Martyn A French

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. doi request reprint Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to 'protective' human leukocyte antigen-B alleles in HIV controllers
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia
    AIDS 27:519-28. 2013
  2. ncbi request reprint Immune reconstitution inflammatory syndrome: immune restoration disease 20 years on
    Martyn A H French
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
    Med J Aust 196:318-21. 2012
  3. doi request reprint Vaccine-induced IgG2 anti-HIV p24 is associated with control of HIV in patients with a 'high-affinity' FcgammaRIIa genotype
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
    AIDS 24:1983-90. 2010
  4. ncbi request reprint Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy
    Andrew Lim
    School of Surgery and Pathology, University of Western Australia, Rear 50 Murray Street, Perth 6000, Western Australia
    AIDS 21:1525-34. 2007
  5. doi request reprint The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy
    Sonia Fernandez
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Immunol 128:228-37. 2008
  6. ncbi request reprint CXCR4 or CCR5 tropism of human immunodeficiency virus type 1 isolates does not determine the immunological milieu in patients responding to antiretroviral therapy
    Patricia Price
    School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
    Viral Immunol 19:734-40. 2006
  7. doi request reprint CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or gammadelta T-cells, in HIV patients responding to ART
    Sara Tanaskovic
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    Immunol Cell Biol 88:321-7. 2010
  8. ncbi request reprint Interferon-gamma responses to Candida recover slowly or remain low in immunodeficient HIV patients responding to ART
    Kate Burgess
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    J Clin Immunol 26:160-7. 2006
  9. doi request reprint Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy
    Benjamin G Oliver
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    J Infect Dis 202:1728-37. 2010
  10. ncbi request reprint Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy
    Sonia Fernandez
    School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:163-70. 2006

Collaborators

Detail Information

Publications41

  1. doi request reprint Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to 'protective' human leukocyte antigen-B alleles in HIV controllers
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia
    AIDS 27:519-28. 2013
    ..As slower HIV disease progression is associated with high levels of antibodies to HIV Gag proteins, we have examined antibodies to HIV proteins in controllers with and without 'protective' HLA-B alleles...
  2. ncbi request reprint Immune reconstitution inflammatory syndrome: immune restoration disease 20 years on
    Martyn A H French
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
    Med J Aust 196:318-21. 2012
    ..A greater understanding of the immunopathogenesis of IRIS may lead to targeted therapies...
  3. doi request reprint Vaccine-induced IgG2 anti-HIV p24 is associated with control of HIV in patients with a 'high-affinity' FcgammaRIIa genotype
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
    AIDS 24:1983-90. 2010
    ....
  4. ncbi request reprint Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy
    Andrew Lim
    School of Surgery and Pathology, University of Western Australia, Rear 50 Murray Street, Perth 6000, Western Australia
    AIDS 21:1525-34. 2007
    ..Data were compared with established Treg cell markers (FoxP3, CTLA-4 and GITR)...
  5. doi request reprint The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy
    Sonia Fernandez
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Immunol 128:228-37. 2008
    ..015) and levels of IL-10 mRNA were higher in M-DC8(+) cells from low responders (p=0.036). Hence CMV-specific CD4(+) T-cell IFN-gamma responses may be affected by numbers and function of circulating DC...
  6. ncbi request reprint CXCR4 or CCR5 tropism of human immunodeficiency virus type 1 isolates does not determine the immunological milieu in patients responding to antiretroviral therapy
    Patricia Price
    School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
    Viral Immunol 19:734-40. 2006
    ..Levels of LAG-3 (lymphocyte activation gene-3 protein) were elevated in patients with uncontrolled HIV replication. Hence the immunological milieu did not reflect HIV tropism...
  7. doi request reprint CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or gammadelta T-cells, in HIV patients responding to ART
    Sara Tanaskovic
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    Immunol Cell Biol 88:321-7. 2010
    ..In such patients, CD31 expression is unlikely to indicate thymic origin in gammadelta T-cells...
  8. ncbi request reprint Interferon-gamma responses to Candida recover slowly or remain low in immunodeficient HIV patients responding to ART
    Kate Burgess
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    J Clin Immunol 26:160-7. 2006
    ..Slow reconstitution of IFN-gamma responses to CMV and Candida in previously immunodeficient patients with restored CD4+ T-cell counts on CART suggests a broad and nonresolving defect in memory T-cell responses...
