Leon Flicker

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts
    Annette Dobson
    The University of Queensland, School of Population Health, Herston, Australia
    BMC Public Health 12:669. 2012
  2. pmc Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)--PACE AD: study protocol for a randomised controlled trial
    Mandy R Vidovich
    Western Australia Centre for Health and Ageing WACHA, School of Psychiatry and Clinical Neurosciences and Centre for Medical Research, University of Western Australia and Royal Perth Hospital, Australia
    Trials 12:47. 2011
  3. pmc The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease
    Elizabeth V Cyarto
    National Ageing Research Institute, Melbourne, Australia
    Trials 11:120. 2010
  4. pmc A multi-faceted intervention to implement guideline care and improve quality of care for older people who present to the emergency department with falls
    Nicholas Waldron
    Department of Rehabilitation and Aged Care, Sir Charles Gairdner Hospital, Perth, Australia
    BMC Geriatr 11:6. 2011
  5. pmc Screening for pre-clinical disability in different residential settings
    Kate Gibson
    1Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    BMC Geriatr 10:52. 2010
  6. ncbi request reprint Modifiable lifestyle risk factors for Alzheimer's disease
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research and Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Alzheimers Dis 20:803-11. 2010
  7. ncbi request reprint Body mass index and survival in men and women aged 70 to 75
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
    J Am Geriatr Soc 58:234-41. 2010
  8. doi request reprint Cardiovascular risk factors, cerebrovascular disease burden, and healthy brain aging
    Leon Flicker
    Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Clin Geriatr Med 26:17-27. 2010
  9. doi request reprint Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 169:401-8. 2013
  10. doi request reprint Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    J Vasc Surg 58:364-70. 2013

Detail Information

Publications108 found, 100 shown here

  1. pmc Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts
    Annette Dobson
    The University of Queensland, School of Population Health, Herston, Australia
    BMC Public Health 12:669. 2012
    ..The aim of this paper is to calculate population based estimates and display them using simple charts that may be useful communication tools for public health authorities, health care providers and policy makers...
  2. pmc Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)--PACE AD: study protocol for a randomised controlled trial
    Mandy R Vidovich
    Western Australia Centre for Health and Ageing WACHA, School of Psychiatry and Clinical Neurosciences and Centre for Medical Research, University of Western Australia and Royal Perth Hospital, Australia
    Trials 12:47. 2011
    ....
  3. pmc The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease
    Elizabeth V Cyarto
    National Ageing Research Institute, Melbourne, Australia
    Trials 11:120. 2010
    ..This paper describes the background, objectives of the study, and an overview of the protocol including design, organization and data collection methods...
  4. pmc A multi-faceted intervention to implement guideline care and improve quality of care for older people who present to the emergency department with falls
    Nicholas Waldron
    Department of Rehabilitation and Aged Care, Sir Charles Gairdner Hospital, Perth, Australia
    BMC Geriatr 11:6. 2011
    ..We aimed to improve the delivery of evidence based care to patients presenting to the Emergency Department (ED) following a fall...
  5. pmc Screening for pre-clinical disability in different residential settings
    Kate Gibson
    1Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    BMC Geriatr 10:52. 2010
    ....
  6. ncbi request reprint Modifiable lifestyle risk factors for Alzheimer's disease
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research and Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Alzheimers Dis 20:803-11. 2010
    ..For many of these modifiable lifestyle factors, such trials may never be performed, and an individual's choice may need to be based on the available evidence...
  7. ncbi request reprint Body mass index and survival in men and women aged 70 to 75
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
    J Am Geriatr Soc 58:234-41. 2010
    ..To examine in an older population all-cause and cause-specific mortality associated with underweight (body mass index (BMI)<18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25.0-29.9), and obesity (BMI> or =30.0)...
  8. doi request reprint Cardiovascular risk factors, cerebrovascular disease burden, and healthy brain aging
    Leon Flicker
    Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Clin Geriatr Med 26:17-27. 2010
    ..However, as there are considerable other health benefits from targeting cardiovascular risk factors, these interventions should be more widely adopted, which would also probably result in positive outcomes for the brain...
  9. doi request reprint Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 169:401-8. 2013
    ..In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in older men without thyroid disease...
