Kathryn L Gatford

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. pmc Prenatal programming of insulin secretion in intrauterine growth restriction
    Kathryn L Gatford
    Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA, Australia, USA
    Clin Obstet Gynecol 56:520-8. 2013
  2. pmc Neonatal exendin-4 reduces growth, fat deposition and glucose tolerance during treatment in the intrauterine growth-restricted lamb
    Kathryn L Gatford
    Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 8:e56553. 2013
  3. doi request reprint Maternal low-dose porcine somatotropin treatment in late gestation increases progeny weight at birth and weaning in sows but not in gilts
    K L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, University of Adelaide, Southern Australia 5005, Australia
    J Anim Sci 90:1428-35. 2012
  4. doi request reprint Testing the plasticity of insulin secretion and β-cell function in vivo: responses to chronic hyperglycaemia in the sheep
    Kathryn L Gatford
    Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    Exp Physiol 97:663-75. 2012
  5. doi request reprint Responses to maternal GH or ractopamine during early-mid pregnancy are similar in primiparous and multiparous pregnant pigs
    Kathryn L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Endocrinol 203:143-54. 2009
  6. doi request reprint Maternal responses to daily maternal porcine somatotropin injections during early-mid pregnancy or early-late pregnancy in sows and gilts
    K L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, University of Adelaide SA 5005, Australia
    J Anim Sci 88:1365-78. 2010
  7. ncbi request reprint Acute ethanol exposure in pregnancy alters the insulin-like growth factor axis of fetal and maternal sheep
    Kathryn L Gatford
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E494-500. 2007
  8. pmc Review: Placental programming of postnatal diabetes and impaired insulin action after IUGR
    K L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    Placenta 31:S60-5. 2010
  9. ncbi request reprint Long-term, but not short-term, treatment with somatotropin during pregnancy in underfed pigs increases the body size of progeny at birth
    K L Gatford
    Department of Physiology, University of Adelaide, Adelaide 5005, Australia
    J Anim Sci 82:93-101. 2004
  10. ncbi request reprint Variable maternal nutrition and growth hormone treatment in the second quarter of pregnancy in pigs alter semitendinosus muscle in adolescent progeny
    Kathryn L Gatford
    Research Centre for Physiology of Early Development, School of Molecular and Biomedical Science, University of Adelaide, Adelaide 5005, Australia
    Br J Nutr 90:283-93. 2003

Detail Information

Publications31

  1. pmc Prenatal programming of insulin secretion in intrauterine growth restriction
    Kathryn L Gatford
    Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA, Australia, USA
    Clin Obstet Gynecol 56:520-8. 2013
    ..Animal models of IUGR sharing similar insulin secretion outcomes as the IUGR human are allowing underlying mechanisms to be identified. This review will focus on models of uteroplacental insufficiency. ..
  2. pmc Neonatal exendin-4 reduces growth, fat deposition and glucose tolerance during treatment in the intrauterine growth-restricted lamb
    Kathryn L Gatford
    Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 8:e56553. 2013
    ..We therefore investigated effects of neonatal exendin-4 administration on insulin action and β-cell mass and function in the IUGR neonate in the sheep, a species with a more developed pancreas at birth...
  3. doi request reprint Maternal low-dose porcine somatotropin treatment in late gestation increases progeny weight at birth and weaning in sows but not in gilts
    K L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, University of Adelaide, Southern Australia 5005, Australia
    J Anim Sci 90:1428-35. 2012
    ....
  4. doi request reprint Testing the plasticity of insulin secretion and β-cell function in vivo: responses to chronic hyperglycaemia in the sheep
    Kathryn L Gatford
    Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    Exp Physiol 97:663-75. 2012
    ..This marked plasticity of insulin secretion in response to moderate hyperglycaemia provides a novel model for the investigation of factors affecting its capacity and underlying determinants...
  5. doi request reprint Responses to maternal GH or ractopamine during early-mid pregnancy are similar in primiparous and multiparous pregnant pigs
    Kathryn L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Endocrinol 203:143-54. 2009
    ..We therefore predict that sustained pGH treatment will increase progeny birth weight, postnatal growth and survival, in both sows and gilts...
  6. doi request reprint Maternal responses to daily maternal porcine somatotropin injections during early-mid pregnancy or early-late pregnancy in sows and gilts
    K L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, University of Adelaide SA 5005, Australia
    J Anim Sci 88:1365-78. 2010
    ..Greater pST-induced birth weight increases in sows than in gilts may mean that underlying metabolic or placental mechanisms for pST action are constrained by maternal competition for nutrients in rapidly growing gilts...
