Simon C Gandevia

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. doi request reprint The combined effect of muscle contraction history and motor commands on human position sense
    Lee D Walsh
    Prince of Wales Medical Research Institute, University of New South Wales, NSW, Australia
    Exp Brain Res 195:603-10. 2009
  2. pmc Is this my finger? Proprioceptive illusions of body ownership and representation
    Martin E Héroux
    S Gandevia Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 591:5661-70. 2013
  3. pmc The contribution of motor commands to position sense differs between elbow and wrist
    Lee D Walsh
    S C Gandevia Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 591:6103-14. 2013
  4. pmc Twitch interpolation: superimposed twitches decline progressively during a tetanic contraction of human adductor pollicis
    S C Gandevia
    Neuroscience Research Australia, Barker Street, Randwick, NSW 2031, Australia
    J Physiol 591:1373-83. 2013
  5. pmc Dynamic changes in the perceived posture of the hand during ischaemic anaesthesia of the arm
    N Inui
    Neuroscience Research Australia, Sydney, 2031, Australia
    J Physiol 589:5775-84. 2011
  6. ncbi request reprint Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
  7. ncbi request reprint Balancing acts: respiratory sensations, motor control and human posture
    S C Gandevia
    Prince of Wales Medical Research Institute, Sydney, Randwick, New South Wales, Australia
    Clin Exp Pharmacol Physiol 29:118-21. 2002
  8. pmc Spatial distribution of inspiratory drive to the parasternal intercostal muscles in humans
    Simon C Gandevia
    Prince of Wales Medical Research Institute, Barker St Randwick, NSW 2031 Australia
    J Physiol 573:263-75. 2006
  9. pmc Constraints for control of the human hand
    Hiske van Duinen
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Physiol 589:5583-93. 2011
  10. pmc Mental rehearsal of motor tasks recruits alpha-motoneurones but fails to recruit human fusimotor neurones selectively
    S C Gandevia
    Department of Clinical Neurophysiology, Prince Henry and Prince of Wales Hospitals, Sydney, NSW, Australia
    J Physiol 505:259-66. 1997

Collaborators

Detail Information

Publications165 found, 100 shown here

  1. doi request reprint The combined effect of muscle contraction history and motor commands on human position sense
    Lee D Walsh
    Prince of Wales Medical Research Institute, University of New South Wales, NSW, Australia
    Exp Brain Res 195:603-10. 2009
    ..We propose that central signals combine with afferent signals to determine limb position and that multiple sources of information are weighted according to their reliability...
  2. pmc Is this my finger? Proprioceptive illusions of body ownership and representation
    Martin E Héroux
    S Gandevia Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 591:5661-70. 2013
    ..01). We propose that the brain generates possible scenarios and tests them against available sensory information. This process can function without vision or motor commands, and with only one channel of somatic information...
  3. pmc The contribution of motor commands to position sense differs between elbow and wrist
    Lee D Walsh
    S C Gandevia Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 591:6103-14. 2013
    ..In contrast, contraction of elbow flexors or extensors did not alter significantly the perceived position of the elbow, compared with rest. The contribution of central commands to position sense differs between the elbow and the wrist. ..
  4. pmc Twitch interpolation: superimposed twitches decline progressively during a tetanic contraction of human adductor pollicis
    S C Gandevia
    Neuroscience Research Australia, Barker Street, Randwick, NSW 2031, Australia
    J Physiol 591:1373-83. 2013
    ....
  5. pmc Dynamic changes in the perceived posture of the hand during ischaemic anaesthesia of the arm
    N Inui
    Neuroscience Research Australia, Sydney, 2031, Australia
    J Physiol 589:5775-84. 2011
    ..Hence it is unlikely that block of small-fibre afferents is critical for phantom formation in an ischaemic block...
  6. ncbi request reprint Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
    ..A number of other central changes occur during fatigue and affect, for example, proprioception, tremor, and postural control. Human muscle fatigue does not simply reside in the muscle...
  7. ncbi request reprint Balancing acts: respiratory sensations, motor control and human posture
    S C Gandevia
    Prince of Wales Medical Research Institute, Sydney, Randwick, New South Wales, Australia
    Clin Exp Pharmacol Physiol 29:118-21. 2002
    ..4. Thus, challenges to posture can indirectly challenge ventilation, while coordinated diaphragm contraction may contribute to control of the trunk...
  8. pmc Spatial distribution of inspiratory drive to the parasternal intercostal muscles in humans
    Simon C Gandevia
    Prince of Wales Medical Research Institute, Barker St Randwick, NSW 2031 Australia
    J Physiol 573:263-75. 2006
    ..The distribution of inspiratory neural drive to the parasternal intercostals parallels the spatial distribution of inspiratory mechanical advantage, while tonic activity was higher where mechanical advantage was lower...