  10. doi request reprint Plasma total homocysteine is associated with abdominal aortic aneurysm and aortic diameter in older men
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    J Vasc Surg 58:364-70. 2013
    ..This study was conducted to determine whether plasma total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are associated with abdominal aortic aneurysm (AAA) and aortic diameter...
  11. ncbi request reprint Anxiety, depression, and comorbid anxiety and depression: risk factors and outcome over two years
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
    Int Psychogeriatr 24:1622-32. 2012
    ..This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months...
  12. pmc A randomized trial to reduce the prevalence of depression and self-harm behavior in older primary care patients
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Ann Fam Med 10:347-56. 2012
    ..We wanted to determine whether an educational intervention targeting general practitioners reduces the 2-year prevalence of depression and self-harm behavior among their older patients...
  13. pmc The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life
    Andrew H Ford
    Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia
    Trials 11:8. 2010
    ..We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment...
  14. pmc Dementia in residential care: education intervention trial (DIRECT); protocol for a randomised controlled trial
    Christopher D Beer
    WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
    Trials 11:63. 2010
    ..The DIRECT study will determine if delivery of education to General Practitioners (GPs) and care staff improves the quality of life of residential care recipients with cognitive impairment...
  15. doi request reprint Cardiovascular diseases do not influence the mental health outcome of older men with depression over 6 years
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    J Affect Disord 144:248-52. 2013
    ....
  16. doi request reprint Higher luteinizing hormone is associated with poor memory recall: the health in men study
    Zoe Hyde
    Western Australian Institute for Medical Research, Australia
    J Alzheimers Dis 19:943-51. 2010
    ..These findings suggest a role for both androgens and gonadotropins in differing cognitive domains, and that gonadotropins may influence cognition independent of sex steroids...
  17. ncbi request reprint Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Clin Endocrinol (Oxf) 70:455-63. 2009
    ..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men...
  18. doi request reprint Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:E2230-7. 2012
    ..Both hypothyroidism and subclinical hyperthyroidism hinder cognitive function...
  19. pmc A cluster-randomised trial of staff education to improve the quality of life of people with dementia living in residential care: the DIRECT study
    Christopher Beer
    WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
    PLoS ONE 6:e28155. 2011
    ....
  20. pmc Factors associated with self and informant ratings of the quality of life of people with dementia living in care facilities: a cross sectional study
    Christopher Beer
    WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
    PLoS ONE 5:e15621. 2010
    ..We undertook the present study to describe and determine the factors associated with ratings of the quality of life of a cohort of people with dementia living in a residential care facility...
  21. doi request reprint Homocysteine and depression in later life
    Osvaldo P Almeida
    FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Arch Gen Psychiatry 65:1286-94. 2008
    ..Genetic association studies are not prone to the same sources of error and offer an opportunity to explore the consistency and external validity of this association...
  22. doi request reprint In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality
    Bu B Yeap
    School of Medicine and Pharmacology B B Y, S A P C, G J H, L F, University of Western Australia, Perth, Western Australia 6009, Australia Department of Endocrinology and Diabetes B B Y, Fremantle Hospital, Fremantle, Western Australia 6160, Australia Western Australian Centre for Health and Ageing H A, O P A, L F, Centre for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australia PathWest Laboratory Medicine S A P C, Fremantle and Royal Perth Hospitals, Perth, Western Australia 6009, Australia ANZAC Research Institute D J H, University of Sydney, Sydney, New South Wales 2139, Australia School of Psychiatry and Clinical Neurosciences O P A, University of Western Australia, Perth, Western Australia 6009, Australia Vascular Biology Unit J G, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine, James Cook University, Townsville, Queensland 4811, Australia and School of Surgery P E N, University of Western Australia, Perth, Western Australia 6009, Australia
    J Clin Endocrinol Metab 99:E9-18. 2014
    ..Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined...
  23. doi request reprint Factors associated with suicidal thoughts in a large community study of older adults
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing M573, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Br J Psychiatry 201:466-72. 2012
    ..Thoughts about death and self-harm in old age have been commonly associated with the presence of depression, but other risk factors may also be important...
  24. doi request reprint Elevated homocysteine is associated with poorer self-perceived physical health in older men: the Health in Men Study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, Perth, WA, Australia
    Maturitas 73:158-63. 2012
    ....
