Ian H Frazer

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer
    Ian H Frazer
    Translational Research Institute, The University of Queensland Diamantina Institute, PO Box 6116, Buranda Queensland 4102, Australia
    Curr Opin Virol 1:268-79. 2011
  2. ncbi request reprint Prevention of cancer through immunization: Prospects and challenges for the 21st century
    Ian H Frazer
    Diamantina Institute for Cancer Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Eur J Immunol 37:S148-55. 2007
  3. ncbi request reprint HPV immunisation: a significant advance in cancer control
    Ian H Frazer
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Australia
    Gynecol Oncol 107:S1. 2007
  4. doi request reprint Measuring serum antibody to human papillomavirus following infection or vaccination
    Ian H Frazer
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Gynecol Oncol 118:S8-11. 2010
  5. doi request reprint Autoimmunity and persistent viral infection: two sides of the same coin?
    Ian H Frazer
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Queensland 4102, Australia
    J Autoimmun 31:216-8. 2008
  6. doi request reprint Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses
    Germain J P Fernando
    The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia
    J Control Release 159:215-21. 2012
  7. pmc Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation
    Wenyi Gu
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
    Nucleic Acids Res 35:4820-32. 2007
  8. doi request reprint Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes
    Jianmin Ding
    Diamantina Institute for Cancer Immunology and Metabolic Medicine, University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Virology 399:46-58. 2010
  9. ncbi request reprint TLR7 stimulation augments T effector-mediated rejection of skin expressing neo-self antigen in keratinocytes
    Jie Zhong
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
    Eur J Immunol 38:73-81. 2008
  10. doi request reprint Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin
    Xianfeng Chen
    The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia
    J Control Release 158:78-84. 2012

Detail Information

Publications78

  1. pmc Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer
    Ian H Frazer
    Translational Research Institute, The University of Queensland Diamantina Institute, PO Box 6116, Buranda Queensland 4102, Australia
    Curr Opin Virol 1:268-79. 2011
    ..Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifically to prevent cancers...
  2. ncbi request reprint Prevention of cancer through immunization: Prospects and challenges for the 21st century
    Ian H Frazer
    Diamantina Institute for Cancer Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Eur J Immunol 37:S148-55. 2007
    ....
  3. ncbi request reprint HPV immunisation: a significant advance in cancer control
    Ian H Frazer
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Australia
    Gynecol Oncol 107:S1. 2007
  4. doi request reprint Measuring serum antibody to human papillomavirus following infection or vaccination
    Ian H Frazer
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Gynecol Oncol 118:S8-11. 2010
    ....
  5. doi request reprint Autoimmunity and persistent viral infection: two sides of the same coin?
    Ian H Frazer
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Queensland 4102, Australia
    J Autoimmun 31:216-8. 2008
    ..This article discusses Ian Mackay's interests in autoimmunity when I was his assistant physician, and their influence on my group's subsequent research on persistent viral infection...
  6. doi request reprint Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses
    Germain J P Fernando
    The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia
    J Control Release 159:215-21. 2012
    ..Successfully extending these findings to humans with a practical delivery device - like the Nanopatch - could have a huge impact on improving vaccines...
  7. pmc Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation
    Wenyi Gu
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
    Nucleic Acids Res 35:4820-32. 2007
    ..It appears that aa-tRNAs in less-differentiated and differentiated KCs differentially match the PV Nat and Mod L1 mRNAs to regulate their translations in vitro...
  8. doi request reprint Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes
    Jianmin Ding
    Diamantina Institute for Cancer Immunology and Metabolic Medicine, University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Virology 399:46-58. 2010
    ....
  9. ncbi request reprint TLR7 stimulation augments T effector-mediated rejection of skin expressing neo-self antigen in keratinocytes
    Jie Zhong
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
    Eur J Immunol 38:73-81. 2008
    ..Thus, local pro-inflammatory signalling via TLR7 can promote effector T cell function against skin cells displaying their nominal antigen...
