Research Topics
Genomes and Genes
| Ian H FrazerSummaryAffiliation: University of Queensland Country: Australia Publications
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Detail Information
Publications
Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancerIan H Frazer
Translational Research Institute, The University of Queensland Diamantina Institute, PO Box 6116, Buranda Queensland 4102, Australia
Curr Opin Virol 1:268-79. 2011..Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifically to prevent cancers...
Prevention of cancer through immunization: Prospects and challenges for the 21st centuryIan H Frazer
Diamantina Institute for Cancer Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Eur J Immunol 37:S148-55. 2007....
Autoimmunity and persistent viral infection: two sides of the same coin?Ian H Frazer
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Queensland 4102, Australia
J Autoimmun 31:216-8. 2008..This article discusses Ian Mackay's interests in autoimmunity when I was his assistant physician, and their influence on my group's subsequent research on persistent viral infection...- Measuring serum antibody to human papillomavirus following infection or vaccinationIan H Frazer
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Gynecol Oncol 118:S8-11. 2010.... - HPV immunisation: a significant advance in cancer controlIan H Frazer
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Australia
Gynecol Oncol 107:S1. 2007 - Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responsesGermain J P Fernando
The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia
J Control Release 159:215-21. 2012..Successfully extending these findings to humans with a practical delivery device - like the Nanopatch - could have a huge impact on improving vaccines... - Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiationWenyi Gu
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
Nucleic Acids Res 35:4820-32. 2007..It appears that aa-tRNAs in less-differentiated and differentiated KCs differentially match the PV Nat and Mod L1 mRNAs to regulate their translations in vitro... - Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytesJianmin Ding
Diamantina Institute for Cancer Immunology and Metabolic Medicine, University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Virology 399:46-58. 2010.... - TLR7 stimulation augments T effector-mediated rejection of skin expressing neo-self antigen in keratinocytesJie Zhong
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
Eur J Immunol 38:73-81. 2008..Thus, local pro-inflammatory signalling via TLR7 can promote effector T cell function against skin cells displaying their nominal antigen... - Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skinXianfeng Chen
The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia
J Control Release 158:78-84. 2012.... - Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced hostXiao Song Liu
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia
J Immunol 177:2873-9. 2006..This finding demonstrates a strategy for overcoming inhibition of MHC class I epitopes upon immunization of a host already primed to Ag, which may facilitate immunotherapy for chronic viral infection or cancer... - Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivoKong Nan Zhao
Centre for Immunology and Cancer Research, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
Mol Cell Biol 25:8643-55. 2005..Analysis of two structural proteins of KCs, involucrin and keratin 14, suggests that translation of their mRNAs is also regulated, in association with KC differentiation in vitro, by a similar mechanism... - Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytesJennifer K Broom
Immunology and Metabolic Medicine, The University of Queensland Diamantina Institute for Cancer, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland, Australia
J Invest Dermatol 130:1581-9. 2010..Effective immunotherapy directed at antigens expressed in squamous cancer may therefore be facilitated by induction of tumor antigen-specific CD4 helper T cells, as well as cytotoxic CD8 T cells... - IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed hostXiao Song Liu
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia
J Immunol 171:4765-72. 2003..Induction of virus- or tumor Ag-specific CD8 effector T cells in the partially Ag-primed host may thus be facilitated by local neutralization of IL-10... - Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilizationXianfeng Chen
The University of Queensland, Delivery of Drugs and Genes Group D 2 G 2, Australian Institute for Bioengineering and Nanotechnology, Brisbane
J Control Release 152:349-55. 2011.... - Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigenStephen R Mattarollo
The University of Queensland Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
J Immunol 184:5663-9. 2010..Thus, NKT cells can promote adaptive immunity to cell-associated Ag expressed in skin by local regulation of IFN-gamma production in secondary lymphoid tissue during cross-priming of effector CD8 T cells... - Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skinXianfeng Chen
Delivery of Drugs and Genes Group D 2 G 2, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
J Control Release 139:212-20. 2009..In summary, this paper presents a simple, practical and versatile method to achieve uniform coating on very small and densely packed MPs for a needle-free and targeted vaccine delivery technology... - Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-kappaB-mediated signalling, moderated by TGF-betaMengyong Yan
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Immunol Cell Biol 83:83-91. 2005..LC may resist activation in normal epithelium abundant in TGF-beta, but not in situations in which TGF-beta concentrations are reduced... - Functional memory CD8+ T cells can be generated in vivo without evident T helpMelanie R Andrews
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
Vaccine 23:739-42. 2004..This observation may have implications for the formulation of therapeutic anti-cancer and anti-virus peptide vaccines where a strong induction of CD4 T help would be undesirable... - Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genesNing Xia Fang
