Research Topics
Genomes and Genes
| Dale I GodfreySummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Control points in NKT-cell developmentDale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Nat Rev Immunol 7:505-18. 2007..Here, we review the current state of knowledge of NKT-cell development and attempt to highlight the most important questions in this field...- Immunology. The elusive NKT cell antigen--is the search over?Dale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
Science 306:1687-9. 2004 
New ways to turn on NKT cellsDale Ian Godfrey
Dept of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Exp Med 208:1121-5. 2011....- Chewing the fat on natural killer T cell developmentDale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
J Exp Med 203:2229-32. 2006..This suggests that lysosomal storage diseases (LSDs) in general, rather than one specific defect, can disrupt CD1d antigen presentation, leading to impaired development of NKT cells... 
Raising the NKT cell familyDale I Godfrey
University of Melbourne, Department of Microbiology and Immunology, Parkville, Victoria, Australia
Nat Immunol 11:197-206. 2010..Because their frequency and number vary widely between individuals, it is important to understand the mechanisms that regulate the development and maintenance of NKT cells and subsets thereof, which is the subject of this review...- Going both ways: immune regulation via CD1d-dependent NKT cellsDale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Clin Invest 114:1379-88. 2004..This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy... - NKT cells: what's in a name?Dale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Nat Rev Immunol 4:231-7. 2004 - Antigen recognition by CD1d-restricted NKT T cell receptorsDale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
Semin Immunol 22:61-7. 2010.... - The fidelity, occasional promiscuity, and versatility of T cell receptor recognitionDale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Immunity 28:304-14. 2008..Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system... - Differential antitumor immunity mediated by NKT cell subsets in vivoNadine Y Crowe
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
J Exp Med 202:1279-88. 2005.... - NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challengeAdam P Uldrich
Department Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 175:3092-101. 2005..In summary, this study significantly enhances our understanding of how NKT cells respond to primary and secondary antigenic challenge in vivo... - Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cellsNadine Y Crowe
Department of Pathology and Immunology, Monash University, Central and Eastern Clinical School, Prahran, Victoria, Australia
J Immunol 171:4020-7. 2003..This study provides critical new insight into how NKT cells can have such a major impact on immune responses, lasting many days beyond the initial stimulation of these cells... - Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunityHenrik Søndergaard
Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
J Immunol 183:7326-36. 2009.... - DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cellsDaniel G Pellicci
University of Melbourne, Department of Microbiology and Immunology, Parkville, Victoria, Australia
J Immunol 175:4416-25. 2005..In summary, our data demonstrate that DX5/CD49b is a poor marker for identifying CD1d-dependent NKT cells... - MR1 presents microbial vitamin B metabolites to MAIT cellsLars Kjer-Nielsen
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Nature 491:717-23. 2012..As many vitamin biosynthetic pathways are unique to bacteria and yeast, our data suggest that MAIT cells use these metabolites to detect microbial infection... - Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cellsShayna E A Street
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre Peter Mac, 8006, Victoria, Australia
J Exp Med 199:879-84. 2004..These results reflect a critical role for NK cells and gammadeltaTCR+ T cells in innate immune surveillance of B cell lymphomas, mediated by as yet undetermined pathway(s) of tumor recognition... - Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterpartsFinlay W McNab
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 179:6630-7. 2007..1(+) NKT cells in the periphery. We conclude that the vast majority of peripheral NK1.1(-) NKT cells are part of a previously unrecognized, mature NKT cell subset... - Antigen challenge inhibits thymic emigrationAdam P Uldrich
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 176:4553-61. 2006..Thus, in addition to its accepted role in intrathymic selection events, TCR signaling can also play an important role in the regulation of thymic emigration... - Expression of the glucocorticoid receptor from the 1A promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell deathJared F Purton
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 173:3816-24. 2004..These data suggest that tissue-specific differences in GR promoter use determine T cell sensitivity to glucocorticoid-induced cell death... - Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signalingAndreas Villunger
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Proc Natl Acad Sci U S A 101:7052-7. 2004..These results reveal the mechanisms of apoptosis in negative selection of semimature thymocytes and have implications for immunological tolerance and autoimmunity... - The influence of CD1d in postselection NKT cell maturation and homeostasisFinlay W McNab
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
J Immunol 175:3762-8. 2005.... - Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell populationJonathan M Coquet
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Proc Natl Acad Sci U S A 105:11287-92. 2008..1(+) but not into CD4(+)NK1.1(+) NKT cells, indicating that CD4(-)NK1.1(-) NKT cells include an IL-17-producing subpopulation, and also mark the elusive branch point for CD4(+) and CD4(-) NKT cell sublineages... - Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasisAnn L Cornish