  10. doi request reprint Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin
    Xianfeng Chen
    The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, QLD 4072, Australia
    J Control Release 158:78-84. 2012
    ....
  11. pmc Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes
    Allison Choyce
    The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
    PLoS ONE 8:e57798. 2013
    ..Our data suggests that expression of a single oncoprotein in the epidermis is sufficient for lymphocyte trafficking (including immunosuppressive lymphocytes) to premalignant skin...
  12. ncbi request reprint Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host
    Xiao Song Liu
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia
    J Immunol 177:2873-9. 2006
    ..This finding demonstrates a strategy for overcoming inhibition of MHC class I epitopes upon immunization of a host already primed to Ag, which may facilitate immunotherapy for chronic viral infection or cancer...
  13. ncbi request reprint IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host
    Xiao Song Liu
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia
    J Immunol 171:4765-72. 2003
    ..Induction of virus- or tumor Ag-specific CD8 effector T cells in the partially Ag-primed host may thus be facilitated by local neutralization of IL-10...
  14. doi request reprint Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes
    Jennifer K Broom
    Immunology and Metabolic Medicine, The University of Queensland Diamantina Institute for Cancer, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland, Australia
    J Invest Dermatol 130:1581-9. 2010
    ..Effective immunotherapy directed at antigens expressed in squamous cancer may therefore be facilitated by induction of tumor antigen-specific CD4 helper T cells, as well as cytotoxic CD8 T cells...
  15. pmc Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo
    Kong Nan Zhao
    Centre for Immunology and Cancer Research, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
    Mol Cell Biol 25:8643-55. 2005
    ..Analysis of two structural proteins of KCs, involucrin and keratin 14, suggests that translation of their mRNAs is also regulated, in association with KC differentiation in vitro, by a similar mechanism...
  16. doi request reprint Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization
    Xianfeng Chen
    The University of Queensland, Delivery of Drugs and Genes Group D 2 G 2, Australian Institute for Bioengineering and Nanotechnology, Brisbane
    J Control Release 152:349-55. 2011
    ....
  17. doi request reprint Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin
    Xianfeng Chen
    Delivery of Drugs and Genes Group D 2 G 2, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
    J Control Release 139:212-20. 2009
    ..In summary, this paper presents a simple, practical and versatile method to achieve uniform coating on very small and densely packed MPs for a needle-free and targeted vaccine delivery technology...
  18. ncbi request reprint Functional memory CD8+ T cells can be generated in vivo without evident T help
    Melanie R Andrews
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Vaccine 23:739-42. 2004
    ..This observation may have implications for the formulation of therapeutic anti-cancer and anti-virus peptide vaccines where a strong induction of CD4 T help would be undesirable...
  19. pmc Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen
    Stephen R Mattarollo
    The University of Queensland Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    J Immunol 184:5663-9. 2010
    ..Thus, NKT cells can promote adaptive immunity to cell-associated Ag expressed in skin by local regulation of IFN-gamma production in secondary lymphoid tissue during cross-priming of effector CD8 T cells...
  20. ncbi request reprint Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-kappaB-mediated signalling, moderated by TGF-beta
    Mengyong Yan
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Immunol Cell Biol 83:83-91. 2005
    ..LC may resist activation in normal epithelium abundant in TGF-beta, but not in situations in which TGF-beta concentrations are reduced...
  21. doi request reprint Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis
    Fang Zhou
    The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Exp Dermatol 18:1053-9. 2009
    ..These results suggest that primary KCs will be susceptible to CTL-mediated apoptosis when endogenous KC antigens are targeted during immunotherapy...
  22. doi request reprint Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-gamma-dependent mechanism
    Rachel L de Kluyver
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    J Invest Dermatol 130:1841-8. 2010
    ..Thus, antigen-specific cytotoxic T lymphocytes (CTLs) may mediate destruction of epithelium expressing non-self antigen by eliminating KCs with potential for self-renewal through an IFN-gamma-dependent mechanism...
