Dale I Godfrey

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Differential antitumor immunity mediated by NKT cell subsets in vivo
    Nadine Y Crowe
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Exp Med 202:1279-88. 2005
  2. ncbi request reprint Control points in NKT-cell development
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 7:505-18. 2007
  3. pmc New ways to turn on NKT cells
    Dale Ian Godfrey
    Dept of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 208:1121-5. 2011
  4. ncbi request reprint NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  5. pmc Going both ways: immune regulation via CD1d-dependent NKT cells
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Clin Invest 114:1379-88. 2004
  6. ncbi request reprint Immunology. The elusive NKT cell antigen--is the search over?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Science 306:1687-9. 2004
  7. doi request reprint Raising the NKT cell family
    Dale I Godfrey
    University of Melbourne, Department of Microbiology and Immunology, Parkville, Victoria, Australia
    Nat Immunol 11:197-206. 2010
  8. doi request reprint Antigen recognition by CD1d-restricted NKT T cell receptors
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
    Semin Immunol 22:61-7. 2010
  9. doi request reprint The fidelity, occasional promiscuity, and versatility of T cell receptor recognition
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 28:304-14. 2008
  10. pmc Chewing the fat on natural killer T cell development
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Exp Med 203:2229-32. 2006

Detail Information

Publications86

  1. pmc Differential antitumor immunity mediated by NKT cell subsets in vivo
    Nadine Y Crowe
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Exp Med 202:1279-88. 2005
    ....
  2. ncbi request reprint Control points in NKT-cell development
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 7:505-18. 2007
    ..Here, we review the current state of knowledge of NKT-cell development and attempt to highlight the most important questions in this field...
  3. pmc New ways to turn on NKT cells
    Dale Ian Godfrey
    Dept of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 208:1121-5. 2011
    ....
  4. ncbi request reprint NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  5. pmc Going both ways: immune regulation via CD1d-dependent NKT cells
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Clin Invest 114:1379-88. 2004
    ..This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy...
  6. ncbi request reprint Immunology. The elusive NKT cell antigen--is the search over?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Science 306:1687-9. 2004
  7. doi request reprint Raising the NKT cell family
    Dale I Godfrey
    University of Melbourne, Department of Microbiology and Immunology, Parkville, Victoria, Australia
    Nat Immunol 11:197-206. 2010
    ..Because their frequency and number vary widely between individuals, it is important to understand the mechanisms that regulate the development and maintenance of NKT cells and subsets thereof, which is the subject of this review...
  8. doi request reprint Antigen recognition by CD1d-restricted NKT T cell receptors
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
    Semin Immunol 22:61-7. 2010
    ....
  9. doi request reprint The fidelity, occasional promiscuity, and versatility of T cell receptor recognition
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 28:304-14. 2008
    ..Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system...
  10. pmc Chewing the fat on natural killer T cell development
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Exp Med 203:2229-32. 2006
    ..This suggests that lysosomal storage diseases (LSDs) in general, rather than one specific defect, can disrupt CD1d antigen presentation, leading to impaired development of NKT cells...
  11. pmc NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge
    Adam P Uldrich
    Department Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 175:3092-101. 2005
    ..In summary, this study significantly enhances our understanding of how NKT cells respond to primary and secondary antigenic challenge in vivo...
  12. ncbi request reprint Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells
    Nadine Y Crowe
    Department of Pathology and Immunology, Monash University, Central and Eastern Clinical School, Prahran, Victoria, Australia
    J Immunol 171:4020-7. 2003
    ..This study provides critical new insight into how NKT cells can have such a major impact on immune responses, lasting many days beyond the initial stimulation of these cells...
  13. doi request reprint Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity
    Henrik Søndergaard
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 183:7326-36. 2009
    ....
  14. ncbi request reprint DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells
    Daniel G Pellicci
    University of Melbourne, Department of Microbiology and Immunology, Parkville, Victoria, Australia
    J Immunol 175:4416-25. 2005
    ..In summary, our data demonstrate that DX5/CD49b is a poor marker for identifying CD1d-dependent NKT cells...
  15. doi request reprint MR1 presents microbial vitamin B metabolites to MAIT cells
    Lars Kjer-Nielsen
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nature 491:717-23. 2012
    ..As many vitamin biosynthetic pathways are unique to bacteria and yeast, our data suggest that MAIT cells use these metabolites to detect microbial infection...
