R E Gilbert

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Localization of secreted protein acidic and rich in cysteine (SPARC) expression in the rat eye
    R E Gilbert
    Department of Medicine, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
    Connect Tissue Res 40:295-303. 1999
  2. ncbi request reprint Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetes
    R E Gilbert
    University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Circ Res 86:158-65. 2000
  3. ncbi request reprint The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
    R E Gilbert
    University of Melbourne, Department of Medicine, West Heidelberg, Victoria, 3081, Australia
    Kidney Int 56:1627-37. 1999
  4. pmc Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy. Implications for the pathogenesis of tubulointerstitial fibrosis
    R E Gilbert
    Department of Medicine, University of Melbourne, Australia
    Am J Pathol 155:429-40. 1999
  5. ncbi request reprint Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats
    R E Gilbert
    University of Melbourne Department of Medicine, Victoria, Australia
    Kidney Int 54:1052-62. 1998
  6. ncbi request reprint Drug administration in patients with diabetes mellitus. Safety considerations
    R E Gilbert
    Melbourne University Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Drug Saf 18:441-55. 1998
  7. ncbi request reprint Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition
    R E Gilbert
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Diabetes 47:414-22. 1998
  8. ncbi request reprint Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats
    Z Cao
    University of Melbourne Department of Medicine at Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia
    Kidney Int 60:715-21. 2001
  9. ncbi request reprint Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade
    S A Mifsud
    Department of Physiology, University of Melbourne, Victoria, Australia
    Diabetologia 44:878-82. 2001
  10. ncbi request reprint Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy
    D J Kelly
    University of Melbourne Department of Medicine, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, 3065 Victoria, Australia
    J Am Soc Nephrol 12:2098-107. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Localization of secreted protein acidic and rich in cysteine (SPARC) expression in the rat eye
    R E Gilbert
    Department of Medicine, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
    Connect Tissue Res 40:295-303. 1999
    ..The demonstrated anatomical distribution of SPARC in the rat eye is consistent with several of the biological functions ascribed to this matricellular protein and provides a rational basis for its examination in pathological conditions...
  2. ncbi request reprint Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetes
    R E Gilbert
    University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Circ Res 86:158-65. 2000
    ..These findings suggest that endogenous endothelin and EGF may play a role in diabetes-induced vascular hypertrophy and that mast cells may be pathogenetically involved in this process...
  3. ncbi request reprint The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
    R E Gilbert
    University of Melbourne, Department of Medicine, West Heidelberg, Victoria, 3081, Australia
    Kidney Int 56:1627-37. 1999
    ..Continued exploration into tubulointerstitial disease in addition to glomerular injury in diabetes may help provide further insights into the pathogenesis of diabetic nephropathy and additional targets for therapeutic intervention...
  4. pmc Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy. Implications for the pathogenesis of tubulointerstitial fibrosis
    R E Gilbert
    Department of Medicine, University of Melbourne, Australia
    Am J Pathol 155:429-40. 1999
    ..Furthermore, in contrast to the juxtaglomerular apparatus, tubular renin expression was reduced with ACE inhibition. These changes within the intrarenal RAS may be pathogenetically linked to the development of tubulointerstitial injury...
  5. ncbi request reprint Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats
    R E Gilbert
    University of Melbourne Department of Medicine, Victoria, Australia
    Kidney Int 54:1052-62. 1998
    ..TGF-beta inducible gene-h3 (beta ig-h3) is a recently identified TGF-beta-induced gene product. The present study sought to examine beta ig-h3 expression in normal and diabetic rats...
  6. ncbi request reprint Drug administration in patients with diabetes mellitus. Safety considerations
    R E Gilbert
    Melbourne University Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Drug Saf 18:441-55. 1998
    ..Although caution should also be used with beta-blocker therapy in patients with diabetes mellitus, current evidence suggests that, like ACE inhibitors, these drugs may be particularly useful in this patient group...
  7. ncbi request reprint Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition
    R E Gilbert
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Diabetes 47:414-22. 1998
    ..The observed beneficial effects of ramipril on the tubulointerstitium in experimental diabetes suggest that this mechanism may contribute to the therapeutic effect of ACE inhibitors in diabetic nephropathy...
  8. ncbi request reprint Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats
    Z Cao
    University of Melbourne Department of Medicine at Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia
    Kidney Int 60:715-21. 2001
    ..The aim of the present study was to explore the effects of omapatrilat, a vasopeptidase inhibitor, on renal function and pathology in subtotally nephrectomized (STNx) rats...
