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Genomes and Genes | Leon FlickerSummaryAffiliation: University of Western Australia Country: Australia Publications
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Publications
Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)--PACE AD: study protocol for a randomised controlled trialMandy R Vidovich
Western Australia Centre for Health and Ageing WACHA, School of Psychiatry and Clinical Neurosciences and Centre for Medical Research, University of Western Australia and Royal Perth Hospital, Australia
Trials 12:47. 2011....- The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's diseaseElizabeth V Cyarto
National Ageing Research Institute, Melbourne, Australia
Trials 11:120. 2010..This paper describes the background, objectives of the study, and an overview of the protocol including design, organization and data collection methods... - A multi-faceted intervention to implement guideline care and improve quality of care for older people who present to the emergency department with fallsNicholas Waldron
Department of Rehabilitation and Aged Care, Sir Charles Gairdner Hospital, Perth, Australia
BMC Geriatr 11:6. 2011..We aimed to improve the delivery of evidence based care to patients presenting to the Emergency Department (ED) following a fall... - Screening for pre-clinical disability in different residential settingsKate Gibson
1Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
BMC Geriatr 10:52. 2010.... 
Modifiable lifestyle risk factors for Alzheimer's diseaseLeon Flicker
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research and Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
J Alzheimers Dis 20:803-11. 2010..For many of these modifiable lifestyle factors, such trials may never be performed, and an individual's choice may need to be based on the available evidence...- Body mass index and survival in men and women aged 70 to 75Leon Flicker
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
J Am Geriatr Soc 58:234-41. 2010..To examine in an older population all-cause and cause-specific mortality associated with underweight (body mass index (BMI)<18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25.0-29.9), and obesity (BMI> or =30.0)... - Cardiovascular risk factors, cerebrovascular disease burden, and healthy brain agingLeon Flicker
Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Clin Geriatr Med 26:17-27. 2010..However, as there are considerable other health benefits from targeting cardiovascular risk factors, these interventions should be more widely adopted, which would also probably result in positive outcomes for the brain... - Anxiety, depression, and comorbid anxiety and depression: risk factors and outcome over two yearsOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
Int Psychogeriatr 24:1622-32. 2012..This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months... - A randomized trial to reduce the prevalence of depression and self-harm behavior in older primary care patientsOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
Ann Fam Med 10:347-56. 2012..We wanted to determine whether an educational intervention targeting general practitioners reduces the 2-year prevalence of depression and self-harm behavior among their older patients... - The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later lifeAndrew H Ford
Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia
Trials 11:8. 2010..We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment... - Dementia in residential care: education intervention trial (DIRECT); protocol for a randomised controlled trialChristopher D Beer
WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
Trials 11:63. 2010..The DIRECT study will determine if delivery of education to General Practitioners (GPs) and care staff improves the quality of life of residential care recipients with cognitive impairment... - Higher luteinizing hormone is associated with poor memory recall: the health in men studyZoe Hyde
Western Australian Institute for Medical Research, Australia
J Alzheimers Dis 19:943-51. 2010..These findings suggest a role for both androgens and gonadotropins in differing cognitive domains, and that gonadotropins may influence cognition independent of sex steroids... - Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
Clin Endocrinol (Oxf) 70:455-63. 2009..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men... - Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men StudyBu B Yeap
School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia
J Clin Endocrinol Metab 97:E2230-7. 2012..Both hypothyroidism and subclinical hyperthyroidism hinder cognitive function... - A cluster-randomised trial of staff education to improve the quality of life of people with dementia living in residential care: the DIRECT studyChristopher Beer
WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
PLoS ONE 6:e28155. 2011.... - Factors associated with self and informant ratings of the quality of life of people with dementia living in care facilities: a cross sectional studyChristopher Beer
WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
PLoS ONE 5:e15621. 2010..We undertook the present study to describe and determine the factors associated with ratings of the quality of life of a cohort of people with dementia living in a residential care facility... - Homocysteine and depression in later lifeOsvaldo P Almeida
FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
Arch Gen Psychiatry 65:1286-94. 2008..Genetic association studies are not prone to the same sources of error and offer an opportunity to explore the consistency and external validity of this association... - Factors associated with suicidal thoughts in a large community study of older adultsOsvaldo P Almeida
Western Australia Centre for Health and Ageing M573, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
Br J Psychiatry 201:466-72. 2012..Thoughts about death and self-harm in old age have been commonly associated with the presence of depression, but other risk factors may also be important... - Elevated homocysteine is associated with poorer self-perceived physical health in older men: the Health in Men StudyYuen Y E Wong
Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, Perth, WA, Australia
Maturitas 73:158-63. 2012.... - Older men who use computers have lower risk of dementiaOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
PLoS ONE 7:e44239. 2012..To determine if older men who use computers have lower risk of developing dementia... - Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men StudyZoe Hyde
Western Australian Centre for Health and Ageing, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
J Clin Endocrinol Metab 97:179-89. 2012..Low testosterone is associated with all-cause mortality, but the relationship with cause-specific mortality is uncertain... - Falls, injuries from falls, health related quality of life and mortality in older adults with vision and hearing impairment--is there a gender difference?Derrick Lopez
Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
Maturitas 69:359-64. 2011..Our objective was to determine if there are gender differences in the associations between visual and hearing impairment and these outcomes... - Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational studyChristopher Beer
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, WA, Australia
Br J Clin Pharmacol 71:592-9. 2011..To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes... 
