Ross Grant

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels
    Ross Grant
    Biomedical Mass Spectrometry Facility, Faculty of Medicine, University of NSW, Sydney 2000, Australia
    Biochem Pharmacol 66:1033-6. 2003
  2. ncbi The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents
    Ross Grant
    School of Medical Sciences, University of NSW, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia 2076
    Asia Pac J Clin Nutr 17:107-15. 2008
  3. ncbi Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia
    FEBS J 278:4425-34. 2011
  4. ncbi Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 7:e42357. 2012
  5. ncbi NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Faculty of Medicine, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia
    Redox Rep 17:28-46. 2012
  6. ncbi Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    FEBS J 277:368-82. 2010
  7. ncbi The kynurenine pathway in brain tumor pathogenesis
    Seray Adams
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Cancer Res 72:5649-57. 2012
  8. ncbi The kynurenine pathway and inflammation in amyotrophic lateral sclerosis
    Yiquan Chen
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Neurotox Res 18:132-42. 2010
  9. ncbi Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
    Nady Braidy
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e19194. 2011
  10. ncbi Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Int J Tryptophan Res 2:61-9. 2009

Collaborators

Detail Information

Publications16

  1. ncbi Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels
    Ross Grant
    Biomedical Mass Spectrometry Facility, Faculty of Medicine, University of NSW, Sydney 2000, Australia
    Biochem Pharmacol 66:1033-6. 2003
    ..Inhibition of kynurenine pathway metabolism under these conditions may significantly decrease cell viability and CNS functions unless alternate precursors for NAD synthesis are available...
  2. ncbi The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents
    Ross Grant
    School of Medical Sciences, University of NSW, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia 2076
    Asia Pac J Clin Nutr 17:107-15. 2008
    ..Surprisingly, exercise on its own was not statistically associated with any of the risk factors tested suggesting that diet may be the most significant factor in promoting health in this age group...
  3. ncbi Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia
    FEBS J 278:4425-34. 2011
    ....
  4. ncbi Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 7:e42357. 2012
    ..The resulting NAD(+) depletion may play a major role in the aging process, by limiting energy production, DNA repair and genomic signalling...
  5. ncbi NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns
    Hassina Massudi
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Faculty of Medicine, and Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia
    Redox Rep 17:28-46. 2012
    ..NAD+ precursors have been shown to slow down ageing and extend lifespan in yeasts, and protect severed axons from degeneration in animal models neurodegenerative diseases...
  6. ncbi Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    FEBS J 277:368-82. 2010
    ....
  7. ncbi The kynurenine pathway in brain tumor pathogenesis
    Seray Adams
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Cancer Res 72:5649-57. 2012
    ..Targeting the KP in brain tumors may represent a viable strategy likely to prevent QUIN-induced neurotoxicity and KYN and 3-HAA-mediated immune suppression...
  8. ncbi The kynurenine pathway and inflammation in amyotrophic lateral sclerosis
    Yiquan Chen
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Neurotox Res 18:132-42. 2010
    ..These data point to an inflammation-driven excitotoxic-chelation defective mechanism in ALS, which may be amenable to inhibitors of the KP...
  9. ncbi Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
    Nady Braidy
    Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e19194. 2011
    ..The strong positive correlation observed between DNA damage associated NAD+ depletion and Sirt1 activity suggests that adequate NAD+ concentrations may be an important longevity assurance factor...
  10. ncbi Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Int J Tryptophan Res 2:61-9. 2009
    ..Therefore, the differing responses of astrocytes and neurons to an increase in KP metabolites should be considered when assessing KP toxicity during neuroinflammation...
  11. ncbi Inhibition of indoleamine 2,3 dioxygenase activity by H2O2
    Anne Poljak
    Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia
    Arch Biochem Biophys 450:9-19. 2006
    ..We present evidence that cysteine oxidation represents one mechanism of indoleamine 2,3-dioxygenase inhibition...
  12. ncbi ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue
    George A Smythe
    Biomedical Mass Spectrometry Facility, UNSW, Sydney, NSW 2052, Australia
    Adv Exp Med Biol 527:705-12. 2003
    ..The site and mechanism of amidation of PIC and QUIN needs investigation...
  13. ncbi Predicting overall viability of cord blood harvests
    Belinda Pope
    Pathology Department and the Australasian Research Institute, Sydney Adventist Hospital, Wahroonga, NSW 2076, Australia
    Transfusion 52:1079-85. 2012
    ..These processes can lead to compromised white blood cell (WBC) viability. This study investigates the factors that affect WBC viability before freezing of the cells...
  14. ncbi Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Int J Tryptophan Res 4:29-37. 2011
    ..Inhibition of KP metabolism under these conditions can compromise cell viability, NAD-dependent SIRT1 activity and CNS function, unless alternative precursors for NAD(+) synthesis are made available...
  15. ncbi Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
    Nady Braidy
    Department of Pharmacology, Faculty of Medicine, University of New South Wales, Sydney, 2052, Australia
    Neurotox Res 16:77-86. 2009
    ..These results contribute significantly to our understanding of the pathophysiological mechanisms involved in QUIN neuro- and gliotoxicity and are relevant for the development of therapies for neuroinflammatory diseases...
  16. ncbi Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease
    Nady Braidy
    University of New South Wales, Faculty of Medicine, Sydney, Australia
    Neurotox Res 13:173-84. 2008
    ....