M A Febbraio

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Effect of epinephrine on muscle glycogenolysis during exercise in trained men
    M A Febbraio
    Department of Physiology, University of Melbourne, Parkville, Australia
    J Appl Physiol (1985) 84:465-70. 1998
  2. ncbi request reprint Skeletal muscle energy metabolism during prolonged, fatiguing exercise
    M A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3052, Australia
    J Appl Physiol (1985) 87:2341-7. 1999
  3. ncbi request reprint HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise
    M A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3052, Australia
    J Appl Physiol (1985) 89:1055-60. 2000
  4. ncbi request reprint Preexercise carbohydrate ingestion, glucose kinetics, and muscle glycogen use: effect of the glycemic index
    M A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville 3052, Australia
    J Appl Physiol (1985) 89:1845-51. 2000
  5. ncbi request reprint Does muscle function and metabolism affect exercise performance in the heat?
    M A Febbraio
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Exerc Sport Sci Rev 28:171-6. 2000
  6. ncbi request reprint Alterations in energy metabolism during exercise and heat stress
    M A Febbraio
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Sports Med 31:47-59. 2001
  7. pmc Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle
    Mark A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 538:911-7. 2002
  8. ncbi request reprint Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E803-8. 2001
  9. pmc Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Physiol 533:585-91. 2001
  10. ncbi request reprint Glucose kinetics and exercise performance during phases of the menstrual cycle: effect of glucose ingestion
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E817-25. 2001

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Effect of epinephrine on muscle glycogenolysis during exercise in trained men
    M A Febbraio
    Department of Physiology, University of Melbourne, Parkville, Australia
    J Appl Physiol (1985) 84:465-70. 1998
    ..05) in Epi compared with Con. These data indicate that intramuscular glycogen utilization, glycolysis, and carbohydrate oxidation are augmented by elevated epinephrine during submaximal exercise in trained men...
  2. ncbi request reprint Skeletal muscle energy metabolism during prolonged, fatiguing exercise
    M A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3052, Australia
    J Appl Physiol (1985) 87:2341-7. 1999
    ....
  3. ncbi request reprint HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise
    M A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3052, Australia
    J Appl Physiol (1985) 89:1055-60. 2000
    ..These data demonstrate that HSP72 mRNA increases progressively during acute cycling, suggesting that processes that take place throughout concentric exercise are capable of initiating a stress response...
  4. ncbi request reprint Preexercise carbohydrate ingestion, glucose kinetics, and muscle glycogen use: effect of the glycemic index
    M A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville 3052, Australia
    J Appl Physiol (1985) 89:1845-51. 2000
    ..These results demonstrate that preexercise carbohydrate feeding with a HGI, but not a LGI, meal augments carbohydrate utilization during exercise but does not effect exercise performance...
  5. ncbi request reprint Does muscle function and metabolism affect exercise performance in the heat?
    M A Febbraio
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Exerc Sport Sci Rev 28:171-6. 2000
    ..However, this review presents evidence that a temperature-induced dysfunction to skeletal muscle contraction may contribute to a reduction in performance during exercise in the heat...
  6. ncbi request reprint Alterations in energy metabolism during exercise and heat stress
    M A Febbraio
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Sports Med 31:47-59. 2001
    ....
  7. pmc Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle
    Mark A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 538:911-7. 2002
    ..In addition, because CK did not increase and we found no evidence of HSP72 in the venous effluent, our data suggest that skeletal muscle is impermeable to HSP72...
  8. ncbi request reprint Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E803-8. 2001
    ..01); however, treatment with E(2) returned beta-HAD activity to C levels. These results suggest that E(2) plays a role in lipid metabolism by increasing the maximal activity of key enzymes in the fat oxidative pathway of skeletal muscle...
  9. pmc Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Physiol 533:585-91. 2001
    ..However, because IL-6 mRNA expression was unaffected by CHO ingestion, it is likely that the ingestion of CHO during exercise attenuates IL-6 production by tissues other than skeletal muscle...
