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Genomes and Genes | R E GilbertSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Localization of secreted protein acidic and rich in cysteine (SPARC) expression in the rat eyeR E Gilbert
Department of Medicine, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
Connect Tissue Res 40:295-303. 1999..The demonstrated anatomical distribution of SPARC in the rat eye is consistent with several of the biological functions ascribed to this matricellular protein and provides a rational basis for its examination in pathological conditions...- Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetesR E Gilbert
University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Circ Res 86:158-65. 2000..These findings suggest that endogenous endothelin and EGF may play a role in diabetes-induced vascular hypertrophy and that mast cells may be pathogenetically involved in this process... - The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?R E Gilbert
University of Melbourne, Department of Medicine, West Heidelberg, Victoria, 3081, Australia
Kidney Int 56:1627-37. 1999..Continued exploration into tubulointerstitial disease in addition to glomerular injury in diabetes may help provide further insights into the pathogenesis of diabetic nephropathy and additional targets for therapeutic intervention... 
Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy. Implications for the pathogenesis of tubulointerstitial fibrosisR E Gilbert
Department of Medicine, University of Melbourne, Australia
Am J Pathol 155:429-40. 1999..Furthermore, in contrast to the juxtaglomerular apparatus, tubular renin expression was reduced with ACE inhibition. These changes within the intrarenal RAS may be pathogenetically linked to the development of tubulointerstitial injury...- Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic ratsR E Gilbert
University of Melbourne Department of Medicine, Victoria, Australia
Kidney Int 54:1052-62. 1998..TGF-beta inducible gene-h3 (beta ig-h3) is a recently identified TGF-beta-induced gene product. The present study sought to examine beta ig-h3 expression in normal and diabetic rats... - Drug administration in patients with diabetes mellitus. Safety considerationsR E Gilbert
Melbourne University Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Drug Saf 18:441-55. 1998..Although caution should also be used with beta-blocker therapy in patients with diabetes mellitus, current evidence suggests that, like ACE inhibitors, these drugs may be particularly useful in this patient group... - Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibitionR E Gilbert
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Diabetes 47:414-22. 1998..The observed beneficial effects of ramipril on the tubulointerstitium in experimental diabetes suggest that this mechanism may contribute to the therapeutic effect of ACE inhibitors in diabetic nephropathy... - Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized ratsZ Cao
University of Melbourne Department of Medicine at Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia
Kidney Int 60:715-21. 2001..The aim of the present study was to explore the effects of omapatrilat, a vasopeptidase inhibitor, on renal function and pathology in subtotally nephrectomized (STNx) rats... - Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockadeS A Mifsud
Department of Physiology, University of Melbourne, Victoria, Australia
Diabetologia 44:878-82. 2001..CONCLUSION/INTERPRETATION: Preservation of podocyte architecture could contribute to the renoprotective effects of renin-angiotensin system blockade in diabetic nephropathy... - Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathyD J Kelly
University of Melbourne Department of Medicine, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, 3065 Victoria, Australia
J Am Soc Nephrol 12:2098-107. 2001.... - Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuriaG Jerums
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg 3084, Vic, Australia
Am J Kidney Dis 37:890-9. 2001.... - Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetesF Bonnet
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria
Diabetes Metab 29:386-92. 2003..The present study thus sought to determine the effects of tranilast on both TGF-B and EGF expression and mast cells in mediating the trophic vascular changes in experimental diabetes... - Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 ratD J Kelly
Department of Medicine, Austin and Repatriation Medical Center, Heidelberg West, and Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
Kidney Int 57:1882-94. 2000.... - Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetesM E Cooper
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
Diabetes 48:2229-39. 1999..In addition, an early and transient increase in renal VEGF receptors was also observed in diabetic rats. These findings are consistent with a role for VEGF in mediating some of the changes observed in the diabetic kidney... - Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesisG Paizis
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre Melbourne, Australia
J Hepatol 35:376-85. 2001..The aim of this study was to investigate whether in the liver, as in other tissues, there is evidence that angiotensin II, acting via the angiotensin II type 1 receptor (AT1-R), plays a role in fibrogenesis... - SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophyK Jandeleit-Dahm
Department of Medicine, University of Melbourne, West Heidelberg, Victoria, Australia
Microvasc Res 59:61-71. 2000..The modulation of SPARC expression in mesenteric vessels of diabetic rats might be of pathogenetic significance in the development of vascular remodeling in diabetes... - Macrophage and myofibroblast proliferation in remnant kidney: role of angiotensin IIL L Wu
Department of Medicine, Austin and Repatriation Medical Center, Victoria, Australia
Kidney Int Suppl 63:S221-5. 1997..In conclusion, inhibition of local macrophage and myofibroblast proliferation may be an important mechanism by which Ang II blockade attenuated renal injury following renal ablation... 