  16. pmc Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells
    Shayna E A Street
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre Peter Mac, 8006, Victoria, Australia
    J Exp Med 199:879-84. 2004
    ..These results reflect a critical role for NK cells and gammadeltaTCR+ T cells in innate immune surveillance of B cell lymphomas, mediated by as yet undetermined pathway(s) of tumor recognition...
  17. ncbi request reprint Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts
    Finlay W McNab
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 179:6630-7. 2007
    ..1(+) NKT cells in the periphery. We conclude that the vast majority of peripheral NK1.1(-) NKT cells are part of a previously unrecognized, mature NKT cell subset...
  18. ncbi request reprint Antigen challenge inhibits thymic emigration
    Adam P Uldrich
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 176:4553-61. 2006
    ..Thus, in addition to its accepted role in intrathymic selection events, TCR signaling can also play an important role in the regulation of thymic emigration...
  19. ncbi request reprint Expression of the glucocorticoid receptor from the 1A promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell death
    Jared F Purton
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 173:3816-24. 2004
    ..These data suggest that tissue-specific differences in GR promoter use determine T cell sensitivity to glucocorticoid-induced cell death...
  20. pmc Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
    Andreas Villunger
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:7052-7. 2004
    ..These results reveal the mechanisms of apoptosis in negative selection of semimature thymocytes and have implications for immunological tolerance and autoimmunity...
  21. ncbi request reprint The influence of CD1d in postselection NKT cell maturation and homeostasis
    Finlay W McNab
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 175:3762-8. 2005
    ....
  22. doi request reprint Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors
    Daniel G Pellicci
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 12:827-33. 2011
    ..Thus, the NKT cell TCR molds the β-linked self ligands to resemble the conformation of foreign α-linked ligands, which shows that induced-fit molecular mimicry can underpin the self-reactivity of NKT cell TCRs to β-linked antigens...
  23. ncbi request reprint Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies
    Stuart P Berzins
    Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria, Australia
    Immunol Cell Biol 82:247-52. 2004
    ..This re-establishes the correlation between NKT cell deficiency and type 1 diabetes and raises important questions regarding the assaying of NKT cell levels in humans...
  24. pmc Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population
    Jonathan M Coquet
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Proc Natl Acad Sci U S A 105:11287-92. 2008
    ..1(+) but not into CD4(+)NK1.1(+) NKT cells, indicating that CD4(-)NK1.1(-) NKT cells include an IL-17-producing subpopulation, and also mark the elusive branch point for CD4(+) and CD4(-) NKT cell sublineages...
  25. ncbi request reprint Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis
    Ann L Cornish
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:878-86. 2003
    ..Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-gamma signaling...
  26. ncbi request reprint IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
    Jonathan M Coquet
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Immunol 178:2827-34. 2007
    ..The influence of IL-21 in NKT cell-dependent models of tumor rejection, microbial clearance, autoimmunity, and allergy should be the subject of future investigations...
  27. doi request reprint CD1d-lipid antigen recognition by the γδ TCR
    Adam P Uldrich
    1 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia 2
    Nat Immunol 14:1137-45. 2013
    ..Accordingly, we provide insight into how a γδ TCR binds specifically to a lipid-loaded antigen-presenting molecule. ..
  28. ncbi request reprint Functional analysis of granzyme M and its role in immunity to infection
    Lily I Pao
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 175:3235-43. 2005
    ..These data confirm a role for GrzM in the host response to MCMV infection, but suggest that GrzM is not critical for NK cell-mediated cytotoxicity...
  29. pmc A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas
    Nadine Y Crowe
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria 3181, Australia
    J Exp Med 196:119-27. 2002
    ....
  30. ncbi request reprint Parallels and distinctions between T and NKT cell development in the thymus
    Stuart P Berzins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010 Australia
    Immunol Cell Biol 82:269-75. 2004
    ..It is here that NKT cell-specific disorders may originate and may best be addressed...
  31. ncbi request reprint Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
    Mark M W Chong
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 18:475-87. 2003
    ..These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines...
  32. ncbi request reprint Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 99:1259-66. 2002
    ....
  33. ncbi request reprint NKT cells - conductors of tumor immunity?
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Curr Opin Immunol 14:165-71. 2002
    ....
  34. pmc Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity
    Carole Guillonneau
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 106:3330-5. 2009
    ....
  35. ncbi request reprint Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples
    Stuart P Berzins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
    Eur J Immunol 35:1399-407. 2005
    ..Interestingly, while thymus and peripheral NKT cell frequencies vary widely between patients and are relatively stable between age groups, there is no clear relationship between the NKT cell frequency in thymus and blood...