  10. ncbi request reprint Glucose kinetics and exercise performance during phases of the menstrual cycle: effect of glucose ingestion
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E817-25. 2001
    ..05) with the ingestion of glucose throughout exercise. These data demonstrate that substrate metabolism and exercise performance are influenced by the menstrual cycle phase, but ingestion of glucose minimizes these effects...
  11. ncbi request reprint Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, University of Melbourne, Parkville 3052, Victoria, Australia
    Am J Physiol Cell Physiol 280:C769-74. 2001
    ..In addition, it is likely that stress hormones result in a decrease in the amount of cytokine produced by LPS-stimulated cells postexercise...
  12. pmc Exercise increases serum Hsp72 in humans
    R C Walsh
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Stress Chaperones 6:386-93. 2001
    ..This study is the first to demonstrate that acute exercise can increase Hsp72 in the peripheral circulation, suggesting that during stress these proteins may indeed have a systemic role...
  13. ncbi request reprint No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise
    P U Saunders
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Appl Physiol 91:2282-8. 2001
    ....
  14. ncbi request reprint Heat stress, cytokines, and the immune response to exercise
    R L Starkie
    Department of Physiology, The University of Melbourne, Parkville, Australia
    Brain Behav Immun 19:404-12. 2005
    ..Heat stress did not, however, augment the suppression in the amount of cytokine produced by circulating monocytes upon stimulation, despite elevated catecholamines...
  15. pmc Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice
    S M Turpin
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, Fitzroy, Australia
    J Physiol 587:1593-605. 2009
    ..A broad transcriptional suppression of pro-apoptotic proteins may explain this resistance to lipid-induced cell death in skeletal muscle...
  16. ncbi request reprint Ionomycin, but not physiologic doses of epinephrine, stimulates skeletal muscle interleukin-6 mRNA expression and protein release
    A G Holmes
    Skeletal Muscle Research Laboratory, The School of Medical Sciences, RMIT University, Bundoora 3038, Victoria, Australia
    Metabolism 53:1492-5. 2004
    ..In addition, ionomycin can stimulate IL-6 gene expression and protein release after only 1 hour of exposure...
  17. ncbi request reprint Effect of caffeine co-ingested with carbohydrate or fat on metabolism and performance in endurance-trained men
    T L Jacobson
    Exercise Metabolism Group, Department of Human Biology and Movement Science, RMIT University, Bundoora 3083, Victoria, Australia
    Exp Physiol 86:137-44. 2001
    ..Experimental Physiology (2001) 86.1, 137-144...
  18. ncbi request reprint Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise
    R L Starkie
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Cell Physiol 281:C1233-40. 2001
    ....
  19. ncbi request reprint Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes
    M J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 27, Bundoora 3083, Victoria, Australia
    J Mol Endocrinol 33:533-44. 2004
    ..Despite these changes in transcription factors/coactivators, the mRNA content of lipid regulatory proteins was generally unaffected by plasma FFA availability...
  20. ncbi request reprint Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
    S K Pinnamaneni
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Diabetologia 49:3027-37. 2006
    ..The aim of the present study was to assess the molecular mechanisms that implicate SCD1 in the aetiology of fatty acid-induced insulin resistance...
  21. ncbi request reprint Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    A L Carey
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Diabetologia 47:1029-37. 2004
    ..Our aim was to examine the possible direct relationship of interleukin-6 and TNFalpha with insulin sensitivity in humans...
  22. ncbi request reprint Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake
    S E Campbell
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 282:E1139-46. 2002
    ..However, changes in contraction-stimulated glucose uptake could not be explained by altered transporter protein content, since the absence of E(2) had no effect on GLUT4 protein...
  23. ncbi request reprint Effect of glycerol-induced hyperhydration on thermoregulation and metabolism during exercise in heat
    M J Anderson
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Vic, 3052, Australia
    Int J Sport Nutr Exerc Metab 11:315-33. 2001
    ..Furthermore, this practice increases exercise performance in the heat by mechanisms other than alterations in muscle metabolism...