  25. pmc Older men who use computers have lower risk of dementia
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e44239. 2012
    ..To determine if older men who use computers have lower risk of developing dementia...
  26. doi request reprint Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men Study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:179-89. 2012
    ..Low testosterone is associated with all-cause mortality, but the relationship with cause-specific mortality is uncertain...
  27. doi request reprint Falls, injuries from falls, health related quality of life and mortality in older adults with vision and hearing impairment--is there a gender difference?
    Derrick Lopez
    Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
    Maturitas 69:359-64. 2011
    ..Our objective was to determine if there are gender differences in the associations between visual and hearing impairment and these outcomes...
  28. ncbi request reprint Successful mental health aging: results from a longitudinal study of older Australian men
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, WA 6009, Australia
    Am J Geriatr Psychiatry 14:27-35. 2006
    ..The authors investigated the associations of medical and lifestyle factors with the mental health of men in their 80s...
  29. doi request reprint Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 161:591-8. 2009
    ..We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity...
  30. pmc Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational study
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, WA, Australia
    Br J Clin Pharmacol 71:592-9. 2011
    ..To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes...
  31. ncbi request reprint The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS)
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Australia
    Psychol Med 37:1775-86. 2007
    ..This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account...
  32. doi request reprint Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Eur J Heart Fail 15:850-8. 2013
    ....
  33. doi request reprint Higher free thyroxine levels are associated with frailty in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
    Clin Endocrinol (Oxf) 76:741-8. 2012
    ..Some symptoms of frailty overlap those of thyroid dysfunction, but it is unclear whether differences in thyroid status influence risk of frailty. We evaluated associations between thyroid status and frailty in older men...
  34. ncbi request reprint Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 166:191-7. 2012
    ..However, the relationship of the IGF1 system with aortic dilation and AAA is unclear. We tested the hypothesis that circulating IGF1 and IGFBPs are associated with AAA and aortic diameter in older men...
  35. doi request reprint Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia
    Andrew H Ford
    School of Psychiatry and Clinical Neurosciences M573, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Neurol Neurosurg Psychiatry 83:70-5. 2012
    ..The authors designed this longitudinal study to determine if high tHcy and the MTHFR C677T polymorphism increase the risk of incident dementia among older men...
  36. doi request reprint Two-year course of cognitive function and mood in adults with congestive heart failure and coronary artery disease: the Heart-Mind Study
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Int Psychogeriatr 24:38-47. 2012
    ..We designed this study to determine if adults with CHF show evidence of cognitive decline compared with adults with and without coronary artery disease (CAD)...
  37. doi request reprint Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
    Am J Geriatr Psychiatry 17:889-98. 2009
    ....
  38. doi request reprint Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 164:715-23. 2011
    ..We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular mortality in older men...
  39. ncbi request reprint B-vitamins reduce plasma levels of beta amyloid
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Neurobiol Aging 29:303-5. 2008
    ..E.) increase of A beta 40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD...
  40. doi request reprint Use of emergency departments by older people from residential care: a population based study
    Sharyn L Ingarfield
    Emergency Medicine, School of Primary, Aboriginal and Rural Health Care, The University of Western Australia, Australia
    Age Ageing 38:314-8. 2009
    ..to investigate the differences between emergency department (ED) presentations of older people who do and do not live in residential care facilities (RCFs)...
  41. doi request reprint Low free testosterone predicts frailty in older men: the health in men study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 95:3165-72. 2010
    ..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome...
  42. doi request reprint Low vitamin D status is an independent predictor of increased frailty and all-cause mortality in older men: the Health in Men Study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Western Australia Institute for Medical Research, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 98:3821-8. 2013
    ..Hypovitaminosis D and frailty are common in the older population. We aimed to determine whether 25-hydroxyvitamin D [25(OH)D] concentrations are associated with frailty and mortality...
  43. doi request reprint Homocysteine, frailty, and all-cause mortality in older men: the health in men study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Perth, Australia
    J Gerontol A Biol Sci Med Sci 68:590-8. 2013
    ..Frailty and hyperhomocysteinemia are common in the older population. The researchers' objectives were to determine whether elevated homocysteine (tHcy) is associated with frailty and mortality...