  9. pmc Constraints for control of the human hand
    Hiske van Duinen
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Physiol 589:5583-93. 2011
    ..The pattern of these latter constraints correlates with amounts of daily use of each digit and favours enslaved extension to lift fingers from an object but selective flexion of fingers to contact it...
  10. pmc Mental rehearsal of motor tasks recruits alpha-motoneurones but fails to recruit human fusimotor neurones selectively
    S C Gandevia
    Department of Clinical Neurophysiology, Prince Henry and Prince of Wales Hospitals, Sydney, NSW, Australia
    J Physiol 505:259-66. 1997
    ..Similar changes occur with preparation for movement following a cue. It is likely that mental rehearsal usually involves unintentional performance of the planned motor task...
  11. ncbi request reprint Proprioception: peripheral inputs and perceptual interactions
    Simon C Gandevia
    Prince of Wales Medical Research Institute, NSW, Sydney, Australia
    Adv Exp Med Biol 508:61-8. 2002
    ..Evidence is presented that body image can be affected by the tonic discharge of non-muscle receptors...
  12. pmc Perceptual distortions of the human body image produced by local anaesthesia, pain and cutaneous stimulation
    S C Gandevia
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney 2031, Australia
    J Physiol 514:609-16. 1999
    ..The data may reveal perceptual consequences of acute changes in central somatosensory maps, changes which are known to occur with deafferentation...
  13. ncbi request reprint Human respiratory muscles: sensations, reflexes and fatiguability
    S C Gandevia
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 25:757-63. 1998
    ..However, recent studies using phrenic nerve stimulation to test the force produced by the diaphragm show that carbon dioxide retention (hypoventilation) and voluntary cessation of loading occur before the muscles become overtly fatigued...
  14. pmc Voluntary activation of human elbow flexor muscles during maximal concentric contractions
    S C Gandevia
    Prince of Wales Medical Research Institute, University of New South Wales, Australia
    J Physiol 512:595-602. 1998
    ..4. It is concluded that voluntary drive to elbow flexor muscles during maximal concentric contractions is usually maximal or near-maximal, and that this level of drive can be maintained during development of peripheral fatigue...
  15. pmc Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres
    S C Gandevia
    Prince of Wales Medical Research Institute and Department of Clinical Neurophysiology, Prince of Wales Hospital and University of New South Wales, Sydney, NSW 2031, Australia
    J Physiol 511:289-300. 1998
    ..The results cast doubt on the ability of the J reflex to limit exercise in humans...
  16. pmc Impaired response of human motoneurones to corticospinal stimulation after voluntary exercise
    S C Gandevia
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 521:749-59. 1999
    ..6. This study describes a novel depression of effectiveness of corticospinal actions on human motoneurones. This depression may involve the corticomotoneuronal synapse...
  17. ncbi request reprint Fatigue-sensitive afferents inhibit extensor but not flexor motoneurons in humans
    Peter G Martin
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, New South Wales 2031, Australia
    J Neurosci 26:4796-802. 2006
    ..The more pronounced inhibitory influence of these afferents on extensors suggests that these muscles may require greater cortical drive to generate force during fatigue...
  18. doi request reprint Effect of experimental muscle pain on maximal voluntary activation of human biceps brachii muscle
    Serajul I Khan
    Neuroscience Research Australia, Randwick, New South Wales, Australia 2031
    J Appl Physiol (1985) 111:743-50. 2011
    ..Hence, the present study suggests that transient experimental muscle pain in biceps brachii has a limited effect on central motor pathways...
  19. ncbi request reprint Responses of human motoneurons to corticospinal stimulation during maximal voluntary contractions and ischemia
    Jane E Butler
    Prince of Wales Medical Research Institute and University of New South Wales, Randwick, New South Wales, 2031 Australia
    J Neurosci 23:10224-30. 2003
    ....
  20. pmc The reduction in human motoneurone responsiveness during muscle fatigue is not prevented by increased muscle spindle discharge
    Chris J McNeil
    Neuroscience Research Australia formerly Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, New South Wales, Australia 2031
    J Physiol 589:3731-8. 2011
    ..Therefore, a change to intrinsic motoneurone properties caused by repetitive discharge is most probably responsible...
  21. ncbi request reprint Gastrocnemius muscle contracture after spinal cord injury: a longitudinal study
    Joanna Diong
    The George Institute for Global Health, Sydney, Australia
    Am J Phys Med Rehabil 92:565-74. 2013
    ..The aim of this study was to examine changes in passive length and stiffness of the gastrocnemius muscle-tendon unit in people after spinal cord injury...