  24. ncbi request reprint Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
    A L Carey
    Department of Physiology, The University of Melbourne, Parkville 3010, Vic, Australia
    Biochem Biophys Res Commun 302:837-40. 2003
    ..It is likely that the differences observed when comparing healthy with insulin resistant muscle are due to the differential activation of insulin sensitive signalling proteins responsible for activating IL-6...
  25. ncbi request reprint Interleukin-6 and insulin sensitivity: friend or foe?
    A L Carey
    The Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Diabetologia 47:1135-42. 2004
  26. ncbi request reprint 17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle
    S E Campbell
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Mol Endocrinol 31:37-45. 2003
    ..05) by E(2) treatment, although protein content remained unaltered. These data demonstrate the novel regulation of E(2) on PPARalpha and genes encoding key proteins that are pivotal in regulating skeletal muscle lipid oxidative flux...
  27. doi request reprint Targeting gp130 to prevent inflammation and promote insulin action
    M J Kraakman
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Obes Metab 15:170-5. 2013
    ..However, this may not be the most optimal strategy to block inflammation associated with IL-6 and may result in unwanted side effects that, paradoxically, could actually promote metabolic disease...
  28. pmc Exercise induces the release of heat shock protein 72 from the human brain in vivo
    G I Lancaster
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, Bundoora, 3083, Victoria, Australia
    Cell Stress Chaperones 9:276-80. 2004
    ..These data demonstrate that the human brain is able to release Hsp72 in vivo in response to a physical stressor such as exercise. Further study is required to determine the biological significance of these observations...
  29. doi request reprint Adipose tissue inflammation in glucose metabolism
    H L Kammoun
    Cellular and Molecular Metabolism Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Rev Endocr Metab Disord 15:31-44. 2014
    ..In particular, we focus on the role of major immune cell types in regulating nutrient homeostasis and potential initiating stimuli for WAT inflammation. ..
  30. ncbi request reprint Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1445-6. 2004
    ..However, the increased IMTG degradation in LG suggests factors other than HSL activity are important for IMTG degradation...
  31. ncbi request reprint Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction
    M H Stanley Chan
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1785-7. 2004
    ..Furthermore, phosphorylation of p38 MAPK in the nucleus appears to be an upstream target for IL-6, providing new insights into the regulation of IL-6 gene transcription...
  32. ncbi request reprint Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
    Mark A Febbraio
    Skeletal Muscle Research Laboratory, Center for Nutrition, Metabolism and Endocrinology, RMIT University, P O Box 71, Bundoora 3083, Victoria, Australia
    Diabetes 53:1643-8. 2004
    ..These data suggest that IL-6 influences glucose homeostasis during exercise. Our results provide potential new insights into factors that mediate glucose production and disposal and implicates IL-6 in the so-called "work factor."..
  33. ncbi request reprint Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise
    Mark A Febbraio
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Metabolism 52:939-44. 2003
    ..In contrast with IL-6, exercise does not result in the release of TNF-alpha from the contracting limbs of either healthy subjects or patients with type 2 diabetes...
  34. pmc Glucose ingestion attenuates the exercise-induced increase in circulating heat shock protein 72 and heat shock protein 60 in humans
    Mark A Febbraio
    The Copenhagen Muscle Research Center, Copenhagen, Denmark
    Cell Stress Chaperones 9:390-6. 2004
    ..We detected neither hepatosplanchnic nor contracting limb Hsp60 release in either trial. In conclusion, maintaining glucose availability during exercise attenuates the circulating Hsp response in healthy humans...
  35. ncbi request reprint Does the aging skeletal muscle maintain its endocrine function?
    Maria Pedersen
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Exerc Immunol Rev 10:42-55. 2004
    ....
  36. ncbi request reprint Skeletal muscle phenotype is associated with exercise tolerance in patients with peripheral arterial disease
    Christopher D Askew
    Department of Surgery, University of Queensland, Royal Brisbane Hospital, Australia
    J Vasc Surg 41:802-7. 2005
    ..We hypothesized that gastrocnemius muscle characteristics would be altered in PAD compared with control subjects and that exercise tolerance in patients PAD would be related to muscle phenotype...
