Jacob George

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    Hepatology 48:449-57. 2008
  2. doi request reprint Effect of a lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factors
    Alexis St George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, Australia
    J Gastroenterol Hepatol 24:399-407. 2009
  3. ncbi request reprint Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance
    Kerry Lee Milner
    Garvan Institute for Medical Research, University of New South Wales 2010, Sydney, Australia
    Gastroenterology 138:932-41.e1-3. 2010
  4. pmc IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study
    Vijayaprakash Suppiah
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    PLoS Med 8:e1001092. 2011
  5. ncbi request reprint Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines
    Ian Homer Y Cua
    Storr Liver Unit, Westmead Millennium Institute and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Hepatology 46:66-73. 2007
  6. pmc Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research NCHECR, University of New South Wales UNSW, Sydney, Australia
    Hepatology 52:1216-24. 2010
  7. ncbi request reprint Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3
    Hossein Poustchi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, NSW, Australia
    J Hepatol 48:28-34. 2008
  8. ncbi request reprint Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis
    Nghi Phung
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Int J Mol Med 24:171-80. 2009
  9. pmc Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study
    J Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 107:244-9. 2010
  10. ncbi request reprint Virological responses during treatment for recent hepatitis C virus: potential benefit for ribavirin use in HCV/HIV co-infection
    Jason Grebely
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales UNSW, Sydney, Australia
    AIDS 26:1653-61. 2012

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    Hepatology 48:449-57. 2008
    ..Visceral fat should therefore be a central target for future interventions in nonalcoholic steatohepatitis and indeed all metabolic disease...
  2. doi request reprint Effect of a lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factors
    Alexis St George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, Australia
    J Gastroenterol Hepatol 24:399-407. 2009
    ..We sought to assess the effect at 3 months of a behavior change-based lifestyle intervention on the metabolic profile of patients characterised by elevated liver enzymes...
  3. ncbi request reprint Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance
    Kerry Lee Milner
    Garvan Institute for Medical Research, University of New South Wales 2010, Sydney, Australia
    Gastroenterology 138:932-41.e1-3. 2010
    ..Chronic hepatitis C (CHC) is associated with insulin resistance (IR), liver steatosis (genotype 3), and increased diabetes risk. The site and mechanisms of IR are unclear...
  4. pmc IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study
    Vijayaprakash Suppiah
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    PLoS Med 8:e1001092. 2011
    ....
  5. ncbi request reprint Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines
    Ian Homer Y Cua
    Storr Liver Unit, Westmead Millennium Institute and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Hepatology 46:66-73. 2007
    ..HCV-associated IR is most likely an adipocytokine-independent effect of the virus to modulate insulin sensitivity...
  6. pmc Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research NCHECR, University of New South Wales UNSW, Sydney, Australia
    Hepatology 52:1216-24. 2010
    ..Early therapeutic intervention could be recommended for individuals with unfavorable IL28B genotypes...
  7. ncbi request reprint Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3
    Hossein Poustchi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, NSW, Australia
    J Hepatol 48:28-34. 2008
    ..The aim of this study was to determine the relationship between the insulin resistance frequently seen in obese subjects and sustained virological response to anti-viral therapy (SVR) in patients with genotype 2 or 3 infection...
  8. ncbi request reprint Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis
    Nghi Phung
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Int J Mol Med 24:171-80. 2009
    ..Oxidative stress or products of lipid peroxidation mediate HSC activation and collagen gene expression directly in the MCD model of steatohepatitis. Vitamin E but not glutathione augmentation can interrupt this pathogenic process...
  9. pmc Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study
    J Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 107:244-9. 2010
    ..Decisions about whether to initiate treatment for recently acquired HCV were mainly driven by clinical factors, rather than factors related to sociodemographics or injecting behaviors...
  10. ncbi request reprint Virological responses during treatment for recent hepatitis C virus: potential benefit for ribavirin use in HCV/HIV co-infection
    Jason Grebely
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales UNSW, Sydney, Australia
    AIDS 26:1653-61. 2012
    ..This study evaluated early virological decline during recent HCV therapy in HIV-uninfected individuals receiving pegylated interferon (PEG-IFN) monotherapy and HIV-infected individuals receiving PEG-IFN/RBV...