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 170:878-86. 2003..Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-gamma signaling... - Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptorsDaniel G Pellicci
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Nat Immunol 12:827-33. 2011..Thus, the NKT cell TCR molds the β-linked self ligands to resemble the conformation of foreign α-linked ligands, which shows that induced-fit molecular mimicry can underpin the self-reactivity of NKT cell TCRs to β-linked antigens... - IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine productionJonathan M Coquet
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Immunol 178:2827-34. 2007..The influence of IL-21 in NKT cell-dependent models of tumor rejection, microbial clearance, autoimmunity, and allergy should be the subject of future investigations... - Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studiesStuart P Berzins
Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria, Australia
Immunol Cell Biol 82:247-52. 2004..This re-establishes the correlation between NKT cell deficiency and type 1 diabetes and raises important questions regarding the assaying of NKT cell levels in humans... - A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognitionLars Kjer-Nielsen
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Exp Med 203:661-73. 2006..The findings define a structural basis for the selection of the semi-invariant alphabeta TCR and the unique antigen specificity of NKT cells... - Parallels and distinctions between T and NKT cell development in the thymusStuart P Berzins
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010 Australia
Immunol Cell Biol 82:269-75. 2004..It is here that NKT cell-specific disorders may originate and may best be addressed... - A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomasNadine Y Crowe
Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria 3181, Australia
J Exp Med 196:119-27. 2002.... - Functional analysis of granzyme M and its role in immunity to infectionLily I Pao
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
J Immunol 175:3235-43. 2005..These data confirm a role for GrzM in the host response to MCMV infection, but suggest that GrzM is not critical for NK cell-mediated cytotoxicity... - Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramideMark J Smyth
Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
Blood 99:1259-66. 2002.... - Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samplesStuart P Berzins
Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Australia
Eur J Immunol 35:1399-407. 2005..Interestingly, while thymus and peripheral NKT cell frequencies vary widely between patients and are relatively stable between age groups, there is no clear relationship between the NKT cell frequency in thymus and blood... - Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunityCarole Guillonneau
Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Australia
Proc Natl Acad Sci U S A 106:3330-5. 2009.... - Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiationMark M W Chong
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Immunity 18:475-87. 2003..These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines... - NKT cells - conductors of tumor immunity?Mark J Smyth
Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
Curr Opin Immunol 14:165-71. 2002.... - Directing traffic on the NKT-cell highway: a key role for ThPOKSumone Chakravarti
Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
Eur J Immunol 40:2372-5. 2010..Furthermore, ThPOK-deficient mice generate an unusual population of CD8(+) NKT cells, which are absent in control mice. This study sheds new light on the underlying molecular events leading to the emergence of distinct NKT-cell subsets... - NKT cells are not critical for HSV-1 disease resolutionAnn L Cornish
Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
Immunol Cell Biol 84:13-9. 2006..Instead, the resolution or severity of the infection may depend on the HSV-1 strain under investigation... - A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCRKwok S Wun
Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
J Exp Med 205:939-49. 2008..Accordingly, although the structural footprint at the NKT TCR-CD1d-alpha-GalCer is small, the energetic footprint is smaller still, and reveals the minimal requirements for CD1d restriction... - A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition propertiesAdam P Uldrich
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
Nat Immunol 12:616-23. 2011..Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses... - Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitisJonathan M Coquet
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
J Immunol 180:7097-101. 2008..Thus, our results challenge the notion that IL-21 is a key factor in driving Th17 immunity and disease... - Normal thymocyte negative selection in TRAIL-deficient miceErika Cretney
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
J Exp Med 198:491-6. 2003..We were unable to demonstrate a role for TRAIL signaling in any of these models, suggesting that this pathway is not a critical factor for thymocyte negative selection... - Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient miceFlorian Wiede
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
PLoS ONE 7:e36703. 2012..Taken together these results reaffirm TCPTP's important role in lymphocyte development and indicate that the effects on morbidity, mortality, bone development and the myeloid compartment are strain-dependent... - Long-term retention of mature NK1.1+ NKT cells in the thymusStuart P Berzins
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