  22. doi request reprint Evoked corticospinal output to the human scalene muscles is altered by lung volume
    Anna L Hudson
    Neuroscience Research Australia, and University of New South Wales, Sydney, Australia
    Respir Physiol Neurobiol 180:263-8. 2012
    ..001). The change in MEP size was not due to differences in pre-stimulus EMG amplitude (p=0.29). The results suggest a differential effect of lung inflation on the automatic and voluntary control of breathing in humans...
  23. pmc The response to paired motor cortical stimuli is abolished at a spinal level during human muscle fatigue
    Chris J McNeil
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, New South Wales 2031, Australia
    J Physiol 587:5601-12. 2009
    ..The spinal mechanisms exposed here may contribute to the development of central fatigue in human muscles...
  24. doi request reprint Unilateral strength training increases voluntary activation of the opposite untrained limb
    Michael Lee
    Health and Exercise Science, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Clin Neurophysiol 120:802-8. 2009
    ..We investigated whether an increase in neural drive from the motor cortex contributes to the cross-limb transfer of strength that can occur after unilateral strength training...
  25. pmc Neural drive to human genioglossus in obstructive sleep apnoea
    Julian P Saboisky
    Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW, 2031, Australia
    J Physiol 585:135-46. 2007
    ..In addition, the differences in the timing and firing frequency of the inspiratory classes of genioglossus motor units indicate that the output of the hypoglossal nucleus may have changed...
  26. doi request reprint Long-interval intracortical inhibition in a human hand muscle
    Chris J McNeil
    Neuroscience Research Australia, Barker Street, Randwick, NSW 2031, Australia
    Exp Brain Res 209:287-97. 2011
    ..Further, because motoneurons are facilitated during contraction but disfacilitated after a strong conditioning stimulus, the standard ratio of LICI is of questionable validity during voluntary contractions...
  27. pmc Activity-dependent depression of the recurrent discharge of human motoneurones after maximal voluntary contractions
    Serajul I Khan
    Neuroscience Research Australia, Barker Street, Randwick, New South Wales, 2031, Australia
    J Physiol 590:4957-69. 2012
    ..Hence, we propose that activity-dependent changes at the soma or the initial segment depress the recurrent discharge of human motoneurones and that this may contribute to central fatigue...
  28. doi request reprint Passive mechanical properties of the gastrocnemius after spinal cord injury
    Joanna H L Diong
    The George Institute for Global Health, Sydney, New South Wales, Australia
    Muscle Nerve 46:237-45. 2012
    ..In this study we compared passive mechanical properties of gastrocnemius muscle-tendon units, muscle fascicles, and tendons in control subjects and people with ankle contractures after spinal cord injury...
  29. doi request reprint Posterolateral surface electrical stimulation of abdominal expiratory muscles to enhance cough in spinal cord injury
    Jane E Butler
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    Neurorehabil Neural Repair 25:158-67. 2011
    ..Spinal cord injury (SCI) patients have respiratory complications because of abdominal muscle weakness and paralysis, which impair the ability to cough...
  30. ncbi request reprint Differential activation among five human inspiratory motoneuron pools during tidal breathing
    Julian P Saboisky
    Prince of Wales Medical Research Inst and University of New South Wales, Sydney, Australia
    J Appl Physiol 102:772-80. 2007
    ..05). There was a unimodal distribution of recruitment times of motor units in all muscles. Neural drive to human inspiratory pump muscles differs in timing, strength, and distribution, presumably to achieve efficient ventilation...
  31. doi request reprint High-frequency submaximal stimulation over muscle evokes centrally generated forces in human upper limb skeletal muscles
    Jean Sébastien Blouin
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney 2031, Australia
    J Appl Physiol (1985) 106:370-7. 2009
    ....
  32. pmc Role of the diaphragm in trunk rotation in humans
    Anna L Hudson
    Neuroscience Research Australia and University of New South Wales, Sydney, Australia
    J Neurophysiol 106:1622-8. 2011
    ....
  33. doi request reprint Interplay between the inspiratory and postural functions of the human parasternal intercostal muscles
    Anna L Hudson
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, New South Wales, Australia
    J Neurophysiol 103:1622-9. 2010
    ..Furthermore the postural and inspiratory drives depolarize the same motoneurons, and the postural contraction of the muscles alters their output during inspiration in a direction-dependent manner...
  34. ncbi request reprint Reproducible measurement of human motoneuron excitability with magnetic stimulation of the corticospinal tract
    Peter G Martin
    Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney NSW 2031 Australia
    J Neurophysiol 102:606-13. 2009
    ..87 and 0.62. These results suggest that responses to magnetic stimulation of the corticospinal tract can be assessed in relaxation and contraction and can be reliably obtained for longitudinal studies of motoneuronal excitability...