  37. ncbi request reprint Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
    Gregory R Steinberg
    Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Appl Physiol Nutr Metab 31:302-12. 2006
    ..We suggest that increased activation of AMPK alpha2 under conditions of low muscle glycogen enhances AMPK alpha2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle...
  38. ncbi request reprint Exercise and inflammation
    Mark A Febbraio
    J Appl Physiol 103:376-7. 2007
  39. ncbi request reprint Effect of active versus passive recovery on metabolism and performance during subsequent exercise
    Andrew J McAinch
    School of Life Sciences and Technology at the Victoria University of Technology, Footscray, Australia
    Int J Sport Nutr Exerc Metab 14:185-96. 2004
    ..01), with no difference in work performed between trials. These data do not support the benefit of AR when compared to PR in the maintenance of subsequent intense aerobic exercise performance...
  40. ncbi request reprint Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humans
    Anna G Holmes
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, P O Box 71, Bundoora 3083, Victoria, Australia
    J Appl Physiol (1985) 97:689-96. 2004
    ..98 pg/ml; NA, 19.23 +/- 2.50 pg/ml; P < 0.05) during exercise. In conclusion, these data demonstrate that circulating IL-6 is markedly elevated at rest and during prolonged moderate-intensity exercise when lipolysis is suppressed...
  41. ncbi request reprint Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability
    M H Stanley Chan
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Am J Physiol Regul Integr Comp Physiol 287:R322-7. 2004
    ..Furthermore, the mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle...
  42. pmc Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation
    Adam Steensberg
    The Copenhagen Muscle Research Centre and The Department of Infectious Diseases, Rigshospitalet, The University of Copenhagen, Copenhagen, Denmark
    J Physiol 541:273-81. 2002
    ..However, this is only the case when delivery of substrates and hormones remains constant. When delivery of substrates and hormones is altered, the potential effect of glycogen on glucose uptake is negated...
  43. ncbi request reprint Muscle-derived interleukin-6: mechanisms for activation and possible biological roles
    Mark A Febbraio
    The Copenhagen Muscle Research Centre, The University of Copenhagen, Copenhagen, Denmark
    FASEB J 16:1335-47. 2002
    ..It may do so via local and/or systemic effects. This review also explores the efficacy that IL-6 may be used as a therapeutic drug in treating metabolic disorders such as obesity, type 2 diabetes, and atherosclerosis...
  44. ncbi request reprint IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle
    Adam Steensberg
    Copenhagen Muscle Research Centre and Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 283:E1272-8. 2002
    ..In contrast, IL-6 increased throughout exercise in arterial plasma, and a net IL-6 release from the contracting limb was observed after 120 min of exercise (P < 0.05)...
  45. pmc Exercise induces hepatosplanchnic release of heat shock protein 72 in humans
    Mark A Febbraio
    Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    J Physiol 544:957-62. 2002
    ..2 +/- 0.2 pg min(-1) after 120 min. These data demonstrate that the splanchnic tissues release HSP72 during exercise and this release is responsible, in part, for the elevated systemic concentration of this protein during exercise...
  46. pmc Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
    Adam Steensberg
    The Copenhagen Muscle Research Centre, Denmark
    J Physiol 548:631-8. 2003
    ..These data demonstrate that acute IL-6 administration does not impair whole-body glucose disposal, net leg-glucose uptake, or increase endogenous glucose production at rest in healthy young humans...
  47. ncbi request reprint Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects
    Bente Klarlund Pedersen
    Dept of Infectious Diseases, Rigshospitalet, Section 7641, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Pflugers Arch 446:9-16. 2003
    ..Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise..
  48. pmc Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
    Mark A Febbraio
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, DK 2100, Copenhagen Ø, Denmark
    J Physiol 549:607-12. 2003
    ..05) glucose uptake and a reduced (P < 0.05) FFA uptake in GLU. These results demonstrate that glucose ingestion during exercise attenuates leg IL-6 release but does not decrease intramuscular expression of IL-6 mRNA...