  23. doi request reprint Up-regulated expression of Sp1 protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker
    Bo Li
    Diamantina Institute for Cancer Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Differentiation 76:1068-80. 2008
    ..The data suggest that coincident expression of Sp1 with L1 proteins in differentiating KCs is mediated by a calcium-dependent signaling pathway...
  24. ncbi request reprint Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX adjuvant in women with cervical intraepithelial neoplasia
    Ian H Frazer
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Queensland 4102, Australia
    Vaccine 23:172-81. 2004
    ..A study was undertaken to evaluate the safety and immunogenicity of an HPV16 immunotherapeutic consisting of a mixture of HPV16 E6E7 fusion protein and ISCOMATRIX adjuvant (HPV16 Immunotherapeutic) for patients with CIN...
  25. pmc NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins
    Stephen R Mattarollo
    University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    J Immunol 187:1601-8. 2011
    ..Therefore, in the context of viral Ag challenge in the skin, systemic NKT cells limit the capacity for effective priming of adaptive immunity...
  26. ncbi request reprint Impaired antigen presentation and effectiveness of combined active/passive immunotherapy for epithelial tumors
    Koji Matsumoto
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
    J Natl Cancer Inst 96:1611-9. 2004
    ..Although immunization with tumor antigens can eliminate many transplantable tumors in animal models, immune effector mechanisms associated with successful immunotherapy of epithelial cancers remain undefined...
  27. ncbi request reprint Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genes
    Ning Xia Fang
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Research Extension, Building 1, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
    Virology 365:187-97. 2007
    ..Importantly, the Ca(2+) experimental model provides evidence that mouse primary KCs could be transiently infected by BPV1 virus to express L1 mRNA and protein, which is very useful for future HPV virus infection study...
  28. ncbi request reprint Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes
    Graham R Leggatt
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    J Leukoc Biol 76:787-95. 2004
    ..These observations are relevant to in vitro expansion of CTL for immunotherapy and strategies to elicit regulatory or therapeutic immunity to neo-self-antigen when central tolerance has eliminated high-avidity, cognate T cells...
  29. pmc A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin
    Salvatore Fiorenza
    University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    J Immunol 189:5622-31. 2012
    ..Thus, adoptive T cell therapy efficacy can be enhanced if CD8(+) T cells with a central memory T cell phenotype are transferred, and IL-2 is present with contemporaneous local inflammation...
  30. pmc γδ T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen
    Azad Rahimpour
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    J Invest Dermatol 132:1656-64. 2012
    ....
  31. doi request reprint LPAR1 and ITGA4 regulate peripheral blood monocyte counts
    Narelle Maugeri
    Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mutat 32:873-6. 2011
    ..Further studies that investigate the downstream mechanism involved and the impact on immune function are warranted...
  32. ncbi request reprint Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation
    Trina J Stewart
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, QLD 4102, Australia
    Immunol Cell Biol 82:455-61. 2004
    ..The requirement for IFN-gamma and perforin also changes with each stage of tumour development. Our data suggest that effective adoptive T-cell therapy of tumour will need to be matched with the stage of tumour development...
  33. doi request reprint IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host
    Xiao Song Liu
    University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
    J Immunol 183:51-8. 2009
    ..Systemic inhibition of both IL-10 and IFN-gamma at the time of immunization may therefore facilitate induction of effective immunotherapeutic responses against tumor specific and viral Ags...
  34. doi request reprint Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production
    Stephen R Mattarollo
    The University of Queensland Diamantina Institute, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    J Immunol 184:1242-50. 2010
    ..Thus, inhibition of NKT cell recruitment or function may enable effective immunity against tumor and viral Ags expressed in epithelial cells...
  35. pmc Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein e7
    Deepak Mittal
    The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
    J Invest Dermatol 133:2686-94. 2013
    ..Our data support a hypothesis that induction of IDO1 in HPV-infected skin contributes to evasion of host immunity. ..