  11. pmc Adherence to treatment for recently acquired hepatitis C virus (HCV) infection among injecting drug users
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    J Hepatol 55:76-85. 2011
    ..We assessed 80/80 adherence (≥80% of PEG-IFN doses, ≥80% treatment), on-treatment adherence, and treatment completion in a study of treatment of recent HCV infection (ATAHC)...
  12. pmc Effective treatment of injecting drug users with recently acquired hepatitis C virus infection
    Gregory J Dore
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Gastroenterology 138:123-35.e1-2. 2010
    ..We evaluated the efficacy of treatment of recent HCV infection in IDUs with acute and early chronic HCV...
  13. ncbi request reprint Improved prediction of fibrosis in chronic hepatitis C using measures of insulin resistance in a probability index
    Archana Sud
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia
    Hepatology 39:1239-47. 2004
    ..Such an index should prove useful to guide decision making regarding the need for liver biopsy, and potentially for avoiding or deferring biopsy in a large proportion of patients with mild liver disease...
  14. ncbi request reprint Hepatitis C treatment outcomes in Australian clinics
    Heather F Gidding
    University of New South Wales, Sydney, NSW, Australia
    Med J Aust 196:633-7. 2012
    ..To determine hepatitis C (HCV) treatment effectiveness and predictors of response in the "real-world" Australian clinic setting...
  15. ncbi request reprint Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Insitute, and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, New South Wales, Australia
    Gastroenterology 125:1695-704. 2003
    ..Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection...
  16. ncbi request reprint Effects of interferon treatment response on liver complications of chronic hepatitis C: 9-year follow-up study
    Shirley A Coverdale
    Storr Liver Unit, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Am J Gastroenterol 99:636-44. 2004
    ..After accounting for these factors, we tested whether interferon treatment or the treatment response reduces the rate of liver cancer, liver-related death or transplantation, and other liver complications during extended follow-up...
  17. ncbi request reprint Changes in antipyrine clearance and platelet count, but not conventional liver tests, correlate with fibrotic change in chronic hepatitis C: value for predicting fibrotic progression
    Shirley A Coverdale
    The Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, NSW, Australia
    Am J Gastroenterol 98:1384-90. 2003
    ..We tested whether fibrotic progression in chronic hepatitis C could be predicted by liver tests, antipyrine clearance, or platelet count...
  18. ncbi request reprint Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Department of Anatomical Pathology, New South Wales, Australia
    J Gastroenterol Hepatol 17:873-81. 2002
    ..In the present prospective study, we examined metabolic factors associated with non-alcoholic fatty liver and viral genotype as predictors of steatosis and fibrosis in chronic hepatitis C infection...
  19. ncbi request reprint Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, and Department of Gastroenterology and Hepatology, Westmead Hospital, University of Sydney, NSW, Australia
    Hepatology 38:420-7. 2003
    ..In conclusion, liver failure is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis, except that HCC appears less common...
  20. doi request reprint Antiviral therapy for hepatitis B-related liver cancer prevention is more cost-effective than cancer screening
    Monica C Robotin
    The Cancer Council NSW, Research Strategy and Scientific Development Unit, 153 Dowling St, Woolloomooloo, NSW 2011, Sydney, Australia
    J Hepatol 50:990-8. 2009
    ..We therefore, modelled the consequences of different management strategies for chronic hepatitis B (CHB) in Asian-born adults aged > or = 35 years...
  21. ncbi request reprint Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, New South Wales, Australia
    Hepatology 36:403-9. 2002
    ..We propose that the relationship between leptin and steatosis reflects a pathogenic role of leptin in hepatic insulin resistance and/or a failure of the antisteatotic actions of leptin ("peripheral leptin resistance")...
  22. ncbi request reprint HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, New South Wales 2145, Australia
    Hepatology 36:142-9. 2002
    ..In conclusion, hepatic iron is not a factor linked to hepatic fibrogenesis in patients with NASH. HFE mutations do not confer an additional risk of hepatic fibrosis in this disorder...