  9. ncbi request reprint Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade
    S A Mifsud
    Department of Physiology, University of Melbourne, Victoria, Australia
    Diabetologia 44:878-82. 2001
    ..CONCLUSION/INTERPRETATION: Preservation of podocyte architecture could contribute to the renoprotective effects of renin-angiotensin system blockade in diabetic nephropathy...
  10. ncbi request reprint Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy
    D J Kelly
    University of Melbourne Department of Medicine, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, 3065 Victoria, Australia
    J Am Soc Nephrol 12:2098-107. 2001
    ....
  11. ncbi request reprint Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuria
    G Jerums
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg 3084, Vic, Australia
    Am J Kidney Dis 37:890-9. 2001
    ....
  12. ncbi request reprint Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes
    F Bonnet
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria
    Diabetes Metab 29:386-92. 2003
    ..The present study thus sought to determine the effects of tranilast on both TGF-B and EGF expression and mast cells in mediating the trophic vascular changes in experimental diabetes...
  13. ncbi request reprint Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat
    D J Kelly
    Department of Medicine, Austin and Repatriation Medical Center, Heidelberg West, and Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Kidney Int 57:1882-94. 2000
    ....
  14. ncbi request reprint Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
    M E Cooper
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
    Diabetes 48:2229-39. 1999
    ..In addition, an early and transient increase in renal VEGF receptors was also observed in diabetic rats. These findings are consistent with a role for VEGF in mediating some of the changes observed in the diabetic kidney...
  15. ncbi request reprint Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis
    G Paizis
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre Melbourne, Australia
    J Hepatol 35:376-85. 2001
    ..The aim of this study was to investigate whether in the liver, as in other tissues, there is evidence that angiotensin II, acting via the angiotensin II type 1 receptor (AT1-R), plays a role in fibrogenesis...
  16. ncbi request reprint SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy
    K Jandeleit-Dahm
    Department of Medicine, University of Melbourne, West Heidelberg, Victoria, Australia
    Microvasc Res 59:61-71. 2000
    ..The modulation of SPARC expression in mesenteric vessels of diabetic rats might be of pathogenetic significance in the development of vascular remodeling in diabetes...
  17. ncbi request reprint Macrophage and myofibroblast proliferation in remnant kidney: role of angiotensin II
    L L Wu
    Department of Medicine, Austin and Repatriation Medical Center, Victoria, Australia
    Kidney Int Suppl 63:S221-5. 1997
    ..In conclusion, inhibition of local macrophage and myofibroblast proliferation may be an important mechanism by which Ang II blockade attenuated renal injury following renal ablation...
  18. doi request reprint Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control
    R G Langham
    University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Vic, Australia
    Diabetologia 51:668-74. 2008
    ..We sought to determine whether in addition to activation, diabetes may lead to increased transcription of two PKC isoforms that have been implicated in the pathogenesis of diabetic nephropathy, PKC-alpha and PKC-beta...
  19. ncbi request reprint Serum total renin is increased before microalbuminuria in diabetes
    T J Allen
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centere, Heidelberg, Victoria, Australia
    Kidney Int 50:902-7. 1996
    ..Microalbuminuria in patients with IDDM is preceded by a substantial increase in serum TRC, suggesting that serum TRC may predict the subsequent development of incipient nephropathy...
  20. ncbi request reprint Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat
    K A Connelly
    University of Melbourne Department of Medicine, St Vincent s Hospital, Victoria, Australia
    Cardiovasc Res 76:280-91. 2007
    ....
  21. ncbi request reprint Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases
    S V McLennan
    Department of Medicine, University of Sydney, New South Wales, Australia
    Diabetologia 45:268-75. 2002
    ..We investigated the degradative pathway of type IV collagen and the effects of ACE inhibition in experimental diabetic nephropathy...
  22. ncbi request reprint Long-term renoprotection by perindopril or nifedipine in non-hypertensive patients with Type 2 diabetes and microalbuminuria
    G Jerums
    Department of Medicine, University of Melbourne, and Endocrinology Unit, Austin Health, Studley Road, Heidelberg, 3084 Victoria, Australia
    Diabet Med 21:1192-9. 2004
    ....
  23. ncbi request reprint Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition
    R G Langham
    University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Diabetologia 45:1572-6. 2002
    ....
  24. ncbi request reprint Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model
    D J Kelly
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Victoria, Australia
    Kidney Int 69:1954-60. 2006
    ....
  25. ncbi request reprint Novel approaches to the treatment of progressive renal disease
    R E Gilbert
    University of Melbourne Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria 3065, Australia
    Curr Opin Pharmacol 1:183-9. 2001
    ....
  26. ncbi request reprint Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells
    W Qi
    Department of Medicine, Kolling Institute, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Kidney Int 69:989-95. 2006
    ....
