Peter G Gibson

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Pattern of airway inflammation and its determinants in children with acute severe asthma
    P G Gibson
    Airway Research Centre, Respiratory Medicine Unit, John Hunter Hospital and School of Paediatrics, University of New South Wales, Randwick, New South Wales, Australia
    Pediatr Pulmonol 28:261-70. 1999
  2. ncbi request reprint Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital and School of Medical Practice and Population Health, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
    Eur Respir J 21:582-8. 2003
  3. ncbi request reprint Sputum induction in children
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Eur Respir J Suppl 37:44s-46s. 2002
  4. ncbi request reprint Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation
    Peter G Gibson
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, New South Wales, Australia
    Pediatr Pulmonol 36:209-15. 2003
  5. ncbi request reprint Outpatient monitoring of asthma
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Curr Opin Allergy Clin Immunol 2:161-6. 2002
  6. ncbi request reprint Asthma education
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Locked Bag 1, Hunter Region Mail Centre, NSW 2310, Australia
    Respir Med 97:1036-44. 2003
  7. pmc Written action plans for asthma: an evidence-based review of the key components
    P G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Thorax 59:94-9. 2004
  8. pmc Eosinophilic bronchitis: clinical manifestations and implications for treatment
    P G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, NSW 2310, Australia
    Thorax 57:178-82. 2002
  9. ncbi request reprint Airway eosinophilia is associated with wheeze but is uncommon in children with persistent cough and frequent chest colds
    P G Gibson
    Airways Research Centre, John Hunter Hospital NSW, Australia
    Am J Respir Crit Care Med 164:977-81. 2001
  10. ncbi request reprint Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8
    P G Gibson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Chest 119:1329-36. 2001

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Pattern of airway inflammation and its determinants in children with acute severe asthma
    P G Gibson
    Airway Research Centre, Respiratory Medicine Unit, John Hunter Hospital and School of Paediatrics, University of New South Wales, Randwick, New South Wales, Australia
    Pediatr Pulmonol 28:261-70. 1999
    ..These different inflammatory cell profiles imply different etiological agents and may require differing treatment strategies...
  2. ncbi request reprint Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital and School of Medical Practice and Population Health, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
    Eur Respir J 21:582-8. 2003
    ..The interleukin-8-mediated neutrophil influx in allergic bronchopulmonary aspergillosis may induce lung damage via release of matrix metalloproteinase-9, potentially leading to bronchiectasis...
  3. ncbi request reprint Sputum induction in children
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Eur Respir J Suppl 37:44s-46s. 2002
  4. ncbi request reprint Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation
    Peter G Gibson
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, New South Wales, Australia
    Pediatr Pulmonol 36:209-15. 2003
    ..The development of wheeze after migration to Australia was independent of eosinophilic inflammation and consistent with noneosinophilic asthma mechanisms...
  5. ncbi request reprint Outpatient monitoring of asthma
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Curr Opin Allergy Clin Immunol 2:161-6. 2002
    ..Additional monitoring tools are under evaluation, and these include measures of airway responsiveness, airway inflammation, and Internet-based monitoring systems...
  6. ncbi request reprint Asthma education
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Locked Bag 1, Hunter Region Mail Centre, NSW 2310, Australia
    Respir Med 97:1036-44. 2003
    ..While a structured asthma self-management programme is effective in a hospital setting, attempts to deliver these programmes in primary care have met with varying success...
  7. pmc Written action plans for asthma: an evidence-based review of the key components
    P G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Thorax 59:94-9. 2004
    ..Several versions of action plans have been published but the key components have not been determined. A study was undertaken to determine the impact of individual components of written action plans on asthma health outcomes...
  8. pmc Eosinophilic bronchitis: clinical manifestations and implications for treatment
    P G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, NSW 2310, Australia
    Thorax 57:178-82. 2002
    ..Airway wall remodelling can occur in rhinitis, COPD, and cough variant asthma with EB. The mechanisms and long term implications of this complication in EB without asthma need to be clarified...