  9. doi request reprint Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy
    Benjamin G Oliver
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    J Infect Dis 202:1728-37. 2010
    ..Both conditions appear to be immune restoration disease but their immunopathogenesis is not completely understood...
  10. ncbi request reprint Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy
    Sonia Fernandez
    School of Surgery and Pathology, University of Western Australia, Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, The University of Melbourne, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:163-70. 2006
    ..However, the data are consistent with extrathymic T cell production contributing to the naive T cell pool in some patients...
  11. pmc A T2 cytokine environment may not limit T1 responses in human immunodeficiency virus patients with a favourable response to antiretroviral therapy
    Patricia Price
    School of Surgery and Pathology, University of Western Australia, Australia
    Immunology 119:74-82. 2006
    ..These analyses provide no evidence for an inverse relationship between T1 and T2 cytokine responses in HIV patients, but suggest that the elevation of IgE marks low cytokine responses...
  12. ncbi request reprint CD4+ and CD8+ T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy
    Andrew Lim
    School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Perth, Western Australia 6000, Australia
    J Acquir Immune Defic Syndr 51:248-57. 2009
    ..We assessed whether FoxP3 expression in CD8 T cells is associated with suppressive potential and/or with HIV-associated immune activation...
  13. ncbi request reprint Recovery of CD4+ T Cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genes
    Sonia Fernandez
    Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia, Australia
    J Acquir Immune Defic Syndr 41:1-5. 2006
    ..We suggest that immune activation and/or CD4 T-cell apoptosis in HIV patients on effective ART is influenced by genetic factors...
  14. doi request reprint Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cells
    Lloyd J D'Orsogna
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    Biol Blood Marrow Transplant 15:795-803. 2009
    ..The increased susceptibility of allogeneic HSCT patients to infection may reflect a combination of memory B cell defects, which are most common in patients with a history of GVHD...
  15. ncbi request reprint Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function
    Sonia Fernandez
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
    Clin Immunol 120:163-70. 2006
    ..This was clearest in patients with a small/undetectable thymus. IFN-gamma responses to CMV were similar in patients with low or high CD4(+) T-cell counts...
  16. pmc Immunosenescent CD57+CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART
    Sonia Fernandez
    School of Pathology and Laboratory Medicine, University of Western Australia and PathWest Laboratory Medicine, Perth, Australia
    Dis Markers 31:337-42. 2011
    ..The findings provide evidence of an accumulation of immunosenescent T-cells able to make IFN-γ. This may influence the pathogenesis of secondary viral infections in HIV patients receiving ART...
  17. ncbi request reprint Circulating memory B-cell subpopulations are affected differently by HIV infection and antiretroviral therapy
    Rom G Krueger
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, WA 6847, Australia
    AIDS 21:1747-52. 2007
    ....
  18. doi request reprint CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells
    Sonia Fernandez
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    J Infect Dis 204:1927-35. 2011
    ..Therefore, CD4(+) T-cell recovery may be adversely affected by the effects of IFN-α, which may be amenable to therapeutic intervention...
  19. ncbi request reprint Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapy
    Andrew Y F Lim
    School of Surgery and Pathology, University of Western Australia, Perth, WA, Australia
    Immunol Cell Biol 84:530-6. 2006
    ..Hence, none of the putative Treg cell surface markers identified T-cell populations in peripheral blood that mirrored the effects of HIV infection and antiretroviral therapy on Foxp3 expression...
  20. doi request reprint Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection
    Andrew Lim
    School of Pathology and Laboratory Medicine, University of Western Australia, Australia
    AIDS 25:1379-83. 2011
    ..To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection...
  21. ncbi request reprint HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirus
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
    AIDS 19:555-62. 2005
    ..To assess the frequency and phenotype of cytomegalovirus (CMV)-specific CD8 T cells in previously immunocompromised HIV patients with stable undetectable HIV viremia due to highly active antiretroviral therapy (HAART)...
