Ross Grant

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations
    Jade Guest
    Australasian Research Institute, Sydney Adventist Hospital, Sydney, NSW, Australia
    J Neuroinflammation 11:117. 2014
  2. pmc Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 7:e42357. 2012
  3. pmc Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Int J Tryptophan Res 4:29-37. 2011
  4. pmc Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
    Nady Braidy
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e19194. 2011
  5. pmc Kynurenine Pathway Metabolism is Involved in the Maintenance of the Intracellular NAD Concentration in Human Primary Astrocytes
    Ross Grant
    School of Medical Sciences, University of New South Wales, Sydney NSW Australia
    Int J Tryptophan Res 3:151-6. 2010
  6. pmc The physiological action of picolinic Acid in the human brain
    R S Grant
    School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW, 2052
    Int J Tryptophan Res 2:71-9. 2009
  7. ncbi request reprint Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels
    Ross Grant
    Biomedical Mass Spectrometry Facility, Faculty of Medicine, University of NSW, Sydney 2000, Australia
    Biochem Pharmacol 66:1033-6. 2003
  8. ncbi request reprint The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents
    Ross Grant
    School of Medical Sciences, University of NSW, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia 2076
    Asia Pac J Clin Nutr 17:107-15. 2008
  9. doi request reprint Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia
    FEBS J 278:4425-34. 2011
  10. doi request reprint NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Faculty of Medicine, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia
    Redox Rep 17:28-46. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations
    Jade Guest
    Australasian Research Institute, Sydney Adventist Hospital, Sydney, NSW, Australia
    J Neuroinflammation 11:117. 2014
    ....
  2. pmc Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 7:e42357. 2012
    ..The resulting NAD(+) depletion may play a major role in the aging process, by limiting energy production, DNA repair and genomic signalling...
  3. pmc Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Int J Tryptophan Res 4:29-37. 2011
    ..Inhibition of KP metabolism under these conditions can compromise cell viability, NAD-dependent SIRT1 activity and CNS function, unless alternative precursors for NAD(+) synthesis are made available...
  4. pmc Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
    Nady Braidy
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e19194. 2011
    ..The strong positive correlation observed between DNA damage associated NAD+ depletion and Sirt1 activity suggests that adequate NAD+ concentrations may be an important longevity assurance factor...
  5. pmc Kynurenine Pathway Metabolism is Involved in the Maintenance of the Intracellular NAD Concentration in Human Primary Astrocytes
    Ross Grant
    School of Medical Sciences, University of New South Wales, Sydney NSW Australia
    Int J Tryptophan Res 3:151-6. 2010
    ..This decrease in NAD(+) was partially restored by supplementation of the culture media with either tryptophan or kynurenine, or nicotinic acid or with supply of the salvage pathway precursor nicotinamide...
  6. pmc The physiological action of picolinic Acid in the human brain
    R S Grant
    School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW, 2052
    Int J Tryptophan Res 2:71-9. 2009
    ..Discrepancies and gaps in our current knowledge of picolinic acid are identified highlighting areas of research to promote a more complete understanding of its endogenous function in the brain...
  7. ncbi request reprint Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels
    Ross Grant
    Biomedical Mass Spectrometry Facility, Faculty of Medicine, University of NSW, Sydney 2000, Australia
    Biochem Pharmacol 66:1033-6. 2003
    ..Inhibition of kynurenine pathway metabolism under these conditions may significantly decrease cell viability and CNS functions unless alternate precursors for NAD synthesis are available...
  8. ncbi request reprint The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents
    Ross Grant
    School of Medical Sciences, University of NSW, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia 2076
    Asia Pac J Clin Nutr 17:107-15. 2008
    ..Surprisingly, exercise on its own was not statistically associated with any of the risk factors tested suggesting that diet may be the most significant factor in promoting health in this age group...
  9. doi request reprint Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia
    FEBS J 278:4425-34. 2011
    ....
  10. doi request reprint NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Faculty of Medicine, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia
    Redox Rep 17:28-46. 2012
    ..NAD+ precursors have been shown to slow down ageing and extend lifespan in yeasts, and protect severed axons from degeneration in animal models neurodegenerative diseases...
  11. doi request reprint Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    FEBS J 277:368-82. 2010
    ....
