Research Topics
| A FornitoSummaryAffiliation: University of Melbourne Country: Australia Publications
| Collaborators
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Detail Information
Publications
Schizophrenia, neuroimaging and connectomicsAlex Fornito
Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
Neuroimage 62:2296-314. 2012....
Competitive and cooperative dynamics of large-scale brain functional networks supporting recollectionAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Victoria 3053, Australia
Proc Natl Acad Sci U S A 109:12788-93. 2012..Our findings highlight the dynamic, context-dependent nature of large-scale brain dynamics and shed light on their contribution to individual differences in behavior...- Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individualsAlex Fornito
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, Victoria, Australia
Biol Psychiatry 64:758-65. 2008..In this study, we characterized prepsychotic ACC abnormalities in a sample of individuals at ultra-high-risk (UHR) for psychosis... - Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studiesA Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
Schizophr Res 108:104-13. 2009.... - Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathologyAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Schizophr Bull 35:973-93. 2009..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research... - Reconciling neuroimaging and neuropathological findings in schizophrenia and bipolar disorderAlex Fornito
Faculty of Medicine, Dentistry and Health Science, Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne, Parkville, Victoria, Australia
Curr Opin Psychiatry 22:312-9. 2009..In this study, we overview recent sMRI findings in schizophrenia and bipolar disorder and consider how they relate to neuropathological data... - Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorderAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, School of Behavioural Science, University of Melbourne, National Neuroscience Facility, 161 Barry Street, Carlton South, VIC 3053, Australia
Br J Psychiatry 194:426-33. 2009.... - Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorderAlex Fornito
Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
Psychiatry Res 162:123-32. 2008..These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences... 
In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorderA Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Vic, Australia
Acta Psychiatr Scand 116:467-72. 2007..We investigated the evidence for early neurodevelopmental anomalies in the ACC and adjacent paracingulate cortex (PaC) of BD patients by studying cortical folding patterns of the region...- Variability of the paracingulate sulcus and morphometry of the medial frontal cortex: associations with cortical thickness, surface area, volume, and sulcal depthAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Hum Brain Mapp 29:222-36. 2008.... - Genetic influences on cost-efficient organization of human cortical functional networksAlex Fornito
Brain Mapping Unit, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 31:3261-70. 2011.... - Surface-based morphometry of the anterior cingulate cortex in first episode schizophreniaAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
Hum Brain Mapp 29:478-89. 2008.... - Characterizing anterior cingulate activation in chronic schizophrenia: a group and single-subject fMRI studyB J Harrison
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia
Acta Psychiatr Scand 116:271-9. 2007..In this study, we sought to further evaluate the notion of dAC hypofunction in chronic schizophrenia patients using a cognitive task specifically designed to activate this region, enabling both group and single-subject level analyses... - A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addictionM Yucel
ORYGEN Research Centre, Melbourne, Vic, Australia
Mol Psychiatry 12:611, 691-702. 2007.... - A disturbed sense of self in the psychosis prodrome: linking phenomenology and neurobiologyB Nelson
Orygen Youth Health Research Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Neurosci Biobehav Rev 33:807-17. 2009..Further empirical work examining the relationship between neurobiological and phenomenological variables may be of value in identifying risk markers for psychosis onset... - Major psychoses with mixed psychotic and mood symptoms: are mixed psychoses associated with different neurobiological markers?E Bora
Department of Psychiatry, Melbourne Neuropsychiatry Centre, and Melbourne Health, ORYGEN Research Centre, The University of Melbourne, Melbourne, Vic, Australia
Acta Psychiatr Scand 118:172-87. 2008..As controversies mainly arise in mixed psychoses that occupy the intermediate zone between schizophrenia and BD, investigating neurobiological markers of mixed psychoses may be relevant to understanding the nature of psychotic disorders... - Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studiesValentina Lorenzetti
Melbourne Neuropsychiatry Centre, Department of Psychiatry, Australia
J Affect Disord 117:1-17. 2009..While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear... - Anterior cingulate activation in antipsychotic-naïve first-episode schizophreniaM Yucel
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Carlton South, VIC 3053, Australia
Acta Psychiatr Scand 115:155-8. 2007..Anterior cingulate (ACC) hypo-activity is commonly observed in chronically ill schizophrenia patients. However, it is unclear whether this is secondary to persistent illness and/or medication... - A DTI-derived measure of cortico-cortical connectivityAndrew Zalesky
Melbourne Neuropsychiatry Centre, University ofMelbourne, 3053 Carlton South, Australia
IEEE Trans Med Imaging 28:1023-36. 2009..Finally, we present connectivity maps of some notoriously difficult to track longitudinal and contralateral fasciculi... - Anterior cingulate volume in adolescents with first-presentation borderline personality disorderSarah Whittle
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Psychiatry Res 172:155-60. 2009..Longitudinal studies are needed to examine the nature of this abnormality over the course of the disorder... - White-matter abnormalities in adolescents with long-term inhalant and cannabis use: a diffusion magnetic resonance imaging studyMurat Yucel