  36. pmc Normal thymocyte negative selection in TRAIL-deficient mice
    Erika Cretney
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    J Exp Med 198:491-6. 2003
    ..We were unable to demonstrate a role for TRAIL signaling in any of these models, suggesting that this pathway is not a critical factor for thymocyte negative selection...
  37. pmc A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR
    Kwok S Wun
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    J Exp Med 205:939-49. 2008
    ..Accordingly, although the structural footprint at the NKT TCR-CD1d-alpha-GalCer is small, the energetic footprint is smaller still, and reveals the minimal requirements for CD1d restriction...
  38. doi request reprint Directing traffic on the NKT-cell highway: a key role for ThPOK
    Sumone Chakravarti
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    Eur J Immunol 40:2372-5. 2010
    ..Furthermore, ThPOK-deficient mice generate an unusual population of CD8(+) NKT cells, which are absent in control mice. This study sheds new light on the underlying molecular events leading to the emergence of distinct NKT-cell subsets...
  39. ncbi request reprint NKT cells are not critical for HSV-1 disease resolution
    Ann L Cornish
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:13-9. 2006
    ..Instead, the resolution or severity of the infection may depend on the HSV-1 strain under investigation...
  40. pmc A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition
    Lars Kjer-Nielsen
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 203:661-73. 2006
    ..The findings define a structural basis for the selection of the semi-invariant alphabeta TCR and the unique antigen specificity of NKT cells...
  41. ncbi request reprint Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    Jonathan M Coquet
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:7097-101. 2008
    ..Thus, our results challenge the notion that IL-21 is a key factor in driving Th17 immunity and disease...
  42. doi request reprint A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties
    Adam P Uldrich
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 12:616-23. 2011
    ..Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses...
  43. pmc Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
    Rangsima Reantragoon
    Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity and 2 Department of Anatomy and Neuroscience The University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 210:2305-20. 2013
    ..Accordingly, MR1 tetramers allow precise phenotypic characterization of human and mouse MAIT cells and revealed unanticipated TCR heterogeneity in this population...
  44. pmc Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice
    Florian Wiede
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 7:e36703. 2012
    ..Taken together these results reaffirm TCPTP's important role in lymphocyte development and indicate that the effects on morbidity, mortality, bone development and the myeloid compartment are strain-dependent...
  45. pmc Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation
    Dale Christiansen
    Department of Surgery, The University of Melbourne, Austin Health Northern Health, Heidelberg, Victoria, Australia
    PLoS Biol 6:e172. 2008
    ..Furthermore, the absence of iGb3 in humans implies that it is another source of foreign Galalpha(1,3)Gal xenoantigen, with obvious significance in the field of xenotransplantation...
  46. ncbi request reprint Working with NKT cells--pitfalls and practicalities
    Stuart P Berzins
    Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria, 3010, Australia
    Curr Opin Immunol 17:448-54. 2005
    ..This should help determine the most appropriate ways to investigate NKT cell function, thus bringing us closer to successfully exploiting these cells in the treatment of human diseases...
  47. ncbi request reprint Long-term retention of mature NK1.1+ NKT cells in the thymus
    Stuart P Berzins
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 176:4059-65. 2006
    ..1(+) NKT cells being more abundant in the thymus. This is the first study to identify a mature T cell subset retained within the thymus and is additional evidence of the distinct developmental pathways of mainstream T cells and NKT cells...
  48. pmc Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors
    Daniel G Pellicci
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 31:47-59. 2009
    ..2 and V beta 7 residues within the CDR2 beta loop in mediating contacts with CD1d. Collectively we provide a structural basis for the differential NKT TCR V beta usage in NKT cells...
  49. doi request reprint Antibody responses to glycolipid-borne carbohydrates require CD4+ T cells but not CD1 or NKT cells
    Dale Christiansen
    Department of Surgery, The University of Melbourne, Austin Health Northern Health, Heidelberg, Victoria, Australia
    Immunol Cell Biol 89:502-10. 2011
    ..These data provide new insight into glycolipid antigen recognition by the immune system and indicate the existence of a previously unrecognised population of glycolipid antigen-specific, CD1-independent, CD4(+) T cells...
  50. doi request reprint NKT cell development in the absence of the autoimmune regulator gene (Aire)
    Lauren A Pitt
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Eur J Immunol 38:2689-96. 2008
    ..We conclude that Aire has little or no effect on regulatory T cell development in general and NKT cells in particular...
