C M Grant

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation
    C M Grant
    CRC for Food Industry Innovation, University of New South Wales, Sydney, Australia
    Mol Microbiol 21:171-9. 1996
  2. ncbi Stationary-phase induction of GLR1 expression is mediated by the yAP-1 transcriptional regulatory protein in the yeast Saccharomyces cerevisiae
    C M Grant
    C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Mol Microbiol 22:739-46. 1996
  3. pmc Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stress
    C M Grant
    Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Mol Cell Biol 19:2650-6. 1999
  4. ncbi Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae
    C M Grant
    C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    FEBS Lett 410:219-22. 1997
  5. ncbi Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae
    C M Grant
    Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Biochem Biophys Res Commun 253:893-8. 1998
  6. pmc Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde
    H E Turton
    School of Biochemistry and Molecular Genetics and C R C for Food Industry Innovation, University of New South Wales, Sydney, Australia
    J Bacteriol 179:1096-101. 1997
  7. ncbi The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
  8. ncbi The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing
    J I Park
    School of Biochemistry and Molecular Genetics and Cooperative Research Center for Food Industry Innovation, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 273:22921-8. 1998
  9. ncbi A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae
    T Draculic
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Mol Microbiol 36:1167-74. 2000
  10. ncbi Identification of a Saccharomyces cerevisiae mitochondrial-DNA which can act as a promoter tightly regulated by carbon source when placed in the nucleus
    F H MacIver
    C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Curr Genet 31:119-21. 1997

Collaborators

Detail Information

Publications13

  1. ncbi Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation
    C M Grant
    CRC for Food Industry Innovation, University of New South Wales, Sydney, Australia
    Mol Microbiol 21:171-9. 1996
    ..Thus, GLR1 is one of a growing number of genes involved in the protection of yeast cells against oxidative stress and regulated by yAP-1...
  2. ncbi Stationary-phase induction of GLR1 expression is mediated by the yAP-1 transcriptional regulatory protein in the yeast Saccharomyces cerevisiae
    C M Grant
    C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Mol Microbiol 22:739-46. 1996
    ..In addition, strains lacking GLR or yAP-1 do not accumulate GSSG during stationary-phase growth, indicating that the cell possesses alternative means of preventing an accumulation of GSSG during stationary phase...
  3. pmc Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stress
    C M Grant
    Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Mol Cell Biol 19:2650-6. 1999
    ..We propose a model in which both enzymes are required during conditions of oxidative stress but play complementary roles depending on their ability to undergo S-thiolation...
  4. ncbi Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae
    C M Grant
    C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    FEBS Lett 410:219-22. 1997
    ..We suggest that the oxidant sensitivity is due to a defect in an energy-requiring process that is needed for detoxification of ROS or for the repair of oxidatively damaged molecules...
  5. ncbi Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae
    C M Grant
    Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Biochem Biophys Res Commun 253:893-8. 1998
    ....
  6. pmc Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde
    H E Turton
    School of Biochemistry and Molecular Genetics and C R C for Food Industry Innovation, University of New South Wales, Sydney, Australia
    J Bacteriol 179:1096-101. 1997
    ..Elevated levels were detected following treatment with hydrogen peroxide. However, the MDA-adaptive response was independent of that to H2O2...
  7. ncbi The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain
    J C Lee
    School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
    FEMS Yeast Res 1:57-65. 2001
    ..Interestingly, the gsh1 sgr1 mutant generated petites at a lower rate than the gsh1 mutant. Thus, it is suggested that the essential role of GSH is involved in the maintenance of the mitochondrial genome...
  8. ncbi The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing
    J I Park
    School of Biochemistry and Molecular Genetics and Cooperative Research Center for Food Industry Innovation, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 273:22921-8. 1998
    ....
  9. ncbi A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae
    T Draculic
    School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Mol Microbiol 36:1167-74. 2000
    ....
  10. ncbi Identification of a Saccharomyces cerevisiae mitochondrial-DNA which can act as a promoter tightly regulated by carbon source when placed in the nucleus
    F H MacIver
    C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
    Curr Genet 31:119-21. 1997
    ..These observations are discussed both with respect to the origin of the S. cerevisiae COX1 gene in particular and with respect to the origin of introns in general...
  11. pmc The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species
    S Luikenhuis
    Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, New South Wales 2052, Australia
    Mol Biol Cell 9:1081-91. 1998
    ..Thus, Grx1 and Grx2 function differently in the cell, and we suggest that glutaredoxins may act as one of the primary defenses against mixed disulfides formed following oxidative damage to proteins...
  12. pmc Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine
    C M Grant
    Cooperative Research Centre for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
    Mol Biol Cell 8:1699-707. 1997
    ..We suggest that this function may be the detoxification of harmful intermediates that are generated during normal cellular metabolism...
  13. ncbi Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions
    C M Grant
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Mol Microbiol 39:533-41. 2001
    ..This review describes recent findings in the lower eukaryote Saccharomyces cerevisiae that are leading to a better understanding of their role in redox homeostasis in eukaryotic cell metabolism...