  12. ncbi request reprint Evidence for under-nutrition in adolescent females using routine dieting practices
    Jade Guest
    Australasian Research Institute, Sydney Adventist Hospital, Wahroonga, NSW, 2076 Australia
    Asia Pac J Clin Nutr 19:526-33. 2010
    ..These data suggest that the use of common weight control techniques by healthy weight adolescent females can produce a metabolically divergent group whose biochemical markers are consistent with subtle levels of chronic under-nutrition...
  13. ncbi request reprint Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Neurotox Res 13:173-84. 2008
    ....
  14. ncbi request reprint Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence
    Nady Braidy
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
    Biogerontology 15:177-98. 2014
    ....
  15. doi request reprint Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
    Nady Braidy
    Department of Pharmacology, Faculty of Medicine, University of New South Wales, Sydney, 2052, Australia
    Neurotox Res 16:77-86. 2009
    ..These results contribute significantly to our understanding of the pathophysiological mechanisms involved in QUIN neuro- and gliotoxicity and are relevant for the development of therapies for neuroinflammatory diseases...
  16. doi request reprint The kynurenine pathway in brain tumor pathogenesis
    Seray Adams
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Cancer Res 72:5649-57. 2012
    ..Targeting the KP in brain tumors may represent a viable strategy likely to prevent QUIN-induced neurotoxicity and KYN and 3-HAA-mediated immune suppression...
  17. ncbi request reprint The kynurenine pathway and inflammation in amyotrophic lateral sclerosis
    Yiquan Chen
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Neurotox Res 18:132-42. 2010
    ..These data point to an inflammation-driven excitotoxic-chelation defective mechanism in ALS, which may be amenable to inhibitors of the KP...
  18. ncbi request reprint Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis
    Nady Braidy
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
    Brain Res 1537:267-72. 2013
    ..Serum NAD(+) and NADH levels are may be associated with disease progression in MS. Given the importance of NAD(+) in the maintenance of normal cellular function, it is likely that this molecule is of therapeutic relevance in MS...
  19. pmc Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Int J Tryptophan Res 2:61-9. 2009
    ..Therefore, the differing responses of astrocytes and neurons to an increase in KP metabolites should be considered when assessing KP toxicity during neuroinflammation...
  20. ncbi request reprint ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue
    George A Smythe
    Biomedical Mass Spectrometry Facility, UNSW, Sydney, NSW 2052, Australia
    Adv Exp Med Biol 527:705-12. 2003
    ..The site and mechanism of amidation of PIC and QUIN needs investigation...
  21. pmc Relationship between central and peripheral fatty acids in humans
    Jade Guest
    School of Medical Sciences, University of New South Wales, Wallace Wurth Building, office 203, Sydney, NSW 2052, Australia
    Lipids Health Dis 12:79. 2013
    ..However surprisingly limited research has been conducted comparing the fatty acid composition of central and peripheral lipid stores...
  22. pmc Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid
    Jade Guest
    Australasian Research Institute, Sydney Adventist Hospital, Sydney, New South Wales, Australia Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 9:e85335. 2014
    ..Taken together these data suggest a progressive age associated increase in oxidative damage, inflammation and reduced [NAD(H)] in the brain which may be exacerbated by alcohol intake. ..
  23. ncbi request reprint Postprandial oxidative stress is increased after a phytonutrient-poor food but not after a kilojoule-matched phytonutrient-rich food
    Amanda Khor
    School of Medical Sciences, Faculty of Medicine, University of New South Wales, NSW, Australia Australasian Research Institute, Sydney Adventist Hospital, NSW, Australia
    Nutr Res 34:391-400. 2014
    ..This is not observed after ingestion of a kilojoule-equivalent phytonutrient-rich food. ..
  24. ncbi request reprint Inhibition of indoleamine 2,3 dioxygenase activity by H2O2
    Anne Poljak
    Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia
    Arch Biochem Biophys 450:9-19. 2006
    ..We present evidence that cysteine oxidation represents one mechanism of indoleamine 2,3-dioxygenase inhibition...
  25. doi request reprint Predicting overall viability of cord blood harvests
    Belinda Pope
    Pathology Department and the Australasian Research Institute, Sydney Adventist Hospital, Wahroonga, NSW 2076, Australia
    Transfusion 52:1079-85. 2012
    ..These processes can lead to compromised white blood cell (WBC) viability. This study investigates the factors that affect WBC viability before freezing of the cells...