  23. pmc Using a population-based approach to prevent hepatocellular cancer in New South Wales, Australia: effects on health services utilisation
    Monica C Robotin
    School of Public Health, University of Sydney NSW, Sydney, Australia
    BMC Health Serv Res 10:215. 2010
    ..In this paper we examine the program's potential impact on health services utilisation in the study area...
  24. ncbi request reprint Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, and Department of Gastroenterology and Hepatology, Westmead Hospital, NSW, Australia
    Hepatology 40:46-54. 2004
    ..Reduced adiponectin level is associated with more extensive necroinflammation and may contribute to the development of necroinflammatory forms of NAFLD...
  25. ncbi request reprint Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C
    Priyanka Bandara
    Storr Liver Unit, Westmead Millennium Institute, Sydney, Australia
    Liver Int 25:518-26. 2005
    ..We then determined whether regular antioxidant supplementation influenced these antioxidant levels or disease severity...
  26. ncbi request reprint Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C
    Ian Homer Y Cua
    Storr Liver Unit, Westmead Millennium Institute and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Hepatology 48:723-31. 2008
    ..Genotype-specific subgroup analyses did not alter this finding. The extent of HOMA-IR remained significantly associated with fibrosis in lean patients, independent of the confounding effect of body mass index on IR (OR, 8.02; P = 0.003)...
  27. pmc Plasma interferon-gamma-inducible protein-10 (IP-10) levels during acute hepatitis C virus infection
    Jason Grebely
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia
    Hepatology 57:2124-34. 2013
    ..hepatology 2013;)...
  28. doi request reprint Pioglitazone and vitamin E for nonalcoholic steatohepatitis: a cost utility analysis
    Suzanne E Mahady
    School of Public Health, University of Sydney, Sydney, Australia
    Hepatology 56:2172-9. 2012
    ..Sensitivity analyses indicated that pioglitazone was not cost-effective if either the total drug cost was greater than $A16,000 per annum, or the annual probability of developing cirrhosis in advanced fibrosis was less than 2%...
  29. pmc Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C
    G V Matthews
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Clin Infect Dis 48:650-8. 2009
    ..Enrollment is open to both human immunodeficiency virus (HIV)-infected and -uninfected individuals. The aim of this article was to evaluate characteristics and virological outcomes among HIV-infected individuals enrolled in ATAHC...
  30. doi request reprint Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the 13 C-caffeine breath test
    Gordon J H Park
    Department of Gastroenterology and Hepatology, Concord Hospital, University of Sydney, Sydney, Australia
    J Gastroenterol Hepatol 26:1411-6. 2011
    ..The (13) C-caffeine breath test (CBT) is a non-invasive, quantitative test of liver function. We sought to determine the utility of the CBT in detecting hepatic fibrosis in NAFLD...
  31. doi request reprint IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
    ..These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha...
  32. doi request reprint Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
    George S Wilson
    Storr Liver Unit, Westmead Millennium Institute, the University of Sydney at the Westmead Hospital, Westmead, NSW 2145, Australia
    Cancer Lett 341:224-30. 2013
    ..To our knowledge this study is the first to report on the effect of Ruxolitinib on liver cancer cells. ..
  33. pmc Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
    Mohammed Eslam
    Mohammed Eslam, Jacob George, Golo Ahlenstiel, Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, NSW 2145, Australia
    World J Gastroenterol 19:7055-61. 2013
    ..This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression. ..
  34. ncbi request reprint Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
    Dinesh Kumar
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Australia
    Hepatology 36:1266-72. 2002
    ..7-481, P =.007). In conclusion, these data provide strong support for a direct causal association between HCV genotype 3 infection and hepatic steatosis...
  35. ncbi request reprint Effectiveness of interferon alfa-2b/ribavirin combination therapy for chronic hepatitis C in a clinic setting
    Dinesh Kumar
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Med J Aust 178:267-71. 2003
    ....
  36. ncbi request reprint NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    Aileen Dela Pena
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, NSW, Australia
    Gastroenterology 129:1663-74. 2005
    ..We explored the roles of nuclear factor-kappaB (NF-kappaB) and tumor necrosis factor (TNF) alpha (TNF-alpha) as mediators of inflammation in a nutritional model of steatohepatitis...