  9. ncbi request reprint Airway eosinophilia is associated with wheeze but is uncommon in children with persistent cough and frequent chest colds
    P G Gibson
    Airways Research Centre, John Hunter Hospital NSW, Australia
    Am J Respir Crit Care Med 164:977-81. 2001
    ..Eosinophilic bronchitis did occur in a significant minority of these "variant asthma" syndromes...
  10. ncbi request reprint Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8
    P G Gibson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Chest 119:1329-36. 2001
    ..To identify the characteristics of airway inflammation in persistent asthma and to examine the role of neutrophilic inflammation in noneosinophilic persistent asthma...
  11. ncbi request reprint Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial
    P G Gibson
    Airway Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Am J Respir Crit Care Med 163:32-6. 2001
    ..This may be clinically useful as therapy during mild exacerbations of asthma...
  12. pmc Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma
    P G Gibson
    Department of Respiratory and Sleep Medicine, and Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Thorax 58:116-21. 2003
    ..A study was undertaken to examine the relationship between airway inflammation and clinical asthma in children...
  13. doi request reprint Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    J Immunol 184:4159-69. 2010
    ..Thus, active chlamydial respiratory infection during sensitization enhances subsequent neutrophilic inflammation and Th1/Th17 responses during allergen exposure and may have a role in the pathogenesis of neutrophilic asthma...
  14. doi request reprint Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Free Radic Res 42:94-102. 2008
    ..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention...
  15. doi request reprint Manipulating antioxidant intake in asthma: a randomized controlled trial
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia
    Am J Clin Nutr 96:534-43. 2012
    ..Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes...
  16. doi request reprint Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 125:617-25, 625.e1-625.e6. 2010
    ..The progression of aberrant T(H)2 cell responses and disease development has been attributed to a lack of infections. However, exposure to specific pathogens such as Chlamydia may alter immunologic programming and predispose to asthma...
  17. ncbi request reprint Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 177:148-55. 2008
    ..Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma...
  18. ncbi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
    ..Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms...
  19. doi request reprint Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma
    Heather Powell
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 50:383-9. 2013
    ..To determine the relationship between psychosocial variables, future exacerbation risk during pregnancy, and perinatal outcomes...
  20. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
    ..The objective of this study is to investigate innate immune responses to RV infection in COPD primary BECs (pBECs) in comparison to healthy controls...
  21. doi request reprint Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations...
  22. doi request reprint IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  23. ncbi request reprint Induced sputum 8-isoprostane concentrations in inflammatory airway diseases
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Am J Respir Crit Care Med 171:426-30. 2005
    ..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease...
  24. ncbi request reprint Airway and systemic inflammation in obese children with asthma
    Megan E Jensen
    Hunter Medical Research Institute, Newcastle
    Eur Respir J 42:1012-9. 2013
    ..However, the higher prevalence of non-eosinophilic asthma in female obese asthmatics, compared to males, warrants further investigation. ..
  25. pmc Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    PLoS Pathog 7:e1002244. 2011
    ..This results in a phenotype that is similar to neutrophilic asthma. Infection-induced neutrophilic inflammation in AAD is mediated by IL-17 responses...
  26. doi request reprint A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 127:1133-40. 2011
    ..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown...
  27. ncbi request reprint Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
    Julie A Preston
    Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Newcastle, Australia
    Vaccine 25:8154-62. 2007
    ..This indicates the potential of Spn as an IMT for asthma...
  28. doi request reprint Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    J Asthma 48:1032-40. 2011
    ..Little is known about the psychosocial impact and perceived teratogenic (fetal harm due to medication) risks of asthma treatment (inhaled/oral corticosteroids and β-agonist) during pregnancy...
  29. ncbi request reprint Older peoples' perception of tests used in the assessment and management of COPD and asthma
    Vanessa M McDonald
    Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute John Hunter Hospital, Newcastle, NSW, Australia School of Nursing and Midwifery, The University of Newcastle, Newcastle, NSW, Australia School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Clin Respir J 7:367-74. 2013
    ..This study evaluated the patient perception of tests used for the assessment of airways disease in older people...
  30. pmc Relationship between body composition, inflammation and lung function in overweight and obese asthma
    Hayley A Scott
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
    Respir Res 13:10. 2012
    ..The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma...