  51. ncbi request reprint Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice
    Jared F Purton
    Monash University Medical School, Department of Pathology and Immunology, Victoria, Australia
    Eur J Immunol 32:3546-55. 2002
    ..These data demonstrate that GR signaling is not required for either normal T cell development or peripheral maintenance in embryonic or adult mice...
  52. doi request reprint Ex-vivo α-galactosylceramide activation of NKT cells in humans and macaques
    Caroline S Fernandez
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
    J Immunol Methods 382:150-9. 2012
    ..In conclusion, we describe optimized methods for the ex vivo antigen-specific activation of human and macaque blood NKT cells. These assays should be useful in monitoring NKT cells in disease and in immunotherapy studies...
  53. pmc The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties
    Raffi Gugasyan
    Burnet Institute, Centre for Immunology, Melbourne, Victoria, Australia
    EMBO J 31:692-706. 2012
    ..These findings indicate that NF-κB1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics...
  54. pmc T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
    Florian Wiede
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Clin Invest 121:4758-74. 2011
    ..These data indicate that TCPTP is a critical negative regulator of TCR signaling that sets the threshold for TCR-induced naive T cell responses to prevent autoimmune and inflammatory disorders arising...
  55. doi request reprint Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway
    Sanda Stankovic
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 89:294-303. 2011
    ..Thus, individual NF-κB family members have a largely redundant role in early NKT cell development, but each of them has an important and distinct role in NKT cell maturation and/or function...
  56. ncbi request reprint Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
    Janice M Kelly
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    Nat Immunol 3:83-90. 2002
    ..Thus CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity...
  57. ncbi request reprint Genetic control of NKT cell numbers maps to major diabetes and lupus loci
    Luis M Esteban
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Immunol 171:2873-8. 2003
    ..The second most significant locus (Nkt2) mapped to the same region as Idd13, a NOD-derived diabetes susceptibility gene on chromosome 2...
  58. doi request reprint Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells
    Kirstyn T Carey
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    Endocrinology 154:1540-52. 2013
    ..The knockdown of Nfil3 mRNA levels to 20% of normal using specific small interfering RNAs abrogated GICD, indicating that NFIL3 is required for normal GICD in CTLL-2 T cells...
  59. pmc Peripheral NKT cells in simian immunodeficiency virus-infected macaques
    Caroline S Fernandez
    Department of Microbiology and Immunology, University of Melbourne, Australia
    J Virol 83:1617-24. 2009
    ..Further studies of the implications of the loss of NKT cell subsets in the pathogenesis of HIV disease are needed...
  60. doi request reprint Glucocorticoid-mediated repression of T-cell receptor signalling is impaired in glucocorticoid receptor exon 2-disrupted mice
    Douglas R Liddicoat
    1 Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia 2 Department of Immunology, Monash University, Victoria, Australia 3 Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Immunol Cell Biol 92:148-55. 2014
    ..Together, these data strongly re-affirm conclusions derived from earlier studies of these mice that the GR is not obligatory for normal T-cell selection. ..
  61. ncbi request reprint BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection...
  62. doi request reprint NKT cells: the smoking gun in fungal-induced asthma?
    Dale I Godfrey
    Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia
    Nat Med 19:1210-1. 2013
    ..fumigatus–induced asthma and also identifies a glycolipid antigen from this fungus that seems to drive this NKT cell–mediated inflammatory response (pages 1297–1304)...
  63. pmc Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor
    Rangsima Reantragoon
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 209:761-74. 2012
    ..This candidate docking mode contrasts with that of the NKT TCR-CD1d-antigen interaction, in which both the α and β chain of the NKT TCR is required for ligation above the F'-pocket of CD1d...
  64. pmc Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation
    Yifan Zhan
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050, Australia
    Proc Natl Acad Sci U S A 100:1197-202. 2003
    ..Thus, negative selection represents an "abortive" activation different from activation-induced cell death of mature T cells...
  65. ncbi request reprint Discordant regulation of granzyme H and granzyme B expression in human lymphocytes
    Karin A Sedelies
    Cancer Immunology Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, East Melbourne, 8006, Australia
    J Biol Chem 279:26581-7. 2004
    ..The finding that granzyme H is frequently more abundant than granzyme B in NK cells is consistent with a role for granzyme H in complementing the pro-apoptotic function of granzyme B in human NK cells...
  66. pmc A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
    Masaki Terabe
    Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1627-33. 2005
    ....
  67. ncbi request reprint Thymic regeneration: teaching an old immune system new tricks
    Stuart P Berzins
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Dept of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Trends Mol Med 8:469-76. 2002
    ..In the future, thymic regeneration might become a feasible and potentially powerful approach to rejuvenating a depleted peripheral T-cell pool...