  44. doi request reprint Thyroid hormones and depression: the Health in Men study
    Osvaldo P Almeida
    WA Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, WA
    Am J Geriatr Psychiatry 19:763-70. 2011
    ..Current practice guidelines suggest that thyroid function tests should be an integral part of the assessment of adults presenting with a depressive episode, although there is a paucity of data available to support such a recommendation...
  45. ncbi request reprint 'Gotta be sit down and worked out together': views of Aboriginal caregivers and service providers on ways to improve dementia care for Aboriginal Australians
    Kate Smith
    WA Centre for Health and Ageing, University of WA, Perth, Western Australia, Australia
    Rural Remote Health 11:1650. 2011
    ..The objective of this study was to determine ways to overcome factors affecting the successful delivery of services to Aboriginal people with dementia living in remote communities, and to their families and communities...
  46. doi request reprint Prevalence of sexual activity and associated factors in men aged 75 to 95 years: a cohort study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, School of Medicine and Pharmacology, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
    Ann Intern Med 153:693-702. 2010
    ..Knowledge about sexuality in elderly persons is limited, and normative data are lacking...
  47. doi request reprint Traditional risk factors for incident cardiovascular events have limited importance in later life compared with the health in men study cardiovascular risk score
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
    Stroke 42:952-9. 2011
    ..This study aimed to determine, among older men, the risk and independent significant baseline prognostic factors for first-ever stroke and MI...
  48. ncbi request reprint Alcohol use and mortality in older men and women
    Kieran A McCaul
    Western Australian Centre for Health and Ageing, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Addiction 105:1391-400. 2010
    ..To compare the effect of alcohol intake on 10-year mortality for men and women over the age of 65 years...
  49. doi request reprint 24-month effect of smoking cessation on cognitive function and brain structure in later life
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Crawley, Perth, WA, Australia
    Neuroimage 55:1480-9. 2011
    ..We completed this trial to determine if smoking cessation decreases the progression of cognitive decline in later life...
  50. ncbi request reprint A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and older: effect on mood, cognition and quality of life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, The University of Western Australia M573, 35 Stirling Highway, Crawley, and Department of Psychiatry, Royal Perth Hospital, Perth, WA, Australia
    Neurobiol Aging 27:141-9. 2006
    ..Other more efficacious and safer interventions need to be devised with the aim of improving the mental state and quality of life of older women...
  51. ncbi request reprint Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    Nicola T Lautenschlager
    WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
    JAMA 300:1027-37. 2008
    ..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking...
  52. ncbi request reprint Lower plasma testosterone or dihydrotestosterone, but not estradiol, is associated with symptoms of intermittent claudication in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia Department of Endocrinology and Diabetes, Fremantle Hospital, Fremantle, WA, Australia
    Clin Endocrinol (Oxf) 79:725-32. 2013
    ..We assessed associations of T, DHT and E2 with lower limb intermittent claudication in older men...
  53. doi request reprint Associations between testosterone levels and incident prostate, lung, and colorectal cancer. A population-based study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Crawley, WA 6009, Australia
    Cancer Epidemiol Biomarkers Prev 21:1319-29. 2012
    ..The relationship between testosterone and cancer is relatively unexplored. We sought to examine whether testosterone and related hormones are associated with incident prostate, lung, and colorectal cancer...
  54. doi request reprint Socioeconomic disadvantage increases risk of prevalent and persistent depression in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    J Affect Disord 138:322-31. 2012
    ..This study aimed to determine the independent association between socioeconomic disadvantage and depression...
  55. doi request reprint Lower testosterone levels predict incident stroke and transient ischemic attack in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
    J Clin Endocrinol Metab 94:2353-9. 2009
    ..However, it is unclear whether lower testosterone levels predict major cardiovascular events...
  56. doi request reprint B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
    Ann Neurol 68:503-10. 2010
    ..The purpose of this research was to determine if treatment with B-vitamins reduces the hazard of poststroke depression compared with placebo...
  57. doi request reprint Elevated LH predicts ischaemic heart disease events in older men: the Health in Men Study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, Centre for Medical Research, Western Australian Institute for Medical Research School of Medicine and Pharmacology School of Surgery, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Eur J Endocrinol 164:569-77. 2011
    ..However, it is uncertain whether the age-related decline in testosterone is associated with ischaemic heart disease (IHD) events...
