Shelley Gorman

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    PLoS ONE 8:e67823. 2013
  2. pmc Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e46006. 2012
  3. doi request reprint The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Photochem Photobiol Sci 11:1788-96. 2012
  4. doi request reprint Vitamin D(3) deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Pediatr Allergy Immunol 23:83-7. 2012
  5. doi request reprint Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    J Invest Dermatol 130:2368-76. 2010
  6. pmc Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells
    Shelley Gorman
    Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 131:415-25. 2010
  7. doi request reprint Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Western Australia, Australia
    J Steroid Biochem Mol Biol 121:247-9. 2010
  8. pmc 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 130:181-92. 2010
  9. doi request reprint Prior infection with murine cytomegalovirus (MCMV) limits the immunocontraceptive effects of an MCMV vector expressing the mouse zona-pellucida-3 protein
    Shelley Gorman
    Discipline of Microbiology and Immunology, M502, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Vaccine 26:3860-9. 2008
  10. ncbi request reprint Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice
    Shelley Gorman
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, M502, University of Western Australia, Crawley
    J Gen Virol 87:1123-32. 2006

Collaborators

Detail Information

Publications22

  1. pmc Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    PLoS ONE 8:e67823. 2013
    ....
  2. pmc Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e46006. 2012
    ..Thus, in male mice, UVR-induced 25(OH)D(3) is not essential for mediating the immunosuppressive effects of erythemal UVR...
  3. doi request reprint The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Photochem Photobiol Sci 11:1788-96. 2012
    ..We end with discussion of the epigenetic effects of vitamin D and UVR for immunosuppression...
  4. doi request reprint Vitamin D(3) deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Pediatr Allergy Immunol 23:83-7. 2012
    ..These results suggest that vitamin D(3) deficiency modulates the capacity of lymphocytes to respond to allergens...
  5. doi request reprint Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    J Invest Dermatol 130:2368-76. 2010
    ..Therefore, 1,25(OH)(2)D(3) enabled by IL-2 can directly enhance the regulatory potential of CD4+CD25+ T cells to control immune disease...
  6. pmc Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells
    Shelley Gorman
    Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 131:415-25. 2010
    ....
  7. doi request reprint Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Western Australia, Australia
    J Steroid Biochem Mol Biol 121:247-9. 2010
    ..Finally, topical 1,25(OH)2D3 also enhanced the number and suppressive activity of CD4+CD25+ regulatory T cells in the lymphatic tissue draining skin...
  8. pmc 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 130:181-92. 2010
    ..This work highlights how local 1,25(OH)(2)D(3) production by lung epithelial cells may modulate the suppressive activity of local regulatory T cells...
  9. doi request reprint Prior infection with murine cytomegalovirus (MCMV) limits the immunocontraceptive effects of an MCMV vector expressing the mouse zona-pellucida-3 protein
    Shelley Gorman
    Discipline of Microbiology and Immunology, M502, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Vaccine 26:3860-9. 2008
    ..Given that mixed infection of mice with MCMV is common, it is possible that prior immunity acquired by natural mucosal infection may have less a less inhibitory effect on the immunocontraceptive outcome...
  10. ncbi request reprint Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice
    Shelley Gorman
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, M502, University of Western Australia, Crawley
    J Gen Virol 87:1123-32. 2006
    ..2 % of trapped mice. The observations that mixed infections are common in free-living M. domesticus and are acquired by immunocompetent mice through simultaneous or successive infections are important for vaccine development...
  11. doi request reprint Toward homeostasis: regulatory dendritic cells from the bone marrow of mice with inflammation of the airways and peritoneal cavity
    Naomi M Scott
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Pathol 181:535-47. 2012
    ..Our study represents an important homeostatic process with potential for therapeutic use in the future...
  12. doi request reprint Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice
    Royce L X Ng
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth 6008, Western Australia, Australia
    J Immunol 190:5471-84. 2013
    ..Erythemal UVR may imprint a long-lasting epigenetic effect on DC progenitors in the BM and alter the function of their terminally differentiated progeny...
  13. ncbi request reprint CD4+ T cells in lymph nodes of UVB-irradiated mice suppress immune responses to new antigens both in vitro and in vivo
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    J Invest Dermatol 127:915-24. 2007
    ..The potential of these regulatory cells poised to regulate responses to incoming antigens at distant non-irradiated sites broadens the biological impact of UVB irradiation of skin on immunity...
  14. ncbi request reprint Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Australia
    J Immunol 179:6273-83. 2007
    ..These studies suggest that 1,25(OH)(2)D(3) may be an important mediator by which UVB-irradiation exerts some of its immunomodulatory effects...
  15. doi request reprint Differences in control by UV radiation of inflammatory airways disease in naïve and allergen pre-sensitised mice
    Naomi M Scott
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, Australia
    Photochem Photobiol Sci 10:1894-901. 2011
    ..The second, associated with administration to pre-sensitised mice, is weaker and is detected when the mice are sensitised with lower levels of allergen and adjuvant...
  16. ncbi request reprint Primary defect in UVB-induced systemic immunomodulation does not relate to immature or functionally impaired APCs in regional lymph nodes
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth
    J Immunol 174:6677-85. 2005
    ....
  17. doi request reprint UV exposure and protection against allergic airways disease
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, Western Australia, Australia 6872
    Photochem Photobiol Sci 9:571-7. 2010
    ..This review gives some scientific understanding to century-old anecdotal reports that beach and mountain resort holidays associated with increased UV exposure are beneficial in asthma treatment...
  18. ncbi request reprint Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen
    Jacqueline P McGlade
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, WA, Australia
    J Immunol 178:2794-802. 2007
    ....
  19. doi request reprint Modulation of the immune system by UV radiation: more than just the effects of vitamin D?
    Prue H Hart
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, Perth, Western Australia 6872, Australia
    Nat Rev Immunol 11:584-96. 2011
    ..Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection...
  20. doi request reprint Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway
    Royce L X Ng
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    J Immunol 185:7207-15. 2010
    ..These results show that UV irradiation of mice can affect the function of bone marrow-derived CD11c(+) cells via a mechanism inhibitable by indomethacin; this pathway is likely to contribute to systemic UV-induced immunosuppression...
  21. doi request reprint Vitamin D deficiency causes deficits in lung function and alters lung structure
    Graeme R Zosky
    Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
    Am J Respir Crit Care Med 183:1336-43. 2011
    ..Thus, causal data confirming a relationship between vitamin D and lung function are lacking...
  22. pmc Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible?
    Prue H Hart
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, WA 6872, Australia
    Clin Biochem Rev 34:3-13. 2013
    ..Vitamin D3 levels are a measure of past sun exposure but vitamin D3-dependent and vitamin D3-independent immunosuppressive effects of UVR may play a role in control of autoimmune diseases...