The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS)Osvaldo P Almeida
WA Centre for Health and Ageing, University of Western Australia, Australia
Psychol Med 37:1775-86. 2007..This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account...- Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
Eur J Endocrinol 161:591-8. 2009..We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity... - Successful mental health aging: results from a longitudinal study of older Australian menOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, WA 6009, Australia
Am J Geriatr Psychiatry 14:27-35. 2006..The authors investigated the associations of medical and lifestyle factors with the mental health of men in their 80s... - Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementiaAndrew H Ford
School of Psychiatry and Clinical Neurosciences M573, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
J Neurol Neurosurg Psychiatry 83:70-5. 2012..The authors designed this longitudinal study to determine if high tHcy and the MTHFR C677T polymorphism increase the risk of incident dementia among older men... - Higher free thyroxine levels are associated with frailty in older men: the Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
Clin Endocrinol (Oxf) 76:741-8. 2012..Some symptoms of frailty overlap those of thyroid dysfunction, but it is unclear whether differences in thyroid status influence risk of frailty. We evaluated associations between thyroid status and frailty in older men... - Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older menBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Eur J Endocrinol 166:191-7. 2012..However, the relationship of the IGF1 system with aortic dilation and AAA is unclear. We tested the hypothesis that circulating IGF1 and IGFBPs are associated with AAA and aortic diameter in older men... - Two-year course of cognitive function and mood in adults with congestive heart failure and coronary artery disease: the Heart-Mind StudyOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
Int Psychogeriatr 24:38-47. 2012..We designed this study to determine if adults with CHF show evidence of cognitive decline compared with adults with and without coronary artery disease (CAD)... - Low free testosterone predicts frailty in older men: the health in men studyZoe Hyde
Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
J Clin Endocrinol Metab 95:3165-72. 2010..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome... - B-vitamins reduce plasma levels of beta amyloidLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Australia
Neurobiol Aging 29:303-5. 2008..E.) increase of A beta 40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD... - Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men studyOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
Am J Geriatr Psychiatry 17:889-98. 2009.... - Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Eur J Endocrinol 164:715-23. 2011..We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular mortality in older men... - Use of emergency departments by older people from residential care: a population based studySharyn L Ingarfield
Emergency Medicine, School of Primary, Aboriginal and Rural Health Care, The University of Western Australia, Australia
Age Ageing 38:314-8. 2009..to investigate the differences between emergency department (ED) presentations of older people who do and do not live in residential care facilities (RCFs)... - Alcohol use and mortality in older men and womenKieran A McCaul
Western Australian Centre for Health and Ageing, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
Addiction 105:1391-400. 2010..To compare the effect of alcohol intake on 10-year mortality for men and women over the age of 65 years... - Thyroid hormones and depression: the Health in Men studyOsvaldo P Almeida
WA Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, WA
Am J Geriatr Psychiatry 19:763-70. 2011..Current practice guidelines suggest that thyroid function tests should be an integral part of the assessment of adults presenting with a depressive episode, although there is a paucity of data available to support such a recommendation... - Prevalence of sexual activity and associated factors in men aged 75 to 95 years: a cohort studyZoe Hyde
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, School of Medicine and Pharmacology, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
Ann Intern Med 153:693-702. 2010..Knowledge about sexuality in elderly persons is limited, and normative data are lacking... - Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trialNicola T Lautenschlager
WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
JAMA 300:1027-37. 2008..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking... - 24-month effect of smoking cessation on cognitive function and brain structure in later lifeOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Crawley, Perth, WA, Australia