J Immunol 176:4059-65. 2006..1(+) NKT cells being more abundant in the thymus. This is the first study to identify a mature T cell subset retained within the thymus and is additional evidence of the distinct developmental pathways of mainstream T cells and NKT cells... - Working with NKT cells--pitfalls and practicalitiesStuart P Berzins
Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria, 3010, Australia
Curr Opin Immunol 17:448-54. 2005..This should help determine the most appropriate ways to investigate NKT cell function, thus bringing us closer to successfully exploiting these cells in the treatment of human diseases... - Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantationDale Christiansen
Department of Surgery, The University of Melbourne, Austin Health Northern Health, Heidelberg, Victoria, Australia
PLoS Biol 6:e172. 2008..Furthermore, the absence of iGb3 in humans implies that it is another source of foreign Galalpha(1,3)Gal xenoantigen, with obvious significance in the field of xenotransplantation... - Antibody responses to glycolipid-borne carbohydrates require CD4+ T cells but not CD1 or NKT cellsDale Christiansen
Department of Surgery, The University of Melbourne, Austin Health Northern Health, Heidelberg, Victoria, Australia
Immunol Cell Biol 89:502-10. 2011..These data provide new insight into glycolipid antigen recognition by the immune system and indicate the existence of a previously unrecognised population of glycolipid antigen-specific, CD1-independent, CD4(+) T cells... - NKT cell development in the absence of the autoimmune regulator gene (Aire)Lauren A Pitt
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Eur J Immunol 38:2689-96. 2008..We conclude that Aire has little or no effect on regulatory T cell development in general and NKT cells in particular... - Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult miceJared F Purton
Monash University Medical School, Department of Pathology and Immunology, Victoria, Australia
Eur J Immunol 32:3546-55. 2002..These data demonstrate that GR signaling is not required for either normal T cell development or peripheral maintenance in embryonic or adult mice... - Ex-vivo α-galactosylceramide activation of NKT cells in humans and macaquesCaroline S Fernandez
Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
J Immunol Methods 382:150-9. 2012..In conclusion, we describe optimized methods for the ex vivo antigen-specific activation of human and macaque blood NKT cells. These assays should be useful in monitoring NKT cells in disease and in immunotherapy studies... - The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory propertiesRaffi Gugasyan
Burnet Institute, Centre for Immunology, Melbourne, Victoria, Australia
EMBO J 31:692-706. 2012..These findings indicate that NF-κB1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics... - T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceFlorian Wiede
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
J Clin Invest 121:4758-74. 2011..These data indicate that TCPTP is a critical negative regulator of TCR signaling that sets the threshold for TCR-induced naive T cell responses to prevent autoimmune and inflammatory disorders arising... - Induction of tumor-specific T cell memory by NK cell-mediated tumor rejectionJanice M Kelly
Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, St. Andrews Place, East Melbourne, Victoria, Australia
Nat Immunol 3:83-90. 2002..Thus CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity... - Genetic control of NKT cell numbers maps to major diabetes and lupus lociLuis M Esteban
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
J Immunol 171:2873-8. 2003..The second most significant locus (Nkt2) mapped to the same region as Idd13, a NOD-derived diabetes susceptibility gene on chromosome 2... - Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathwaySanda Stankovic
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 89:294-303. 2011..Thus, individual NF-κB family members have a largely redundant role in early NKT cell development, but each of them has an important and distinct role in NKT cell maturation and/or function... - Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptorsDaniel G Pellicci
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Immunity 31:47-59. 2009..2 and V beta 7 residues within the CDR2 beta loop in mediating contacts with CD1d. Collectively we provide a structural basis for the differential NKT TCR V beta usage in NKT cells... - Peripheral NKT cells in simian immunodeficiency virus-infected macaquesCaroline S Fernandez
Department of Microbiology and Immunology, University of Melbourne, Australia
J Virol 83:1617-24. 2009..Further studies of the implications of the loss of NKT cell subsets in the pathogenesis of HIV disease are needed... - Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cellsKirstyn T Carey
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
Endocrinology 154:1540-52. 2013..The knockdown of Nfil3 mRNA levels to 20% of normal using specific small interfering RNAs abrogated GICD, indicating that NFIL3 is required for normal GICD in CTLL-2 T cells... - BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytesPhilippe Bouillet
The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
Nature 415:922-6. 2002..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection... - Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptorRangsima Reantragoon
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
J Exp Med 209:761-74. 2012..This candidate docking mode contrasts with that of the NKT TCR-CD1d-antigen interaction, in which both the α and β chain of the NKT TCR is required for ligation above the F'-pocket of CD1d... - No requirement for TRAIL in intrathymic negative selectionErika Cretney
Cancer Immunology Program, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Int Immunol 20:267-76. 2008..These results, combined with the fact that aged C57BL/6 TRAIL(-/-) mice showed no signs of spontaneous autoimmunity, strongly indicate that intrathymic negative selection occurs normally in the absence of TRAIL signaling... - Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptorsYoshihiro Hayakawa
