Peter G Gibson

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi Pattern of airway inflammation and its determinants in children with acute severe asthma
    P G Gibson
    Airway Research Centre, Respiratory Medicine Unit, John Hunter Hospital and School of Paediatrics, University of New South Wales, Randwick, New South Wales, Australia
    Pediatr Pulmonol 28:261-70. 1999
  2. ncbi Written action plans for asthma: an evidence-based review of the key components
    P G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Thorax 59:94-9. 2004
  3. ncbi Asthma education
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Locked Bag 1, Hunter Region Mail Centre, NSW 2310, Australia
    Respir Med 97:1036-44. 2003
  4. ncbi Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation
    Peter G Gibson
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, New South Wales, Australia
    Pediatr Pulmonol 36:209-15. 2003
  5. ncbi Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital and School of Medical Practice and Population Health, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
    Eur Respir J 21:582-8. 2003
  6. ncbi Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma
    P G Gibson
    Department of Respiratory and Sleep Medicine, and Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Thorax 58:116-21. 2003
  7. ncbi Sputum induction in children
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Eur Respir J Suppl 37:44s-46s. 2002
  8. ncbi Outpatient monitoring of asthma
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Curr Opin Allergy Clin Immunol 2:161-6. 2002
  9. ncbi Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8
    P G Gibson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Chest 119:1329-36. 2001
  10. ncbi Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial
    P G Gibson
    Airway Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Am J Respir Crit Care Med 163:32-6. 2001

Detail Information

Publications107 found, 100 shown here

  1. ncbi Pattern of airway inflammation and its determinants in children with acute severe asthma
    P G Gibson
    Airway Research Centre, Respiratory Medicine Unit, John Hunter Hospital and School of Paediatrics, University of New South Wales, Randwick, New South Wales, Australia
    Pediatr Pulmonol 28:261-70. 1999
    ..These different inflammatory cell profiles imply different etiological agents and may require differing treatment strategies...
  2. ncbi Written action plans for asthma: an evidence-based review of the key components
    P G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Thorax 59:94-9. 2004
    ..Several versions of action plans have been published but the key components have not been determined. A study was undertaken to determine the impact of individual components of written action plans on asthma health outcomes...
  3. ncbi Asthma education
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Locked Bag 1, Hunter Region Mail Centre, NSW 2310, Australia
    Respir Med 97:1036-44. 2003
    ..While a structured asthma self-management programme is effective in a hospital setting, attempts to deliver these programmes in primary care have met with varying success...
  4. ncbi Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation
    Peter G Gibson
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, New South Wales, Australia
    Pediatr Pulmonol 36:209-15. 2003
    ..The development of wheeze after migration to Australia was independent of eosinophilic inflammation and consistent with noneosinophilic asthma mechanisms...
  5. ncbi Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital and School of Medical Practice and Population Health, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
    Eur Respir J 21:582-8. 2003
    ..The interleukin-8-mediated neutrophil influx in allergic bronchopulmonary aspergillosis may induce lung damage via release of matrix metalloproteinase-9, potentially leading to bronchiectasis...
  6. ncbi Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma
    P G Gibson
    Department of Respiratory and Sleep Medicine, and Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Thorax 58:116-21. 2003
    ..A study was undertaken to examine the relationship between airway inflammation and clinical asthma in children...
  7. ncbi Sputum induction in children
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Eur Respir J Suppl 37:44s-46s. 2002
  8. ncbi Outpatient monitoring of asthma
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Curr Opin Allergy Clin Immunol 2:161-6. 2002
    ..Additional monitoring tools are under evaluation, and these include measures of airway responsiveness, airway inflammation, and Internet-based monitoring systems...
  9. ncbi Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8
    P G Gibson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Chest 119:1329-36. 2001
    ..To identify the characteristics of airway inflammation in persistent asthma and to examine the role of neutrophilic inflammation in noneosinophilic persistent asthma...