  37. pmc The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection
    Jason Grebely
    The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
    Hepatology 59:109-20. 2014
    ..26; 95% CI: 1.52, 3.34), and HCV genotype 1 (versus non-genotype 1; AHR: 1.56; 95% CI: 1.06, 2.30). The effect of IL28B genotype and HCV genotype on spontaneous clearance was greater among females, compared to males...
  38. ncbi request reprint Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes
    Moon Sun Kim
    Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia
    Liver Int 33:1583-93. 2013
    ..Here, we examine the effect of compound K (ComK), an active metabolite of ginsenosides, on the regulation of LD formation and on the expression of proteins involved in lipid homeostasis in hepatocytes...
  39. doi request reprint Psychological, lifestyle and social predictors of hepatitis C treatment response: a systematic review
    Victoria A Sublette
    School of Public Health, University of Sydney, Sydney, NSW, Australia
    Liver Int 33:894-903. 2013
    ..To increase cure rates for Hepatitis C, barriers to treatment adherence and completion must be identified and overcome...
  40. ncbi request reprint Hepatic fat loss in advanced nonalcoholic steatohepatitis: are alterations in serum adiponectin the cause?
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia
    Hepatology 57:2180-8. 2013
    ..1 versus 7.4 μg/L, P = 0.001) on multivariate analysis. A relationship between adiponectin, bile acids, and adipocyte fexaramine activation was demonstrated in vivo and in vitro, suggestive of hepatocyte-adipocyte crosstalk...
  41. pmc Kupffer cells mediate leptin-induced liver fibrosis
    Jianhua Wang
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Westmead, Australia
    Gastroenterology 137:713-23. 2009
    ..Leptin has profibrogenic effects in liver, although the mechanisms of this process are unclear. We sought to elucidate the direct and indirect effects of leptin on hepatic stellate cells (HSCs)...
  42. doi request reprint Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease
    Kerry Lee Milner
    Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia
    Hepatology 49:1926-34. 2009
    ..AFABP levels correlated with insulin resistance (homeostasis model assessment of insulin resistance) in controls and NAFLD, whereas lipocalin-2 and RBP4 only correlated positively with insulin resistance in controls...
  43. doi request reprint The population distributions, upper normal limits and correlations between liver tests among Australian adolescents
    Jacob George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
    J Paediatr Child Health 44:579-85. 2008
    ..The purpose of this study was to describe the distributions of liver tests, to identify the upper normal limits (UNLs) and to describe the correlations among liver tests...
  44. doi request reprint Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease
    Nathan A Johnson
    Discipline of Exercise and Sport Science, University of Sydney, Sydney, Australia
    Hepatology 52:370-81. 2010
    ....
  45. doi request reprint Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, Westmead NSW, Australia
    Clin Liver Dis 12:805-24, ix. 2008
    ..This article explores in depth the disease-specific mechanisms of fibrosis in hepatitis C and NASH, with a focus on recent developments...
  46. pmc Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B
    Farzan Fahrtash-Bahin
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, 2145 Sydney, Australia
    World J Gastroenterol 19:721-6. 2013
    ..To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting...
  47. doi request reprint Will IL28B polymorphisms remain relevant to direct-acting antiviral treatment paradigms?
    Golo Ahlenstiel
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, Australia
    Antivir Ther 17:1163-70. 2012
    ....
  48. ncbi request reprint Prevalence of and risk factors for hepatitis C in Aboriginal and non-Aboriginal adolescent offenders
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    Med J Aust 188:610-4. 2008
    ..To define and compare the prevalence, risk factors and understanding of hepatitis C transmission among Aboriginal and non-Aboriginal young offenders...
  49. ncbi request reprint Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis
    Jacob George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, New South Wales, Sydney, Australia
    J Hepatol 39:756-64. 2003
    ..We explored the involvement of cell types, cytokines and lipid peroxidation in a rat dietary model of fibrosing steatohepatitis...
