Affiliation: The University of Adelaide
Location: Adelaide, Australia
Research in brain trauma, brain tumours and the blood-brain barrier
- Severity-dependent expression of pro-inflammatory cytokines in traumatic spinal cord injury in the ratLiqun Yang
Department of Surgery Neurosurgery, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
J Clin Neurosci 12:276-84. 2005....
- Clostridium perfringens prototoxin-induced alteration of endothelial barrier antigen (EBA) immunoreactivity at the blood-brain barrier (BBB)C Zhu
Department of Anatomical Sciences, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5005
Exp Neurol 169:72-82. 2001..This is the first report to show endothelial cell damage, mild reversible cerebral edema, and alteration in BBB markers following administration of Cl p prototoxin. This model of mild brain edema may be useful for BBB studies...
- Early expression and cellular localization of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in human traumatic spinal cord injuryLiqun Yang
Department of Neurosurgery, Royal Adelaide Hospital, Adelaide, Australia
Spine (Phila Pa 1976) 29:966-71. 2004..Post-traumatic inflammatory response was studied in 11 human cases of acute spinal cord contusion injury...
- Hemoglobin crystals: a pro-inflammatory potential confounder of rat experimental intracerebral hemorrhageTimothy J Kleinig
Discipline of Pathology, University of Adelaide, Adelaide, SA, Australia
Brain Res 1287:164-72. 2009..04 for trend). Although hemoglobin crystallization occurs in both models of ICH, it is particularly prominent following autologous ICH. Accordingly, hemoglobin crystallization may exaggerate the importance of inflammation in this model...
- Characterisation of Walker 256 breast carcinoma cells from two tumour cell banks as assessed using two models of secondary brain tumoursKate M Lewis
Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Cancer Cell Int 13:5. 2013..abstract:..
- Electron microscope study of blood-brain barrier opening induced by immunological targeting of the endothelial barrier antigenMounir N Ghabriel
Department of Anatomical Sciences, Medical School, Adelaide University, Adelaide, South Australia 5005, Australia
Brain Res 934:140-51. 2002..This model is useful for the study of vascular permeability in the CNS and experimental manipulation of the BBB. It may have a potential application in experimental studies on drug delivery throughout the CNS...
- Magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to a pre-injury stateM N Ghabriel
Department of Anatomical Sciences, Medical School, University of Adelaide, South Australia, Australia
Acta Neurochir Suppl 96:402-6. 2006..We conclude that magnesium decreases brain edema formation after TBI, possibly by restoring the polarized state of astrocytes and by down-regulation of AQP4 channels in astrocytes...
- Expression of a blood-brain barrier-specific antigen in the reproductive tract of the male ratM N Ghabriel
Department of Anatomical Sciences, Adelaide University, Adelaide 5005, South Australia
Reproduction 123:389-97. 2002..However, Sertoli cells, which are the main site of the blood-testis barrier, were negative for EBA. In conclusion, EBA may have a wider role in rat tissues than has been previously appreciated...
- Changes in the blood-CSF barrier in experimental traumatic brain injuryMounir N Ghabriel
Discipline of Anatomical Sciences, School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia
Acta Neurochir Suppl 106:239-45. 2010..Choroidal epithelial cells (CEC) form the blood-CSF barrier and their integrity is essential for controlling CSF production. In the current study, the morphology of the CEC was studied from 5 h to 28 day after TBI in the rat...
- Immunological targeting of the endothelial barrier antigen (EBA) in vivo leads to opening of the blood-brain barrierM N Ghabriel
Department of Anatomical Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia
Brain Res 878:127-35. 2000..This study demonstrated for the first time, that immunological 'neutralisation' of EBA leads to opening of the BBB, and provided direct evidence for the importance of EBA in maintaining the integrity of the BBB in the rat...
- Peripheral nervous system and central nervous system pathology in rapidly progressive lower motor neuron syndrome with immunoglobulin M anti-GM1 ganglioside antibodyZhao Cai
Department of Neurology and University Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
J Peripher Nerv Syst 9:79-91. 2004....