  22. doi request reprint Tuberculosis after commencing antiretroviral therapy for HIV infection is associated with elevated CXCL9 and CXCL10 responses to Mycobacterium tuberculosis antigens
    Benjamin G Oliver
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    J Acquir Immune Defic Syndr 61:287-92. 2012
    ..We have shown that whole-blood interferon-gamma release assays may aid in the prediction and diagnosis of ART-TB. Here, we investigate interferon-gamma-inducible chemokines CXCL9 and CXCL10...
  23. ncbi request reprint Immune restoration disease: a consequence of dysregulated immune responses after HAART
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    Curr HIV Res 2:235-42. 2004
    ..It is therefore important to understand the immunopathology so that prevention, diagnosis and treatment can be improved...
  24. ncbi request reprint Alleles of the gene encoding IL-1alpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapy
    Patricia Price
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia
    AIDS 18:1495-501. 2004
    ..We investigate whether polymorphisms in cytokine genes affect the control of plasma HIV RNA over 5 years on HAART...
  25. ncbi request reprint Immune restoration disease after antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    AIDS 18:1615-27. 2004
    ..Investigation of strategies to prevent IRD is a priority, particularly in developing countries, and requires the development of risk assessment methods and diagnostic criteria...
  26. doi request reprint Thymic tissue is not evident on high-resolution computed tomography and [¹⁸F]fluoro-deoxy-glucose positron emission tomography scans of aviraemic HIV patients with poor recovery of CD4⁺ T cells
    Sara Tanaskovic
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    AIDS 25:1235-7. 2011
    ..High-resolution computed tomography and PET scans found no residual thymic tissue even though metabolic activity was demonstrable by PET in lymph nodes...
  27. pmc Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection
    Vivek Naranbhai
    aCentre for the AIDS Programme of Research in South Africa bHIV Pathogenesis Programme, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa cNuffield Department of Medicine, University of Oxford, Oxford, UK dDepartment of Infectious Diseases, Monash University and Alfred Hospital eCentre for Biomedical Research, Burnet Institute, Melbourne fSchool of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia gDepartment of Infectious Diseases, Nelson R Mandela School of Medicine hKwaZulu Natal Research Institute for Tuberculosis and HIV K RITH, University of KwaZulu Natal, Durban, South Africa iMax Planck Institute for Infection Biology, Berlin, Germany jMedgar Evers College City University of New York, Brooklyn, New York, USA Vivek Naranbhai and Christina C Chang contributed equally to the writing of the article
    AIDS 28:657-66. 2014
    ....
  28. doi request reprint TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration disease
    Dino B A Tan
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    AIDS 25:1455-60. 2011
    ..Recognition of mycobacteria-associated molecular patterns through toll-like receptors (TLRs) on dendritic cells and monocytes induces cytokine production. Here, we investigate TLR-induced responses in IRD...
  29. doi request reprint Interferon-γ and IL-5 production correlate directly in HIV patients co-infected with mycobacterium tuberculosis with or without immune restoration disease
    Benjamin G Oliver
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    AIDS Res Hum Retroviruses 26:1287-9. 2010
    ..tuberculosis disease or IRD associated with M. tuberculosis upon starting ART...
  30. doi request reprint Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells
    Martyn A French
    School of Pathology and Laboratory Medicine, University of Western Australia, and Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    J Infect Dis 200:1212-5. 2009
    ..Further investigation of the clinical usefulness of assaying immunoglobulin A, neopterin, and sCTLA-4 levels to assess the effectiveness of treatments for human immunodeficiency virus (HIV) disease are warranted...
  31. doi request reprint TB-IRIS after initiation of antiretroviral therapy is associated with expansion of preexistent Th1 responses against Mycobacterium tuberculosis antigens
    Ramachandran Vignesh
    Infectious Diseases Laboratory, YR Gaitonde Centre for AIDS Research and Education YRG CARE, Chennai, India School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD HIV Prevention Research, Beth Israel Deaconess Medical Center, Boston, MA Division of Infectious Diseases, University of California, San Diego, CA and Medical Centre, Centre for AIDS Research and Education, Chennai, India
    J Acquir Immune Defic Syndr 64:241-8. 2013
    ..The role of T-cell responses against Mycobacterium tuberculosis antigens in tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is unclear...