  7. ncbi request reprint Acute ethanol exposure in pregnancy alters the insulin-like growth factor axis of fetal and maternal sheep
    Kathryn L Gatford
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E494-500. 2007
    ..We conclude that suppression of maternal and fetal IGF abundance may contribute to fetal growth restriction induced by acute or binge ethanol exposure...
  8. pmc Review: Placental programming of postnatal diabetes and impaired insulin action after IUGR
    K L Gatford
    Research Centre for Early Origins of Health and Disease, Robinson Institute, and School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    Placenta 31:S60-5. 2010
    ....
  9. ncbi request reprint Long-term, but not short-term, treatment with somatotropin during pregnancy in underfed pigs increases the body size of progeny at birth
    K L Gatford
    Department of Physiology, University of Adelaide, Adelaide 5005, Australia
    J Anim Sci 82:93-101. 2004
    ....
  10. ncbi request reprint Variable maternal nutrition and growth hormone treatment in the second quarter of pregnancy in pigs alter semitendinosus muscle in adolescent progeny
    Kathryn L Gatford
    Research Centre for Physiology of Early Development, School of Molecular and Biomedical Science, University of Adelaide, Adelaide 5005, Australia
    Br J Nutr 90:283-93. 2003
    ..Thus, maternal nutrition and pGH treatment during the second quarter of pregnancy in pigs independently alter muscle characteristics in progeny...
  11. ncbi request reprint Perinatal growth and plasma GH profiles in adolescent and adult sheep
    K L Gatford
    Department of Physiology, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Endocrinol 173:151-9. 2002
    ..This suggests that restricted fetal growth and reduced neonatal growth rate in sheep are followed by elevated circulating GH in adolescent and adult males, but GH deficiency or increased GH clearance in adult females...
  12. pmc Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny
    Kathryn L Gatford
    Research Centre for Early Origins of Adult Disease, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 295:E170-8. 2008
    ..We conclude that repeated exposure to synthetic glucocorticoids in utero programs the IGF axis before and after birth, which may contribute to the adverse effects of betamethasone exposure on growth and metabolism...
  13. pmc Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth
    Julie A Owens
    Department of Physiology, University of Adelaide, SA, Australia
    J Physiol 584:935-49. 2007
    ....
  14. doi request reprint Impaired beta-cell function and inadequate compensatory increases in beta-cell mass after intrauterine growth restriction in sheep
    Kathryn L Gatford
    Research Centre for Early Origins of Adult Disease, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, South Australia 5005, Australia
    Endocrinology 149:5118-27. 2008
    ..With aging, the insulin secretory capacity of the beta-cell is impaired in males, and their increases in beta-cell mass are inadequate to maintain adequate insulin secretion relative to sensitivity...
  15. ncbi request reprint Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb
    Miles J De Blasio
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 148:1350-8. 2007
    ....
  16. doi request reprint Placental restriction increases adipose leptin gene expression and plasma leptin and alters their relationship to feeding activity in the young lamb
    Miles J De Blasio
    Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Pediatr Res 67:603-8. 2010
    ....
  17. doi request reprint Increased placental nutrient transporter expression at midgestation after maternal growth hormone treatment in pigs: a placental mechanism for increased fetal growth
    Elena Tung
    Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 87:126. 2012
    ....
  18. ncbi request reprint Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb
    Miles J De Blasio
    Discipline of Obstetrics and Gynaecology, School of Paediatric and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Regul Integr Comp Physiol 292:R875-86. 2007
    ..Increased feeding activity may contribute to these alterations in growth and body composition following prenatal restraint and, if they persist, may lead to adverse metabolic and cardiovascular outcomes in later life...
  19. doi request reprint Placental restriction reduces insulin sensitivity and expression of insulin signaling and glucose transporter genes in skeletal muscle, but not liver, in young sheep
    Miles J De Blasio
    The Robinson Institute and School of Pediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 153:2142-51. 2012
    ..Onset of insulin resistance after PR and IUGR is accompanied by, and can be accounted for by, reduced expression of insulin signaling and metabolic genes in skeletal muscle but not liver...