  35. ncbi request reprint Reproducibility of the short-latency reflex inhibition to loading of human inspiratory muscles
    Nicholas P S Murray
    Prince of Wales Medical Research Institute, Randwick, NSW, Australia
    Respir Physiol Neurobiol 162:216-22. 2008
    ..7-48%). These results show good measurement reliability. The abnormalities seen in disease are significantly larger than these CVs. The reflex response to airway occlusion may be assessed reliably using our method...
  36. pmc Proprioceptive movement illusions due to prolonged stimulation: reversals and aftereffects
    Tatjana Seizova-Cajic
    School of Psychology, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 2:e1037. 2007
    ..We investigated them using vibration as a stimulus because vibration of muscle tendons results in a powerful illusion of movement...
  37. pmc Effects of aging and sex on voluntary activation and peak relaxation rate of human elbow flexors studied with motor cortical stimulation
    Joery P Molenaar
    Neuroscience Research Australia, Barker Street, Randwick, NSW, 2031, Australia
    Age (Dordr) 35:1327-37. 2013
    ..In contrast, peak relaxation rate was markedly faster in men than women and slowed with age in men but not women. Normalization of relaxation rates to strength did not affect the influence of age or sex...
  38. ncbi request reprint New display of the timing and firing frequency of single motor units
    Julian P Saboisky
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, New South Wales 2031, Australia
    J Neurosci Methods 162:287-92. 2007
    ..This new display provides a simple, qualitative and quantitative tool to study the neural control of rhythmical or repetitive motor tasks...
  39. ncbi request reprint Signals of motor command bias joint position sense in the presence of feedback from proprioceptors
    Janette L Smith
    Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia
    J Appl Physiol (1985) 106:950-8. 2009
    ..7 +/- 4.9 degrees . Before paralysis, isometric efforts changed it by 6.7 +/- 3.6 degrees . Thus all studies concur: when joint movement is prevented, signals of motor command contribute to joint position sense...
  40. ncbi request reprint Diaphragm length and neural drive after lung volume reduction surgery
    Robert B Gorman
    Prince of Wales Medical Research Institute, Barker Street, Sydney, Randwick NSW 2031, Australia
    Am J Respir Crit Care Med 172:1259-66. 2005
    ..Lung volume reduction surgery (LVRS) in patients with chronic obstructive pulmonary disease improves lung function, exercise capacity, and quality of life...
  41. ncbi request reprint Depression of activity in the corticospinal pathway during human motor behavior after strong voluntary contractions
    Nicolas T Petersen
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia 2031
    J Neurosci 23:7974-80. 2003
    ..Our findings support the view that synapses in the corticospinal system are depressed after strong voluntary contractions during both relaxation and activity. Furthermore, this depression can affect the production of voluntary movement...
  42. ncbi request reprint Sustained contraction at very low forces produces prominent supraspinal fatigue in human elbow flexor muscles
    Janette L Smith
    Prince of Wales Medical Research Institute and University of New South Wales, Randwick, New South Wales, Australia
    J Appl Physiol 103:560-8. 2007
    ..The effect of central fatigue on performance of the weak contraction is less clear, but it may contribute to the increase in perceived effort...
  43. pmc Maximal force, voluntary activation and muscle soreness after eccentric damage to human elbow flexor muscles
    O Prasartwuth
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 567:337-48. 2005
    ..The impairment of voluntary activation to nerve stimulation but not motor cortical stimulation suggests that the activation deficit lies in the motor cortex or at a spinal level...
  44. ncbi request reprint Abdominal muscle training can enhance cough after spinal cord injury
    Rachel A McBain
    1Neuroscience Research Australia, Randwick, New South Wales, Australia
    Neurorehabil Neural Repair 27:834-43. 2013
    ..Respiratory complications in people with high-level spinal cord injury (SCI) are a major cause of morbidity and mortality, particularly because of a reduced ability to cough as a result of abdominal muscle paralysis...
  45. doi request reprint Passive mechanical properties of gastrocnemius muscles of people with ankle contracture after stroke
    Li Khim Kwah
    George Institute For Global Health, Sydney, NSW, Australia
    Arch Phys Med Rehabil 93:1185-90. 2012
    ....
  46. pmc Behaviour of the motoneurone pool in a fatiguing submaximal contraction
    Chris J McNeil
    Neuroscience Research Australia, and University of New South Wales, Barker Street, Randwick, New South Wales, Australia, 2031
    J Physiol 589:3533-44. 2011
    ....
  47. doi request reprint Common rostrocaudal gradient of output from human intercostal motoneurones during voluntary and automatic breathing
    Anna L Hudson
    Neuroscience Research Australia, University of New South Wales, Barker St Randwick, Sydney, NSW 2031, Australia
    Respir Physiol Neurobiol 175:20-8. 2011
    ..A rostrocaudal gradient of motor unit activation across parasternal intercostal muscles was preserved in voluntary and involuntary tasks. A common mechanism may mediate this pattern of recruitment...