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
Virology 365:187-97. 2007..Importantly, the Ca(2+) experimental model provides evidence that mouse primary KCs could be transiently infected by BPV1 virus to express L1 mRNA and protein, which is very useful for future HPV virus infection study... - Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX adjuvant in women with cervical intraepithelial neoplasiaIan H Frazer
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Queensland 4102, Australia
Vaccine 23:172-81. 2004..A study was undertaken to evaluate the safety and immunogenicity of an HPV16 immunotherapeutic consisting of a mixture of HPV16 E6E7 fusion protein and ISCOMATRIX adjuvant (HPV16 Immunotherapeutic) for patients with CIN... - Impaired antigen presentation and effectiveness of combined active/passive immunotherapy for epithelial tumorsKoji Matsumoto
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
J Natl Cancer Inst 96:1611-9. 2004..Thus, effective cancer immunotherapy in humans may need to invoke sufficient effector as well as memory T cells... - Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysisFang Zhou
The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia
Exp Dermatol 18:1053-9. 2009..These results suggest that primary KCs will be susceptible to CTL-mediated apoptosis when endogenous KC antigens are targeted during immunotherapy... - Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation markerBo Li
Diamantina Institute for Cancer Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Differentiation 76:1068-80. 2008..The data suggest that coincident expression of Sp1 with L1 proteins in differentiating KCs is mediated by a calcium-dependent signaling pathway... - NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteinsStephen R Mattarollo
University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
J Immunol 187:1601-8. 2011..Therefore, in the context of viral Ag challenge in the skin, systemic NKT cells limit the capacity for effective priming of adaptive immunity... - Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-gamma-dependent mechanismRachel L de Kluyver
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
J Invest Dermatol 130:1841-8. 2010..Thus, antigen-specific cytotoxic T lymphocytes (CTLs) may mediate destruction of epithelium expressing non-self antigen by eliminating KCs with potential for self-renewal through an IFN-gamma-dependent mechanism... - A combination of local inflammation and central memory T cells potentiates immunotherapy in the skinSalvatore Fiorenza
University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
J Immunol 189:5622-31. 2012..Thus, adoptive T cell therapy efficacy can be enhanced if CD8(+) T cells with a central memory T cell phenotype are transferred, and IL-2 is present with contemporaneous local inflammation... - γδ T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigenAzad Rahimpour
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
J Invest Dermatol 132:1656-64. 2012.... - IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced hostXiao Song Liu
University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
J Immunol 183:51-8. 2009..Systemic inhibition of both IL-10 and IFN-gamma at the time of immunization may therefore facilitate induction of effective immunotherapeutic responses against tumor specific and viral Ags... - Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma productionStephen R Mattarollo
The University of Queensland Diamantina Institute, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
J Immunol 184:1242-50. 2010..Thus, inhibition of NKT cell recruitment or function may enable effective immunity against tumor and viral Ags expressed in epithelial cells... - LPAR1 and ITGA4 regulate peripheral blood monocyte countsNarelle Maugeri
Queensland Institute of Medical Research, Brisbane, Australia
Hum Mutat 32:873-6. 2011..Further studies that investigate the downstream mechanism involved and the impact on immune function are warranted... - Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturationTrina J Stewart
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, QLD 4102, Australia
Immunol Cell Biol 82:455-61. 2004..The requirement for IFN-gamma and perforin also changes with each stage of tumour development. Our data suggest that effective adoptive T-cell therapy of tumour will need to be matched with the stage of tumour development... - Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytesGraham R Leggatt
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
J Leukoc Biol 76:787-95. 2004..These observations are relevant to in vitro expansion of CTL for immunotherapy and strategies to elicit regulatory or therapeutic immunity to neo-self-antigen when central tolerance has eliminated high-avidity, cognate T cells... - Inhibition of early tumor growth requires J alpha 18-positive (natural killer T) cellsTrina J Stewart
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia
Cancer Res 63:3058-60. 2003..This suggests that recruitment/activation of J alpha 18(+) NKT cells is an important consideration during the immune therapy of early stage tumors... - ISCOMATRIX adjuvant: an adjuvant suitable for use in anticancer vaccinesTrina J Stewart
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
Vaccine 22:3738-43. 2004..These findings demonstrate the potential of ISCOMATRIX adjuvant to stimulate both cellular and humoral immune responses to endogenously processed target antigens, and hence is the preferred adjuvant when CTL responses are desirable... - Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4+CD25+ T cellsSharmal Narayan
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
Eur J Immunol 39:481-90. 2009..This may have important consequences for the treatment of cervical pre-cancers and provides a model for understanding differential suppression of T and B lymphocyte subsets by Treg... - tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genesWenyi Gu
