Research Topics
| Bryan G FrySummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Early evolution of the venom system in lizards and snakesBryan G Fry
Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
Nature 439:584-8. 2006..These results provide new insights into the evolution of the venom system in squamate reptiles and open new avenues for biomedical research and drug design using hitherto unexplored venom proteins...- Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activityJoanna Pawlak
Department of Biological Sciences, Faculty of Science, National University of Singapore
J Biol Chem 281:29030-41. 2006..Denmotoxin illustrates the relationship between toxin specificity and the primary prey type that constitutes the snake's diet... - Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implicationsBryan G Fry
Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, VIC 3010 Australia
Rapid Commun Mass Spectrom 16:600-8. 2002..Mass profiling of Acanthophis venoms clearly demonstrates the effectiveness of this technique which underpins fundamental studies ranging from chemotaxonomy to drug design... - Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)Bryan G Fry
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Mol Cell Proteomics 7:215-46. 2008.... 
Tentacles of venom: toxic protein convergence in the Kingdom AnimaliaB G Fry
Department of Biochemistry and Molecular Biology, Venomics Research Laboratory, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, 3010, Australia
J Mol Evol 68:311-21. 2009....
A central role for venom in predation by Varanus komodoensis (Komodo Dragon) and the extinct giant Varanus (Megalania) priscusBryan G Fry
Venomics Research Laboratory, Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
Proc Natl Acad Sci U S A 106:8969-74. 2009..Anatomical comparisons of V. komodoensis with V. (Megalania) priscus fossils suggest that the closely related extinct giant was the largest venomous animal to have ever lived...- Evolution and diversification of the Toxicofera reptile venom systemBryan G Fry
Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, 3010, Australia
J Proteomics 72:127-36. 2009.... - The toxicogenomic multiverse: convergent recruitment of proteins into animal venomsBryan G Fry
Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne 3010 Australia
Annu Rev Genomics Hum Genet 10:483-511. 2009..Given the large number of striking similarities between the protein compositions of conventional venoms and hematophagous secretions, we argue that the latter should also fall under the same definition... - Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma)Bryan G Fry
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
Mol Biol Evol 27:395-407. 2010..These results highlight the importance of utilizing evolutionary-based search strategies for biodiscovery and the virtually unexplored potential of lizard venoms in drug design and discovery... - Functional and structural diversification of the Anguimorpha lizard venom systemBryan G Fry
Venomics Research Laboratory, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia
Mol Cell Proteomics 9:2369-90. 2010..The results obtained highlight the importance of utilizing evolution-based search strategies for biodiscovery and emphasize the largely untapped drug design and development potential of lizard venoms... - From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteinsBryan G Fry
Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010 Australia
Genome Res 15:403-20. 2005..However, this study revealed that the toxin types, where the ancestral protein was extensively cysteine cross-linked, were the ones that flourished into functionally diverse, novel toxin multigene families... - Molecular evolution and phylogeny of elapid snake venom three-finger toxinsB G Fry
Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia
J Mol Evol 57:110-29. 2003..It is anticipated that this "three-finger toxin toolkit" will prove to be useful in providing a clearer picture of the diversity of investigational ligands or potential therapeutics available within this important family... - Isolation of a neurotoxin (alpha-colubritoxin) from a nonvenomous colubrid: evidence for early origin of venom in snakesBryan G Fry
Department of Biological Sciences, Faculty of Science, National University of Singapore, 119260 Singapore
J Mol Evol 57:446-52. 2003..These results support the role of venom as a key evolutionary innovation in the early diversification of advanced snakes and provide evidence that forces a fundamental rethink of the very concept of nonvenomous snake... - Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implicationsBryan G Fry
Department of Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia
Rapid Commun Mass Spectrom 17:2047-62. 2003..The data will also be useful in biodiscovery... - The in vitro neurotoxic and myotoxic effects of the venom from the Suta genus (curl snakes) of elapid snakesSanjaya Kuruppu
Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Victoria, Australia
Basic Clin Pharmacol Toxicol 101:407-10. 2007..This effect was not reversed by antivenom (5 units/ml). This study highlights the danger of underestimating the potential severe clinical effects posed by these small but highly venomous snakes... - Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adderJanith C Wickramaratna
Department of Pharmacology, Monash University, Victoria 3800, Australia
Biochem Pharmacol 68:383-94. 2004..While long-chain neurotoxin resistant [3H]-MLA binding in hippocampus homogenate requires further investigation, we have shown that a short-chain (Type I) neurotoxin is capable of fully inhibiting specific [3H]-MLA binding... - In vitro neuromuscular activity of 'colubrid' venoms: clinical and evolutionary implicationsNatalie G Lumsden
Monash Venom Group, Department of Pharmacology, Monash University, Melbourne, Vic. 3800, Australia
Toxicon 43:819-27. 2004..dhara and P. mossambicus venoms. The results demonstrate a hitherto unsuspected diversity of pharmacological actions in all lineages which may have implications ranging from clinical management of envenomings to venom evolution... 