  48. doi request reprint Facilitation and inhibition of tibialis anterior responses to corticospinal stimulation after maximal voluntary contractions
    Sabine Giesebrecht
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    J Neurophysiol 103:1350-6. 2010
    ..This behavior differs markedly from that in elbow flexor muscles and suggests that activity-dependent changes in the motor pathway may be muscle specific...
  49. doi request reprint Single motor unit recordings in human geniohyoid reveal minimal respiratory activity during quiet breathing
    Elizabeth C Brown
    Neuroscience Research Australia, Barker St, Randwick, NSW, Australia
    J Appl Physiol (1985) 110:1054-9. 2011
    ..In contrast to previous findings, the geniohyoid shows some tonic activity but minimal respiration-related activity in healthy subjects in quiet breathing. The geniohyoid has little active role in airway stability under these conditions...
  50. doi request reprint Cortical voluntary activation can be reliably measured in human wrist extensors using transcranial magnetic stimulation
    Michael Lee
    Health and Exercise Science, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Clin Neurophysiol 119:1130-8. 2008
    ..Here, we described studies designed to test the applicability and reliability of the technique for the human wrist extensors and to provide new evidence regarding the sensitivity of the technique to inadvertent antagonist activation...
  51. ncbi request reprint Reflex inhibition of human inspiratory muscles in response to contralateral phrenic nerve stimulation
    Jane E Butler
    Prince of Wales Medical Research Institute, University of New South Wales, High Street, Randwick NSW 2031, Australia
    Respir Physiol Neurobiol 138:87-96. 2003
    ..The latency of this potent inhibitory response to contralateral phrenic nerve stimulation is too long to be mediated via a simple spinal circuit and may involve a brainstem projection...
  52. pmc The history of contraction of the wrist flexors can change cortical excitability
    Meg Stuart
    School of Biomedical Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia
    J Physiol 545:731-7. 2002
    ....
  53. pmc Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation
    Gabrielle Todd
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney 2031, Australia
    J Physiol 551:661-71. 2003
    ....
  54. ncbi request reprint Reproducible measurement of voluntary activation of human elbow flexors with motor cortical stimulation
    Gabrielle Todd
    Prince of Wales Medical Research Institute, University of Wales, New South Wales 2031, Australia
    J Appl Physiol 97:236-42. 2004
    ..Furthermore, its reliability and variability were similar to the resting twitch estimated from 30 contractions and to that evoked by conventional motor nerve stimulation...
  55. pmc Firing of antagonist small-diameter muscle afferents reduces voluntary activation and torque of elbow flexors
    David S Kennedy
    Neuroscience Research Australia, Randwick, NSW, Australia
    J Physiol 591:3591-604. 2013
    ..Therefore, firing of small-diameter muscle afferents from one muscle can affect voluntary activation and hence torque generation of another muscle in the same limb...
  56. doi request reprint Training in a ballistic task but not a visuomotor task increases responses to stimulation of human corticospinal axons
    Sabine Giesebrecht
    Neuroscience Research Australia, Barker St, Randwick, NSW 2031, Australia
    J Neurophysiol 107:2485-92. 2012
    ..Thus, changes at a spinal level may contribute to improved performance in some motor tasks...
  57. ncbi request reprint Myofascial force transmission between the human soleus and gastrocnemius muscles during passive knee motion
    Maoyi Tian
    Neuroscience Research Australia, Randwick, New South Wales, Australia
    J Appl Physiol (1985) 113:517-23. 2012
    ..The approximate change in passive soleus force as a result of the observed change in fascicle length was estimated and appears to be <5 N, but this estimate is sensitive to the assumed slack length of soleus...
  58. ncbi request reprint Origin of the low-level EMG during the silent period following transcranial magnetic stimulation
    Jane E Butler
    Neuroscience Research Australia, Randwick, NSW 2031, Australia
    Clin Neurophysiol 123:1409-14. 2012
    ..We hypothesised that it arises through spinal reflexes. Sudden lengthening of the muscle as force drops during the silent period could excite muscle spindles and facilitate motoneurones...
  59. pmc Proprioceptive signals contribute to the sense of body ownership
    Lee D Walsh
    Neuroscience Research Australia, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 589:3009-21. 2011
    ..It seems that the congruence of sensory stimuli ismore important to establish body ownership than the presence of multiple sensory signals...
  60. pmc Illusory movements of a phantom hand grade with the duration and magnitude of motor commands
    Lee D Walsh
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, NSW 2031, Australia
    J Physiol 588:1269-80. 2010
    ..Hence, we have shown that motor command signals have a novel proprioceptive role in the perception of movement of human joints...