  27. ncbi request reprint Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats
    D J Kelly
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Fitzroy, VIC 3065, Australia
    Diabetologia 50:2398-404. 2007
    ..However, it is not known whether drugs in this class also reduce the structural and functional manifestations of diabetic nephropathy...
  28. ncbi request reprint The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations
    R E Gilbert
    University of Melbourne, Department of Medicine St Vincent s Hospital, Victoria, Australia
    Diabet Med 20:607-21. 2003
    ....
  29. ncbi request reprint SPARC gene expression is reduced in early diabetes-related kidney growth
    R E Gilbert
    Endocrinology Unit, Austin Hospital, Victoria, Australia
    Kidney Int 48:1216-25. 1995
    ..In the context of the known biological actions of SPARC, the findings in the present study implicate this matrix protein in the pathogenesis of diabetes related kidney growth...
  30. doi request reprint Combination angiotensin converting enzyme and direct renin inhibition in heart failure following experimental myocardial infarction
    K A Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, Canada
    Cardiovasc Ther 31:84-91. 2013
    ..We sought to determine the effectiveness of this strategy after myocardial infarction (MI) in the setting of preexisting hypertension, a common premorbid condition in patients with ischemic heart disease...
  31. ncbi request reprint PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis
    R E Gilbert
    Department of Medicine, University of Melbourne, St Vincent s, Victoria, Australia
    Kidney Int 59:1324-32. 2001
    ..In the present study, the effects of a potent and selective inhibitor of PDGF receptor tyrosine kinase, STI 571, were examined in vitro and in vivo...
  32. ncbi request reprint Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy
    H Krum
    National Health and Medical Research Council of Australia Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University Alfred Hospital, Prahran, Victoria, Australia
    Diabet Med 20:708-12. 2003
    ....
  33. ncbi request reprint Interlaboratory variation of GHb assays in Victoria, Australia
    R E Gilbert
    Endocrinology Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Diabetes Care 19:730-4. 1996
    ..To determine the extent of interlaboratory variation and accuracy in the measurement of glycated hemoglobin (GHb)...
  34. ncbi request reprint Relationship between ambulatory blood pressure and albuminuria in normal subjects
    R E Gilbert
    Endocrinology Unit, Austin Hospital, Heidelberg, Australia
    Am J Hypertens 4:959-62. 1991
    ..We conclude that systemic blood pressure may influence AER in normal subjects...
  35. ncbi request reprint Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures
    K A Connelly
    Dept of Medicine, University of Melbourne, St Vincent s Hospital, Victoria, Australia
    Am J Physiol Heart Circ Physiol 290:H1699-705. 2006
    ..To accurately identify changes in systolic function, we suggest that a combination of echocardiography with assessment of load-insensitive measures be used routinely...
  36. ncbi request reprint Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?
    S V McLennan
    Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Kidney Int 72:481-8. 2007
    ..Our findings suggest that diminished expression of the glycoprotein-degrading enzyme, MMP-7, may play a role in fibronectin accumulation in the diabetic kidney in response to AGEs and/or TGF-beta...
  37. ncbi request reprint Transforming growth factor-beta1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporine nephropathy
    R G Langham
    Monash University, Department of Medicine, Prahran, Melbourne, Vic, Australia 3181
    Transplantation 72:1826-9. 2001
    ..05). These findings support the hypothesis that TGF-beta1 is an important cytokine in the development of CyAN, independent of its role in chronic rejection in renal allografts...
  38. ncbi request reprint Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy
    G R Fulcher
    Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, New South Wales, Australia
    Intern Med J 35:536-42. 2005
    ..To compare glycaemic control and symptomatic hypoglycaemia rates with glargine versus neutral protamine Hagedorn (NPH) in poorly controlled type 1 diabetes patients...
  39. ncbi request reprint Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis
    W Qi
    Dept of Medicine, Level 3, Wallace Freeborn Professorial Block, Royal North Shore Hospital, St Leonards, New South Wales, Australia 2065, USA
    Am J Physiol Renal Physiol 288:F800-9. 2005
    ..It has further uniquely demonstrated that CTGF requires TGF-beta, signaling through the TbetaRII in both PTCs and CFs, to exert its fibrogenic response in this in vitro model...
  40. ncbi request reprint Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetes
    S E Jones
    Department of Medicine, University Hospital of Hartlepool, Hartlepool, UK
    J Diabetes Complications 18:309-15. 2004
    ..The amelioration of diabetes-induced vessel fibrosis may be due to a reduction in the liberation of angiotensin II by inhibiting mast cell chymase...