  10. ncbi Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial
    P G Gibson
    Airway Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Am J Respir Crit Care Med 163:32-6. 2001
    ..This may be clinically useful as therapy during mild exacerbations of asthma...
  11. ncbi Airway eosinophilia is associated with wheeze but is uncommon in children with persistent cough and frequent chest colds
    P G Gibson
    Airways Research Centre, John Hunter Hospital NSW, Australia
    Am J Respir Crit Care Med 164:977-81. 2001
    ..Eosinophilic bronchitis did occur in a significant minority of these "variant asthma" syndromes...
  12. ncbi Eosinophilic bronchitis: clinical manifestations and implications for treatment
    P G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, NSW 2310, Australia
    Thorax 57:178-82. 2002
    ..Airway wall remodelling can occur in rhinitis, COPD, and cough variant asthma with EB. The mechanisms and long term implications of this complication in EB without asthma need to be clarified...
  13. ncbi Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    J Immunol 184:4159-69. 2010
    ..Thus, active chlamydial respiratory infection during sensitization enhances subsequent neutrophilic inflammation and Th1/Th17 responses during allergen exposure and may have a role in the pathogenesis of neutrophilic asthma...
  14. ncbi Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Free Radic Res 42:94-102. 2008
    ..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention...
  15. ncbi Manipulating antioxidant intake in asthma: a randomized controlled trial
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia
    Am J Clin Nutr 96:534-43. 2012
    ..Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes...
  16. ncbi Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 125:617-25, 625.e1-625.e6. 2010
    ..The progression of aberrant T(H)2 cell responses and disease development has been attributed to a lack of infections. However, exposure to specific pathogens such as Chlamydia may alter immunologic programming and predispose to asthma...
  17. ncbi Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 177:148-55. 2008
    ..Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma...
  18. ncbi Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations...
  19. ncbi Induced sputum 8-isoprostane concentrations in inflammatory airway diseases
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Am J Respir Crit Care Med 171:426-30. 2005
    ..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease...
  20. ncbi IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  21. ncbi Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    PLoS Pathog 7:e1002244. 2011
    ..This results in a phenotype that is similar to neutrophilic asthma. Infection-induced neutrophilic inflammation in AAD is mediated by IL-17 responses...
  22. ncbi Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
    Julie A Preston
    Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Newcastle, Australia
    Vaccine 25:8154-62. 2007
    ..This indicates the potential of Spn as an IMT for asthma...
  23. ncbi A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 127:1133-40. 2011
    ..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown...
  24. ncbi Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    J Asthma 48:1032-40. 2011
    ..Little is known about the psychosocial impact and perceived teratogenic (fetal harm due to medication) risks of asthma treatment (inhaled/oral corticosteroids and β-agonist) during pregnancy...
  25. ncbi Relationship between body composition, inflammation and lung function in overweight and obese asthma
    Hayley A Scott
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
    Respir Res 13:10. 2012
    ..The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma...
  26. ncbi Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    Thorax 67:588-99. 2012
    ..The relationship between chronic airway colonisation and the development of steroid-resistant neutrophilic asthma is unclear...
  27. ncbi Asthma in older adults
    Peter G Gibson
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Lancet 376:803-13. 2010
    ....
  28. ncbi A comparison of two approaches to the treatment of chronic cough: perceptual, acoustic, and electroglottographic outcomes
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    J Voice 22:581-9. 2008
    ..These results demonstrated that SPEICH-C can improve perceptual aspects of voice quality suggesting that dysphonia may be a fundamental characteristic of CC...
  29. ncbi Neutrophilic asthma has different radiographic features to COPD and smokers
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    Respir Med 103:881-7. 2009
    ..The aim of this study was to examine the airway and parenchymal abnormalities using high resolution computed tomographic (HRCT) scanning in participants with neutrophilic asthma, COPD and smoking controls...
  30. ncbi Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Br J Nutr 101:533-40. 2009
    ..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation...