  61. pmc Overestimation of force during matching of externally generated forces
    Lee D Walsh
    Neuroscience Research Australia, Randwick, Sydney, NSW, Australia
    J Physiol 589:547-57. 2011
    ..We suggest that the two components are generated in different phases of the force-matching task, are due to different processes, and must have an influence on all proprioceptive judgements of force...
  62. ncbi request reprint Respiratory muscle function and activation in chronic obstructive pulmonary disease
    David K McKenzie
    Department of Respiratory and Sleep Medicine, Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Barker St, Randwick, NSW 2031, Australia
    J Appl Physiol (1985) 107:621-9. 2009
    ..The improvement in exercise capacity and dyspnea following lung volume reduction surgery is associated with a substantial reduction in neural drive to the inspiratory muscles...
  63. doi request reprint Altered corticospinal transmission to the hand after maximum voluntary efforts
    Sabine Giesebrecht
    Neuroscience Research Australia and the University of New South Wales, Barker Street, Randwick, Sydney, New South Wales 2031, Australia
    Muscle Nerve 43:679-87. 2011
    ..After maximal voluntary contractions (MVCs), responses to corticospinal tract stimulation change differently in arm and leg muscles. This study we examined responses in the first dorsal interosseous muscle (FDI)...
  64. ncbi request reprint A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions
    Janet L Taylor
    Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 104:542-50. 2008
    ..The best indication that central fatigue is important during submaximal tasks is the disproportionate increase in subjects' perceived effort when maintaining a low target force...
  65. ncbi request reprint Noninvasive stimulation of human corticospinal axons innervating leg muscles
    P G Martin
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Neurophysiol 100:1080-6. 2008
    ..Thus it is possible to examine the excitability of lower limb motoneuron pools to corticospinal inputs without the confounding effects of changes occurring within the motor cortex...
  66. pmc Group III and IV muscle afferents differentially affect the motor cortex and motoneurones in humans
    P G Martin
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW 2031, Australia
    J Physiol 586:1277-89. 2008
    ..05). Activity in group III and IV muscle afferents produced by hypertonic saline facilitates motoneurones innervating elbow flexor and extensor muscles but depresses motor cortical cells projecting to these muscles...
  67. pmc Muscle fatigue changes cutaneous suppression of propriospinal drive to human upper limb muscles
    P G Martin
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 580:211-23. 2007
    ..This pattern of changes may maintain coordination during multimuscle movements when one group of muscles is fatigued...
  68. ncbi request reprint Large involuntary forces consistent with plateau-like behavior of human motoneurons
    D F Collins
    Spinal Injury Research Centre, Prince of Wales Medical Research Institute and University of New South Wales, Randwick, Sydney, Australia 2031
    J Neurosci 21:4059-65. 2001
    ..The phenomenon is consistent with activation of plateau potentials within motoneurons and, if so, the present findings imply that plateau potentials can make a large contribution to forces produced by the human nervous system...
  69. ncbi request reprint Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing
    Julian P Saboisky
    Prince of Wales Medical Research Institute, Randwick, Australia
    J Neurophysiol 95:2213-21. 2006
    ..The presence of different drives to GG implies that complex premotor networks can differentially engage human hypoglossal motoneurons during respiration. This is unlike the ordered recruitment of motor units in limb and axial muscles...
  70. doi request reprint Effect of airway inflammation on short-latency reflex inhibition to inspiratory loading in human scalene muscles
    Nicholas P S Murray
    Neuroscience Research Australia and University of New South Wales, Sydney, Australia
    Respir Physiol Neurobiol 181:148-53. 2012
    ..12), and IR offset 87 vs 90 ms (p=0.23), between the inflamed and well conditions, respectively). There was no difference in any measure of the size of the reflex inhibition...
  71. ncbi request reprint Short-term strength training does not change cortical voluntary activation
    Michael Lee
    Health and Exercise Science, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Med Sci Sports Exerc 41:1452-60. 2009
    ..One hypothesis is that strength increases because of increased neural drive to the trained muscles. Here, we used twitch interpolation to assess voluntary activation before and after a 4-wk strength training program...
  72. pmc The effect of electrical stimulation of the corticospinal tract on motor units of the human biceps brachii
    Nicolas T Petersen
    Prince of Wales Medical Research Institute and University of New South Wales, Randwick, Sydney, Australia
    J Physiol 544:277-84. 2002
    ..We propose that in response to electrical stimulation of the descending tract fibres, biceps motoneurones receive a large excitatory input with minimal dispersion and it presumably contains a dominant monosynaptic component...
