reprint Flexible bronchoscopy in managing a child with pulmonary hydatid disease
    Christopher Burgess
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland, Australia
    Pediatr Pulmonol 47:1140-2. 2012
    ..This child did not require thoracic surgery and made a full clinical recovery, demonstrating that in selected cases FB may offer curative treatment...
  20. doi request reprint Human rotavirus vaccines: too early for the strain to tell
    Keith Grimwood
    Queensland Paediatric Infectious Disease Laboratory, Discipline of Paediatrics and Child Health, Royal Children s Hospital and University of Queensland, Brisbane, QLD 4029, Australia
    Lancet 371:1144-5. 2008
  21. ncbi request reprint Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland
    Stephen B Lambert
    Queensland Paediatric Infectious Diseases Laboratory, Royal Children s Hospital, and Discipline of Paediatrics and Child Health, University of Queensland, Brisbane, QLD, Australia
    Med J Aust 191:157-60. 2009
    ..To assess the impact of introducing a publicly funded infant rotavirus vaccination program on disease notifications and on laboratory testing and results...
  22. doi request reprint Vaccines for children and adults with chronic lung disease: efficacy against acute exacerbations
    Kerry Ann F O'Grady
    The University of Queensland, Queensland Children s Medical Research Institute, Herston, QLD 4029, Australia
    Expert Rev Respir Med 8:43-55. 2014
    ..For vaccination to play an important role in managing chronic lung disease efforts need to be directed at understanding how various pathogens cause exacerbations and alter long-term lung function. ..
  23. pmc Comparison of DNA extraction methods for microbial community profiling with an application to pediatric bronchoalveolar lavage samples
    Dana Willner
    Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute of Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia
    PLoS ONE 7:e34605. 2012
    ..This study should help guide researchers to formulate sampling, extraction and analysis strategies for respiratory and other human microbiome samples...
  24. ncbi request reprint Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities
    Anne B Chang
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, QLD
    Med J Aust 189:386-93. 2008
    ..Physiotherapy and exercise should be encouraged, nutrition optimised, environmental pollutants (including tobacco smoke) avoided, and immunisations maintained...
  25. pmc Does a 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine prevent respiratory exacerbations in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: protocol for a randomised c
    Kerry Ann F O'Grady
    Queensland Children s Medical Research Institute, Royal Children s Hospital, The University of Queensland, Brisbane, QLD, Australia
    Trials 14:282. 2013
    ....
  26. doi request reprint Nocardia brasiliensis infection mimicking juvenile idiopathic arthritis in a 4-year-old girl
    Nitin Kapur
    Queensland Children s Medical Research Institute, 4th Floor, Foundation Building, Royal Children s Hospital, Herston Rd, Herston, Queensland 4029, Australia
    Pediatrics 132:e1424-7. 2013
    ..This is especially relevant when a single joint is involved and response to antiinflammatory therapy is suboptimal because antiinflammatory agents may mask evolving signs of infection. ..
  27. doi request reprint Community-associated methicillin-resistant Staphylococcus aureus causing orbital cellulitis in Australian children
    Vikram L Vaska
    The University of Queensland, UQ Centre for Clinical Research, Herston, QLD, Australia
    Pediatr Infect Dis J 30:1003-6. 2011
    ..At a tertiary pediatric hospital in Brisbane, Australia, community-associated methicillin-resistant S. aureus orbital cellulitis was first noted in 2009. Since then, it has caused 4 of 9 such infections...
  28. pmc Low rates of Pseudomonas aeruginosa misidentification in isolates from cystic fibrosis patients
    Timothy J Kidd
    School of Medicine, University of Queensland, Brisbane, Queensland, Australia
    J Clin Microbiol 47:1503-9. 2009
    ..aeruginosa isolates. Isolates exhibiting atypical phenotypic features should be evaluated further by additional phenotypic or genotypic identification techniques...
  29. doi request reprint Safety of bronchoalveolar lavage in young children with cystic fibrosis
    Claire E Wainwright
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Australia
    Pediatr Pulmonol 43:965-72. 2008
    ..Our aim was to determine the safety of BAL in young children <6 years with CF...
  30. ncbi request reprint Rotavirus vaccines must perform in low-income countries too
    Keith Grimwood
    Queensland Paediatric Infectious Disease Laboratory, Royal Children s Hospital, Department of Paediatrics and Child Health, University of Queensland, Brisbane, QLD 4029, Australia
    Lancet 370:1739-40. 2007