  50. ncbi request reprint Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders
    Nathan A Johnson
    Discipline of Exercise and Sport Science, The University of Sydney, Sydney, Australia
    Hepatology 47:1513-23. 2008
    ..Obesity-related hepatic steatosis is characterized by further depletion of polyunsaturated hepatic lipids...
  51. ncbi request reprint Independent effects of physical activity in patients with nonalcoholic fatty liver disease
    Alexis St George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Canberra, Australia
    Hepatology 50:68-76. 2009
    ..This effect was independent of weight loss and was corroborated by an objective measure of fitness. There was no dose-response effect on liver enzymes with incremental increases in physical activity above 60 minutes/week...
  52. ncbi request reprint Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C
    Dinesh Kumar
    Storr Liver Unit, Westmead Millennium Institute, Westmead, New South Wales, Australia
    J Gastroenterol Hepatol 20:1395-400. 2005
    ..Obesity associated hepatic steatosis has been suggested to have a premalignant potential. We determined whether hepatic steatosis predisposes to liver cancer in persons with chronic hepatitis C virus (HCV) infection...
  53. ncbi request reprint The role of diet and nutritional intervention for the management of patients with NAFLD
    Francisco Barrera
    Storr Liver Unit, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Darcy Road, Westmead, New South Wales 2145, Australia Department of Gastroenterology, Pontificia Universidad Catolica de Chile, Marcoleta 367, Santiago 8330024, Chile
    Clin Liver Dis 18:91-112. 2014
    ....
  54. doi request reprint Visceral adiposity in gastrointestinal and hepatic carcinogenesis
    Roslyn Vongsuvanh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Australia
    Cancer Lett 330:1-10. 2013
    ..This review examines the evidence linking visceral fat in gastrointestinal and hepatic carcinogenesis and explores our current understanding of the mechanisms underlying this relationship...
  55. pmc Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
    Katherine R Smith
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
    Genome Med 3:57. 2011
    ..In people of European ancestry, there are 6 common (more than 1%) haplotypes for IL28B, one tagged by the rs8099917 minor allele, four tagged by rs12979860...
  56. doi request reprint Leptin and acetaldehyde synergistically promotes αSMA expression in hepatic stellate cells by an interleukin 6-dependent mechanism
    Yingdi Liu
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Australia
    Alcohol Clin Exp Res 35:921-8. 2011
    ..We sought to assess whether leptin contributes to alcoholic liver fibrosis by in vitro studies in hepatic stellate cells (HSC)...
  57. ncbi request reprint Feasibility of conducting a randomized control trial for liver cancer screening: is a randomized controlled trial for liver cancer screening feasible or still needed?
    Hossein Poustchi
    Digestive Disease Research Centre, Tehran University of Medical Science, Tehran, Iran
    Hepatology 54:1998-2004. 2011
    ..Eighteen of 21 patients in "usual care" received ad hoc screening. A simultaneous survey on the quality of the DA showed that the majority of participants believed that the information provided was unbiased...
  58. ncbi request reprint Preventing primary liver cancer: how well are we faring towards a national hepatitis B strategy?
    Monica C Robotin
    The Cancer Council NSW, Sydney, NSW, Australia
    Med J Aust 188:363-5. 2008
    ..Lessons learned in the development of the National Hepatitis C Strategy and the experience of international hepatitis B control programs need to inform this process...
  59. ncbi request reprint Liver disease in adolescents: A cohort study of high-risk individuals
    David Van der Poorten
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, Australia
    Hepatology 46:1750-8. 2007
    ..High rates of HCV infection and obesity-related liver disease exist in this group, and targeted interventions are needed to reduce future health-related morbidity...
  60. ncbi request reprint Interaction of iron, insulin resistance, and nonalcoholic steatohepatitis
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead, New South Wales 2145, Australia
    Curr Gastroenterol Rep 5:18-25. 2003
    ..A recent study showed improvement in insulin sensitivity with the use of venesection in patients with NAFLD, but this approach cannot be implemented without extensive review...
  61. pmc Efficacy of using cancer stem cell markers in isolating and characterizing liver cancer stem cells
    George S Wilson
    1 Storr Liver Unit, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, Australia
    Stem Cells Dev 22:2655-64. 2013
    ..LCSCs have unique subtypes that express distinctive combinations of LCSC markers and altered drug resistance profiles, making their identification problematic. ..