  73. pmc Postural control at the human wrist
    John Z Z Chew
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, NSW 2031 Australia
    J Physiol 586:1265-75. 2008
    ..We propose that postural control and movement control are fundamentally different neural processes...
  74. pmc Coupling between mechanical and neural behaviour in the human first dorsal interosseous muscle
    Anna L Hudson
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, NSW, Australia
    J Physiol 587:917-25. 2009
    ..This is linked to changes in neural drive to FDI such that neural drive increases when the mechanical contribution increases, and provides a central mechanism to produce efficient voluntary movements...
  75. doi request reprint Viscous elements have little impact on measured passive length-tension properties of human gastrocnemius muscle-tendon units in vivo
    Maoyi Tian
    Neuroscience Research Australia, The University of New South Wales, Sydney, Australia
    J Biomech 44:1334-9. 2011
    ....
  76. doi request reprint A study using transcranial magnetic stimulation to investigate motor mechanisms in psychomotor retardation in depression
    Colleen K Loo
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Int J Neuropsychopharmacol 11:935-46. 2008
    ..Our study suggests that although the motor pathway from the motor cortex to the muscle is unimpaired, psychomotor retardation in depression is characterized by a reduced ability to drive the motor cortex...
  77. ncbi request reprint Evidence for a supraspinal contribution to human muscle fatigue
    Janet L Taylor
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 33:400-5. 2006
    ..One factor that may contribute to supraspinal fatigue is the firing of fatigue-sensitive muscle afferents that may act to impair voluntary descending drive...
  78. pmc Postural activity of the diaphragm is reduced in humans when respiratory demand increases
    P W Hodges
    Department of Physiology, Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 537:999-1008. 2001
    ..This attenuation can affect the key inspiratory and expiratory muscles and is likely to be co-ordinated at a pre-motoneuronal site...
  79. pmc External perturbation of the trunk in standing humans differentially activates components of the medial back muscles
    G Lorimer Moseley
    Prince of Wales Medical Research Institute, Sydney, Australia
    J Physiol 547:581-7. 2003
    ....
  80. doi request reprint Control of human inspiratory motoneurones during voluntary and involuntary contractions
    Anna L Hudson
    Neuroscience Research Australia and University of New South Wales, Sydney 2031, Australia
    Respir Physiol Neurobiol 179:23-33. 2011
    ....
  81. doi request reprint Voluntary activation of the different compartments of the flexor digitorum profundus
    Hiske van Duinen
    Neuroscience Research Australia and University of New South Wales, Sydney, Australia
    J Neurophysiol 104:3213-21. 2010
    ..When altered mechanical connections between the compartments decrease voluntary force output there is little difference in neural drive...
  82. pmc Motor commands contribute to human position sense
    Simon C Gandevia
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 571:703-10. 2006
    ..These results establish for the first time a definitive role for 'outflow' signals in position sense...
  83. ncbi request reprint Effects of intramuscular anesthesia on the expression of primary and referred pain induced by intramuscular injection of hypertonic saline
    Troy K Rubin
    Prince of Wales Medical Research Institute, Sydney NSW, Australia
    J Pain 10:829-35. 2009
    ..We conclude that the maintenance of referred muscle pain usually depends on ongoing noxious inputs from the site of primary muscle pain...
  84. ncbi request reprint Panic attacks and perception of inspiratory resistive loads in chronic obstructive pulmonary disease
    Nicole Livermore
    Department of Respiratory Medicine, Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia
    Am J Respir Crit Care Med 178:7-12. 2008
    ..In the current study, we examined resistive load perception in patients with COPD with and without panic attacks...
  85. pmc The ipsilateral motor cortex contributes to cross-limb transfer of performance gains after ballistic motor practice
    Michael Lee
    Exercise Physiology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Physiol 588:201-12. 2010
    ..Thus, cortical processes within the untrained hemisphere, ipsilateral to the trained hand, contribute to early retention of ballistic performance gains for the untrained limb...
  86. ncbi request reprint Contralateral effects of unilateral strength training: evidence and possible mechanisms
    Timothy J Carroll
    Health and Exercise Science, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Appl Physiol 101:1514-22. 2006
    ..Although the size of the effect is small and may not be clinically significant, study of the phenomenon provides insight into neural mechanisms associated with exercise and training...
  87. ncbi request reprint Output of human motoneuron pools to corticospinal inputs during voluntary contractions
    P G Martin
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Neurophysiol 95:3512-8. 2006
    ..001). This suggests that motoneuron firing rates are important determinants of evoked output from the motoneuron pool. However, motor cortical output does not appear to be limited at high contraction strengths...
  88. pmc The detection of human finger movement is not facilitated by input from receptors in adjacent digits
    K M Refshauge
    Prince of Wales Medical Research Institute, High St, Randwick, NSW 2031, Australia
    J Physiol 551:371-7. 2003
    ..However, the reduced detection during stimulation of the adjacent digits shows that there is nevertheless some interaction between the various proprioceptive inputs from the digits...
