David Findlay

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi Regulation of cell growth mediated by the calcitonin receptor
    D M Findlay
    Department of Orthopaedics and Trauma, The University of Adelaide, Bice Building Royal Adelaide, Hospital, North Terrace, Adelaide, South Australia, Australia
    Cell Mol Biol (Noisy-le-grand) 52:3-8. 2006
  2. doi Osteoblast-chondrocyte interactions in osteoarthritis
    David M Findlay
    Centre for Orthopaedic and Trauma Research, The University of Adelaide, Royal Adelaide Hospital, Level 4 Bice Building, Adelaide, South Australia, 5000, Australia
    Curr Osteoporos Rep 12:127-34. 2014
  3. pmc Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
    Naoki Kato
    Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan
    J Neuroinflammation 10:1. 2013
  4. pmc TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis
    Anak A S S K Dharmapatni
    Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
    Arthritis Res Ther 13:R51. 2011
  5. pmc Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium
    Anak A S S K Dharmapatni
    Discipline of Pathology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, North Terrace, Adelaide, 5005 South Australia, Australia
    Arthritis Res Ther 11:R13. 2009
  6. pmc Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling
    Blair Hopwood
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia
    Arthritis Res Ther 9:R100. 2007
  7. pmc Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
    David Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide, North Terrace, Adelaide, 5000, Australia
    Arthritis Res Ther 10:R2. 2008
  8. ncbi Vascular pathology and osteoarthritis
    D M Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide and The Hanson Institute, Adelaide, South Australia 5000, Australia
    Rheumatology (Oxford) 46:1763-8. 2007
  9. ncbi Calcitonin
    David M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Growth Factors 22:217-24. 2004
  10. doi Relationship between serum RANKL and RANKL in bone
    D M Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide, Level 4 Bice Building, Royal Adelaide Hospital, Adelaide 5000, SA, Australia
    Osteoporos Int 22:2597-602. 2011

