Research Topics
Species | David FindlaySummaryAffiliation: University of Adelaide Country: Australia Publications
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Detail Information
Publications
TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritisAnak A S S K Dharmapatni
Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
Arthritis Res Ther 13:R51. 2011..Effects of sTWEAK on osteoclasts and osteoblasts were investigated in vitro...- Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synoviumAnak A S S K Dharmapatni
Discipline of Pathology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, North Terrace, Adelaide, 5005 South Australia, Australia
Arthritis Res Ther 11:R13. 2009..Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumour necrosis factor (TNF) family member capable of inducing apoptosis in many cell types... - Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signallingBlair Hopwood
Division of Tissue Pathology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia
Arthritis Res Ther 9:R100. 2007..Altered expression of these sets of genes suggests altered bone remodelling and may in part explain the sex disparity observed in OA... 
Regulation of cell growth mediated by the calcitonin receptorD M Findlay
Department of Orthopaedics and Trauma, The University of Adelaide, Bice Building Royal Adelaide, Hospital, North Terrace, Adelaide, South Australia, Australia
Cell Mol Biol (Noisy-le-grand) 52:3-8. 2006..More recently, evidence has also been obtained for a role for CT in cell survival, in cells as diverse as osteoblast--like and osteocyte--like cells, osteoclasts and neurons...- Vascular pathology and osteoarthritisD M Findlay
Discipline of Orthopaedics and Trauma, University of Adelaide and The Hanson Institute, Adelaide, South Australia 5000, Australia
Rheumatology (Oxford) 46:1763-8. 2007..It may be important to recognize these potential aetiological factors in order to develop more effective treatments to inhibit the progression of OA... - Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic malesDavid Findlay
Discipline of Orthopaedics and Trauma, University of Adelaide, North Terrace, Adelaide, 5000, Australia
Arthritis Res Ther 10:R2. 2008..The objective of this study was to measure, in humans, the serum levels of RANKL and OPG, and the corresponding levels in bone of mRNA encoding these proteins... - CalcitoninDavid M Findlay
Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
Growth Factors 22:217-24. 2004 - The proliferation and phenotypic expression of human osteoblasts on tantalum metalDavid M Findlay
Department of Orthopaedics and Trauma, University of Adelaide, South Australia
Biomaterials 25:2215-27. 2004..No substrate-dependent differences were seen in the extent of in vitro mineralisation by NHBC. These results indicate that Ta is a good substrate for the attachment, growth and differentiated function of human osteoblasts... 
Relationship between serum RANKL and RANKL in boneD M Findlay
Discipline of Orthopaedics and Trauma, University of Adelaide, Level 4 Bice Building, Royal Adelaide Hospital, Adelaide 5000, SA, Australia
Osteoporos Int 22:2597-602. 2011..This review explores this subject, documenting the possible origins of circulating RANKL and suggesting additional information that is required before serum RANKL levels can provide useful diagnostic or research information...- Calcitonin decreases the adherence and survival of HEK-293 cells by a caspase-independent mechanismD M Findlay
Department of Orthopaedics and Trauma, University of Adelaide, The Royal Adelaide Hospital, Adelaide 5000, South Australia, Australia
J Endocrinol 175:715-25. 2002..These results demonstrate that CT can negatively affect cell survival and they identify roles for cell adherence and MAP kinase activation in this process... - The correlation of RANK, RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implantsChristopher A Holding
Department of Pathology, The University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
Biomaterials 27:5212-9. 2006..This suggests that the interaction of TNFalpha and RANKL promotes osteoclast activity associated with polyethylene wear and therapies targeting TNF activity may be useful to treat peri-implant osteolysis... - Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neckHelen Tsangari
Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
Bone 35:334-42. 2004.... - Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorptionMasakazu Kogawa
Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5000
Endocrinology 151:4613-25. 2010..We conclude that 25D metabolism is an important intrinsic mechanism for optimizing osteoclast differentiation, ameliorating osteoclast activity, and potentially promoting the coupling of bone resorption to formation... - Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblastsCristina Vincent
Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
J Bone Miner Res 24:1434-49. 2009..Together, our findings suggest that TWEAK, alone and with TNF, can regulate osteoblast function, at least in part by inducing sclerostin expression. Our results also suggest new roles and modes of action for sclerostin... - The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE)Beiqing Pan