  89. pmc Limited ability to extend the digits of the human hand independently with extensor digitorum
    Hiske van Duinen
    Prince of Wales Medical Research Institute, Barker St, Randwick 2031, NSW, Australia
    J Physiol 587:4799-810. 2009
    ..This level of control of the extrinsic extensor muscles is more independent than the control of the deep extrinsic flexor muscle but less independent than that of the superficial extrinsic flexor muscle...
  90. ncbi request reprint Optimal electrode placement for noninvasive electrical stimulation of human abdominal muscles
    Julianne Lim
    Prince of Wales Medical Research Institute and University of New South Wales, Randwick, Sydney, Australia
    J Appl Physiol 102:1612-7. 2007
    ..The posterolateral stimulation site is the optimal site for generating gastric and esophageal twitch pressures with electrical stimulation...
  91. doi request reprint Stress relaxation of human ankles is only minimally affected by knee and ankle angle
    Maoyi Tian
    Prince of Wales Medical Research Institute, The University of New South Wales, Sydney, Australia
    J Biomech 43:990-3. 2010
    ..Consequently quasi-linear viscoelastic models of the relaxed human ankle can use a common stress relaxation modulus at different knee and ankle angles with minimal error...
  92. pmc Surface functional electrical stimulation of the abdominal muscles to enhance cough and assist tracheostomy decannulation after high-level spinal cord injury
    Bonsan B Lee
    Prince of Wales Spinal Medicine Department, Prince of Wales Hospital, Sydney, New South Wales, Australia
    J Spinal Cord Med 31:78-82. 2008
    ..Evaluation of noninvasive stimulation modalities to augment cough and assist tracheostomy decannulation in high-level tetraplegia...
  93. pmc The output from human inspiratory motoneurone pools
    Jane E Butler
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 586:1257-64. 2008
    ..There is much to be learned about the neural drive to pools of human inspiratory and expiratory muscles, not only during respiratory tasks but also in automatic and volitional tasks, and in diseases that alter the required drive...
  94. pmc The effect of lung volume on the co-ordinated recruitment of scalene and sternomastoid muscles in humans
    Anna L Hudson
    Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW, 2031, Australia
    J Physiol 584:261-70. 2007
    ..Thus, in humans, the mechanism responsible for the differential activation of these two inspiratory muscles has an element that is preset...
  95. ncbi request reprint The effect of high-frequency cutaneous vibration on different inputs subserving detection of joint movement
    N S Weerakkody
    Prince of Wales Medical Research Institute, The University of New South Wales, Barker Street, Randwick, Sydney, 2031, Australia
    Exp Brain Res 197:347-55. 2009
    ..We suggest that activation of PC afferents, either in or near the moving digit, impairs movement detection through an interaction predominantly between the classes of cutaneous afferents...
  96. pmc Impairment of human proprioception by high-frequency cutaneous vibration
    N S Weerakkody
    Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia
    J Physiol 581:971-80. 2007
    ..These findings suggest that stimuli which preferentially activate Pacinian, but not Meissner corpuscles, impair proprioceptive acuity in a movement detection task...
  97. ncbi request reprint Discharge frequencies of single motor units in human diaphragm and parasternal muscles in lying and standing
    J E Butler
    Prince of Wales Medical Research Institute, and University of New South Wales, Sydney, New South Wales 2031, Australia
    J Appl Physiol (1985) 90:147-54. 2001
    ..4%; P < 0.05). We conclude that there is no major difference in the phasic inspiratory drive to the diaphragm with the change in posture...
  98. pmc Sustained contractions produced by plateau-like behaviour in human motoneurones
    D F Collins
    Spinal Injuries Research Centre, Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 538:289-301. 2002
    ..Large forces can be produced through this mechanism. The interaction with volitional drives suggests that plateau behaviour may contribute significantly to the normal output of human motoneurones...
  99. pmc Length-dependent changes in voluntary activation, maximum voluntary torque and twitch responses after eccentric damage in humans
    O Prasartwuth
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Physiol 571:243-52. 2006
    ..Therefore, it appears that both central and peripheral factors limit muscle performance following eccentric damage, with limits to voluntary drive being especially important at short lengths...
  100. pmc Paradoxical muscle contractions and the neural control of movement and balance
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    J Physiol 564:2. 2005
  101. ncbi request reprint Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury
    Sylvia M Gustin
    Department of Anatomy and Histology, F13, The University of Sydney, Sydney, NSW 2006, Australia
    Pain 137:237-44. 2008
    ..The potential mechanisms underlying this sensory enhancement with movement imagery are discussed...