Neuroimage 55:1480-9. 2011..We completed this trial to determine if smoking cessation decreases the progression of cognitive decline in later life... - A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and older: effect on mood, cognition and quality of lifeOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, The University of Western Australia M573, 35 Stirling Highway, Crawley, and Department of Psychiatry, Royal Perth Hospital, Perth, WA, Australia
Neurobiol Aging 27:141-9. 2006..Other more efficacious and safer interventions need to be devised with the aim of improving the mental state and quality of life of older women... - 'Gotta be sit down and worked out together': views of Aboriginal caregivers and service providers on ways to improve dementia care for Aboriginal AustraliansKate Smith
WA Centre for Health and Ageing, University of WA, Perth, Western Australia, Australia
Rural Remote Health 11:1650. 2011..The objective of this study was to determine ways to overcome factors affecting the successful delivery of services to Aboriginal people with dementia living in remote communities, and to their families and communities... - Traditional risk factors for incident cardiovascular events have limited importance in later life compared with the health in men study cardiovascular risk scoreChristopher Beer
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
Stroke 42:952-9. 2011..This study aimed to determine, among older men, the risk and independent significant baseline prognostic factors for first-ever stroke and MI... - Associations between testosterone levels and incident prostate, lung, and colorectal cancer. A population-based studyZoe Hyde
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Crawley, WA 6009, Australia
Cancer Epidemiol Biomarkers Prev 21:1319-29. 2012..The relationship between testosterone and cancer is relatively unexplored. We sought to examine whether testosterone and related hormones are associated with incident prostate, lung, and colorectal cancer... - Socioeconomic disadvantage increases risk of prevalent and persistent depression in later lifeOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
J Affect Disord 138:322-31. 2012..This study aimed to determine the independent association between socioeconomic disadvantage and depression... - Complaints of difficulty to fall asleep increase the risk of depression in later life: the health in men studyOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA 6009, Australia
J Affect Disord 134:208-16. 2011..To determine if complaints of poor sleep are associated with incident depression in older men... - B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trialOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
Ann Neurol 68:503-10. 2010..The purpose of this research was to determine if treatment with B-vitamins reduces the hazard of poststroke depression compared with placebo... - Elevated LH predicts ischaemic heart disease events in older men: the Health in Men StudyZoe Hyde
Western Australian Centre for Health and Ageing M570, Centre for Medical Research, Western Australian Institute for Medical Research School of Medicine and Pharmacology School of Surgery, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
Eur J Endocrinol 164:569-77. 2011..However, it is uncertain whether the age-related decline in testosterone is associated with ischaemic heart disease (IHD) events... - Awareness of cognitive deficits in older adults with cognitive-impairment-no-dementia (CIND): comparison with informant reportKathryn R Greenop
Division of Population Sciences, Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Subiaco, WA, Australia
Alzheimer Dis Assoc Disord 25:24-33. 2011..In addition, self-report of cognitive complaints may be at least as useful as informant report when screening community-dwelling older adults at risk of cognitive decline and dementia... - Factors associated with dementia in Aboriginal AustraliansKate Smith
Western Australian Centre for Health and Ageing M570, Centre for Health Research, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia
Aust N Z J Psychiatry 44:888-93. 2010..This study was designed to determine the demographic, lifestyle and clinical factors associated with dementia in Aboriginal Australians living in the Kimberley region of Western Australia... - Development and evaluation of an educational intervention for general practitioners and staff caring for people with dementia living in residential facilitiesChristopher Beer
Western Australian Centre for Health and Ageing M570, Centre for Medical Research, The University of Western Australia, Crawley, Western Australia, Australia
Int Psychogeriatr 23:221-9. 2011..Small group education, which is flexible, individualized, practical and case-based, is sought. We aimed to develop educational interventions for GPs and RCF staff tailored to meet their perceived educational needs... - Lower testosterone levels predict incident stroke and transient ischemic attack in older menBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
J Clin Endocrinol Metab 94:2353-9. 2009..However, it is unclear whether lower testosterone levels predict major cardiovascular events... - Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trialAndrew H Ford