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
Nat Immunol 5:590-6. 2004..These observations emphasize the acquisition of self-recognizing inhibitory receptors on NKT cells as a previously unknown mechanism of thymic tolerance after chronic antigen exposure... - CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptorNatalie A Borg
The Protein Crystallography Unit, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nature 448:44-9. 2007..These findings provide direct insight into how a T-cell receptor recognizes a lipid-antigen-presenting molecule of the immune system... - Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activationYifan Zhan
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050, Australia
Proc Natl Acad Sci U S A 100:1197-202. 2003..Thus, negative selection represents an "abortive" activation different from activation-induced cell death of mature T cells... - Discordant regulation of granzyme H and granzyme B expression in human lymphocytesKarin A Sedelies
Cancer Immunology Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, East Melbourne, 8006, Australia
J Biol Chem 279:26581-7. 2004..The finding that granzyme H is frequently more abundant than granzyme B in NK cells is consistent with a role for granzyme H in complementing the pro-apoptotic function of granzyme B in human NK cells... - Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramideDaniel G Pellicci
Department of Pathology and Immunology, Monash University Central and Eastern Clinical School, Commercial Road, Prahran, Victoria 3181, Australia
Eur J Immunol 33:1816-23. 2003.... - Thymic regeneration: teaching an old immune system new tricksStuart P Berzins
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Dept of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Trends Mol Med 8:469-76. 2002..In the future, thymic regeneration might become a feasible and potentially powerful approach to rejuvenating a depleted peripheral T-cell pool... - A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stageDaniel G Pellicci
Department of Immunology and Pathology, Monash University Medical School, Prahran, Victoria 3181, Australia
J Exp Med 195:835-44. 2002..1(-). Further elucidation of this NKT cell developmental pathway should prove to be invaluable for studying the mechanisms that regulate the development of these cells... - Regulation of antitumour immunity by CD1d-restricted NKT cellsJeremy Swann
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia
Immunol Cell Biol 82:323-31. 2004..This intriguing cell type is the focus of this review... - TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced deathYifan Zhan
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050, Australia
Int Immunol 16:1315-21. 2004..Our findings also have implications for GC treatment in that it would be more difficult to abrogate an ongoing T-cell mediated inflammatory response than to prevent its induction... - Are we really on the right TRAIL?Erika Cretney
Immunol Res 31:161-4. 2005 - Activation of invariant NKT cells exacerbates experimental visceral leishmaniasisAmanda C Stanley
Immunology and Infection Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
PLoS Pathog 4:e1000028. 2008..Our data clearly illustrate the double-edged sword of NKT cell-based therapy, showing that in some circumstances, such as when sub-clinical or chronic infections exist, iNKT cell activation can have adverse outcomes... - CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancerMark J Smyth
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Australia
J Immunol 176:1582-7. 2006..Our data illustrate at least one mechanism by which Treg can suppress NK cell antitumor activity and highlight the effectiveness of combining Treg inhibition with subsequent NK cell activation to promote strong innate antitumor immunity... - A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillanceMasaki Terabe
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:1627-33. 2005.... - Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD miceThomas C Brodnicki
Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050 Australia
Diabetes 54:3453-7. 2005.... - NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogsEdward S Morris
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
J Clin Invest 115:3093-103. 2005.... - CD1d antigen presentation: treats for NKT cellsDale I Godfrey
Nat Immunol 6:754-6. 2005 - Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancerMark J Smyth
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
J Exp Med 201:1973-85. 2005..Overall, the data suggest that NK cell antitumor function can be enhanced greatly by strategies that are designed to expand and differentiate NK cells via DC activation of NKT cells... - Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4Julie M Fletcher
Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
J Immunol 181:3400-12. 2008..These findings raise the possibility that peroxisomes play a role in modulating glycolipid availability for CD1d presentation, thereby influencing NKT cell function... - Alpha-galactosylceramide: potential immunomodulatory activity and future applicationYoshihiro Hayakawa
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia
Curr Med Chem 11:241-52. 2004..In this review, we discuss the potential immunomodulatory activity of alpha-GalCer and its possible future application for clinical studies in humans... - Natural killer T cells are targets for human immunodeficiency virus infectionNadine Y Crowe
Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Prahran, Australia
Immunology 108:1-2. 2003 - NKT cells join the war on Lyme diseaseDale I Godfrey
Nat Immunol 7:904-6. 2006 - Intrathymic glucocorticoid production and thymocyte survival: another piece in the puzzleTimothy J Cole
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Endocrinology 146:2499-500. 2005