  36. ncbi request reprint Inhibition of early tumor growth requires J alpha 18-positive (natural killer T) cells
    Trina J Stewart
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia
    Cancer Res 63:3058-60. 2003
    ..This suggests that recruitment/activation of J alpha 18(+) NKT cells is an important consideration during the immune therapy of early stage tumors...
  37. ncbi request reprint ISCOMATRIX adjuvant: an adjuvant suitable for use in anticancer vaccines
    Trina J Stewart
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Vaccine 22:3738-43. 2004
    ..These findings demonstrate the potential of ISCOMATRIX adjuvant to stimulate both cellular and humoral immune responses to endogenously processed target antigens, and hence is the preferred adjuvant when CTL responses are desirable...
  38. pmc Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
    Beben Benyamin
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 41:1173-5. 2009
    ..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis...
  39. ncbi request reprint Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection
    Jie Zhong
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Immunol Cell Biol 82:577-86. 2004
    ..Therefore, in vitro immune responses and in vivo delayed type hypersensitivity are not surrogate markers for immune responses effective against epithelial cells expressing neoantigens...
  40. ncbi request reprint IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
    Judy C Peng
    Centre for Immunology and Cancer Research, Princes Alexandra Hospital, Brisbane, Queensland, Australia
    Immunol Cell Biol 84:227-32. 2006
    ..These observations provide a further genetic control of IL-12p70 regulation and emphasize the complexity of production of this cytokine. They also suggest genotypes that might influence the outcome of DC immunotherapy...
  41. doi request reprint Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4+CD25+ T cells
    Sharmal Narayan
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Eur J Immunol 39:481-90. 2009
    ..This may have important consequences for the treatment of cervical pre-cancers and provides a model for understanding differential suppression of T and B lymphocyte subsets by Treg...
  42. pmc Sequence variants in three loci influence monocyte counts and erythrocyte volume
    Manuel A R Ferreira
    Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
    Am J Hum Genet 85:745-9. 2009
    ..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate...
  43. pmc tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genes
    Wenyi Gu
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Nucleic Acids Res 32:4448-61. 2004
    ..These findings demonstrate for the first time in eukaryotic cells that translation of the target genes can be differentially influenced by the provision of a single tRNA expression construct...
  44. ncbi request reprint Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16
    Vithagna Khammanivong
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Immunol Cell Biol 81:1-7. 2003
    ..This might be advantageous to the virus. Furthermore here we present a quick and easy method to exhaustively determine CD8 T cell epitopes in proteins using a unique set of overlapping 8, 9 and 10 mer synthetic peptides...
  45. pmc IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes
    Usriansyah Hadis
    The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
    Exp Dermatol 19:723-9. 2010
    ..Enhancing IL-1beta signalling, via blocking of the IL-1 receptor antagonist, may represent an alternative strategy for treatment of HPV16E7-associated cancers...
  46. ncbi request reprint Route of administration of chimeric BPV1 VLP determines the character of the induced immune responses
    Xiao Song Liu
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Immunol Cell Biol 80:21-9. 2002
    ..m. or i.r. immunization. Thus, mucosal or systemic immunization with PV VLP induces mucosal CTL responses and this may be important for vaccines for mucosal infection with human papillomaviruses and for other viruses...
  47. doi request reprint Interaction of human papillomaviruses with the host immune system: a well evolved relationship
    Ian H Frazer
    The University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
    Virology 384:410-4. 2009
    ..However, molecular and cellular mechanisms responsible for protection from and clearance of HPV infection are not completely established...
  48. doi request reprint Human papillomavirus 16 E7 protein inhibits interferon-γ-mediated enhancement of keratinocyte antigen processing and T-cell lysis
    Fang Zhou
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, QLD, Australia
    FEBS J 278:955-63. 2011
    ..Thus, expression of HPV 16 E7 protein in KCs may inhibit enhancement by IFN-γ of KC sensitivity to T-cell lysis, by impairing antigen presentation...