Myeloma and Mesenchymal Research Group, Matthew Robert Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
J Bone Miner Res 19:147-54. 2004..CONCLUSIONS: Our studies indicate that ZOL, in addition to its direct effects on mature OCs, may inhibit the recruitment and differentiation of OCs by cleavage of transmembrane RANKL in OB-like cells by upregulating the sheddase, TACE... - Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patientsHelen Tsangari
Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science, Hanson Institute, and the University of Adelaide, Frome Road, Adelaide 5000, Australia
Bone 39:1226-35. 2006..These data suggest that perturbations in bone formation surface, relative to resorption surface, are potentially important in producing bone in the proximal femur with increased propensity to fracture... - Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivoAmanda N Farrugia
Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia
Cancer Res 63:5438-45. 2003.... - The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAILLisa M Butler
Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide and Hanson Institute, Adelaide, SA, Australia
Int J Cancer 119:944-54. 2006..Taken together, our findings indicate that the use of these 2 agents in combination may be effective for the treatment of breast cancer... - The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitroBeiqing Pan
Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, Australia
Bone 34:112-23. 2004..These results show that, in addition to its direct effects on OCs, ZOL also directly affects the proliferation and differentiation of human OB-like cells in vitro and may enhance bone formation in vivo... - The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particlesGerald J Atkins
Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA 5005, Australia
Biomaterials 30:3672-81. 2009..Overall, our results suggest that PE particles directly induce a change in the phenotype of mature osteoblasts and osteocytes, consistent with the net loss of bone near orthopaedic implants... - Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanismsGerald J Atkins
Univ of Adelaide, Hanson Institute, SA, Australia
Am J Physiol Cell Physiol 297:C1358-67. 2009..These may be mechanisms by which vitamin K optimizes bone formation and integrity in vivo and may help explain the net positive effect of vitamin K on bone formation... - Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3Gerald J Atkins
Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
Bone 40:1517-28. 2007..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures... - Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat modelAgatha Labrinidis
University of Adelaide, The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Int J Cancer 127:345-54. 2010..ZOL may have potential value as an adjuvant therapy in patients with established OS... - Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotypeKatie J Welldon
Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
J Biomed Mater Res A 84:691-701. 2008..No substrate-dependent differences were seen in the extent of in vitro mineralization by HOB. These results indicate that porous Ta is a good substrate for the attachment, growth, and differentiated function of HOB... - Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosisAndreas Evdokiou
Department of Orthopaedics, Level 4 Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
Int J Cancer 99:491-504. 2002..Our results indicate that chemotherapy and Apo2L/TRAIL act synergistically to kill cancer cells but not normal bone-derived osteoblast-like cells, which has implications for future therapy of osteosarcoma... - RANKL expression is related to the differentiation state of human osteoblastsGerald J Atkins
Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
J Bone Miner Res 18:1088-98. 2003..Additionally, the dual roles of osteoblasts, in supporting osteoclastogenesis or forming bone, may be performed by the same lineage of cells at different stages of their maturation... - RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of boneGerald J Atkins
Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
J Bone Miner Res 21:1339-49. 2006..The ability to reliably detect committed pre-OC in peripheral blood could have important clinical applications in the management of diseases characterized by abnormal osteoclastic activity... - Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free mediumGerald J Atkins
Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, South Australia, Australia
J Cell Physiol 203:573-82. 2005..This study demonstrates that under the appropriate conditions, adult human primary osteoblasts can support de novo osteoclast formation, and this model will enable the detailed study of the role of both cell types in this process... - Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse modelAgatha Labrinidis
Discipline of Orthopaedics and Trauma, University of Adelaide, The Royal Adelaide Hospital and The Hanson Institute, Adelaide, South Australia, Australia
