Affiliation: University of Melbourne
Stankovic S, Harpur C, Macleod B, Whitney P, Gebhardt T, Brooks A. Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1. J Immunol. 2015;195:4892-9 pubmed publisher
..Our results highlight a limited anatomical diversification of TFH responses and germinal center reactions that were imprinted within the first few cell divisions during TFH differentiation in LNs draining the site of initial infection. ..
Whitney P, Makhlouf C, MacLeod B, Ma J, Gressier E, Greyer M, et al
. Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells. J Virol. 2018;92: pubmed publisher
Mackay L, Braun A, Macleod B, Collins N, Tebartz C, Bedoui S, et al
. Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J Immunol. 2015;194:2059-63 pubmed publisher
..Our results define an important step in the generation of long-lived adaptive immune memory at body surfaces. ..
Park S, Buzzai A, Rautela J, Hor J, Hochheiser K, Effern M, et al
. Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin. Nature. 2018;: pubmed publisher
..As such, they provide strong impetus for exploring these cells as targets of future anticancer immunotherapies. ..
Gebhardt T, Whitney P, Zaid A, Mackay L, Brooks A, Heath W, et al
. Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature. 2011;477:216-9 pubmed publisher
..Overall, these results identify a complexity in memory T-cell migration, illuminating previously unappreciated differences between the CD4(+) and CD8(+) subsets. ..
Gebhardt T, Harvey K. Hippo Wades into Cancer Immunology. Dev Cell. 2016;39:635-637 pubmed publisher
..This could explain the rarity of pathway mutations in cancers and suggests Hippo pathway repression as a cancer immunotherapy modality. ..