  49. doi request reprint Regulation of immune responses to HPV infection and during HPV-directed immunotherapy
    Purnima Bhat
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
    Immunol Rev 239:85-98. 2011
    ..This review describes HPV-specific immune responses induced by viral proteins, their regulation by host and viral factors, and highlights some conclusions from our own recent research...
  50. doi request reprint Prevention and treatment of papillomavirus-related cancers through immunization
    Ian H Frazer
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
    Annu Rev Immunol 29:111-38. 2011
    ..HPV prophylactic vaccines are the first vaccines designed to prevent a human cancer and are the practical outcome of a global collaborative effort between basic and applied scientists, clinicians, and industry...
  51. ncbi request reprint Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells
    Mengyong Yan
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Australia
    Virology 324:297-310. 2004
    ..These data suggest fundamentally different routes of VLP uptake by DC and LC. Despite these differences, VLP taken up by DC and LC were each able to prime naive CD8(+) T cells and induce cytolytic effector T cells in vitro...
  52. ncbi request reprint Codon usage bias and A+T content variation in human papillomavirus genomes
    Kong Nan Zhao
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, QLD 4102, Woolloongabba, Australia
    Virus Res 98:95-104. 2003
    ....
  53. doi request reprint Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice
    Tarl W Prow
    The University of Queensland, Delivery of Drugs and Genes Group D2G2, Australian Institute for Bioengineering and Nanotechnology, St Lucia, Queensland 4072, Australia
    Small 6:1776-84. 2010
    ..The NP thus offers a needle-free, versatile, highly effective vaccine delivery system that is potentially inexpensive and simple to use...
  54. pmc Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model
    Holly J Corbett
    Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 5:e13460. 2010
    ....
  55. ncbi request reprint Advances in prevention of cervical cancer and other human papillomavirus-related diseases
    Ian H Frazer
    University of Queensland, Center for Immunology and Cancer Research, Brisbane, QLD 4072, Australia
    Pediatr Infect Dis J 25:S65-81, quiz S82. 2006
  56. pmc Replication of bovine papillomavirus type 1 (BPV-1) DNA in Saccharomyces cerevisiae following infection with BPV-1 virions
    Kong Nan Zhao
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    J Virol 76:3359-64. 2002
    ..These data suggest that BPV-1 can infect S. cerevisiae and that BPV-1 episomes can replicate in the infected S. cerevisiae cells...
  57. ncbi request reprint The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation
    Germain J P Fernando
    Center for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Eur J Immunol 32:1541-9. 2002
    ....
  58. ncbi request reprint Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide
    Graham R Leggatt
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Immunol Cell Biol 80:415-24. 2002
    ..Thus, failure of CTL to eliminate KC expressing endogenous E7, and by inference squamous tumours expressing E7, may reflect the need for a sustained, local inflammatory environment during the immune effector phase...
  59. ncbi request reprint Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell
    Feng Guang Gao
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Cancer Res 62:6438-41. 2002
    ..In contrast, effector CTLs do not need T help to kill tumors. These results have implications for induction of tumor immunotherapy by immunization...
  60. ncbi request reprint Effects of additional sequences directly downstream from the AUG on the expression of GFP gene
    Kong Nan Zhao
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, 4102, Australia
    Biochim Biophys Acta 1630:84-95. 2003
    ....
  61. pmc Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis
    Lisa Carroll
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia
    Arthritis Res Ther 9:R39. 2007
    ..Thus, the RAGE Ser82 allele, associated with enhanced RAGE signaling, does not predispose to CV events in RA. However, treatment of hyperlipidemia with statins reduces the probability of a CV event...
  62. ncbi request reprint Prevention of cervical cancer through papillomavirus vaccination
    Ian H Frazer
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia
    Nat Rev Immunol 4:46-54. 2004
    ..Such vaccines test principles for the growing field of tumour-antigen-specific immunotherapy. This article reviews progress in the field and draws conclusions for the development of future prophylactic and therapeutic viral vaccines...
  63. pmc Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Am J Hum Genet 86:88-92. 2010
    ....