Collaborators

Detail Information

Publications48

  1. ncbi Regulation of cell growth mediated by the calcitonin receptor
    D M Findlay
    Department of Orthopaedics and Trauma, The University of Adelaide, Bice Building Royal Adelaide, Hospital, North Terrace, Adelaide, South Australia, Australia
    Cell Mol Biol (Noisy-le-grand) 52:3-8. 2006
    ..More recently, evidence has also been obtained for a role for CT in cell survival, in cells as diverse as osteoblast--like and osteocyte--like cells, osteoclasts and neurons...
  2. doi Osteoblast-chondrocyte interactions in osteoarthritis
    David M Findlay
    Centre for Orthopaedic and Trauma Research, The University of Adelaide, Royal Adelaide Hospital, Level 4 Bice Building, Adelaide, South Australia, 5000, Australia
    Curr Osteoporos Rep 12:127-34. 2014
    ..If, indeed, the cartilage and subchondral bone behave as an interconnected functional unit, normalization of cell behavior in one compartment may have benefits in both tissues. ..
  3. pmc Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
    Naoki Kato
    Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan
    J Neuroinflammation 10:1. 2013
    ..However, the results regarding whether p38α promotes or inhibits nerve regeneration in vivo have been controversial...
  4. pmc TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis
    Anak A S S K Dharmapatni
    Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
    Arthritis Res Ther 13:R51. 2011
    ..Effects of sTWEAK on osteoclasts and osteoblasts were investigated in vitro...
  5. pmc Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium
    Anak A S S K Dharmapatni
    Discipline of Pathology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, North Terrace, Adelaide, 5005 South Australia, Australia
    Arthritis Res Ther 11:R13. 2009
    ..Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumour necrosis factor (TNF) family member capable of inducing apoptosis in many cell types...
  6. pmc Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling
    Blair Hopwood
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia
    Arthritis Res Ther 9:R100. 2007
    ..Altered expression of these sets of genes suggests altered bone remodelling and may in part explain the sex disparity observed in OA...
  7. pmc Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
    David Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide, North Terrace, Adelaide, 5000, Australia
    Arthritis Res Ther 10:R2. 2008
    ..The objective of this study was to measure, in humans, the serum levels of RANKL and OPG, and the corresponding levels in bone of mRNA encoding these proteins...
  8. ncbi Vascular pathology and osteoarthritis
    D M Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide and The Hanson Institute, Adelaide, South Australia 5000, Australia
    Rheumatology (Oxford) 46:1763-8. 2007
    ..It may be important to recognize these potential aetiological factors in order to develop more effective treatments to inhibit the progression of OA...
  9. ncbi Calcitonin
    David M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Growth Factors 22:217-24. 2004
  10. doi Relationship between serum RANKL and RANKL in bone
    D M Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide, Level 4 Bice Building, Royal Adelaide Hospital, Adelaide 5000, SA, Australia
    Osteoporos Int 22:2597-602. 2011
    ..This review explores this subject, documenting the possible origins of circulating RANKL and suggesting additional information that is required before serum RANKL levels can provide useful diagnostic or research information...
  11. ncbi Calcitonin decreases the adherence and survival of HEK-293 cells by a caspase-independent mechanism
    D M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, The Royal Adelaide Hospital, Adelaide 5000, South Australia, Australia
    J Endocrinol 175:715-25. 2002
    ..These results demonstrate that CT can negatively affect cell survival and they identify roles for cell adherence and MAP kinase activation in this process...
  12. ncbi The proliferation and phenotypic expression of human osteoblasts on tantalum metal
    David M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, South Australia
    Biomaterials 25:2215-27. 2004
    ..No substrate-dependent differences were seen in the extent of in vitro mineralisation by NHBC. These results indicate that Ta is a good substrate for the attachment, growth and differentiated function of human osteoblasts...
  13. ncbi The correlation of RANK, RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implants
    Christopher A Holding
    Department of Pathology, The University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
    Biomaterials 27:5212-9. 2006
    ..This suggests that the interaction of TNFalpha and RANKL promotes osteoclast activity associated with polyethylene wear and therapies targeting TNF activity may be useful to treat peri-implant osteolysis...
  14. ncbi Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck
    Helen Tsangari
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
    Bone 35:334-42. 2004
    ....
  15. ncbi Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts
    Cristina Vincent
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
    J Bone Miner Res 24:1434-49. 2009
    ..Together, our findings suggest that TWEAK, alone and with TNF, can regulate osteoblast function, at least in part by inducing sclerostin expression. Our results also suggest new roles and modes of action for sclerostin...
  16. ncbi The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE)
    Beiqing Pan
    Myeloma and Mesenchymal Research Group, Matthew Robert Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Bone Miner Res 19:147-54. 2004
    ..The decreased transmembrane RANKL expression seems to be related to the upregulation of the RANKL sheddase, TACE...
  17. doi Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption
    Masakazu Kogawa
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5000
    Endocrinology 151:4613-25. 2010
    ..We conclude that 25D metabolism is an important intrinsic mechanism for optimizing osteoclast differentiation, ameliorating osteoclast activity, and potentially promoting the coupling of bone resorption to formation...
  18. ncbi The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
    Beiqing Pan
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, Australia
    Bone 34:112-23. 2004
    ..These results show that, in addition to its direct effects on OCs, ZOL also directly affects the proliferation and differentiation of human OB-like cells in vitro and may enhance bone formation in vivo...
  19. ncbi The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAIL
    Lisa M Butler
    Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide and Hanson Institute, Adelaide, SA, Australia
    Int J Cancer 119:944-54. 2006
    ..Taken together, our findings indicate that the use of these 2 agents in combination may be effective for the treatment of breast cancer...
  20. ncbi Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patients
    Helen Tsangari
    Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science, Hanson Institute, and the University of Adelaide, Frome Road, Adelaide 5000, Australia
    Bone 39:1226-35. 2006
    ..These data suggest that perturbations in bone formation surface, relative to resorption surface, are potentially important in producing bone in the proximal femur with increased propensity to fracture...
  21. ncbi Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    Amanda N Farrugia
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Cancer Res 63:5438-45. 2003
    ....
  22. doi Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms
    Gerald J Atkins
    Univ of Adelaide, Hanson Institute, SA, Australia
    Am J Physiol Cell Physiol 297:C1358-67. 2009
    ..These may be mechanisms by which vitamin K optimizes bone formation and integrity in vivo and may help explain the net positive effect of vitamin K on bone formation...
  23. ncbi Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model
    Agatha Labrinidis