Clin Cancer Res 15:3451-61. 2009..To evaluate the efficacy of zoledronic acid (ZOL) against osteosarcoma (OS) growth, progression, and metastatic spread using an animal model of human OS that closely resembles the human disease... - Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myelomaAgatha Labrinidis
Discipline of Orthopaedics and Trauma, The University of Adelaide, Royal Adelaide Hospital, and Hanson Institute, South Australia, Australia
Clin Cancer Res 15:1998-2009. 2009..Here, we report on the efficacy of recombinant soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to inhibit tumor progression and bone destruction in a xenogeneic model of human multiple myeloma... - Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arraysKaran Gulati
School of Chemical Engineering, The University of Adelaide, N 119 North Engineering Building, Adelaide, SA 5005, Australia
Ther Deliv 3:857-73. 2012..An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented... - The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditionsCristina Vincent
Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide and The Hanson Institute, North Terrace, Adelaide, SA 5000, Australia
J Bone Miner Metab 27:114-9. 2009..In conclusion, we describe a defined model for studying osteoclast differentiation and activity in the absence of serum, which will be ideal for studying the role of agonistic and antagonistic molecules in this process... - Apo2l/Tumor necrosis factor-related apoptosis-inducing ligand prevents breast cancer-induced bone destruction in a mouse modelLe Minh Thai
Department of Orthopaedics, Royal Adelaide Hospital, Adelaide University, Adelaide, Australia
Cancer Res 66:5363-70. 2006..These studies show for the first time that Apo2L/TRAIL can prevent breast cancer-induced bone destruction and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone... - Stability of RNA isolated from human trabecular bone at post-mortem and surgeryJulia S Kuliwaba
Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Frome Road, Adelaide 5000, South Australia, Australia
Biochim Biophys Acta 1740:1-11. 2005.... - Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancerIrene Zinonos
Discipline of Orthopaedics and Trauma Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
Mol Cancer Ther 8:2969-80. 2009..Apomab represents a potent immunotherapeutic agent with strong activity against the development and progression of breast cancer and should be evaluated in patients with primary and metastatic disease... - The use of OP-1 in femoral impaction grafting in a sheep modelMargaret A McGee
Department of Orthopaedics and Trauma, University of Adelaide and Royal Adelaide Hospital, L4 Bice Building, Adelaide, South Australia 5000, Australia
J Orthop Res 22:1008-15. 2004.... - Progression of acetabular periprosthetic osteolytic lesions measured with computed tomographyDonald W Howie
Department of Orthopaedics and Trauma, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, Australia
J Bone Joint Surg Am 89:1818-25. 2007..A better understanding of the factors associated with the size and/or progression of osteolytic lesions has been hampered by a lack of sensitivity of radiographic measurement techniques... - Distribution of periacetabular osteolytic lesions varies according to component designRoumen B Stamenkov
Department of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, South Australia
J Arthroplasty 25:913-9. 2010.... - Structural and remodeling indices in the cancellous bone of the proximal femur across adulthoodHelen Tsangari
Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Adelaide, Australia
Bone 40:211-7. 2007.... - Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclastsYun Shan Hu
Bone, Joint, and Cancer Unit, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
J Bone Miner Res 19:89-99. 2004..OCIL shows promise as a new antiresorptive... - Calcitonin receptor plays a physiological role to protect against hypercalcemia in miceRachel A Davey
Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
J Bone Miner Res 23:1182-93. 2008..These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress... - Genetically modified animal models as tools for studying bone and mineral metabolismRachel A Davey
Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
J Bone Miner Res 19:882-92. 2004..This technology provides a unique and powerful way to probe the function of genes and is already revolutionizing our approach to understanding the physiology of bone development and metabolism... - TWEAK is a novel arthritogenic mediatorStuart J Perper
Exploratory Sciences, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
J Immunol 177:2610-20. 2006.... - Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?Agatha Labrinidis
Blood 111:5411-2; autor reply 5413. 2008 - Regulation of bone mass by mechanical loading: microarchitecture and geneticsLarry J Suva
Department of Orthopaedic Surgery, Physiology, and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham Street, Mail 644, Little Rock, AR 72205, USA
Curr Osteoporos Rep 3:46-51. 2005..It is the focus of this paper to evaluate the evidence underlying roles for genetics, osteocytes, and interstitial fluid flow in mediating disuse osteopenia...