  31. doi request reprint Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    Thorax 67:588-99. 2012
    ..The relationship between chronic airway colonisation and the development of steroid-resistant neutrophilic asthma is unclear...
  32. ncbi request reprint A comparison of two approaches to the treatment of chronic cough: perceptual, acoustic, and electroglottographic outcomes
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    J Voice 22:581-9. 2008
    ..These results demonstrated that SPEICH-C can improve perceptual aspects of voice quality suggesting that dysphonia may be a fundamental characteristic of CC...
  33. doi request reprint Oxidized vitamin E and glutathione as markers of clinical status in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Clin Nutr 27:579-86. 2008
    ....
  34. doi request reprint Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 16:291-9. 2011
    ..This study investigates the frequency of viral persistence after acute asthma, assesses viral infectivity and determines the host inflammatory responses to viral persistence...
  35. doi request reprint Asthma in older adults
    Peter G Gibson
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Lancet 376:803-13. 2010
    ....
  36. doi request reprint Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Br J Nutr 101:533-40. 2009
    ..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation...
  37. doi request reprint Neutrophilic asthma has different radiographic features to COPD and smokers
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    Respir Med 103:881-7. 2009
    ..The aim of this study was to examine the airway and parenchymal abnormalities using high resolution computed tomographic (HRCT) scanning in participants with neutrophilic asthma, COPD and smoking controls...
  38. pmc Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy
    Joerg Mattes
    Experimental and Translational Respiratory Medicine Group, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
    Thorax 69:383-4. 2014
    ..Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are strongly associated with the development of childhood asthma...
  39. doi request reprint Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease, University of Newcastle, Newcastle, New South Wales 2300, Australia
    J Immunol 191:4112-20. 2013
    ..Therefore, bacterial components (T+P) drive the differentiation of highly suppressive Tregs, which suppress the Th2 response, prevent the Th17 response and disable the DC response resulting in the effective suppression of AAD. ..
  40. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  41. doi request reprint Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, University of Newcastle, Callaghan, NSW, Australia
    Free Radic Res 44:146-54. 2010
    ..The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients...
  42. ncbi request reprint Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  43. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  44. doi request reprint Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma
    Lisa G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Br J Nutr 103:735-41. 2010
    ..This highlights the potential role for antioxidant supplementation in these subjects...
  45. doi request reprint Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    Peter A B Wark
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, UK
    Respirology 14:180-6. 2009
    ..Infection with rhinovirus (RV) is the most common trigger for acute asthma and COPD. The aim of this study was to characterize the variability in the response of primary bronchial epithelial cells to infection with several strains of RV...
  46. ncbi request reprint Proteomic study of plasma proteins in pregnant women with asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NWS, Australia
    Respirology 11:41-8. 2006
    ..This study used the novel proteomic technique, surface-enhanced laser desorption ionization-time of flight mass spectrometry to determine if the presence of asthma during pregnancy was associated with alterations in plasma proteins...
  47. doi request reprint Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    OMICS 17:187-99. 2013
    ..Our findings suggest that targeting systemic inflammation might provide a novel therapeutic strategy for neutrophilic asthma...
  48. doi request reprint The importance of clinical management problems in older people with COPD and asthma: do patients and physicians agree?
    Vanessa M McDonald
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia
    Prim Care Respir J 20:389-95. 2011
    ..COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physicians and the level of agreement between them is largely unknown...
  49. doi request reprint Characterization of laryngeal dysfunction in chronic persistent cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia
    Laryngoscope 119:640-5. 2009
    ....
  50. ncbi request reprint Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized...
  51. ncbi request reprint Acoustic and electroglottographic voice characteristics in chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, Australia
    Folia Phoniatr Logop 60:210-6. 2008
    ..Objective acoustic and electroglottographic (EGG) measures have the capacity to delineate these vocal characteristics. This study investigated acoustic and EGG voice features of CC and PVFM...
  52. ncbi request reprint Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
    ..Innate immune responses of airway neutrophil cells are impaired in asthmatic subjects on prophylactic therapy and may impact on susceptibility to, and severity of, airway infections...
