Affiliation: University of Queensland
Gabrielli B, Bokhari F, Ranall M, Oo Z, Stevenson A, Wang W, et al
. Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer. Mol Cancer Ther. 2015;14:2753-61 pubmed publisher
..Here, we show for the first time that targeting of the Aurora A kinase in mice using drugs such as Alisertib results in a curative sterilizing therapy that may be useful in treating HPV-driven cancers. ..
Oo Z, Stevenson A, Proctor M, Daignault S, Walpole S, Lanagan C, et al
. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018;24:2901-2912 pubmed publisher
..The level of endogenous replication is marked by the pRPA2Ser4/8 foci in the untreated tumors, and may be a useful marker of replication stress in vivoClin Cancer Res; 24(12); 2901-12. ©2018 AACR. ..
Stevenson A, Ager E, Proctor M, Å kalamera D, Heaton A, Brown D, et al
. Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo. Sci Rep. 2018;8:5144 pubmed publisher
..These findings indicate these BP compounds may offer a novel anti-microtubule strategy for cancer intervention and provides the basis for further investigation into biomarkers of clinical sensitivity. ..
Pinder A, Loo D, Harrington B, Oakes V, Hill M, Gabrielli B. JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase. Cell Signal. 2015;27:2296-303 pubmed publisher
..Finally, JIP4 is a target for caspase-dependent cleavage in mitotically arrested cells. The role for the PLK1-JIP4 regulated p38MAPK activation in G2 phase is unclear, but it does not affect either progression into or through mitosis. ..
Martin D, Fallaha S, Proctor M, Stevenson A, Perrin L, McMillan N, et al
. Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors. Mol Cancer Ther. 2017;16:1934-1941 pubmed publisher
..This work demonstrates that inhibition of Aurora A and B is required for effective control of HPV-driven cancers by Aurora kinase inhibitors. Mol Cancer Ther; 16(9); 1934-41. ©2017 AACR. ..