Orygen Youth Health Research Centre, 35 Poplar Rd, Parkville, Victoria 3052, Australia
J Psychiatry Neurosci 35:409-12. 2010.... - Network-based statistic: identifying differences in brain networksAndrew Zalesky
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Australia
Neuroimage 53:1197-207. 2010.... - Whole-brain anatomical networks: does the choice of nodes matter?Andrew Zalesky
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Neuroimage 50:970-83. 2010..9 vs. sigma(4000)=53.6+/-2.2). These findings indicate that any comparison of network parameters across studies must be made with reference to the spatial scale of the nodal parcellation... - Regional brain abnormalities associated with long-term heavy cannabis useMurat Yucel
MAPS, ORYGEN Research Centre, 35 Poplar Rd, Melbourne, Victoria, Australia
Arch Gen Psychiatry 65:694-701. 2008..Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examining its long-term effect on the human brain... - State, trait and biochemical influences on human anterior cingulate functionMurat Yucel
Melbourne Neuropsychiatry Centre, Australia
Neuroimage 34:1766-73. 2007..They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships... - Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorderMurat Yucel
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
Arch Gen Psychiatry 64:946-55. 2007..However, the precise regions and the neural alterations associated with this abnormality remain unclear... - Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic riskStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
Schizophr Bull 34:322-9. 2008..Active changes during transition to illness may present the potential to intervene and ameliorate these changes with potential benefit clinically... - Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivityMarc L Seal
Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia
Schizophr Res 101:106-10. 2008..This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage... - Modulation of brain resting-state networks by sad mood inductionBen J Harrison
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
PLoS ONE 3:e1794. 2008..While these 'resting-state networks' may be relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state of subjects during scanning... - Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorderMurat Yucel
Melbourne Neuropsychiatry Centre, National Neuroscience Facility, Carlton South, Australia
Aust N Z J Psychiatry 42:467-77. 2008..The purpose of the present study was to investigate how ACC biochemistry in OCD varies as a function of gender, hemisphere, subregion, and symptomatology... - Morphology of the paracingulate sulcus and executive cognition in schizophreniaAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, National Neuroscience Facility, Levels 2 and 3, Alan Gilbert Building, 161 Barry St, Carlton South, Victoria 3053, Australia
Schizophr Res 88:192-7. 2006..This suggests that prior reports of impaired performance on such tasks in schizophrenia may be partly explained by the reduced frequency of a leftward PCS asymmetry in this population... - The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortexAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia
Neuroimage 33:843-54. 2006.... - A tale of two cities: a neuroimaging investigation of Melbourne-Sydney rivalry comparing cortical thickness in healthy adultsDennis Velakoulis
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Vic, Australia
Australas Psychiatry 15:67-71. 2007..We sought to identify neurobiological correlates of Melbourne-Sydney rivalry through neuroimaging measures of a key brain region involved in cognitive and emotional regulation... - Evidence for neuronal dysfunction in the anterior cingulate of patients with schizophrenia: a proton magnetic resonance spectroscopy study at 3 TStephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia
Schizophr Res 94:328-31. 2007..Anterior cingulate involvement in schizophrenia is likely to be a result of neuronal loss or dysfunction... - Voxelwise meta-analysis of gray matter abnormalities in bipolar disorderEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia
Biol Psychiatry 67:1097-105. 2010..We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition... - Neuroanatomical correlates of temperament in early adolescentsSarah Whittle
Department of Psychiatry, University of Melbourne, Victoria 3052, Australia
J Am Acad Child Adolesc Psychiatry 47:682-93. 2008..In the present study, we examined the relation between four core temperament dimensions and anatomically defined regions of the limbic and prefrontal cortices... - Prefrontal and amygdala volumes are related to adolescents' affective behaviors during parent-adolescent interactionsSarah Whittle
ORYGEN Research Centre, University of Melbourne, Parkville 3052, Victoria, Australia
Proc Natl Acad Sci U S A 105:3652-7. 2008..Particularly as adolescence marks a period of rapid brain maturation, our findings have implications for mental health outcomes that may be revealed later along the developmental trajectory... - Generic aspects of complexity in brain imaging data and other biological systemsEd Bullmore
Behavioural and Clinical Neurosciences Institute, University of Cambridge, Department of Psychiatry, Addenbrooke s, Hospital, Cambridge, UK
Neuroimage 47:1125-34. 2009..The aim is to provide a didactic, focussed and user-friendly introduction to the concepts of complexity science for neuroscientists and neuroimagers... - Pituitary gland volume in currently depressed and remitted depressed patientsValentina Lorenzetti
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC Australia
Psychiatry Res 172:55-60. 2009..In conclusion, PGV does not appear to be a marker of current or past MDD in adult patients... - Variations in cortical folding patterns are related to individual differences in temperamentSarah Whittle
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Psychiatry Res 172:68-74. 2009..These findings suggest that early neurodevelopmental processes contribute to individual differences in temperament. They also illustrate sexual dimorphisms in the neural underpinnings of temperament...