  53. pmc Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW 2308, Australia
    Mediators Inflamm 2013:462934. 2013
    ..TLR2 stimulation activates neutrophils for MMP-9 release. Efforts to understand the mechanisms of TLR2 signalling and subsequent MMP-9 production in COPD may assist in understanding neutrophilic inflammation in COPD...
  54. doi request reprint Obesity and childhood asthma - mechanisms and manifestations
    Megan E Jensen
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2310, Australia
    Curr Opin Allergy Clin Immunol 12:186-92. 2012
    ..This review highlights the most recent findings over the past 18 months in understanding the presentation and potential mechanisms of obesity in childhood asthma...
  55. doi request reprint How to set up a severe asthma service
    Vanessa M McDonald
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
    Respirology 16:900-11. 2011
    ..In this article we describe the purpose of a severe asthma clinic, the necessary components of a service including staffing and facilities and the processes for trialling additional therapies used in the management of severe asthma...
  56. pmc Innate immune activation in neutrophilic asthma and bronchiectasis
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, Newcastle, Australia
    Thorax 62:211-8. 2007
    ..The inflammatory response in asthma is heterogeneous...
  57. ncbi request reprint The effect of maternal asthma on placental and cord blood protein profiles
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Soc Gynecol Investig 12:349-55. 2005
    ....
  58. ncbi request reprint Persistent airway obstruction after virus infection is not associated with airway inflammation
    Lisa G Wood
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Chest 131:415-23. 2007
    ..This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations...
  59. doi request reprint Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma
    Rebecca L Vanders
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 18:827-33. 2013
    ..Asthma exacerbations are caused most frequently by respiratory viruses. A balance between antiviral and inflammatory immune responses is critical during pregnancy; the balance may be altered by asthma and respiratory virus infection...
  60. doi request reprint Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease, Newcastle, New South Wales 2300, Australia
    J Immunol 188:4611-20. 2012
    ..These data suggest that S. pneumoniae components may have potential as a therapeutic strategy for the suppression of allergic asthma through the induction of Tregs and suppression of NKT cells...
  61. doi request reprint Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma
    Rebecca Louise Forbes
    Department of Respiratory Medicine, Centre for Asthma and Respiratory Disease, The University of Newcastle, School of Medicine and Public Health, New Lambton, NSW, Australia, 2350
    Thorax 67:209-14. 2012
    ..Pregnant women have increased susceptibility and disease severity to viral infections like influenza and HRVs, as do asthmatics. Successful pregnancy requires immunological modulation to permit fetal tolerance...
  62. ncbi request reprint Interleukin-10 gene expression in acute virus-induced asthma
    Terry V Grissell
    School of Medical Practice and Population Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:433-9. 2005
    ..Virus-induced asthma is characterized by marked neutrophil influx and eosinophil degranulation, suggesting a mode of immunopathogenesis different from that of allergen-induced asthma...
  63. doi request reprint Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 65:1053-60. 2010
    ..Components of S pneumoniae may have the potential to modulate allergic inflammatory responses and suppress the development of asthma...
  64. doi request reprint Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers
    Anne E Vertigan
    Department of Speech Pathology, John Hunter Hospital, Newcastle, Australia
    J Voice 25:596-601. 2011
    ....
  65. doi request reprint Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
    J Nutr Biochem 20:577-85. 2009
    ..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation...
  66. ncbi request reprint Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, New Lambton, Australia
    J Allergy Clin Immunol 119:344-50. 2007
    ..Combination therapy with long-acting beta-agonists (LABAs)/inhaled corticosteroids (ICSs) has become established as effective maintenance treatment for asthma...
  67. ncbi request reprint Airway and circulating levels of carotenoids in asthma and healthy controls
    Lisa G Wood
    Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    J Am Coll Nutr 24:448-55. 2005
    ..Elevated oxidative stress and impaired antioxidant defences are increasingly recognised features of asthma. Carotenoids are potent dietary antioxidants that may protect against asthma by reducing oxidative damage...
