Research Topics
| Manohar L GargSummaryAffiliation: University of Newcastle Country: Australia Publications
| Collaborators
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Detail Information
Publications
Airway and circulating levels of carotenoids in asthma and healthy controlsLisa G Wood
Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
J Am Coll Nutr 24:448-55. 2005..Plasma carotenoid levels reflect airway carotenoid levels and when plasma levels are improved using oral supplements this is reflected in the airways...
Prior supplementation with long chain omega-3 polyunsaturated fatty acids promotes weight loss in obese adults: a double-blinded randomised controlled trialIrene A Munro
Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, 305CMedical Sciences Building, University Drive, Callaghan, NSW 2308, Australia
Food Funct 4:650-8. 2013..21% vs.-5.82%) and BMI (-7.43% vs.-5.91%) respectively (P < 0.05 for both). It would appear that supplementation with LCω-3PUFA had a time dependent effect on weight loss in females...- Macronutrient intakes and development of type 2 diabetes: a systematic review and meta-analysis of cohort studiesAmani Alhazmi
School of Health Sciences, University of Newcastle, New South Wales, Australia
J Am Coll Nutr 31:243-58. 2012..To synthesize the best available evidence on the association between macronutrient intake and type 2 diabetes risk... 
Relationship between body composition, inflammation and lung function in overweight and obese asthmaHayley A Scott
Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
Respir Res 13:10. 2012..The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma...- Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic menManohar L Garg
Nutrition and Dietetics, School of Health Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
J Nutr 133:1060-3. 2003..This study demonstrates that macadamia nut consumption as part of a healthy diet favorably modifies the plasma lipid profile in hypercholesterolemic men despite their diet being high in fat... - Long-chain n-3 polyunsaturated fatty acid incorporation into human atrium following fish oil supplementationManohar L Garg
Nutraceuticals Research Group, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
Lipids 41:1127-32. 2006.... - Macadamia nut consumption modulates favourably risk factors for coronary artery disease in hypercholesterolemic subjectsManohar L Garg
Nutraceuticals Research Group, School of Biomedical Sciences, Faculty of Health, University of Newcastle, 305C Medical Science Building, Callaghan, NSW 2308, Australia
Lipids 42:583-7. 2007..These data, combined with our previous results on cholesterol-lowering effects of macadamia nuts, suggest that regular consumption of macadamia nuts may play a role in the prevention of coronary artery disease... - Consumption of an n-3 polyunsaturated fatty acid-enriched dip modulates plasma lipid profile in subjects with diabetes type IIM L Garg
Nutraceuticals Research Group, Faculty of Health, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
Eur J Clin Nutr 61:1312-7. 2007..The effects of supplementing the diets of people with diabetes type II with a hummus-based dip enriched with long-chain n-3PUFA on plasma fatty acid composition and lipid levels were examined... - Manipulating antioxidant intake in asthma: a randomized controlled trialLisa G Wood
Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia
Am J Clin Nutr 96:534-43. 2012..Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes... - Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cellsAhmad Saedisomeolia
Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
Br J Nutr 101:533-40. 2009..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation... - A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthmaLisa G Wood
Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
J Allergy Clin Immunol 127:1133-40. 2011..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown... - Oxidative stress and antioxidants in athletes undertaking regular exercise trainingTrent A Watson
Discipline of Nutrition and Dietetics, Faculty of Health, University of Newcastle, NSW 2308, Australia
Int J Sport Nutr Exerc Metab 15:131-46. 2005..These findings suggest that athletes who consume a diet rich in antioxidants have elevated plasma alpha-tocopherol and beta-carotene that were likely to be brought about by adaptive processes resulting from regular exercise... - Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung functionLisa G Wood
Discipline of Nutrition and Dietetics, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
Am J Clin Nutr 77:150-9. 2003..If oxidative stress is deemed to be important to the clinical outcome of CF patients, means of reducing oxidative stress while maintaining a high-fat, high-energy diet must be investigated... - Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy dietIrene A Munro
Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, 305C Medical Sciences Building, The University of Newcastle, Callaghan, NSW 2308, Australia
Br J Nutr 108:1466-74. 2012..However, it would appear that supplementation with LCn-3PUFA had no significant effect on weight loss or weight maintenance over the 14 weeks... - Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemiaMichelle A Micallef
Nutraceuticals Research Group, School of Biomedical Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia
J Nutr Biochem 20:927-39. 2009..This article reviews the health benefits of phytosterols and omega-3 fatty acids, alone or in combination with statins, for the treatment/management of hyperlipidemia, with particular emphasis on the mechanisms involved... - Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of conceptLisa G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
Free Radic Res 42:94-102. 2008..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention... - Dietary antioxidant restriction affects the inflammatory response in athletesBrendan A Plunkett
Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Callaghan, 2308 NSW, Australia
Br J Nutr 103:1179-84. 2010..In conclusion, lower dietary intakes of carotenoids alter the plasma concentrations of antioxidants and markers of inflammation at rest and in response to exercise... - Induced sputum 8-isoprostane concentrations in inflammatory airway diseasesLisa G Wood
Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
Am J Respir Crit Care Med 171:426-30. 2005..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease... - Hypothesis: vitamin E complements polyunsaturated fatty acids in essential fatty acid deficiency in cystic fibrosisLisa G Wood
Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales 2308, Australia
J Am Coll Nutr 22:253-7. 2003..Furthermore, antioxidant supplementation in CF may improve EFA status... - Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individualsMichelle A Micallef
Nutraceuticals Research Group, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
Atherosclerosis 204:476-82. 2009.... - Antioxidant-restricted diet reduces plasma nonesterified fatty acids in trained athletesTrent A Watson
Nutrition and Dietetics, School of Health Sciences, and bHuman Physiology, School of Biomedical Science, University of Newcastle, New South Wales, 2308, Australia
Lipids 40:433-5. 2005..03) elevated. The increase in RPE may have occurred as a result of the R-AO diet and subsequent reduction in plasma NEFA; however, further research is required to confirm this conclusion... - Antioxidant restriction and oxidative stress in short-duration exhaustive exerciseTrent A Watson
Nutrition and Dietetics, School of Health Sciences, School of Medical Practice and Population Health, University of Newcastle, NSW, 2308, Australia
Med Sci Sports Exerc 37:63-71. 2005.... - Using personality as a predictor of diet induced weight loss and weight managementIrene A Munro
School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan NSW 2308, Australia
Int J Behav Nutr Phys Act 8:129. 2011..The aim of this study was to investigate whether personality traits could be used to match individuals to a compatible weight loss program that would maximize weight loss... - The lipid-lowering effects of phytosterols and (n-3) polyunsaturated fatty acids are synergistic and complementary in hyperlipidemic men and womenMichelle A Micallef
Nutraceuticals Research Group, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
J Nutr 138:1086-90. 2008..005), whereas phytosterol treatment alone had no effect. In conclusion, the combined supplementation with phytosterols and (n-3) LCPUFA has both synergistic and complementary lipid-lowering effects in hyperlipidemic men and women... - Vitamin E supplementation in the mitigation of carbon tetrachloride induced oxidative stress in ratsLesley K MacDonald-Wicks
Nutrition and Dietetics, School of Health Science, Faculty of Health, University of Newcastle, 2308 Callaghan, NSW, Australia
J Nutr Biochem 14:211-8. 2003..The results of this study indicate that dl-alpha-tocopherol acetate supplementation was protective of lipid peroxidation when oxidative stress is induced by a pro-oxidant challenge such as CCl4... - Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharideAhmad Saedisomeolia
Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
J Nutr Biochem 20:577-85. 2009..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation... - Antioxidant and anti-inflammatory effects of resveratrol in airway diseaseLisa G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
Antioxid Redox Signal 13:1535-48. 2010..Mechanisms of resveratrol action that may be relevant to respiratory disease are described. We conclude that resveratrol has potential as a therapeutic agent in respiratory disease, which should be further investigated... - Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific-Redefining platelet response to fish oilsMelinda Phang