  62. ncbi request reprint Changes in serum albumin during treatment of chronic hepatitis B with lamivudine: effects of response and emergence of drug resistance
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia
    Am J Gastroenterol 97:1003-9. 2002
    ..The aim of the present study was to assess the effect of lamivudine therapy on hepatic synthetic function in patients with moderately severe chronic hepatitis B and, particularly, to determine the effect of drug resistance...
  63. doi request reprint Visceral adiposity index is not a predictor of liver histology in patients with non-alcoholic fatty liver disease
    Roslyn Vongsuvanh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
    J Hepatol 57:392-8. 2012
    ..We assessed the ability of VAI to predict disease severity in NAFLD and hence its role as a non-invasive marker of liver damage...
  64. doi request reprint Management of nonalcoholic steatohepatitis: an evidence-based approach
    Suzanne E Mahady
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
    Clin Liver Dis 16:631-45. 2012
    ..In particular, behavioral therapies to assist patients in adopting lifestyle changes are highlighted and a research agenda for future NASH management is presented...
  65. doi request reprint Organelle dysfunction in hepatitis C virus-associated steatosis: anything to learn from nonalcoholic steatohepatitis?
    Venessa Pattullo
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Sydney, NSW 2145, Australia
    Expert Rev Gastroenterol Hepatol 5:265-77. 2011
    ..This article outlines our current understanding of the subcellular mechanisms of steatosis in NAFLD and CHC, including their similarities and differences...
  66. doi request reprint Trends in mortality after diagnosis of hepatitis B or C infection: 1992-2006
    Scott R Walter
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia
    J Hepatol 54:879-86. 2011
    ..We examined specific causes of death among a population-based cohort of people infected with HBV or HCV to identify areas of excess risk and examine trends in mortality...
  67. ncbi request reprint Non-alcoholic fatty liver disease
    Ian Homer Y Cua
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Hosp Med 66:106-11. 2005
    ..This article reviews the nomenclature, clinical and histological basis for a diagnosis of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis, its natural history, pathophysiology and an approach to clinical management...
  68. ncbi request reprint Non-alcoholic steatohepatitis in the Asia-Pacific region: future shock?
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    J Gastroenterol Hepatol 19:368-74. 2004
    ..Pharmacotherapy may play a role in selected individuals. A regional agenda for case definition, future study and public health initiatives is urgently required...
  69. ncbi request reprint NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
    Hepatology 35:373-9. 2002
    ..IR is present in mild as well as advanced cases of NASH but is unusual in chronic HCV of similar fibrotic severity...
  70. ncbi request reprint Transjugular liver biopsy effecting changes in clinical management
    David Lee
    Department of Radiology, Westmead Hospital and Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Australas Radiol 47:117-20. 2003
    ..Transjugular liver biopsies can be effectively and safely performed in high-risk patients with impaired coagulation. They aid accurate histological appraisal of liver dysfunction in these patients and influence clinical decision-making...
  71. doi request reprint The population prevalence of adverse concentrations and associations with adiposity of liver tests among Australian adolescents
    Michael L Booth
    School of Public Health, School of Public Health, University of Sydney, New South Wales, Australia
    J Paediatr Child Health 44:686-91. 2008
    ..This paper reports the prevalence of elevated concentrations of four liver enzymes and their associations with adiposity in a representative population sample of Australian adolescents...
  72. doi request reprint The role of thiazolidinediones in non-alcoholic steatohepatitis - a systematic review and meta analysis
    Suzanne E Mahady
    Storr Liver Unit, Westmead Hospital, Wentworthville, New South Wales 2145, Australia
    J Hepatol 55:1383-90. 2011
    ..We performed a systematic review and meta-analysis of the effect of thiazolidinediones on histological and biochemical variables in NASH...
  73. doi request reprint Animal models of nonalcoholic fatty liver disease
    Lionel Hebbard
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
    Nat Rev Gastroenterol Hepatol 8:35-44. 2011
    ..This Review discusses the prevalent dietary and inflammation-based genetic animal models described in recent years...