  68. pmc Validity of the common cold questionnaire (CCQ) in asthma exacerbations
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
    PLoS ONE 3:e1802. 2008
    ..Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing...
  69. doi request reprint Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Lancet 380:1583-9. 2012
    ..We established the efficacy of gabapentin in patients with refractory chronic cough...
  70. doi request reprint Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308 NSW, Australia
    Respir Med 106:138-44. 2012
    ..This study sought to investigate the prevalence, characteristics and mechanism of chronic cough following laboratory-confirmed H1N1 2009 influenza...
  71. doi request reprint Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease
    Nicole M Verrills
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 183:1633-43. 2011
    ..Proteomics may identify a useful panel of biomarkers for identification of asthma and chronic obstructive pulmonary disease (COPD)...
  72. ncbi request reprint CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian cough guidelines summary statement
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Med J Aust 192:265-71. 2010
    ..In ADULTS, refractory cough that persists after therapy is managed by empirical inhaled corticosteroid therapy and speech pathology techniques...
  73. doi request reprint Asthma in pregnancy
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, New South Wales 2310, Australia
    Clin Chest Med 32:93-110, ix. 2011
    ..Barriers to effective asthma management and opportunities for optimized care and treatment are discussed, and a summary of the clinical guidelines for the management of asthma during pregnancy is presented...
  74. ncbi request reprint Perceptual voice characteristics in chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    Folia Phoniatr Logop 59:256-67. 2007
    ..These results have implications for the identification and management of voice disorders in CC and PVFM and suggest that clinicians should be alert to the incidence of voice abnormalities in these populations...
  75. doi request reprint Premenstrual asthma: prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 45:696-704. 2008
    ..PMA resulting in increased symptoms and medication use occurred in 57% of subjects studied for 2-4 menstrual cycles. The use of oral contraceptives is not protective and further work is required to elucidate the mechanisms of PMA...
  76. ncbi request reprint Initial corticosteroid therapy for asthma
    Peter G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, and University of Newcastle, Australia
    Curr Opin Pulm Med 12:48-53. 2006
    ..This review examines the commencement of maintenance pharmacotherapy for asthma: inhaled corticosteroids alone or in combination with long-acting beta2 agonists...
  77. ncbi request reprint Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
    Jodie L Simpson
    School of Medical Practice and Population Health, and Medical Genetics, School of Biomedical Science, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:559-65. 2005
    ..Asthma is characterized by both chronic inflammation and remodeling of the airways. Proteases are important mediators of inflammation, cytokine activation, and tissue remodeling...
  78. ncbi request reprint The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
    Paul S Thomas
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    J Asthma 42:291-5. 2005
    ..eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness...
  79. doi request reprint Multidimensional assessment of older people with asthma and COPD: clinical management and health status
    Vanessa M McDonald
    School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Age Ageing 40:42-9. 2011
    ..the diagnosis and management of obstructive airway diseases (OADs) such as asthma and chronic obstructive pulmonary disease (COPD) can be challenging in older people...
  80. ncbi request reprint Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
    Jay C Horvat
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 176:556-64. 2007
    ..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...
  81. ncbi request reprint Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales 2310, Australia
    J Clin Virol 26:339-46. 2003
    ..Sputum was assayed using IFA and RT-PCR for flu and RSV. Flu serology was performed acutely and at convalescence, 4-5 weeks later...
  82. ncbi request reprint Allergic bronchopulmonary aspergillosis
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Semin Respir Crit Care Med 27:185-91. 2006
    ..Treatment involves corticosteroids and antifungal therapy with oral azoles. Additional management seeks to monitor and control the other disease components of severe asthma, bronchiectasis, and disease exacerbations...
  83. ncbi request reprint Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients
    Lisa G Wood
    Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
    Am J Clin Nutr 75:668-75. 2002
    ..Oxidative stress and depleted antioxidant defenses occur in stable cystic fibrosis patients. During acute infection, the balance between oxidants and antioxidants may be further disturbed...
  84. doi request reprint Dietary factors lead to innate immune activation in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Pharmacol Ther 123:37-53. 2009
    ..Therapeutic strategies aimed at addressing diet-induced innate immune activation are warranted...
