Dorota Gertig

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Centre, St, Andrews Place, East Melbourne, Victoria, Australia
    Breast Cancer Res 7:R353-6. 2005
  2. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Jiun Horng Chang
    Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
    Breast Cancer Res 7:R513-21. 2005
  3. ncbi request reprint Public health aspects of genetic screening for hereditary haemochromatosis in Australia
    Dorota M Gertig
    Centre for Genetic Epidemiology School of Population Health, University of Melbourne, Carlton, Victoria
    Aust N Z J Public Health 26:518-24. 2002
  4. ncbi request reprint Duration of hormone replacement therapy, breast tumour size and grade in a screening programme
    Dorota M Gertig
    Centre for Genetic Epidemiology, School of Population Health, University of Melbourne, Victoria, Australia
    Breast Cancer Res Treat 80:267-73. 2003
  5. ncbi request reprint Hormone therapy and breast cancer: what factors modify the association?
    Dorota M Gertig
    Centre for Genetic Epidemiology, University of Melbourne, Melbourne Victoria, Australia
    Menopause 13:178-84. 2006
  6. ncbi request reprint Urban-rural differences in the management of screen-detected invasive breast cancer and ductal carcinoma in situ in victoria
    David L Kok
    School of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
    ANZ J Surg 76:996-1001. 2006
  7. ncbi request reprint Forecasting age-specific breast cancer mortality using functional data models
    Bircan Erbas
    Centre for Genetic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, VIC 3053, Australia
    Stat Med 26:458-70. 2007
  8. ncbi request reprint A comparison of different methods for including 'age at menopause' in analyses of the association between hormone replacement therapy use and breast cancer
    Julie A Simpson
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne and the Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
    J Fam Plann Reprod Health Care 33:11-6. 2007
  9. ncbi request reprint Hormone replacement therapy, percent mammographic density, and sensitivity of mammography
    Anne M Kavanagh
    Key Centre for Women s Health in Society, School of Population Health, University of Melbourne, Victoria 3010, Australia
    Cancer Epidemiol Biomarkers Prev 14:1060-4. 2005
  10. ncbi request reprint Body size and composition and prostate cancer risk
    Robert J Macinnis
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 12:1417-21. 2003

