Research Topics
| C M GrantSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulationC M Grant
CRC for Food Industry Innovation, University of New South Wales, Sydney, Australia
Mol Microbiol 21:171-9. 1996..Thus, GLR1 is one of a growing number of genes involved in the protection of yeast cells against oxidative stress and regulated by yAP-1...- Stationary-phase induction of GLR1 expression is mediated by the yAP-1 transcriptional regulatory protein in the yeast Saccharomyces cerevisiaeC M Grant
C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
Mol Microbiol 22:739-46. 1996..In addition, strains lacking GLR or yAP-1 do not accumulate GSSG during stationary-phase growth, indicating that the cell possesses alternative means of preventing an accumulation of GSSG during stationary phase... 
Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stressC M Grant
Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
Mol Cell Biol 19:2650-6. 1999..We propose a model in which both enzymes are required during conditions of oxidative stress but play complementary roles depending on their ability to undergo S-thiolation...- Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiaeC M Grant
C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
FEBS Lett 410:219-22. 1997..We suggest that the oxidant sensitivity is due to a defect in an energy-requiring process that is needed for detoxification of ROS or for the repair of oxidatively damaged molecules... - Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiaeC M Grant
Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
Biochem Biophys Res Commun 253:893-8. 1998.... - Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehydeH E Turton
School of Biochemistry and Molecular Genetics and C R C for Food Industry Innovation, University of New South Wales, Sydney, Australia
J Bacteriol 179:1096-101. 1997..Elevated levels were detected following treatment with hydrogen peroxide. However, the MDA-adaptive response was independent of that to H2O2... - The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strainJ C Lee
School of Biochemistry and Molecular Genetics, The CRC for Food Industry Innovation, University of New South Wales, Sydney, NSW 2052, Australia
FEMS Yeast Res 1:57-65. 2001..Interestingly, the gsh1 sgr1 mutant generated petites at a lower rate than the gsh1 mutant. Thus, it is suggested that the essential role of GSH is involved in the maintenance of the mitochondrial genome... - The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawingJ I Park
School of Biochemistry and Molecular Genetics and Cooperative Research Center for Food Industry Innovation, University of New South Wales, Sydney, New South Wales 2052, Australia
J Biol Chem 273:22921-8. 1998.... - A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiaeT Draculic
School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
Mol Microbiol 36:1167-74. 2000.... - Identification of a Saccharomyces cerevisiae mitochondrial-DNA which can act as a promoter tightly regulated by carbon source when placed in the nucleusF H MacIver
C R C for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia
Curr Genet 31:119-21. 1997..These observations are discussed both with respect to the origin of the S. cerevisiae COX1 gene in particular and with respect to the origin of introns in general... - The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen speciesS Luikenhuis
Cooperative Research Center for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, New South Wales 2052, Australia
Mol Biol Cell 9:1081-91. 1998..Thus, Grx1 and Grx2 function differently in the cell, and we suggest that glutaredoxins may act as one of the primary defenses against mixed disulfides formed following oxidative damage to proteins... - Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteineC M Grant
Cooperative Research Centre for Food Industry Innovation, School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia
Mol Biol Cell 8:1699-707. 1997..We suggest that this function may be the detoxification of harmful intermediates that are generated during normal cellular metabolism... - Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditionsC M Grant
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Sackville Street, Manchester M60 1QD, UK
Mol Microbiol 39:533-41. 2001..This review describes recent findings in the lower eukaryote Saccharomyces cerevisiae that are leading to a better understanding of their role in redox homeostasis in eukaryotic cell metabolism...