Expression pattern of three-finger toxin and phospholipase A2 genes in the venom glands of two sea snakes, Lapemis curtus and Acalyptophis peronii: comparison of evolution of these toxins in land snakes, sea kraits and sea snakesSusanta Pahari
Protein Science and Conservation Ecology Laboratories, Department of Biological Sciences, National University of Singapore, 117543, Singapore
BMC Evol Biol 7:175. 2007..It is therefore interesting to examine the evolution of toxins in sea snake venoms compared to that of land snakes...- Species-dependent variations in the in vitro myotoxicity of death adder (Acanthophis) venomsJanith C Wickramaratna
Monash Venom Group, Department of Pharmacology, Monash University, Victoria 3800, Australia
Toxicol Sci 74:352-60. 2003..praelongus, A. rugosus, and A. wellsi venoms (50 microg/ml; n=4-7). In conclusion, clinicians may need to be mindful of possible myotoxicity following envenomations by A. praelongus, A. rugosus, A. sp. Seram, and A. wellsi species... - The in vitro neuromuscular activity of Indo-Pacific sea-snake venoms: efficacy of two commercially available antivenomsNavinisha Chetty
Monash Venom Group, Department of Pharmacology, Monash University, Wellington Rd, Clayton, Vic. 3800, Australia
Toxicon 44:193-200. 2004..However, the effects of CSL tiger snake antivenom are more variable... - Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (mangrove catsnake)Natalie G Lumsden
Monash Venom Group, Department of Pharmacology, Monash University, Clayton Vic. 3800, Australia
Toxicon 45:329-34. 2005..This is the first report of such activity for a toxin isolated from snake venom and reinforces the largely untapped potential of colubrid venoms... - Comparison of the in vitro neuromuscular activity of venom from three Australian snakes (Hoplocephalus stephensi, Austrelaps superbus and Notechis scutatus): efficacy of tiger snake antivenomWayne C Hodgson
Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
Clin Exp Pharmacol Physiol 30:127-32. 2003..All venoms (10-100 microg/mL) also displayed signs of in vitro myotoxicity. 4. The results of the present study indicate that all three venoms contain neurotoxic activity that is effectively attenuated by tiger snake antivenom... - Variations in the pharmacological profile of post-synaptic neurotoxins isolated from the venoms of the Papuan (Oxyuranus scutellatus canni) and coastal (Oxyuranus scutellatus scutellatus) taipansRachelle Kornhauser
Monash Venom Group, Department of Pharmacology, Monash University, Victoria 3800, Australia
Neurotoxicology 31:239-43. 2010..The effect of alpha-oxytoxin 1 is atypical of most snake venom post-synaptic neurotoxins displaying a 'competitive' mode of action, whereas alpha-scutoxin 1 possesses pseudo-irreversible or non-competitive activity... - Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteinsDileep G Nair
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
Biochem J 402:93-104. 2007.... - In vitro neurotoxic and myotoxic effects of the venom from the black whip snake (Demansia papuensis)S Kuruppu
Monash Venom Group, Department of Pharmacology, Monash University, Victoria, Australia
Clin Exp Pharmacol Physiol 33:364-8. 2006..This activity was confirmed by histological examination of the muscle. 4. Fractionation and characterization of venom components is required to further investigate the reasons for the weak neurotoxic activity of D. papuensis venom... - Neurotoxic effects of venoms from seven species of Australasian black snakes (Pseudechis): efficacy of black and tiger snake antivenomsSharmaine Ramasamy
Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Australia