Research Grants

  1. Genetic modifiers of hemochromatosis phenotype
    Dorota Gertig; Fiscal Year: 2006

Detail Information

Publications29

  1. pmc The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Centre, St, Andrews Place, East Melbourne, Victoria, Australia
    Breast Cancer Res 7:R353-6. 2005
    ..It contains a glutamine repeat (CAG/CAA) polymorphism at its carboxyl-terminal region that may alter the transcriptional activation of the receptor and affect susceptibility to breast cancer through altered sensitivity to hormones...
  2. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Jiun Horng Chang
    Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
    Breast Cancer Res 7:R513-21. 2005
    ..We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism...
  3. ncbi request reprint Public health aspects of genetic screening for hereditary haemochromatosis in Australia
    Dorota M Gertig
    Centre for Genetic Epidemiology School of Population Health, University of Melbourne, Carlton, Victoria
    Aust N Z J Public Health 26:518-24. 2002
    ..Two intemational consensus panels on HH concluded that there is insufficient evidence for population-based screening at present. We present recommendations to advance the debate on screening for HH in Australia...
  4. ncbi request reprint Duration of hormone replacement therapy, breast tumour size and grade in a screening programme
    Dorota M Gertig
    Centre for Genetic Epidemiology, School of Population Health, University of Melbourne, Victoria, Australia
    Breast Cancer Res Treat 80:267-73. 2003
    ..Breast tumours that develop in women using HRT have been shown to have prognostically favourable histological features but it is unclear if this is the case for both short- and long-term use...
  5. ncbi request reprint Hormone therapy and breast cancer: what factors modify the association?
    Dorota M Gertig
    Centre for Genetic Epidemiology, University of Melbourne, Melbourne Victoria, Australia
    Menopause 13:178-84. 2006
    ..To determine factors that may modify the association between hormone therapy (HT) and breast cancer risk...
  6. ncbi request reprint Urban-rural differences in the management of screen-detected invasive breast cancer and ductal carcinoma in situ in victoria
    David L Kok
    School of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
    ANZ J Surg 76:996-1001. 2006
    ....
  7. ncbi request reprint Forecasting age-specific breast cancer mortality using functional data models
    Bircan Erbas
    Centre for Genetic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, VIC 3053, Australia
    Stat Med 26:458-70. 2007
    ..This would be particularly useful for evaluating the impact of screening on mortality and incidence from breast cancer...
  8. ncbi request reprint A comparison of different methods for including 'age at menopause' in analyses of the association between hormone replacement therapy use and breast cancer
    Julie A Simpson
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne and the Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
    J Fam Plann Reprod Health Care 33:11-6. 2007
    ....
  9. ncbi request reprint Hormone replacement therapy, percent mammographic density, and sensitivity of mammography
    Anne M Kavanagh
    Key Centre for Women s Health in Society, School of Population Health, University of Melbourne, Victoria 3010, Australia
    Cancer Epidemiol Biomarkers Prev 14:1060-4. 2005
    ..We examine to what extent the lower mammographic sensitivity found in hormone replacement therapy (HRT) users can be explained by any association of HRT use with higher mammographic density and more difficult to detect cancers...
  10. ncbi request reprint Body size and composition and prostate cancer risk
    Robert J Macinnis
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 12:1417-21. 2003
    ..2 (95% confidence interval, 1.2-4.1). For each 10-kg increase in fat mass, the risk ratio was 1.4 (95% confidence interval, 1.0-1.8). Energy imbalance may play a role in the development of aggressive prostate cancer...
  11. ncbi request reprint Incidence of invasive breast cancer and ductal carcinoma in situ in a screening program by age: should older women continue screening?
    Bircan Erbas
    Center for Genetic Epidemiology, School of Population Health, University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 13:1569-73. 2004
    ..We therefore investigated incidence rates for invasive and in situ breast cancer by age as well as prognostic features of tumors within a screening program...
  12. doi request reprint Using mammographic density to improve breast cancer screening outcomes
    Anne M Kavanagh
    Key Centre for Women s Health in Society, School of Population Health, University of Melbourne, Melbourne, Australia
    Cancer Epidemiol Biomarkers Prev 17:2818-24. 2008
    ..There would be little additional benefit in targeting screening based on age and hormone therapy use...
  13. ncbi request reprint The natural history of ductal carcinoma in situ of the breast: a review
    Bircan Erbas
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Carlton, Victoria, Australia
    Breast Cancer Res Treat 97:135-44. 2006
    ..Here we review various sources of evidence regarding the natural history of DCIS...
  14. ncbi request reprint Body size and composition and colon cancer risk in women
    Robert J Macinnis
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
    Int J Cancer 118:1496-500. 2006
    ..Central adiposity appears to be associated with colon cancer risk in women...
  15. pmc SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis
    Clare C Constantine
    The Centre for Molecular, Environmental, Genetic and Analytic MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    BMC Med Genet 9:18. 2008
    ..We report our experience of selecting tag SNPs in 35 genes involved in iron metabolism in a cohort study seeking to discover genetic modifiers of hereditary hemochromatosis...
  16. doi request reprint Iron-overload-related disease in HFE hereditary hemochromatosis
    Katrina J Allen
    Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    N Engl J Med 358:221-30. 2008
    ..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial...
  17. pmc A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis
    Clare C Constantine
    Centre for MEGA Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria, Australia
    Br J Haematol 147:140-9. 2009
    ..004). This putative genetic modifier of iron overload expression accounts for 11% (95% CI 0.4%, 22.6%) of the variance in serum ferritin levels of C282Y homozygotes...
  18. pmc Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study
    Laura Baglietto
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, 100 Drummond Street, Carlton, Victoria 3053, Australia
    BMJ 331:807. 2005
    ..To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk...
  19. doi request reprint The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis
    Lyle C Gurrin
    Centre for MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Gastroenterology 135:1945-52. 2008
    ..We characterized the development of elevated iron measures in C282Y homozygotes followed for 12 years...
  20. pmc HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity
    Lyle C Gurrin
    Centre for MEGA Epidemiology, School Population Health, University of Melbourne, Victoria, Australia
    Hepatology 50:94-101. 2009
    ..Although compound heterozygotes might maintain elevated iron indices during middle age, documented iron overload-related disease is rare...
  21. ncbi request reprint Serous ovarian, fallopian tube and primary peritoneal cancers: a comparative epidemiological analysis
    Susan J Jordan
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 122:1598-603. 2008
    ..These results also call into question the role of the physical effects of ovulation in the development of serous ovarian cancer...
  22. ncbi request reprint Body size and composition and risk of rectal cancer (Australia)
    Robert J Macinnis
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Carlton South, Vic, Australia
    Cancer Causes Control 17:1291-7. 2006
    ..The relationship between rectal cancer risk and central adiposity, overall fat mass, and fat-free mass is unknown...
  23. ncbi request reprint Dietary carbohydrate, fibre, glycaemic index, glycaemic load and the risk of postmenopausal breast cancer
    Graham G Giles
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
    Int J Cancer 118:1843-7. 2006
    ..43, 0.99), p = 0.005. Our data do not support a strong role for GI and GL in breast carcinogenesis but suggest that increased intake of fibre and carbohydrate may be associated with the diagnosis of cancers of more favourable prognosis...
  24. ncbi request reprint Body size and composition and risk of postmenopausal breast cancer
    Robert J Macinnis
    Cancer Epidemiology Centre, Cancer Control Research Institute, The Cancer Council Victoria, 1 Rathdowne Street, Carlton South, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 13:2117-25. 2004
    ....
  25. ncbi request reprint Body size and composition and colon cancer risk in men
    Robert J Macinnis
    Cancer Epidemiology Centre, The Cancer Council Victoria, 1 Rathdowne Street, Carlton South, Melbourne, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 13:553-9. 2004
    ..It is uncertain whether this relationship is due to non-adipose mass, adipose mass, distribution of adipose mass such as central adiposity, or all three...
  26. ncbi request reprint Population genetic screening for hereditary haemochromatosis
    Dorota M Gertig
    Med J Aust 179:517-8. 2003
  27. ncbi request reprint The HER2 I655V polymorphism and risk of breast cancer in women < age 40 years
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Cancer Epidemiol Biomarkers Prev 12:1109-11. 2003
    ..3-6.2; P = 0.005), gave the best fit under parsimony. Although the biological role of the I655V polymorphism is not known, large independent studies of early onset breast cancer are warranted to attempt to replicate this finding...
  28. ncbi request reprint Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study
    Francine Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1560-5. 2002
    ..99-7.82). The majority of studies have concluded that exposure to PCBs is unlikely to be a major cause of breast cancer, but these findings indicate that further studies of genetically susceptible populations are warranted...
  29. doi request reprint Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer 112:1169-77. 2008
    ..Therefore, the associations between these exposures and ovarian cancer risk were prospectively examined among 110,454 women in the Nurses' Health Study (NHS) for the smoking analyses and 80,253 women for the dietary analyses...

Research Grants3

  1. Genetic modifiers of hemochromatosis phenotype
    Dorota Gertig; Fiscal Year: 2006
    ..HH is a model disease for studying gene-gene interaction due to the availability of intermediate markers of iron overload and promising candidate modifier genes in iron transport pathways. ..