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic controlR G Langham
University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Vic, Australia
Diabetologia 51:668-74. 2008..We sought to determine whether in addition to activation, diabetes may lead to increased transcription of two PKC isoforms that have been implicated in the pathogenesis of diabetic nephropathy, PKC-alpha and PKC-beta...- Serum total renin is increased before microalbuminuria in diabetesT J Allen
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centere, Heidelberg, Victoria, Australia
Kidney Int 50:902-7. 1996..Microalbuminuria in patients with IDDM is preceded by a substantial increase in serum TRC, suggesting that serum TRC may predict the subsequent development of incipient nephropathy... - Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 ratK A Connelly
University of Melbourne Department of Medicine, St Vincent s Hospital, Victoria, Australia
Cardiovasc Res 76:280-91. 2007.... - Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinasesS V McLennan
Department of Medicine, University of Sydney, New South Wales, Australia
Diabetologia 45:268-75. 2002..We investigated the degradative pathway of type IV collagen and the effects of ACE inhibition in experimental diabetic nephropathy... - Long-term renoprotection by perindopril or nifedipine in non-hypertensive patients with Type 2 diabetes and microalbuminuriaG Jerums
Department of Medicine, University of Melbourne, and Endocrinology Unit, Austin Health, Studley Road, Heidelberg, 3084 Victoria, Australia
Diabet Med 21:1192-9. 2004.... - Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibitionR G Langham
University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
Diabetologia 45:1572-6. 2002.... - Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney modelD J Kelly
Department of Medicine, University of Melbourne, St. Vincent's Hospital, Victoria, Australia
Kidney Int 69:1954-60. 2006.... - Novel approaches to the treatment of progressive renal diseaseR E Gilbert
University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria 3065, Australia
Curr Opin Pharmacol 1:183-9. 2001.... - Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cellsW Qi
Department of Medicine, Kolling Institute, University of Sydney, Royal North Shore Hospital, Sydney, Australia
Kidney Int 69:989-95. 2006.... - Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in ratsD J Kelly
Department of Medicine, St Vincent s Hospital, University of Melbourne, Fitzroy, VIC 3065, Australia
Diabetologia 50:2398-404. 2007..However, it is not known whether drugs in this class also reduce the structural and functional manifestations of diabetic nephropathy... - The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerationsR E Gilbert
University of Melbourne, Department of Medicine St Vincent s Hospital, Victoria, Australia
Diabet Med 20:607-21. 2003.... - SPARC gene expression is reduced in early diabetes-related kidney growthR E Gilbert
Endocrinology Unit, Austin Hospital, Victoria, Australia
Kidney Int 48:1216-25. 1995..In the context of the known biological actions of SPARC, the findings in the present study implicate this matrix protein in the pathogenesis of diabetes related kidney growth... - Combination angiotensin converting enzyme and direct renin inhibition in heart failure following experimental myocardial infarctionK A Connelly
Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, Canada
Cardiovasc Ther 31:84-91. 2013..We sought to determine the effectiveness of this strategy after myocardial infarction (MI) in the setting of preexisting hypertension, a common premorbid condition in patients with ischemic heart disease... - PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritisR E Gilbert
Department of Medicine, University of Melbourne, St Vincent s, Victoria, Australia
Kidney Int 59:1324-32. 2001..In the present study, the effects of a potent and selective inhibitor of PDGF receptor tyrosine kinase, STI 571, were examined in vitro and in vivo... - Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapyH Krum
National Health and Medical Research Council of Australia Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University Alfred Hospital, Prahran, Victoria, Australia
Diabet Med 20:708-12. 2003.... - Interlaboratory variation of GHb assays in Victoria, AustraliaR E Gilbert
Endocrinology Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Diabetes Care 19:730-4. 1996..To determine the extent of interlaboratory variation and accuracy in the measurement of glycated hemoglobin (GHb)... - Relationship between ambulatory blood pressure and albuminuria in normal subjectsR E Gilbert
Endocrinology Unit, Austin Hospital, Heidelberg, Australia
Am J Hypertens 4:959-62. 1991..We conclude that systemic blood pressure may influence AER in normal subjects... - Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measuresK A Connelly
Dept of Medicine, University of Melbourne, St Vincent s Hospital, Victoria, Australia
Am J Physiol Heart Circ Physiol 290:H1699-705. 2006..To accurately identify changes in systolic function, we suggest that a combination of echocardiography with assessment of load-insensitive measures be used routinely... - Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?S V McLennan
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Kidney Int 72:481-8. 2007..Our findings suggest that diminished expression of the glycoprotein-degrading enzyme, MMP-7, may play a role in fibronectin accumulation in the diabetic kidney in response to AGEs and/or TGF-beta... - Transforming growth factor-beta1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporine nephropathyR G Langham
Monash University, Department of Medicine, Prahran, Melbourne, Vic, Australia 3181
Transplantation 72:1826-9. 2001..05). These findings support the hypothesis that TGF-beta1 is an important cytokine in the development of CyAN, independent of its role in chronic rejection in renal allografts... - Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapyG R Fulcher
Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, New South Wales, Australia
Intern Med J 35:536-42. 2005..To compare glycaemic control and symptomatic hypoglycaemia rates with glargine versus neutral protamine Hagedorn (NPH) in poorly controlled type 1 diabetes patients... - Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosisW Qi
Dept of Medicine, Level 3, Wallace Freeborn Professorial Block, Royal North Shore Hospital, St Leonards, New South Wales, Australia 2065, USA
Am J Physiol Renal Physiol 288:F800-9. 2005..It has further uniquely demonstrated that CTGF requires TGF-beta, signaling through the TbetaRII in both PTCs and CFs, to exert its fibrogenic response in this in vitro model... - Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetesS E Jones
Department of Medicine, University Hospital of Hartlepool, Hartlepool, UK
J Diabetes Complications 18:309-15. 2004..The amelioration of diabetes-induced vessel fibrosis may be due to a reduction in the liberation of angiotensin II by inhibiting mast cell chymase...