  31. ncbi Oxidized vitamin E and glutathione as markers of clinical status in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Clin Nutr 27:579-86. 2008
    ....
  32. ncbi Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 16:291-9. 2011
    ..This study investigates the frequency of viral persistence after acute asthma, assesses viral infectivity and determines the host inflammatory responses to viral persistence...
  33. ncbi The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  34. ncbi Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    Peter A B Wark
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, UK
    Respirology 14:180-6. 2009
    ..Infection with rhinovirus (RV) is the most common trigger for acute asthma and COPD. The aim of this study was to characterize the variability in the response of primary bronchial epithelial cells to infection with several strains of RV...
  35. ncbi Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma
    Lisa G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Br J Nutr 103:735-41. 2010
    ..This highlights the potential role for antioxidant supplementation in these subjects...
  36. ncbi Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, University of Newcastle, Callaghan, NSW, Australia
    Free Radic Res 44:146-54. 2010
    ..The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients...
  37. ncbi Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  38. ncbi Proteomic study of plasma proteins in pregnant women with asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NWS, Australia
    Respirology 11:41-8. 2006
    ..Surface-enhanced laser desorption ionization-time of flight mass spectrometry has potential as a tool to monitor disease progression in situations such as pregnancy...
  39. ncbi Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  40. ncbi The importance of clinical management problems in older people with COPD and asthma: do patients and physicians agree?
    Vanessa M McDonald
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia
    Prim Care Respir J 20:389-95. 2011
    ..COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physicians and the level of agreement between them is largely unknown...
  41. ncbi Acoustic and electroglottographic voice characteristics in chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, Australia
    Folia Phoniatr Logop 60:210-6. 2008
    ..Objective acoustic and electroglottographic (EGG) measures have the capacity to delineate these vocal characteristics. This study investigated acoustic and EGG voice features of CC and PVFM...
  42. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..These inflammatory subtypes have important implications for the investigation and characterization of airway inflammation in asthma...
  43. ncbi Characterization of laryngeal dysfunction in chronic persistent cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia
    Laryngoscope 119:640-5. 2009
    ....
  44. ncbi Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
    ..Innate immune responses of airway neutrophil cells are impaired in asthmatic subjects on prophylactic therapy and may impact on susceptibility to, and severity of, airway infections...
  45. ncbi Obesity and childhood asthma - mechanisms and manifestations
    Megan E Jensen
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2310, Australia
    Curr Opin Allergy Clin Immunol 12:186-92. 2012
    ..This review highlights the most recent findings over the past 18 months in understanding the presentation and potential mechanisms of obesity in childhood asthma...
  46. ncbi Persistent airway obstruction after virus infection is not associated with airway inflammation
    Lisa G Wood
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Chest 131:415-23. 2007
    ..This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations...
  47. ncbi How to set up a severe asthma service
    Vanessa M McDonald
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
    Respirology 16:900-11. 2011
    ..In this article we describe the purpose of a severe asthma clinic, the necessary components of a service including staffing and facilities and the processes for trialling additional therapies used in the management of severe asthma...
  48. ncbi The effect of maternal asthma on placental and cord blood protein profiles
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Soc Gynecol Investig 12:349-55. 2005
    ..Further work to positively identify the candidate peptides found in this study may provide a greater understanding of the placental mechanisms leading to alterations in fetal growth in patients with bronchial asthma...
  49. ncbi Innate immune activation in neutrophilic asthma and bronchiectasis
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, Newcastle, Australia
    Thorax 62:211-8. 2007
    ..The inflammatory response in asthma is heterogeneous...
  50. ncbi Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease, Newcastle, New South Wales 2300, Australia
    J Immunol 188:4611-20. 2012
    ..These data suggest that S. pneumoniae components may have potential as a therapeutic strategy for the suppression of allergic asthma through the induction of Tregs and suppression of NKT cells...