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Nucleic Acids Res 32:4448-61. 2004..These findings demonstrate for the first time in eukaryotic cells that translation of the target genes can be differentially influenced by the provision of a single tRNA expression construct... - Common variants in TMPRSS6 are associated with iron status and erythrocyte volumeBeben Benyamin
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 41:1173-5. 2009..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis... - Sequence variants in three loci influence monocyte counts and erythrocyte volumeManuel A R Ferreira
Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
Am J Hum Genet 85:745-9. 2009..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate... - Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejectionJie Zhong
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Immunol Cell Biol 82:577-86. 2004..Therefore, in vitro immune responses and in vivo delayed type hypersensitivity are not surrogate markers for immune responses effective against epithelial cells expressing neoantigens... - IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPSJudy C Peng
Centre for Immunology and Cancer Research, Princes Alexandra Hospital, Brisbane, Queensland, Australia
Immunol Cell Biol 84:227-32. 2006..These observations provide a further genetic control of IL-12p70 regulation and emphasize the complexity of production of this cytokine. They also suggest genotypes that might influence the outcome of DC immunotherapy... - Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytesAllison Choyce
The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
PLoS ONE 8:e57798. 2013..Our data suggests that expression of a single oncoprotein in the epidermis is sufficient for lymphocyte trafficking (including immunosuppressive lymphocytes) to premalignant skin... - Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16Vithagna Khammanivong
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Immunol Cell Biol 81:1-7. 2003..This might be advantageous to the virus. Furthermore here we present a quick and easy method to exhaustively determine CD8 T cell epitopes in proteins using a unique set of overlapping 8, 9 and 10 mer synthetic peptides... - IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytesUsriansyah Hadis
The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
Exp Dermatol 19:723-9. 2010..Enhancing IL-1beta signalling, via blocking of the IL-1 receptor antagonist, may represent an alternative strategy for treatment of HPV16E7-associated cancers... - Route of administration of chimeric BPV1 VLP determines the character of the induced immune responsesXiao Song Liu
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Immunol Cell Biol 80:21-9. 2002..m. or i.r. immunization. Thus, mucosal or systemic immunization with PV VLP induces mucosal CTL responses and this may be important for vaccines for mucosal infection with human papillomaviruses and for other viruses... - Regulation of immune responses to HPV infection and during HPV-directed immunotherapyPurnima Bhat
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
Immunol Rev 239:85-98. 2011..This review describes HPV-specific immune responses induced by viral proteins, their regulation by host and viral factors, and highlights some conclusions from our own recent research... - Interaction of human papillomaviruses with the host immune system: a well evolved relationshipIan H Frazer
The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
Virology 384:410-4. 2009..However, molecular and cellular mechanisms responsible for protection from and clearance of HPV infection are not completely established... - Codon usage bias and A+T content variation in human papillomavirus genomesKong Nan Zhao
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, QLD 4102, Woolloongabba, Australia
Virus Res 98:95-104. 2003.... - Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cellsMengyong Yan
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Australia
Virology 324:297-310. 2004..These data suggest fundamentally different routes of VLP uptake by DC and LC. Despite these differences, VLP taken up by DC and LC were each able to prime naive CD8(+) T cells and induce cytolytic effector T cells in vitro... - Human papillomavirus 16 E7 protein inhibits interferon-γ-mediated enhancement of keratinocyte antigen processing and T-cell lysisFang Zhou
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, QLD, Australia
FEBS J 278:955-63. 2011..Thus, expression of HPV 16 E7 protein in KCs may inhibit enhancement by IFN-γ of KC sensitivity to T-cell lysis, by impairing antigen presentation... - Prevention and treatment of papillomavirus-related cancers through immunizationIan H Frazer
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
Annu Rev Immunol 29:111-38. 2011..HPV prophylactic vaccines are the first vaccines designed to prevent a human cancer and are the practical outcome of a global collaborative effort between basic and applied scientists, clinicians, and industry... - Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse modelHolly J Corbett
Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia
PLoS ONE 5:e13460. 2010.... - Effects of additional sequences directly downstream from the AUG on the expression of GFP geneKong Nan Zhao
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, 4102, Australia
Biochim Biophys Acta 1630:84-95. 2003.... - Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in miceTarl W Prow
The University of Queensland, Delivery of Drugs and Genes Group D2G2, Australian Institute for Bioengineering and Nanotechnology, St Lucia, Queensland 4072, Australia
Small 6:1776-84. 2010..The NP thus offers a needle-free, versatile, highly effective vaccine delivery system that is potentially inexpensive and simple to use... - Advances in prevention of cervical cancer and other human papillomavirus-related diseasesIan H Frazer
University of Queensland, Center for Immunology and Cancer Research, Brisbane, QLD 4072, Australia
Pediatr Infect Dis J 25:S65-81, quiz S82. 2006 - Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptideGraham R Leggatt