  20. doi request reprint Placental and fetal growth restriction, size at birth and neonatal growth alter cognitive function and behaviour in sheep in an age- and sex-specific manner
    Damien S Hunter
    Robinson Research Institute, University of Adelaide, South Australia, Australia School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia School of Animal and Veterinary Sciences, University of Adelaide, South Australia, Australia
    Physiol Behav 152:1-10. 2015
    ..Rapid neonatal growth predicted improved memory task performance in males, suggesting that strategies to optimize neonatal growth may have long-term cognitive benefits but that these may be sex-specific...
  21. ncbi request reprint Placental restriction alters circulating thyroid hormone in the young lamb postnatally
    Miles J De Blasio
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide SA 5005, Australia
    Am J Physiol Regul Integr Comp Physiol 291:R1016-24. 2006
    ..This suggests that PR and small size at birth may increase activation of T4 to T3 and sensitivity of soft tissues to TH, which may contribute to catch-up growth following IUGR...
  22. ncbi request reprint Reproductive responses to daily injections with porcine somatotropin before mating in gilts
    Kathryn L Gatford
    Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, SA
    J Reprod Dev 56:540-5. 2010
    ....
  23. doi request reprint Effects of intrafetal IGF-I on growth of cardiac myocytes in late-gestation fetal sheep
    Eugenie R Lumbers
    Department of Physiology, University of New South Wales, Sydney, Australia
    Am J Physiol Endocrinol Metab 296:E513-9. 2009
    ..If IGF-I-stimulated cardiomyocyte growth is accompanied by maturation of contractile function, IGF-I may be a potential therapeutic agent for maintaining cardiac output in preterm males...
  24. ncbi request reprint Postnatal ontogeny of glucose homeostasis and insulin action in sheep
    K L Gatford
    Department of Physiology, University of Adelaide, Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 286:E1050-9. 2004
    ..Nevertheless, the capacity for insulin secretion in the adult reflects that early in life, suggesting that it is determined genetically or by persistent influences of the perinatal environment...
  25. ncbi request reprint Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
    J A Owens
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E1879-89. 2007
    ..These sex differences in the onset and extent of adverse metabolic consequences after prenatal restraint in the sheep are consistent with observations in humans...
  26. ncbi request reprint Treatment of underfed pigs with GH throughout the second quarter of pregnancy increases fetal growth
    K L Gatford
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Endocrinol 166:227-34. 2000
    ..This suggests that the availability of amino acids, not glucose, limits fetal growth in the first half of pregnancy in underfed gilts, and that maternal GH treatment may improve amino acid delivery to the fetus...
  27. doi request reprint Do I turn left or right? Effects of sex, age, experience and exit route on maze test performance in sheep
    Damien S Hunter
    Robinson Research Institute, University of Adelaide, South Australia 5005, Australia School of Paediatrics and Reproductive Health, University of Adelaide, South Australia 5005, Australia School of Animal and Veterinary Sciences, Roseworthy, University of Adelaide, South Australia 5371, Australia
    Physiol Behav 139:244-53. 2015
    ..These results provide comparison data, and can be utilised to improve experimental design, for studies of neurodevelopment in the sheep...
  28. doi request reprint Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction
    Kathryn L Gatford
    Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Am J Physiol Endocrinol Metab 306:E999-1012. 2014
    ..Such investigations will have implications for customizing the recommended level and timing of exercise to improve metabolic health after IUGR...
  29. doi request reprint Insulin family polymorphisms in pregnancies complicated by small for gestational age infants
    Prabha H Andraweera
    School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, Australia
    Mol Hum Reprod 21:745-52. 2015
    ..The INSR rs2059806 SNP previously associated with adult vascular and metabolic diseases is also associated with SGA pregnancies. This polymorphism may associate with the risk of vascular and metabolic disorders across the life course. ..
  30. ncbi request reprint The kidney is resistant to chronic hypoglycaemia in late-gestation fetal sheep
    Amanda C Boyce
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    Can J Physiol Pharmacol 85:597-605. 2007
    ..There was, however, increased activity of the circulating renin-angiotensin system similar to that seen during insulin-induced hypoglycaemia...
  31. ncbi request reprint Hypophyseal-portal somatostatin (SRIH) and jugular venous growth hormone secretion in the conscious unrestrained ewe
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neuroendocrinology 75:83-91. 2002
    ..We conclude that, to the extent that in vivo sampling reflects physiological SRIH/somatotrope activity, the female sheep maintains complex time-varying interactions between SRIH and GH release...