    University of Adelaide, The Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Int J Cancer 127:345-54. 2010
    ..ZOL may have potential value as an adjuvant therapy in patients with established OS...
  24. doi The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles
    Gerald J Atkins
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA 5005, Australia
    Biomaterials 30:3672-81. 2009
    ..Overall, our results suggest that PE particles directly induce a change in the phenotype of mature osteoblasts and osteocytes, consistent with the net loss of bone near orthopaedic implants...
  25. ncbi RANKL expression is related to the differentiation state of human osteoblasts
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 18:1088-98. 2003
    ..Additionally, the dual roles of osteoblasts, in supporting osteoclastogenesis or forming bone, may be performed by the same lineage of cells at different stages of their maturation...
  26. ncbi Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis
    Andreas Evdokiou
    Department of Orthopaedics, Level 4 Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Int J Cancer 99:491-504. 2002
    ..Our results indicate that chemotherapy and Apo2L/TRAIL act synergistically to kill cancer cells but not normal bone-derived osteoblast-like cells, which has implications for future therapy of osteosarcoma...
  27. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  28. ncbi RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 21:1339-49. 2006
    ..We describe the lineages that express RANK in bone marrow, peripheral blood, and GCTs. We show that CD14(+)RANK(high) cells constitute a circulating pre-osteoclast pool...
  29. ncbi Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 203:573-82. 2005
    ..This study demonstrates that under the appropriate conditions, adult human primary osteoblasts can support de novo osteoclast formation, and this model will enable the detailed study of the role of both cell types in this process...
  30. ncbi Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype
    Katie J Welldon
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Biomed Mater Res A 84:691-701. 2008
    ..No substrate-dependent differences were seen in the extent of in vitro mineralization by HOB. These results indicate that porous Ta is a good substrate for the attachment, growth, and differentiated function of HOB...
  31. doi Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model
    Agatha Labrinidis
    Discipline of Orthopaedics and Trauma, University of Adelaide, The Royal Adelaide Hospital and The Hanson Institute, Adelaide, South Australia, Australia
    Clin Cancer Res 15:3451-61. 2009
    ..To evaluate the efficacy of zoledronic acid (ZOL) against osteosarcoma (OS) growth, progression, and metastatic spread using an animal model of human OS that closely resembles the human disease...
  32. doi Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma
    Agatha Labrinidis
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Royal Adelaide Hospital, and Hanson Institute, South Australia, Australia
    Clin Cancer Res 15:1998-2009. 2009
    ..Here, we report on the efficacy of recombinant soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to inhibit tumor progression and bone destruction in a xenogeneic model of human multiple myeloma...
  33. ncbi Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays
    Karan Gulati
    School of Chemical Engineering, The University of Adelaide, N 119 North Engineering Building, Adelaide, SA 5005, Australia
    Ther Deliv 3:857-73. 2012
    ..An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented...
  34. doi The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditions
    Cristina Vincent
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide and The Hanson Institute, North Terrace, Adelaide, SA 5000, Australia
    J Bone Miner Metab 27:114-9. 2009
    ..In conclusion, we describe a defined model for studying osteoclast differentiation and activity in the absence of serum, which will be ideal for studying the role of agonistic and antagonistic molecules in this process...
  35. ncbi Apo2l/Tumor necrosis factor-related apoptosis-inducing ligand prevents breast cancer-induced bone destruction in a mouse model
    Le Minh Thai
    Department of Orthopaedics, Royal Adelaide Hospital, Adelaide University, Adelaide, Australia
    Cancer Res 66:5363-70. 2006
    ..These studies show for the first time that Apo2L/TRAIL can prevent breast cancer-induced bone destruction and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone...
  36. ncbi Stability of RNA isolated from human trabecular bone at post-mortem and surgery
    Julia S Kuliwaba
    Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Frome Road, Adelaide 5000, South Australia, Australia
    Biochim Biophys Acta 1740:1-11. 2005
    ....
  37. ncbi Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer
    Irene Zinonos
    Discipline of Orthopaedics and Trauma Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Mol Cancer Ther 8:2969-80. 2009
    ..Apomab represents a potent immunotherapeutic agent with strong activity against the development and progression of breast cancer and should be evaluated in patients with primary and metastatic disease...
  38. ncbi The use of OP-1 in femoral impaction grafting in a sheep model
    Margaret A McGee
    Department of Orthopaedics and Trauma, University of Adelaide and Royal Adelaide Hospital, L4 Bice Building, Adelaide, South Australia 5000, Australia
    J Orthop Res 22:1008-15. 2004
    ....
  39. ncbi Structural and remodeling indices in the cancellous bone of the proximal femur across adulthood
    Helen Tsangari
    Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Adelaide, Australia
    Bone 40:211-7. 2007
    ....
  40. doi Distribution of periacetabular osteolytic lesions varies according to component design
    Roumen B Stamenkov
    Department of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, South Australia
    J Arthroplasty 25:913-9. 2010
    ....
  41. ncbi Progression of acetabular periprosthetic osteolytic lesions measured with computed tomography
    Donald W Howie
    Department of Orthopaedics and Trauma, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, Australia
    J Bone Joint Surg Am 89:1818-25. 2007
    ..A better understanding of the factors associated with the size and/or progression of osteolytic lesions has been hampered by a lack of sensitivity of radiographic measurement techniques...
  42. pmc Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice
    Rachel A Davey
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
    J Bone Miner Res 23:1182-93. 2008
    ..These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress...
  43. ncbi Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    Yun Shan Hu
    Bone, Joint, and Cancer Unit, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    J Bone Miner Res 19:89-99. 2004
    ..OCIL shows promise as a new antiresorptive...
  44. ncbi Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?
    Agatha Labrinidis
    Blood 111:5411-2; autor reply 5413. 2008
  45. ncbi Regulation of bone mass by mechanical loading: microarchitecture and genetics
    Larry J Suva
    Department of Orthopaedic Surgery, Physiology, and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham Street, Mail 644, Little Rock, AR 72205, USA
    Curr Osteoporos Rep 3:46-51. 2005
    ..It is the focus of this paper to evaluate the evidence underlying roles for genetics, osteocytes, and interstitial fluid flow in mediating disuse osteopenia...
  46. ncbi TWEAK is a novel arthritogenic mediator
    Stuart J Perper
    Exploratory Sciences, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 177:2610-20. 2006
    ....
  47. ncbi Genetically modified animal models as tools for studying bone and mineral metabolism
    Rachel A Davey
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Bone Miner Res 19:882-92. 2004
    ..This technology provides a unique and powerful way to probe the function of genes and is already revolutionizing our approach to understanding the physiology of bone development and metabolism...