  74. doi request reprint IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice
    Golo Ahlenstiel
    Storr Liver Unit, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Hawkesbury Road, Westmead, NSW 2145, Australia
    J Gastroenterol 45:903-10. 2010
    ..It will conclude with a discussion on how the research observations may translate into clinical practice and drug development...
  75. ncbi request reprint Angiopoietin-like proteins: another player in the metabolic field
    Jacob George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia
    J Hepatol 44:832-4. 2006
  76. ncbi request reprint Pathogenesis of NASH: animal models
    Roslyn M London
    Westmead Millennium Institute, Storr Liver Unit, Westmead, NSW 2145, Australia
    Clin Liver Dis 11:55-74, viii. 2007
    ..The ultimate aim of this research is to gain insights into the role of hepatic lipid, inflammation, and fibrosis in human non-alcoholic fatty liver disease...
  77. pmc Role of ethanol in the regulation of hepatic stellate cell function
    Jian Hua Wang
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Westmead, New South Wales, Australia
    World J Gastroenterol 12:6926-32. 2006
    ..Ethanol further perpetuates an activated HSC phenotype through extracellular matrix remodeling. The underlying pathophysiologic mechanisms by which ethanol exerts these pro-fibrogenic effects on HSCs are reviewed...
  78. ncbi request reprint Roles of adipokines in liver injury and fibrosis
    Jianhua Wang
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, NSW 2145, Australia
    Expert Rev Gastroenterol Hepatol 2:47-57. 2008
    ..The activities of these adipokines in the pathogenesis of liver injury and fibrosis will be the topic of this review...
  79. ncbi request reprint Modelling the hepatitis C virus epidemic in Australia
    Karina Razali
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 91:228-35. 2007
    ..This paper updates estimates of HCV incidence and prevalence between 1960 and 2005...
  80. ncbi request reprint Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets
    Jacob George
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Westmead NSW 2145, Australia
    Mol Pharm 5:49-59. 2008
    ..However, these drugs have significant limitations, so alternate approaches to nuclear receptor targeting are being explored...
  81. ncbi request reprint Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Semin Liver Dis 22:169-83. 2002
    ..Well-known causes of liver injury such as chlorpromazine, phenytoin, and methyldopa are not discussed...
  82. ncbi request reprint Gliclazide-induced acute hepatitis with hypersensitivity features
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
    Dig Dis Sci 47:1107-10. 2002
  83. ncbi request reprint Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes
    Claudio R Alonso
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biochem Biophys Res Commun 295:1077-84. 2002
    ..These results establish the starting point to investigate the molecular basis of changes in transcriptional regulation of the FN gene involved in liver pathology...
  84. ncbi request reprint The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    ..By applying this model, a liver biopsy would have been avoided in 549 (75%) of the 733 patients, with correct prediction in 496 (90%)...
  85. ncbi request reprint Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    Clin Chem 51:1867-73. 2005
    ..We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients...
  86. ncbi request reprint Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: Role of insulin resistance and hepatic steatosis
    Elisabetta Bugianesi
    Gastroenterology Department, University of Turin, Italy
    Hepatology 44:1648-55. 2006
    ..Virus-induced hepatic steatosis as seen in CHC-3 does not contribute significantly to liver fibrosis...
  87. ncbi request reprint Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data
    Gioacchino Leandro
    IRCSS de Bellis, Castellana Grotte, Italy
    Gastroenterology 130:1636-42. 2006
    ..We evaluated the association between steatosis and fibrosis and their common correlates in persons with CHC and in subgroup analyses according to hepatitis C virus (HCV) genotype and body mass index...
  88. ncbi request reprint N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells
    Adi Mor
    Cardiovascular Research Center, Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Immunol 38:1493-502. 2008
    ..Thus, inhibition of the N- or K-Ras isoform triggers an anti-inflammatory effect by up-regulating, via Foxp3 elevation, the numbers and functional suppressive properties of Treg...
  89. pmc Cell and molecular regulation of endothelin-1 production during hepatic wound healing
    Rong Shao
    Duke University Liver Center, Durham, North Carolina 27710, USA
    Mol Biol Cell 14:2327-41. 2003
    ..The possibility that the same or similar regulatory events are present in other forms of wound healing is raised...