South Metropolitan Health Service, Perth, Australia
J Clin Psychiatry 69:1203-9. 2008..To examine whether use of vitamins B(12), B(6), and folate was associated with reduced severity of depressive symptoms and 2-year incidence of clinically significant depression... - IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older menBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
Eur J Endocrinol 162:249-57. 2010..The relationship between IGF-binding proteins 3 and 1 (IGFBP3 and IGFBP1) with risk of cardiovascular disease remains unclear. We sought to examine associations between IGF1, IGFBP3 and IGFBP1 with metabolic syndrome in older men... - Body adiposity in later life and the incidence of dementia: the health in men studyBrian D Power
Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia
PLoS ONE 6:e17902. 2011..To determine if adiposity in later life increases dementia hazard... - Subjective memory complaints with and without objective memory impairment: relationship with risk factors for dementiaNicola T Lautenschlager
School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
Am J Geriatr Psychiatry 13:731-4. 2005.... - Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older menBu B Yeap
School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
J Clin Endocrinol Metab 97:4030-9. 2012..Objective: We assessed the associations of T, DHT, and E2 in men aged 70 yr or older and established reference ranges for these in healthy older men... - Cardiovascular disease, depression and mortality: the Health In Men StudyOsvaldo P Almeida
Western Australia Centre for Health and Ageing, University of Western Australia, Australia
Am J Geriatr Psychiatry 20:433-40. 2012..One way to further elucidate the nature of this relationship is by determining the joint effect of CVD and depression on a common outcome, such as mortality... - Homocysteine, grey matter and cognitive function in adults with cardiovascular diseaseAndrew H Ford
Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
PLoS ONE 7:e33345. 2012..Elevated total plasma homocysteine (tHcy) has been associated with cognitive impairment, vascular disease and brain atrophy... - Association between physiological serum concentration of estrogen and the mental health of community-dwelling postmenopausal women age 70 years and overOsvaldo P Almeida
UWA School of Psychiatry and Clinical Neurosciences M573, Level 6, Ainslie House, Royal Perth Hospital, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
Am J Geriatr Psychiatry 13:142-9. 2005..The authors investigated the association between physiological levels of estrogen and mood/cognitive functioning among older postmenopausal women... - Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Australia
Clin Endocrinol (Oxf) 68:404-12. 2008..To determine the relationship of total and free serum testosterone to cognitive performance in older men... - Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older menOsvaldo P Almeida
WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
Arch Gen Psychiatry 65:283-9. 2008..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity... - Association of cardiovascular risk factors and disease with depression in later lifeOsvaldo P Almeida
Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
Am J Geriatr Psychiatry 15:506-13. 2007..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men... - Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men StudyOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Perth, WA, Australia
Int J Epidemiol 38:1049-59. 2009..The aim of this study is to determine if polymorphisms of SNPs rs1130864 and rs1205 are associated with prevalent depression... - Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levelsBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
Eur J Endocrinol 163:265-72. 2010..However, the relationship between TOC levels and other cardiovascular risk factors is uncertain. We sought to determine whether serum TOC is associated with metabolic syndrome and its components in older men... - CRP 1846G>A polymorphism increases risk of frailtyOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
Maturitas 71:261-6. 2012.... - The PACE study: a randomised clinical trial of cognitive activity (CA) for older adults with mild cognitive impairment (MCI)Mandy R Vidovich
Western Australia Centre for Health and Ageing, School of Psychiatry and Clinical Neurosciences, Perth, Western Australia, Australia
Trials 10:114. 2009..The Promoting Healthy Ageing with Cognitive Exercise (PACE) study has been designed to determine whether a cognitive activity intervention decreases the rate of cognitive decline amongst older adults with mild cognitive impairment (MCI)... - One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in menOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Mail Point M573 Level 6, Ainslie House, Royal Perth Hospital, 35 Stirling Highway, Perth, WA 6009, Australia
Psychoneuroendocrinology 29:1071-81. 2004..The performance of subjects on the WL test was negatively correlated with plasma levels of Abeta, but the clinical significance of this finding remains to be determined... - Cognitive and brain changes associated with ischaemic heart disease and heart failureOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, Australia