Nutraceuticals Research Group, School of Biomedical Sciences, 305C Medical Sciences Building, University of Newcastle, Callaghan, NSW 2308, Australia
Prostaglandins Leukot Essent Fatty Acids 81:35-40. 2009..EPA was equally effective in reducing platelet aggregation in both groups. These findings show that significant gender differences exist in platelet aggregation in response to various LCn-3 PUFA treatments... - Incorporation of n-3 fatty acids into plasma and liver lipids of rats: importance of background dietary fatLesley K MacDonald-Wicks
Nutrition and Dietetics, University of Newcastle, New South Wales, Australia
Lipids 39:545-51. 2004.... - Validation of overweight children's fruit and vegetable intake using plasma carotenoidsTracy L Burrows
School of Health Sciences, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
Obesity (Silver Spring) 17:162-8. 2009..The lower plasma carotenoid concentrations found in overweight and obese children requires further investigation... - Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorderEdward H Clayton
NSW Department of Primary Industries, Wagga Wagga Agricultural Institute, Pine Gully Rd, Wagga Wagga, NSW, 2650, Australia
Lipids 43:1031-8. 2008..As RBC DHA was also negatively related to symptoms of depression, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this patient population... - Innate immune mechanisms linking non-esterified fatty acids and respiratory diseaseLisa G Wood
Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
Prog Lipid Res 48:27-43. 2009..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets... - Oxidized vitamin E and glutathione as markers of clinical status in asthmaLisa G Wood
Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
Clin Nutr 27:579-86. 2008.... - Elevated plasma levels of F2 alpha isoprostane in cystic fibrosisC E Collins
Department of Dietetics, John Hunter Children s Hospital, Rankin Park, New South Wales, Australia
Lipids 34:551-6. 1999..003; vitamin E, P < 0.001; and beta-carotene, P < 0.01). This study confirms significantly elevated lipid peroxidation in CF using 8-iso-PGF2 alpha levels... - Weight loss and metabolic profiles in obese individuals using two different approachesIrene A Munro
Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, 305C Medical Sciences Building, Callaghan, NSW 2308, Australia
Food Funct 2:611-6. 2011..05) were noted in VLED compared to those for LED diet. Short-term, rapid weight loss produced the desired ≥5% weight loss suggested to substantially reduce metabolic abnormalities associated with obesity, and to reduce health risks... - Circulating markers to assess nutritional therapy in cystic fibrosisLisa G Wood
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310, NSW, Australia
Clin Chim Acta 353:13-29. 2005..This article provides an overview of the biomarkers useful in the prediction of the efficacy of nutritional therapy on improvements in quality and quantity of life in CF... - Oxidative stress in cystic fibrosis: dietary and metabolic factorsL G Wood
Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales, Australia
J Am Coll Nutr 20:157-65. 2001..The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed... - Reproducibility and comparative validity of a food frequency questionnaire for Australian children and adolescentsJane F Watson
School of Health Sciences, Faculty of Health, University of Newcastle, Newcastle NSW, Australia
Int J Behav Nutr Phys Act 6:62. 2009..abstract:.. - Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoaAdam J Koppers
Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, Faculty of Science and IT, University of Newcastle, Callaghan, NSW 2308, Australia
Free Radic Biol Med 48:112-9. 2010.... - Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and womenMelinda Phang
Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, NSW, Australia
J Nutr 143:457-63. 2013..With respect to thrombotic disease risk, men are more likely to benefit from supplementation with EPA, whereas women are more responsive to DHA... - Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patientsLisa G Wood
Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
Am J Clin Nutr 75:668-75. 2002..Thus, antioxidant intervention during treatment for and recovery from acute infection in cystic fibrosis should be considered... - Tomato extract inhibits human platelet aggregation in vitro without increasing basal cAMP levelsSheryl A Lazarus
Nutrition and Dietetics, University of Newcastle, Callaghan, NSW, Australia
Int J Food Sci Nutr 55:249-56. 2004..These results provide a potential mechanism by which tomatoes contribute to cardiovascular health... - An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individualsM A Micallef
Nutraceuticals Research Group, School of Biomedical Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
Eur J Clin Nutr 63:1154-6. 2009..05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk... - Tomato juice and platelet aggregation in type 2 diabetesSheryl A Lazarus
JAMA 292:805-6. 2004