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Immunol Cell Biol 80:415-24. 2002..Thus, failure of CTL to eliminate KC expressing endogenous E7, and by inference squamous tumours expressing E7, may reflect the need for a sustained, local inflammatory environment during the immune effector phase... - The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulationGermain J P Fernando
Center for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Eur J Immunol 32:1541-9. 2002.... - Replication of bovine papillomavirus type 1 (BPV-1) DNA in Saccharomyces cerevisiae following infection with BPV-1 virionsKong-Nan Zhao
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
J Virol 76:3359-64. 2002..These data suggest that BPV-1 can infect S. cerevisiae and that BPV-1 episomes can replicate in the infected S. cerevisiae cells... - Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritisLisa Carroll
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia
Arthritis Res Ther 9:R39. 2007..Thus, the RAGE Ser82 allele, associated with enhanced RAGE signaling, does not predispose to CV events in RA. However, treatment of hyperlipidemia with statins reduces the probability of a CV event... - HPV vaccines: the beginning of the end for cervical cancerGraham R Leggatt
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Curr Opin Immunol 19:232-8. 2007..g. transforming growth factor-beta and interleukin-10) and the consequences of antigen presentation by subsets of skin-associated antigen-presenting cells... - Cervical cancer vaccine developmentIan H Frazer
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia
Sex Health 7:230-4. 2010..These vaccines have the potential to reduce the global burden of cervical cancer by up to 70%... - Prevention of cervical cancer through papillomavirus vaccinationIan H Frazer
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
Nat Rev Immunol 4:46-54. 2004..Such vaccines test principles for the growing field of tumour-antigen-specific immunotherapy. This article reviews progress in the field and draws conclusions for the development of future prophylactic and therapeutic viral vaccines... - Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune controlManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Am J Hum Genet 86:88-92. 2010.... - A randomized trial of immunotherapy for persistent genital wartsDavid Jardine
Princess Alexandra Sexual Health, Princess Alexandra Hospital, Brisbane, QLD, Australia
Hum Vaccin Immunother 8:623-9. 2012..To determine whether immunotherapy with HPV6 L1 virus like particles (VLPs) without adjuvant (VLP immunotherapy) reduces recurrence of genital warts following destructive therapy... - Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse modelGermain J P Fernando
Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia
PLoS ONE 5:e10266. 2010..We hypothesized that successful vaccination could be achieved this way with far lower antigen doses than required by the needle and syringe... - Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activityWen Jun Liu
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Virology 301:43-52. 2002..However, this may be insufficient for priming E7 responses in animals with split tolerance to E7 as a consequence of expression of E7 in somatic cells... - Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cellFeng Guang Gao
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
Cancer Res 62:6438-41. 2002..In contrast, effector CTLs do not need T help to kill tumors. These results have implications for induction of tumor immunotherapy by immunization... - Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigenMerja P Ruutu
The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, QLD, Australia Australian Institute for Bioengineering and Nanotechnology AIBN, The University of Queensland, Brisbane, QLD, Australia
Exp Dermatol 20:534-6. 2011..This observation may have implications for selection of sites of skin immunisation and for immunogenicity of infections at skin sites routinely subjected to mechanical stimuli... - Nuclear RelB+ cells are found in normal lymphoid organs and in peripheral tissue in the context of inflammation, but not under normal resting conditionsAngus G Thompson
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Australia
Immunol Cell Biol 80:164-9. 2002..Nuclear RelB+ cells are found in normal lymphoid organs and in peripheral tissue in the context of inflammation, but not under normal resting conditions... - Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1Kong Nan Zhao
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
J Virol 76:12265-73. 2002..Infectivity was blocked by antisera to BPV1 L1 but not antisera to BPV1 E4. We conclude that S. cerevisiae is permissive for the replication of BPV1 virus... - Mutations in TAP genes are common in cervical carcinomasNina L Fowler
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Gynecol Oncol 92:914-21. 2004..02). CONCLUSION: These data suggest that TAP genes may be relevant to evolution of cervical cancer from precursor lesions... - Delivering papillomavirus vaccines when and where they are most neededIan H Frazer
Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4012, Australia
Hum Vaccin 2:227-9. 2006 - Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: immunogenicity and protective efficacy in macaquesC Jane Dale
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Virology 301:176-87. 2002.... - HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole bloodLigia A Pinto
SAIC Frederick, Inc NCI Frederick, Room 120, Building 469, Frederick, MD 21702, USA
Vaccine 23:3555-64. 2005.... - [Immunogenicity study of HPV 6b virus-like particles]Yuehua Liu
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Zhonghua Yi Xue Za Zhi 82:587-9. 2002..Both HPV6b and HPV11 share neutralizing epitopes which are cross-reactive and HPV6b VLP may be used in prophylactic and therapeutic vaccine for HPV6b and/or HPV 11 infections... - Finding a vaccine for human papillomavirusIan H Frazer
Lancet 367:2058-9. 2006