  58. ncbi request reprint Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial
    Andrew H Ford
    South Metropolitan Health Service, Perth, Australia
    J Clin Psychiatry 69:1203-9. 2008
    ..To examine whether use of vitamins B(12), B(6), and folate was associated with reduced severity of depressive symptoms and 2-year incidence of clinically significant depression...
  59. pmc Body adiposity in later life and the incidence of dementia: the health in men study
    Brian D Power
    Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia
    PLoS ONE 6:e17902. 2011
    ..To determine if adiposity in later life increases dementia hazard...
  60. doi request reprint Development and evaluation of an educational intervention for general practitioners and staff caring for people with dementia living in residential facilities
    Christopher Beer
    Western Australian Centre for Health and Ageing M570, Centre for Medical Research, The University of Western Australia, Crawley, Western Australia, Australia
    Int Psychogeriatr 23:221-9. 2011
    ..Small group education, which is flexible, individualized, practical and case-based, is sought. We aimed to develop educational interventions for GPs and RCF staff tailored to meet their perceived educational needs...
  61. doi request reprint Factors associated with dementia in Aboriginal Australians
    Kate Smith
    Western Australian Centre for Health and Ageing M570, Centre for Health Research, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia
    Aust N Z J Psychiatry 44:888-93. 2010
    ..This study was designed to determine the demographic, lifestyle and clinical factors associated with dementia in Aboriginal Australians living in the Kimberley region of Western Australia...
  62. doi request reprint Awareness of cognitive deficits in older adults with cognitive-impairment-no-dementia (CIND): comparison with informant report
    Kathryn R Greenop
    Division of Population Sciences, Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Subiaco, WA, Australia
    Alzheimer Dis Assoc Disord 25:24-33. 2011
    ..In addition, self-report of cognitive complaints may be at least as useful as informant report when screening community-dwelling older adults at risk of cognitive decline and dementia...
  63. ncbi request reprint IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 162:249-57. 2010
    ..The relationship between IGF-binding proteins 3 and 1 (IGFBP3 and IGFBP1) with risk of cardiovascular disease remains unclear. We sought to examine associations between IGF1, IGFBP3 and IGFBP1 with metabolic syndrome in older men...
  64. doi request reprint Complaints of difficulty to fall asleep increase the risk of depression in later life: the health in men study
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA 6009, Australia
    J Affect Disord 134:208-16. 2011
    ..To determine if complaints of poor sleep are associated with incident depression in older men...
  65. ncbi request reprint Subjective memory complaints with and without objective memory impairment: relationship with risk factors for dementia
    Nicola T Lautenschlager
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Geriatr Psychiatry 13:731-4. 2005
    ....
  66. ncbi request reprint Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
    J Clin Endocrinol Metab 97:4030-9. 2012
    ..Testosterone (T) levels decline with increasing age. Controversy exists over the threshold for classifying T as low vs. normal in older men. The relevance of assessing dihydrotestosterone (DHT) and estradiol (E2) remains unclear...
  67. ncbi request reprint Cardiovascular disease, depression and mortality: the Health In Men Study
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, University of Western Australia, Australia
    Am J Geriatr Psychiatry 20:433-40. 2012
    ..One way to further elucidate the nature of this relationship is by determining the joint effect of CVD and depression on a common outcome, such as mortality...
  68. pmc Homocysteine, grey matter and cognitive function in adults with cardiovascular disease
    Andrew H Ford
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e33345. 2012
    ..Elevated total plasma homocysteine (tHcy) has been associated with cognitive impairment, vascular disease and brain atrophy...
  69. pmc Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Perth, WA, Australia
    Int J Epidemiol 38:1049-59. 2009
    ..The aim of this study is to determine if polymorphisms of SNPs rs1130864 and rs1205 are associated with prevalent depression...
  70. ncbi request reprint Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 163:265-72. 2010
    ..However, the relationship between TOC levels and other cardiovascular risk factors is uncertain. We sought to determine whether serum TOC is associated with metabolic syndrome and its components in older men...