  51. ncbi Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma
    Rebecca Louise Forbes
    Department of Respiratory Medicine, Centre for Asthma and Respiratory Disease, The University of Newcastle, School of Medicine and Public Health, New Lambton, NSW, Australia, 2350
    Thorax 67:209-14. 2012
    ..Pregnant women have increased susceptibility and disease severity to viral infections like influenza and HRVs, as do asthmatics. Successful pregnancy requires immunological modulation to permit fetal tolerance...
  52. ncbi Validity of the common cold questionnaire (CCQ) in asthma exacerbations
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
    PLoS ONE 3:e1802. 2008
    ..Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing...
  53. ncbi Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 65:1053-60. 2010
    ..Components of S pneumoniae may have the potential to modulate allergic inflammatory responses and suppress the development of asthma...
  54. ncbi Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
    J Nutr Biochem 20:577-85. 2009
    ..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation...
  55. ncbi Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers
    Anne E Vertigan
    Department of Speech Pathology, John Hunter Hospital, Newcastle, Australia
    J Voice 25:596-601. 2011
    ....
  56. ncbi Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, New Lambton, Australia
    J Allergy Clin Immunol 119:344-50. 2007
    ..Combination therapy with long-acting beta-agonists (LABAs)/inhaled corticosteroids (ICSs) has become established as effective maintenance treatment for asthma...
  57. ncbi Airway and circulating levels of carotenoids in asthma and healthy controls
    Lisa G Wood
    Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    J Am Coll Nutr 24:448-55. 2005
    ..Plasma carotenoid levels reflect airway carotenoid levels and when plasma levels are improved using oral supplements this is reflected in the airways...
  58. ncbi Interleukin-10 gene expression in acute virus-induced asthma
    Terry V Grissell
    School of Medical Practice and Population Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:433-9. 2005
    ..Airway neutrophilia due to respiratory virus infection is associated with chemokine gene expression involving RANTES and macrophage inflammatory protein-1alpha...
  59. ncbi Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Lancet 380:1583-9. 2012
    ..We established the efficacy of gabapentin in patients with refractory chronic cough...
  60. ncbi Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308 NSW, Australia
    Respir Med 106:138-44. 2012
    ..This study sought to investigate the prevalence, characteristics and mechanism of chronic cough following laboratory-confirmed H1N1 2009 influenza...
  61. ncbi Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease
    Nicole M Verrills
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 183:1633-43. 2011
    ..Proteomics may identify a useful panel of biomarkers for identification of asthma and chronic obstructive pulmonary disease (COPD)...
  62. ncbi Multidimensional assessment of older people with asthma and COPD: clinical management and health status
    Vanessa M McDonald
    School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Age Ageing 40:42-9. 2011
    ..the diagnosis and management of obstructive airway diseases (OADs) such as asthma and chronic obstructive pulmonary disease (COPD) can be challenging in older people...
  63. ncbi CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian cough guidelines summary statement
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Med J Aust 192:265-71. 2010
    ..In ADULTS, refractory cough that persists after therapy is managed by empirical inhaled corticosteroid therapy and speech pathology techniques...
  64. ncbi Asthma in pregnancy
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, New South Wales 2310, Australia
    Clin Chest Med 32:93-110, ix. 2011
    ..Barriers to effective asthma management and opportunities for optimized care and treatment are discussed, and a summary of the clinical guidelines for the management of asthma during pregnancy is presented...
  65. ncbi Premenstrual asthma: prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 45:696-704. 2008
    ..PMA resulting in increased symptoms and medication use occurred in 57% of subjects studied for 2-4 menstrual cycles. The use of oral contraceptives is not protective and further work is required to elucidate the mechanisms of PMA...
  66. ncbi Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
    Jay C Horvat
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 176:556-64. 2007
    ..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...
  67. ncbi The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
    Paul S Thomas
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    J Asthma 42:291-5. 2005
    ..eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness...
  68. ncbi Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
    Jodie L Simpson
    School of Medical Practice and Population Health, and Medical Genetics, School of Biomedical Science, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:559-65. 2005
    ..Asthma is characterized by both chronic inflammation and remodeling of the airways. Proteases are important mediators of inflammation, cytokine activation, and tissue remodeling...