  68. pmc A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage
    Daniel G Pellicci
    Department of Immunology and Pathology, Monash University Medical School, Prahran, Victoria 3181, Australia
    J Exp Med 195:835-44. 2002
    ..1(-). Further elucidation of this NKT cell developmental pathway should prove to be invaluable for studying the mechanisms that regulate the development of these cells...
  69. ncbi request reprint Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide
    Daniel G Pellicci
    Department of Pathology and Immunology, Monash University Central and Eastern Clinical School, Commercial Road, Prahran, Victoria 3181, Australia
    Eur J Immunol 33:1816-23. 2003
    ....
  70. ncbi request reprint Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Nat Immunol 5:590-6. 2004
    ..These observations emphasize the acquisition of self-recognizing inhibitory receptors on NKT cells as a previously unknown mechanism of thymic tolerance after chronic antigen exposure...
  71. ncbi request reprint Regulation of antitumour immunity by CD1d-restricted NKT cells
    Jeremy Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Immunol Cell Biol 82:323-31. 2004
    ..This intriguing cell type is the focus of this review...
  72. ncbi request reprint TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death
    Yifan Zhan
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050, Australia
    Int Immunol 16:1315-21. 2004
    ..Our findings also have implications for GC treatment in that it would be more difficult to abrogate an ongoing T-cell mediated inflammatory response than to prevent its induction...
  73. pmc Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Exp Med 201:1973-85. 2005
    ..Overall, the data suggest that NK cell antitumor function can be enhanced greatly by strategies that are designed to expand and differentiate NK cells via DC activation of NKT cells...
  74. pmc Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis
    Amanda C Stanley
    Immunology and Infection Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS Pathog 4:e1000028. 2008
    ..Our data clearly illustrate the double-edged sword of NKT cell-based therapy, showing that in some circumstances, such as when sub-clinical or chronic infections exist, iNKT cell activation can have adverse outcomes...
  75. ncbi request reprint CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor
    Natalie A Borg
    The Protein Crystallography Unit, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nature 448:44-9. 2007
    ..These findings provide direct insight into how a T-cell receptor recognizes a lipid-antigen-presenting molecule of the immune system...
  76. ncbi request reprint CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Australia
    J Immunol 176:1582-7. 2006
    ..Our data illustrate at least one mechanism by which Treg can suppress NK cell antitumor activity and highlight the effectiveness of combining Treg inhibition with subsequent NK cell activation to promote strong innate antitumor immunity...
  77. ncbi request reprint Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4
    Julie M Fletcher
    Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
    J Immunol 181:3400-12. 2008
    ..These findings raise the possibility that peroxisomes play a role in modulating glycolipid availability for CD1d presentation, thereby influencing NKT cell function...
  78. ncbi request reprint Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice
    Thomas C Brodnicki
    Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050 Australia
    Diabetes 54:3453-7. 2005
    ....
  79. pmc NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs
    Edward S Morris
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Clin Invest 115:3093-103. 2005
    ....
  80. ncbi request reprint CD1d antigen presentation: treats for NKT cells
    Dale I Godfrey
    Nat Immunol 6:754-6. 2005
  81. ncbi request reprint Are we really on the right TRAIL?
    Erika Cretney
    Immunol Res 31:161-4. 2005
  82. doi request reprint No requirement for TRAIL in intrathymic negative selection
    Erika Cretney
    Cancer Immunology Program, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Int Immunol 20:267-76. 2008
    ..These results, combined with the fact that aged C57BL/6 TRAIL(-/-) mice showed no signs of spontaneous autoimmunity, strongly indicate that intrathymic negative selection occurs normally in the absence of TRAIL signaling...
  83. pmc Natural killer T cells are targets for human immunodeficiency virus infection
    Nadine Y Crowe
    Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Prahran, Australia
    Immunology 108:1-2. 2003
  84. ncbi request reprint NKT cells join the war on Lyme disease
    Dale I Godfrey
    Nat Immunol 7:904-6. 2006
  85. ncbi request reprint Alpha-galactosylceramide: potential immunomodulatory activity and future application
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Curr Med Chem 11:241-52. 2004
    ..In this review, we discuss the potential immunomodulatory activity of alpha-GalCer and its possible future application for clinical studies in humans...
  86. ncbi request reprint Intrathymic glucocorticoid production and thymocyte survival: another piece in the puzzle
    Timothy J Cole
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 146:2499-500. 2005