Dorota Gertig

..It contains a glutamine repeat (CAG/CAA) polymorphism at its carboxyl-terminal region that may alter the transcriptional activation of the receptor and affect susceptibility to breast cancer through altered sensitivity to hormones...

..We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism...

..Two intemational consensus panels on HH concluded that there is insufficient evidence for population-based screening at present. We present recommendations to advance the debate on screening for HH in Australia...

..Breast tumours that develop in women using HRT have been shown to have prognostically favourable histological features but it is unclear if this is the case for both short- and long-term use...

..To determine factors that may modify the association between hormone therapy (HT) and breast cancer risk...

..Reasons for this disparity are still unclear and warrant further investigation...

..This would be particularly useful for evaluating the impact of screening on mortality and incidence from breast cancer...

....

..We examine to what extent the lower mammographic sensitivity found in hormone replacement therapy (HRT) users can be explained by any association of HRT use with higher mammographic density and more difficult to detect cancers...

..2 (95% confidence interval, 1.2-4.1). For each 10-kg increase in fat mass, the risk ratio was 1.4 (95% confidence interval, 1.0-1.8). Energy imbalance may play a role in the development of aggressive prostate cancer...

..We therefore investigated incidence rates for invasive and in situ breast cancer by age as well as prognostic features of tumors within a screening program...

..There would be little additional benefit in targeting screening based on age and hormone therapy use...

..Here we review various sources of evidence regarding the natural history of DCIS...

..Central adiposity appears to be associated with colon cancer risk in women...

..We report our experience of selecting tag SNPs in 35 genes involved in iron metabolism in a cohort study seeking to discover genetic modifiers of hereditary hemochromatosis...

..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial...

..004). This putative genetic modifier of iron overload expression accounts for 11% (95% CI 0.4%, 22.6%) of the variance in serum ferritin levels of C282Y homozygotes...

..To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk...

..We characterized the development of elevated iron measures in C282Y homozygotes followed for 12 years...

..Although compound heterozygotes might maintain elevated iron indices during middle age, documented iron overload-related disease is rare...

..These results also call into question the role of the physical effects of ovulation in the development of serous ovarian cancer...

..0) were positively associated with rectal cancer risk. There was no evidence that risk differed by sex for any of the anthropometric measures. CONCLUSIONS: Waist circumference and fat mass may be weakly related to risk of rectal cancer...

..43, 0.99), p = 0.005. Our data do not support a strong role for GI and GL in breast carcinogenesis but suggest that increased intake of fibre and carbohydrate may be associated with the diagnosis of cancers of more favourable prognosis...

....

..CONCLUSION: Male colon cancer appears to be related to body size and composition by two different pathways, via central adiposity and via non-adipose mass...

..3-6.2; P = 0.005), gave the best fit under parsimony. Although the biological role of the I655V polymorphism is not known, large independent studies of early onset breast cancer are warranted to attempt to replicate this finding...

..99-7.82). The majority of studies have concluded that exposure to PCBs is unlikely to be a major cause of breast cancer, but these findings indicate that further studies of genetically susceptible populations are warranted...

..Therefore, the associations between these exposures and ovarian cancer risk were prospectively examined among 110,454 women in the Nurses' Health Study (NHS) for the smoking analyses and 80,253 women for the dietary analyses...

..HH is a model disease for studying gene-gene interaction due to the availability of intermediate markers of iron overload and promising candidate modifier genes in iron transport pathways. ..