  69. ncbi Initial corticosteroid therapy for asthma
    Peter G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, and University of Newcastle, Australia
    Curr Opin Pulm Med 12:48-53. 2006
    ..This review examines the commencement of maintenance pharmacotherapy for asthma: inhaled corticosteroids alone or in combination with long-acting beta2 agonists...
  70. ncbi Perceptual voice characteristics in chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    Folia Phoniatr Logop 59:256-67. 2007
    ..These results have implications for the identification and management of voice disorders in CC and PVFM and suggest that clinicians should be alert to the incidence of voice abnormalities in these populations...
  71. ncbi Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales 2310, Australia
    J Clin Virol 26:339-46. 2003
    ..The improved sensitivity of induced sputum RT-PCR also permits a more rapid diagnosis and the opportunity of early administration of effective treatments...
  72. ncbi Allergic bronchopulmonary aspergillosis
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Semin Respir Crit Care Med 27:185-91. 2006
    ..Treatment involves corticosteroids and antifungal therapy with oral azoles. Additional management seeks to monitor and control the other disease components of severe asthma, bronchiectasis, and disease exacerbations...
  73. ncbi Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients
    Lisa G Wood
    Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
    Am J Clin Nutr 75:668-75. 2002
    ..Thus, antioxidant intervention during treatment for and recovery from acute infection in cystic fibrosis should be considered...
  74. ncbi Role of atypical bacterial infection of the lung in predisposition/protection of asthma
    Philip M Hansbro
    Discipline of Immunology and Microbiology, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Pharmacol Ther 101:193-210. 2004
    ....
  75. ncbi Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 5:4. 2009
    ..Successful treatment for chronic persistent cough leads to improvements in these features of laryngeal dysfunction...
  76. ncbi Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 6:5. 2010
    ..The number of treatments required to effect a response was also assessed...
  77. ncbi Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Prog Lipid Res 48:27-43. 2009
    ..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets...
  78. ncbi The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  79. ncbi Dietary factors lead to innate immune activation in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Pharmacol Ther 123:37-53. 2009
    ..Therapeutic strategies aimed at addressing diet-induced innate immune activation are warranted...
  80. ncbi Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, NSW, Australia
    Pharmacol Ther 124:86-95. 2009
    ..Studies also show improvements in quality of life and exacerbation rates in airways diseases...
  81. ncbi Use of omalizumab in a severe asthma clinic
    Peter G Gibson
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, Australia
    Respirology 12:S35-44; discussion S45-7. 2007
    ....
  82. ncbi Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children
    Terry V Grissell
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, New Lambton, Australia
    Pediatr Pulmonol 42:380-5. 2007
    ..There is evidence for co-regulation of neurokinin (TAC1) and TLR4 gene expression in airway cells from children with airway bacterial colonization and their reduced expression may be associated with an impaired bacterial clearance...
  83. ncbi Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: a quantitative review
    John H Wlodarczyk
    John Wlodarczyk Consulting Services, New Lambton, New South Wales, Australia
    Ann Allergy Asthma Immunol 100:23-30. 2008
    ..Studies examining the effects of inhaled corticosteroids (ICSs) on cortisol suppression show inconsistent results, and there is uncertainty regarding the dose-response relationship between ICSs and cortisol suppression...
  84. ncbi Assessment and reproducibility of non-eosinophilic asthma using induced sputum
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Callaghan, NSW, Australia
    Respiration 79:147-51. 2010
    ..The stability of airway inflammation in asthma over time is not known, yet this information is crucial to inflammation-based patient management...
  85. ncbi Inhaled corticosteroid doses in asthma: an evidence-based approach
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Mail Centre, Newcastle, NSW 2310, Australia
    Med J Aust 178:223-5. 2003
    ..To define the evidence for doses of inhaled corticosteroids in asthma and describe this in clinically meaningful, evidence-based terms...