  71. ncbi request reprint Association of cardiovascular risk factors and disease with depression in later life
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
    Am J Geriatr Psychiatry 15:506-13. 2007
    ..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men...
  72. ncbi request reprint Association between physiological serum concentration of estrogen and the mental health of community-dwelling postmenopausal women age 70 years and over
    Osvaldo P Almeida
    UWA School of Psychiatry and Clinical Neurosciences M573, Level 6, Ainslie House, Royal Perth Hospital, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Geriatr Psychiatry 13:142-9. 2005
    ..The authors investigated the association between physiological levels of estrogen and mood/cognitive functioning among older postmenopausal women...
  73. ncbi request reprint Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Clin Endocrinol (Oxf) 68:404-12. 2008
    ..To determine the relationship of total and free serum testosterone to cognitive performance in older men...
  74. ncbi request reprint Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Arch Gen Psychiatry 65:283-9. 2008
    ..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity...
  75. doi request reprint CRP 1846G>A polymorphism increases risk of frailty
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
    Maturitas 71:261-6. 2012
    ....
  76. pmc The PACE study: a randomised clinical trial of cognitive activity (CA) for older adults with mild cognitive impairment (MCI)
    Mandy R Vidovich
    Western Australia Centre for Health and Ageing, School of Psychiatry and Clinical Neurosciences, Perth, Western Australia, Australia
    Trials 10:114. 2009
    ..The Promoting Healthy Ageing with Cognitive Exercise (PACE) study has been designed to determine whether a cognitive activity intervention decreases the rate of cognitive decline amongst older adults with mild cognitive impairment (MCI)...
  77. ncbi request reprint One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Mail Point M573 Level 6, Ainslie House, Royal Perth Hospital, 35 Stirling Highway, Perth, WA 6009, Australia
    Psychoneuroendocrinology 29:1071-81. 2004
    ..The performance of subjects on the WL test was negatively correlated with plasma levels of Abeta, but the clinical significance of this finding remains to be determined...
  78. doi request reprint Cognitive and brain changes associated with ischaemic heart disease and heart failure
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, Australia
    Eur Heart J 33:1769-76. 2012
    ..This study aimed to determine whether, compared with controls with and without IHD, adults with systolic HF show evidence of cognitive impairment and cerebral grey matter (GM) loss...
  79. ncbi request reprint Effectiveness of a smoking cessation intervention in older adults
    Robert J Tait
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    Addiction 102:148-55. 2007
    ....
  80. ncbi request reprint Association between lifestyle factors and mental health measures among community-dwelling older women
    Kellie Cassidy
    School of Psychiatry, and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Aust N Z J Psychiatry 38:940-7. 2004
    ..To investigate the association between potentially modifiable lifestyle factors and cognitive abilities/depressive symptoms in community-dwelling women aged 70 years and over...
  81. ncbi request reprint In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Eur J Endocrinol 156:585-94. 2007
    ..We sought to determine the distribution and associations of reduced testosterone concentrations in older men...
  82. ncbi request reprint Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Stroke 37:547-9. 2006
    ..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels...
  83. ncbi request reprint Healthy mental ageing
    Leon Flicker
    Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Australia
    J Br Menopause Soc 12:92-6. 2006
    ....
  84. doi request reprint Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia
    Am J Geriatr Psychiatry 16:92-8. 2008
    ..The authors designed this study to determine if older people who smoke have decreased gray matter density in brain regions associated with incipient AD...
  85. pmc Current experiences and educational preferences of general practitioners and staff caring for people with dementia living in residential facilities
    Christopher Beer
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Perth, Australia
    BMC Geriatr 9:36. 2009
    ..We sought to determine participation in dementia education, perceived levels of current knowledge regarding dementia, perceived unmet educational needs, current barriers, facilitators and preferences for dementia education...
  86. doi request reprint Prevalence and predictors of sexual problems in men aged 75-95 years: a population-based study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, University of Western Australia, Crawley, WA, Australia
    J Sex Med 9:442-53. 2012
    ..Hypogonadism is associated with impaired libido and erectile dysfunction in young men, but the causes of sexual dysfunction in older men are less well understood...