Eur Heart J 33:1769-76. 2012..This study aimed to determine whether, compared with controls with and without IHD, adults with systolic HF show evidence of cognitive impairment and cerebral grey matter (GM) loss... - Effectiveness of a smoking cessation intervention in older adultsRobert J Tait
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
Addiction 102:148-55. 2007.... - Healthy mental ageingLeon Flicker
Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Australia
J Br Menopause Soc 12:92-6. 2006.... - Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer diseaseOsvaldo P Almeida
Western Australia Centre for Health and Ageing, School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia
Am J Geriatr Psychiatry 16:92-8. 2008..The authors designed this study to determine if older people who smoke have decreased gray matter density in brain regions associated with incipient AD... - Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemiaLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Stroke 37:547-9. 2006..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels... - Association between lifestyle factors and mental health measures among community-dwelling older womenKellie Cassidy
School of Psychiatry, and Clinical Neurosciences, University of Western Australia, Perth, Australia
Aust N Z J Psychiatry 38:940-7. 2004..Randomised clinical trials should be now designed to clarify whether management of lifestyle factors reduces the incidence of mood disorders and cognitive impairment in later life... - In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
Eur J Endocrinol 156:585-94. 2007..We sought to determine the distribution and associations of reduced testosterone concentrations in older men... - Current experiences and educational preferences of general practitioners and staff caring for people with dementia living in residential facilitiesChristopher Beer
Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Perth, Australia
BMC Geriatr 9:36. 2009..We sought to determine participation in dementia education, perceived levels of current knowledge regarding dementia, perceived unmet educational needs, current barriers, facilitators and preferences for dementia education... - Prevalence and predictors of sexual problems in men aged 75-95 years: a population-based studyZoe Hyde
Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, University of Western Australia, Crawley, WA, Australia
J Sex Med 9:442-53. 2012..Hypogonadism is associated with impaired libido and erectile dysfunction in young men, but the causes of sexual dysfunction in older men are less well understood... - Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trialLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
J Am Geriatr Soc 53:1881-8. 2005..To determine whether vitamin D supplementation can reduce the incidence of falls and fractures in older people in residential care who are not classically vitamin D deficient... - Attitudes toward information and communication technology (ICT) in residential aged care in Western AustraliaPoh Kooi Loh
WA Center for Health and Ageing, Department of Geriatric Medicine, Royal Perth Hospital, Perth, Western Australia, Australia
J Am Med Dir Assoc 10:408-13. 2009..Determine why introduction of health consulting services via Telehealth video conference consultations failed in residential aged care facilities (RACF)... - Students and teachers' preferences for undergraduate dementia education in Western AustraliaChristopher Beer
Western Australian Centre for Health and Ageing, University of Western Australia, Crawley, Perth, Western Australia, Australia
Gerontol Geriatr Educ 32:273-90. 2011..The results of this study present major challenges for professional entry dementia education given the breadth, flexibility, and depth of dementia education recommended by teachers and learners... - A practical approach to assess depression risk and to guide risk reduction strategies in later lifeOsvaldo P Almeida
Western Australian Centre for Health and Ageing, Centre for Medical Research of the University of Western Australia, Perth, Australia
Int Psychogeriatr 23:280-91. 2011..This study gathered information about common modifiable and non-modifiable risk factors for depression with the aim of developing a practical probabilistic model of depression that can be used to guide risk reduction strategies... - Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later lifeOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
Neurobiol Aging 26:251-7. 2005..These results indicate that, in isolation, the MTHFR C677T gene variation does not play an important role in the modulation of mood and cognitive performance in later life... - Depression, antidepressant use and mortality in later life: the Health In Men StudyOsvaldo P Almeida
Western Australia Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
PLoS ONE 5:e11266. 2010..Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants... - Life style interventions to reduce the risk of dementiaLeon Flicker
Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Australia
Maturitas 63:319-22. 2009.... - Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case-control and cohort studiesOsvaldo P Almeida
Department of Psychiatry and Behavioural Science, University of Western Australia, Perth, Australia
Addiction 97:15-28. 2002..To investigate the risk of Alzheimer's disease (AD) associated with smoking... - Testosterone and dementia: too much ado about too little dataOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, Australia
J Br Menopause Soc 9:107-10. 2003..In conclusion, currently available evidence does not support the existence of a strong association between testosterone and cognitive function/AD... - Can testosterone replacement decrease the memory problem of old age?David Lim
University Department of Geriatric Medicine, University of Western Australia, Perth, Australia
Med Hypotheses 60:893-6. 2003..Clinical trials need to be conducted to ascertain the putative role of androgen replacement in Alzheimer's disease... - Latent semantic analysis: a new method to measure prose recallJohn C Dunn
Department of Psychiatry and Behavioural Science, University of Western Australia, Nedlands, WA, Australia
J Clin Exp Neuropsychol 24:26-35. 2002..This suggests that LSA may serve as an improved measure of prose recall... - Inspection time in non-demented older adults with mild cognitive impairmentKathryn R Bonney
Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Australia
Neuropsychologia 44:1452-6. 2006..In combination with other clinical, neuropsychological and biological tests, IT may be a useful assessment tool for improving the identification of older adults at risk for clinically relevant cognitive decline... - Use of gastrostomy tubes in older Western Australians: a population-based study of frequency, indications and outcomesJanine Calver
Western Australian Centre for Health and Ageing, University of Western Australia, Perth, WA, Australia
Med J Aust 190:358-61. 2009.... - Interface between residential aged care facilities and a teaching hospital emergency department in Western AustraliaJudith C Finn
School of Population Health, University of Western Australia, Perth, WA, Australia
Med J Aust 184:432-5. 2006..To estimate the appropriateness of emergency department (ED) presentations by people aged>or=65 years living in residential care facilities... - Metabolic and endocrinological causes of dementiaLeon Flicker
School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6001, Australia
Int Psychogeriatr 17:S79-92. 2005..The existence of these conditions provides some justification for routine investigations commonly performed on patients presenting with possible early dementia... - Assessment of the potential effect of incremental increases in folic acid intake on neural tube defects in Australia and New ZealandCarol Bower
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth
Aust N Z J Public Health 30:369-74. 2006..To estimate the number of neural tube defects that could be prevented in Australia and New Zealand by increasing levels of folic acid intake... - Association between hormone replacement therapy and dementia: is it time to forget?Osvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia and Royal Perth Hospital, Perth, Western Australia
Int Psychogeriatr 17:155-64. 2005.... - Should geriatric medicine remain a specialty? YesLeon Flicker
Western Australian Centre for Health and Ageing, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Perth, Australia 6001
BMJ 337:a516. 2008 - Vascular factors in geriatric psychiatry: time to take a serious lookLeon Flicker
Western Australian Centre for Health and Ageing, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Curr Opin Psychiatry 21:551-4. 2008..This review focuses on the literature, which has explored the possible link between these risk factors and cognitive decline and depression... - Serum vitamin D and falls in older women in residential care in AustraliaLeon Flicker
Department of Medicine Geriatric Medicine, University of Western Australia, Perth, Australia
J Am Geriatr Soc 51:1533-8. 2003..To determine the prevalence of vitamin D deficiency in older people in residential care and the influence that the level of vitamin D may have on their incidence of falls... - Calcium supplementation and the risks of atherosclerotic vascular disease in older women: results of a 5-year RCT and a 4.5-year follow-upJoshua R Lewis
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia
J Bone Miner Res 26:35-41. 2011..This trial provides compelling evidence that calcium supplementation of 1200 mg daily does not significantly increase the risk of atherosclerotic vascular disease in elderly women... - Development of a telemedicine protocol for the diagnosis of Alzheimer's diseasePoh Kooi Loh
Department of Geriatric Medicine, Royal Perth Hospital, Perth, WA, Australia
J Telemed Telecare 13:90-4. 2007..We conclude that it is possible to diagnose AD at a distance using telemedicine, but this requires validation with a larger study...