  86. ncbi Optimization of sputum-processing methods for the measurement of interleukin-5: effects of protease inhibition
    Jodie L Simpson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Respirology 7:111-6. 2002
    ..CONCLUSION: Interleukin-5 recovery is increased by the addition of PI to samples processed using the selected portion method with DTT dispersion. A protease inhibitor cocktail should be added to sputum for IL-5 assay...
  87. ncbi Randomized controlled trial of a teacher-led asthma education program
    Richard L Henry
    School of Women s and Children s Health, University of New South Wales, c o Sydney Children s Hospital, Randwick, New South Wales 2031, Australia
    Pediatr Pulmonol 38:434-42. 2004
    ....
  88. ncbi Pneumococcal vaccines for allergic airways diseases
    Alison N Thorburn
    The University of Newcastle, Hunter Medical Research Institute, Centre for Asthma and Respiratory Disease, Newcastle, Australia
    Expert Opin Biol Ther 9:621-9. 2009
    ..Asthma is a common global health problem. Environmental exposures such as bacteria may protect against asthma development...
  89. ncbi Inhalation-device polypharmacy in asthma
    Vanessa M McDonald
    Med J Aust 182:250-1. 2005
  90. ncbi Clinical usefulness of inflammatory markers in asthma
    Peter A B Wark
    Research Division, Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
    Am J Respir Med 2:11-9. 2003
    ..The place of induced sputum and eNO in the ongoing monitoring of patients with asthma are now being investigated in controlled trials...
  91. ncbi Cough is an airway itch?
    Peter G Gibson
    Am J Respir Crit Care Med 169:1-2. 2004
  92. ncbi S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity
    Zheng Yang
    School of Medical Sciences, The University of New South Wales, Sydney, Australia
    J Allergy Clin Immunol 119:106-14. 2007
    ..The calcium-binding protein S100A12 might provoke inflammation and monocyte recruitment through the receptor for advanced glycation end products...
  93. ncbi Distinguishing asthma and chronic obstructive pulmonary disease: why, why not and how?
    Christine R Jenkins
    Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, PO Box M77, Missenden Road, Camperdown, NSW 2050, Australia
    Med J Aust 183:S35-7. 2005
    ..Maintain research into new drugs and targets for preventing progressive loss of lung function in asthma and COPD...
  94. ncbi Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Division of Speech Pathology, University of Queensland, Brisbane, Australia
    J Voice 21:361-83. 2007
    ..A template has been provided that is a practical method of designing an integrated behavioral treatment program based on those individual patient characteristics...
  95. ncbi A light at the end of the tunnel of inflammation in obstructive airway diseases?
    Peter G Gibson
    Chest 134:475-6. 2008
  96. ncbi IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
    Peter A B Wark
    Brooke Laboratories, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 120:586-93. 2007
    ..Rhinovirus-induced acute asthma is the most frequent trigger for asthma exacerbations...
  97. ncbi The relationship between chronic cough and paradoxical vocal fold movement: a review of the literature
    Anne E Vertigan
    Division of Speech Pathology, University of Queensland, Brisbane, Australia
    J Voice 20:466-80. 2006
    ....
  98. ncbi Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, University of Newcastle, New South Wales, Australia
    J Clin Endocrinol Metab 87:1660-8. 2002
    ....
  99. ncbi Relationship between cough, cough receptor sensitivity and asthma in children
    Anne B Chang
    Department of Respiratory Medicine, Royal Children s Hospital, QLD 4029, Brisbane, Australia
    Pulm Pharmacol Ther 15:287-91. 2002
    ....
  100. ncbi Should we still give our asthmatic patients written individualised management plans?
    Peter G Gibson
    Med J Aust 177:460. 2002
  101. ncbi What do non-eosinophilic asthma and airway remodelling tell us about persistent asthma?
    Peter G Gibson
    Thorax 62:1034-6. 2007