  85. ncbi request reprint Role of atypical bacterial infection of the lung in predisposition/protection of asthma
    Philip M Hansbro
    Discipline of Immunology and Microbiology, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Pharmacol Ther 101:193-210. 2004
    ....
  86. pmc Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 5:4. 2009
    ..Successful treatment for chronic persistent cough leads to improvements in these features of laryngeal dysfunction...
  87. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  88. doi request reprint Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Prog Lipid Res 48:27-43. 2009
    ..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets...
  89. pmc Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 6:5. 2010
    ..The number of treatments required to effect a response was also assessed...
  90. doi request reprint Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, NSW, Australia
    Pharmacol Ther 124:86-95. 2009
    ..Studies also show improvements in quality of life and exacerbation rates in airways diseases...
  91. ncbi request reprint Use of omalizumab in a severe asthma clinic
    Peter G Gibson
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, Australia
    Respirology 12:S35-44; discussion S45-7. 2007
    ....
  92. ncbi request reprint Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children
    Terry V Grissell
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, New Lambton, Australia
    Pediatr Pulmonol 42:380-5. 2007
    ..There is evidence for co-regulation of neurokinin (TAC1) and TLR4 gene expression in airway cells from children with airway bacterial colonization and their reduced expression may be associated with an impaired bacterial clearance...
  93. ncbi request reprint Inhaled corticosteroid doses in asthma: an evidence-based approach
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Mail Centre, Newcastle, NSW 2310, Australia
    Med J Aust 178:223-5. 2003
    ..To define the evidence for doses of inhaled corticosteroids in asthma and describe this in clinically meaningful, evidence-based terms...
  94. doi request reprint Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: a quantitative review
    John H Wlodarczyk
    John Wlodarczyk Consulting Services, New Lambton, New South Wales, Australia
    Ann Allergy Asthma Immunol 100:23-30. 2008
    ..Studies examining the effects of inhaled corticosteroids (ICSs) on cortisol suppression show inconsistent results, and there is uncertainty regarding the dose-response relationship between ICSs and cortisol suppression...
  95. doi request reprint Assessment and reproducibility of non-eosinophilic asthma using induced sputum
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Callaghan, NSW, Australia
    Respiration 79:147-51. 2010
    ..The stability of airway inflammation in asthma over time is not known, yet this information is crucial to inflammation-based patient management...
  96. ncbi request reprint Optimization of sputum-processing methods for the measurement of interleukin-5: effects of protease inhibition
    Jodie L Simpson
    Airways Research Centre, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia
    Respirology 7:111-6. 2002
    ..The aim of the present study was to investigate the effects of dithiothreitol (DTT), sputum protease inhibition and sample storage on IL-5 recovery in order to develop a method to accurately measure IL-5 in dispersed sputum supernatant...
  97. ncbi request reprint Randomized controlled trial of a teacher-led asthma education program
    Richard L Henry
    School of Women s and Children s Health, University of New South Wales, c o Sydney Children s Hospital, Randwick, New South Wales 2031, Australia
    Pediatr Pulmonol 38:434-42. 2004
    ....
  98. ncbi request reprint Pneumococcal vaccines for allergic airways diseases
    Alison N Thorburn
    The University of Newcastle, Hunter Medical Research Institute, Centre for Asthma and Respiratory Disease, Newcastle, Australia
    Expert Opin Biol Ther 9:621-9. 2009
    ..Asthma is a common global health problem. Environmental exposures such as bacteria may protect against asthma development...
  99. ncbi request reprint A light at the end of the tunnel of inflammation in obstructive airway diseases?
    Peter G Gibson
    Chest 134:475-6. 2008
  100. ncbi request reprint Clinical usefulness of inflammatory markers in asthma
    Peter A B Wark
    Research Division, Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, UK
    Am J Respir Med 2:11-9. 2003
    ..The place of induced sputum and eNO in the ongoing monitoring of patients with asthma are now being investigated in controlled trials...
  101. ncbi request reprint Cough is an airway itch?
    Peter G Gibson
    Am J Respir Crit Care Med 169:1-2. 2004