  64. ncbi request reprint HPV vaccines: the beginning of the end for cervical cancer
    Graham R Leggatt
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Curr Opin Immunol 19:232-8. 2007
    ..g. transforming growth factor-beta and interleukin-10) and the consequences of antigen presentation by subsets of skin-associated antigen-presenting cells...
  65. doi request reprint Cervical cancer vaccine development
    Ian H Frazer
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia
    Sex Health 7:230-4. 2010
    ..These vaccines have the potential to reduce the global burden of cervical cancer by up to 70%...
  66. pmc A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice
    Julie L Dutton
    Coridon Pty Ltd, Brisbane, Queensland, Australia
    PLoS ONE 8:e76407. 2013
    ....
  67. pmc A randomized trial of immunotherapy for persistent genital warts
    David Jardine
    Princess Alexandra Sexual Health, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Hum Vaccin Immunother 8:623-9. 2012
    ..To determine whether immunotherapy with HPV6 L1 virus like particles (VLPs) without adjuvant (VLP immunotherapy) reduces recurrence of genital warts following destructive therapy...
  68. doi request reprint Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen
    Merja P Ruutu
    The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, QLD, Australia Australian Institute for Bioengineering and Nanotechnology AIBN, The University of Queensland, Brisbane, QLD, Australia
    Exp Dermatol 20:534-6. 2011
    ..This observation may have implications for selection of sites of skin immunisation and for immunogenicity of infections at skin sites routinely subjected to mechanical stimuli...
  69. pmc Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model
    Germain J P Fernando
    Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 5:e10266. 2010
    ..We hypothesized that successful vaccination could be achieved this way with far lower antigen doses than required by the needle and syringe...
  70. ncbi request reprint Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity
    Wen Jun Liu
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Virology 301:43-52. 2002
    ..However, this may be insufficient for priming E7 responses in animals with split tolerance to E7 as a consequence of expression of E7 in somatic cells...
  71. ncbi request reprint Nuclear RelB+ cells are found in normal lymphoid organs and in peripheral tissue in the context of inflammation, but not under normal resting conditions
    Angus G Thompson
    Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Australia
    Immunol Cell Biol 80:164-9. 2002
    ..Nuclear RelB+ cells are found in normal lymphoid organs and in peripheral tissue in the context of inflammation, but not under normal resting conditions...
  72. ncbi request reprint Delivering papillomavirus vaccines when and where they are most needed
    Ian H Frazer
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4012, Australia
    Hum Vaccin 2:227-9. 2006
  73. ncbi request reprint Mutations in TAP genes are common in cervical carcinomas
    Nina L Fowler
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Gynecol Oncol 92:914-21. 2004
    ..To determine whether squamous cervical cancers exhibit mutations or deletions in MHC class I genes or transport-associated protein (TAP) genes...
  74. pmc Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1
    Kong Nan Zhao
    Centre for Immunology and Cancer Research, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    J Virol 76:12265-73. 2002
    ..Infectivity was blocked by antisera to BPV1 L1 but not antisera to BPV1 E4. We conclude that S. cerevisiae is permissive for the replication of BPV1 virus...
  75. ncbi request reprint Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: immunogenicity and protective efficacy in macaques
    C Jane Dale
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Virology 301:176-87. 2002
    ....
  76. ncbi request reprint HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood
    Ligia A Pinto
    SAIC Frederick, Inc NCI Frederick, Room 120, Building 469, Frederick, MD 21702, USA
    Vaccine 23:3555-64. 2005
    ....
  77. ncbi request reprint [Immunogenicity study of HPV 6b virus-like particles]
    Yuehua Liu
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 82:587-9. 2002
    ..To confirm human papillomavirus (HPV) 6b virus-like particles (VLP) have strong immunogenicity and the protective antibody induced by HPV 6b VLP have cross-reactive immunity against HPV11 VLP and bovine papillomavirus (BPV) 1 VLP...
  78. ncbi request reprint Finding a vaccine for human papillomavirus
    Ian H Frazer
    Lancet 367:2058-9. 2006