  90. ncbi request reprint Immunity to heat shock protein 65--an additional determinant in intimal thickening
    Jacob George
    Cardiovascular Research Laboratory, Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler School of Medicine, 6 Weizman St, Israel
    Atherosclerosis 168:33-8. 2003
    ..These results should be further investigated in humans as they may provide a possible link between infections and restenosis/accelerated arteriosclerosis...
  91. ncbi request reprint Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat
    Jacob George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel
    Exp Mol Pathol 74:314-8. 2003
    ..AG-556 has proven beneficial in reducing myocardial infarct size and attenuated consequent hemodynamic deterioration in the rat model. If reconfirmed, AG-556 may be of potential clinical use in post-MI patients...
  92. ncbi request reprint The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells
    Karin Mausner-Fainberg
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Atherosclerosis 197:829-39. 2008
    ..In conclusion, statins appear to significantly influence the peripheral pool of Tregs in humans. This finding may shed light on the mechanisms governing the plaque stabilizing properties of statins...
  93. ncbi request reprint Mechanisms of disease: the evolving role of regulatory T cells in atherosclerosis
    Jacob George
    Department of Cardiology and the Cardiovascular Research Center, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nat Clin Pract Cardiovasc Med 5:531-40. 2008
    ..The growing knowledge of the role of regulatory T cells could result in the future development of novel therapeutic modalities to attenuate atherosclerosis and stabilize vulnerable plaques...
  94. ncbi request reprint Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions
    Dror Harats
    Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer, Israel
    J Am Coll Cardiol 40:1333-8. 2002
    ..The goal of this study was to explore the efficacy of oral tolerance with heat shock protein (HSP) 65 in two apparently non-overlapping models of murine atherosclerosis...
  95. ncbi request reprint Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor
    Jacob George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Israel
    Arterioscler Thromb Vasc Biol 24:363-8. 2004
    ..In the present study, we tested the hypothesis that systemic administration of FTS will suppress intimal thickening in the rat carotid injury model...
  96. ncbi request reprint Predictive value of high sensitivity CRP in patients with diastolic heart failure
    Yoav Michowitz
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Int J Cardiol 125:347-51. 2008
    ..However, the role of C-reactive protein (CRP) in patients with diastolic HF is not established. We studied the predictive role of high sensitivity CRP (hsCRP) in patients with diastolic HF...
  97. pmc Circulating endothelial progenitor cells in patients with cardiac syndrome X
    Haim Shmilovich
    Department of Cardiology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Heart 93:1071-6. 2007
    ..Endothelial progenitor cells (EPCs) in the peripheral circulation contribute to tissue vascularisation...
  98. ncbi request reprint Stent thrombosis in patients treated with thienopyridines: clinical description of 10 cases
    Yoav Michowitz
    Tel Aviv Sourasky Medical Center, Israel
    Int J Cardiovasc Intervent 6:160-4. 2004
    ..Prospective studies should be performed to elucidate drug interactions that may reduce clopidogrel efficacy and contribute to stent thrombosis...
  99. ncbi request reprint Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis
    Adi Mor
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Arterioscler Thromb Vasc Biol 27:893-900. 2007
    ..We investigated the importance and potential role of Tregs in murine atherogenesis...
  100. ncbi request reprint Circulating erythropoietin levels and prognosis in patients with congestive heart failure: comparison with neurohormonal and inflammatory markers
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Arch Intern Med 165:1304-9. 2005
    ..We prospectively evaluated the predictive value of baseline EPO, N-terminal pro-B-type natriuretic peptide, and C-reactive protein levels in patients with clinically controlled chronic CHF...
  101. ncbi request reprint The effect of tyrphostin AG-556 on intimal thickening in a mouse model of arterial injury
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, 6 Weizman Street, Tel Aviv University, Israel
    Exp Mol Pathol 78:233-8. 2005
    ..In the current study, we investigated the effect of the tyrphostin AG-556 on neointimal thickening and cytokine profile in a model of arterial injury in the mouse...