  87. ncbi request reprint Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Am Geriatr Soc 53:1881-8. 2005
    ..To determine whether vitamin D supplementation can reduce the incidence of falls and fractures in older people in residential care who are not classically vitamin D deficient...
  88. doi request reprint A practical approach to assess depression risk and to guide risk reduction strategies in later life
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Centre for Medical Research of the University of Western Australia, Perth, Australia
    Int Psychogeriatr 23:280-91. 2011
    ..This study gathered information about common modifiable and non-modifiable risk factors for depression with the aim of developing a practical probabilistic model of depression that can be used to guide risk reduction strategies...
  89. ncbi request reprint Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Neurobiol Aging 26:251-7. 2005
    ..These results indicate that, in isolation, the MTHFR C677T gene variation does not play an important role in the modulation of mood and cognitive performance in later life...
  90. ncbi request reprint Attitudes toward information and communication technology (ICT) in residential aged care in Western Australia
    Poh Kooi Loh
    WA Center for Health and Ageing, Department of Geriatric Medicine, Royal Perth Hospital, Perth, Western Australia, Australia
    J Am Med Dir Assoc 10:408-13. 2009
    ..Determine why introduction of health consulting services via Telehealth video conference consultations failed in residential aged care facilities (RACF)...
  91. ncbi request reprint Students and teachers' preferences for undergraduate dementia education in Western Australia
    Christopher Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Crawley, Perth, Western Australia, Australia
    Gerontol Geriatr Educ 32:273-90. 2011
    ..The results of this study present major challenges for professional entry dementia education given the breadth, flexibility, and depth of dementia education recommended by teachers and learners...
  92. pmc Depression, antidepressant use and mortality in later life: the Health In Men Study
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 5:e11266. 2010
    ..Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants...
  93. ncbi request reprint Serum vitamin D and falls in older women in residential care in Australia
    Leon Flicker
    Department of Medicine Geriatric Medicine, University of Western Australia, Perth, Australia
    J Am Geriatr Soc 51:1533-8. 2003
    ..To determine the prevalence of vitamin D deficiency in older people in residential care and the influence that the level of vitamin D may have on their incidence of falls...
  94. ncbi request reprint Testosterone and dementia: too much ado about too little data
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, Australia
    J Br Menopause Soc 9:107-10. 2003
    ..In conclusion, currently available evidence does not support the existence of a strong association between testosterone and cognitive function/AD...
  95. doi request reprint Life style interventions to reduce the risk of dementia
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Australia
    Maturitas 63:319-22. 2009
    ....
  96. ncbi request reprint Can testosterone replacement decrease the memory problem of old age?
    David Lim
    University Department of Geriatric Medicine, University of Western Australia, Perth, Australia
    Med Hypotheses 60:893-6. 2003
    ..Clinical trials need to be conducted to ascertain the putative role of androgen replacement in Alzheimer's disease...
  97. ncbi request reprint Latent semantic analysis: a new method to measure prose recall
    John C Dunn
    Department of Psychiatry and Behavioural Science, University of Western Australia, Nedlands, WA, Australia
    J Clin Exp Neuropsychol 24:26-35. 2002
    ..This suggests that LSA may serve as an improved measure of prose recall...
  98. ncbi request reprint Interface between residential aged care facilities and a teaching hospital emergency department in Western Australia
    Judith C Finn
    School of Population Health, University of Western Australia, Perth, WA, Australia
    Med J Aust 184:432-5. 2006
    ..To estimate the appropriateness of emergency department (ED) presentations by people aged>or=65 years living in residential care facilities...
  99. ncbi request reprint Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case-control and cohort studies
    Osvaldo P Almeida
    Department of Psychiatry and Behavioural Science, University of Western Australia, Perth, Australia
    Addiction 97:15-28. 2002
    ..To investigate the risk of Alzheimer's disease (AD) associated with smoking...
  100. ncbi request reprint Association between hormone replacement therapy and dementia: is it time to forget?
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia and Royal Perth Hospital, Perth, Western Australia
    Int Psychogeriatr 17:155-64. 2005
    ....
  101. ncbi request reprint Use of gastrostomy tubes in older Western Australians: a population-based study of frequency, indications and outcomes
    Janine Calver
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, WA, Australia
    Med J Aust 190:358-61. 2009
    ....