Clin Exp Pharmacol Physiol 32:7-12. 2005..porphyriacus (20+/-7%) venoms. 5. We show, for the first time, the presence of neurotoxins in the venom of these related snake species and that this activity is differentially affected by either black snake or tiger snake antivenoms... - Isolation and pharmacological characterization of a phospholipase A2 myotoxin from the venom of the Irian Jayan death adder (Acanthophis rugosus)Janith C Wickramaratna
Monash Venom Group, Department of Pharmacology, P.O. Box 13E, Monash University, Victoria 3800, Australia
Br J Pharmacol 138:333-42. 2003..1 Hz, 0.2 ms, supramaximal V) stimulated CBCNM preparation. 6. In conclusion, clinicians may need to be mindful of possible myotoxicity following death adder envenomation in Irian Jaya... - Ohanin, a novel protein from king cobra venom: its cDNA and genomic organizationYuh Fen Pung
Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543 Singapore
Gene 371:246-56. 2006..Our results indicate that ohanin and vespryns may have evolved from the same ancestral gene as B30.2 domain... - Putting the brakes on snake venom evolution: the unique molecular evolutionary patterns of Aipysurus eydouxii (Marbled sea snake) phospholipase A2 toxinsMin Li
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
Mol Biol Evol 22:934-41. 2005..This is the first case of decelerated evolution of toxins in snake venom... - Toxinology of venoms from five Australian lesser known elapid snakesKyle Pycroft
Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Vic, Australia
Basic Clin Pharmacol Toxicol 111:268-74. 2012..This study demonstrated that these understudied Australian elapids have varying pharmacological activity, with notable in vitro neurotoxicity for four of the venoms, and may produce mild to moderate effects following systemic envenoming... - Eggs-only diet: its implications for the toxin profile changes and ecology of the marbled sea snake (Aipysurus eydouxii)Min Li
Department of Biological Science, Faculty of Science, National University of Singapore, Singapore 119260
J Mol Evol 60:81-9. 2005..It is interesting to note that a potent venom was not maintained for use in defense, thus reinforcing that the primary use of snake venom is for prey capture... - Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequencesB G Fry
Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Parkville, Australia
Mol Biol Evol 21:870-83. 2004..Moreover, they provide a first insight into the composition of the earliest ophidian venoms and point the way toward a research program that could elucidate the functional context of the evolution of the snake venom proteome... - Presynaptic neuromuscular activity of venom from the brown-headed snake (Glyphodon tristis)S Kuruppu
Monash Venom Group, Department of Pharmacology, Monash University, Victoria 3800, Australia
Toxicon 45:383-8. 2005..The phospholipase A inhibitor 4-BPB (1.8 mM) significantly attenuated the inhibition of indirect and direct twitches of the CBCNM preparation, indicating the involvement of a PLA2 component in the toxic action of the venom... - Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisationBryan G Fry
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia
Biochem Biophys Res Commun 327:1011-5. 2005..Thus, these naturally occurring isoforms provide a new platform for further investigation of structure-function relationships of natriuretic peptides... - Evolutionary origin and development of snake fangsFreek J Vonk
Institute of Biology, Leiden University, Kaiserstraat 63, PO Box 9516, 2300 RA, Leiden, The Netherlands
Nature 454:630-3. 2008..This developmental event could have facilitated the massive radiation of advanced snakes in the Cenozoic era, resulting in the spectacular diversity of snakes seen today...