  32. ncbi request reprint Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome
    Christina C Chang
    aDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia bDepartment of Infectious Diseases, King Edward VIII Hospital cHIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa dCentre for Virology, Burnet Institute, Melbourne, Australia eDepartment of Medical Microbiology, National Health Laboratory Services, Inkosi Albert Luthuli Central Hospital Academic Complex fDepartment of Microbiology and Infection Control, School of Laboratory Medicine and Medical Sciences, University of KwaZulu Natal, Durban, South Africa gCentre for Population Health, Burnet Institute, Melbourne, Australia hCentre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa iSchool of Pathology and Laboratory Medicine, University of Western Australia jDepartment of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    AIDS 27:2089-99. 2013
    ..Identifying predictors of C-IRIS could enable risk stratification...
  33. ncbi request reprint Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia
    Curr HIV/AIDS Rep 4:16-21. 2007
    ..Persistent CD4 T-cell deficiency (< 500/microL) affects up to 60% of patients and appears to reflect depletion of the naïve T-cell pool that results from low production and/or increased turnover of cells...
  34. doi request reprint Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence
    Sara Tanaskovic
    aSchool of Pathology and Laboratory Medicine, University of Western Australia bDepartment of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Western Australia, Australia
    AIDS 28:821-30. 2014
    ....
  35. ncbi request reprint Interferon-gamma response by peripheral blood mononuclear cells to hepatitis C virus core antigen is reduced in patients with liver fibrosis
    Mark W Watson
    Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, and School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, Australia
    J Infect Dis 188:1533-6. 2003
    ..IFN-gamma response by PBMCs to HCV core antigen may provide a useful marker of the severity of liver disease in patients with hepatitis C...
  36. doi request reprint Audit of paired anal cytology and histopathology outcomes in patients referred to a public sexual health clinic
    Vincent M Williams
    Western Australian Biomedical Research Institute, Curtin University of Technology, Perth, WA, Australia
    Sex Health 7:346-51. 2010
    ..The level of agreement between anal cytology and histopathology is not clear with only a few studies evaluating the reliability of anal specimen reporting. Australian data in relation to this are limited...
  37. ncbi request reprint Association of increased hepatitis C virus (HCV)-specific IgG and soluble CD26 dipeptidyl peptidase IV enzyme activity with hepatotoxicity after highly active antiretroviral therapy in human immunodeficiency virus-HCV-coinfected patients
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, and Department of Pathology, University of Western Australia, Perth, Australia
    J Infect Dis 186:1498-502. 2002
    ..Thus, hepatotoxicity in HIV-HCV-coinfected patients who respond to HAART is associated with increased HCV-specific immune responses and T cell activation...
  38. pmc Immune restoration diseases reflect diverse immunopathological mechanisms
    Patricia Price
    School of Pathology and Laboratory Medicine, University of Western Australia, Rear 50 Murray Street, Perth 6000, Western Australia, Australia
    Clin Microbiol Rev 22:651-63. 2009
    ..Here we present salient clinical features and review progress toward understanding their pathogeneses...
  39. ncbi request reprint Perinatal HIV transmission and pregnancy outcomes in indigenous women in Western Australia
    Marisa T Gilles
    Combined Universities Centre for Rural Health, Geraldton, WA, Australia
    Aust N Z J Obstet Gynaecol 47:362-7. 2007
    ..Implementation of obstetric and neonatal interventions has reduced mother to child transmission of HIV. Health outcomes for Aboriginal people are often worse than for non-Aboriginal people; was this the case for HIV infection in pregnancy?..
  40. doi request reprint Audit of emergency department assessment and management of patients presenting with community-acquired needle stick injuries
    Antonio Celenza
    University of Western Australia, QEII Medical Centre, Hospital Avenue, Nedlands, WA 6009, Australia
    Aust Health Rev 35:57-62. 2011
    ..To describe characteristics and management of people with community acquired needle stick injuries (CANSI) attending urban emergency departments; and suggest a guideline to improve assessment, management, and documentation...
  41. doi request reprint HIV/AIDS: immune reconstitution inflammatory syndrome: a reappraisal
    Martyn A French
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia
    Clin Infect Dis 48:101-7. 2009
    ..Immune reconstitution after antiretroviral therapy may also be associated with autoimmune disease or sarcoidosis, both of which appear to have an immunopathogenesis that is different from that of IRD...