  49. ncbi request reprint Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise
    Jacinta Baldwin
    Department of Physiology, University of Melbourne, Parkville 3010, Victoria, Australia
    J Appl Physiol 94:2181-7. 2003
    ..Therefore, our data do not support the concept that a decrease in muscle TCAI during prolonged exercise in humans compromises aerobic energy provision or is the cause of fatigue...
  50. ncbi request reprint Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity
    Natalie Hiscock
    Skeletal Muscle Research Laboratory, Centre for Nutrition, Metabolism and Endocrinology, School of Medical Sciences, RMIT University, Melbourne, Australia
    FASEB J 18:992-4. 2004
    ..05). These data demonstrate that myocytes per se are a source of IL-6 produced during contraction. Our data also suggest that type 2 fibers predominantly produce IL-6 during muscle contractile activity...
  51. ncbi request reprint Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 286:E144-50. 2004
    ..16 +/- 0.59, GLU, 1.37 +/- 0.37 mmol/min) in GLU compared with CON. These results demonstrate that circulating insulin and epinephrine play a role in HSLa in contracting skeletal muscle...
  52. ncbi request reprint Hepatosplanchnic clearance of interleukin-6 in humans during exercise
    Mark A Febbraio
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 285:E397-402. 2003
    ..05). These data demonstrate that the hepatosplanchnic viscera remove IL-6 from the circulation in humans. This removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6...
  53. ncbi request reprint Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 287:E120-7. 2004
    ..These changes in IMTG degradation appear to disassociate, however, from the activity of the key enzymes responsible for synthesis and degradation of this substrate...
  54. ncbi request reprint Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
    Bente K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 102:814-6. 2007
  55. ncbi request reprint Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Gregory R Steinberg
    St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
    Cell Metab 4:465-74. 2006
    ..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity...
  56. ncbi request reprint Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance
    Sarah J Lessard
    School of Medical Sciences, RMIT University, P O Box 71, Bundoora, Victoria 3083, Australia
    Diabetes 56:1856-64. 2007
    ..Accordingly, exercise training and rosiglitazone may act as complementary therapies for the treatment of insulin resistance...
  57. ncbi request reprint Plasma glucose kinetics during prolonged exercise in trained humans when fed carbohydrate
    Damien J Angus
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3052, Australia
    Am J Physiol Endocrinol Metab 283:E573-7. 2002
    ..36 +/- 0.08 g/min. The results of this study demonstrate that glucose uptake increases continuously during prolonged, strenuous exercise when carbohydrate is ingested and does not appear to limit exercise performance...
  58. ncbi request reprint FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, The Baker Heart Research Institute, Commercial Road, Melbourne 3004, Victoria, Australia
    J Biol Chem 282:21176-86. 2007
    ..These data suggest that FOXO1 may be an important therapeutic target for human diseases where anabolism is impaired...
  59. pmc Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    Andrea L Hevener
    Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California, USA
    J Clin Invest 117:1658-69. 2007
    ..These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs...
  60. ncbi request reprint Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle
    Vernon G Coffey
    Exercise Metabolism Group, RMIT University, Bundoora, Australia
    Med Sci Sports Exerc 39:2135-44. 2007
    ..Regulation of skeletal muscle mass is highly dependent on contractile loading. The purpose of this study was to examine changes in growth factor and inflammatory pathways following high-frequency resistance training...
  61. pmc HSP72 protects against obesity-induced insulin resistance
    Jason Chung
    Cellular and Molecular Metabolism Laboratory, Clinical Physiology, and Human Vascular Biology, Baker Heart Research Institute, Prahran, P O Box 6492, Victoria 8008, Australia
    Proc Natl Acad Sci U S A 105:1739-44. 2008
    ..These findings identify an essential role for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding...
  62. doi request reprint Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 88:1379-406. 2008
    ..This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease...
  63. ncbi request reprint The cellular origin of plasma cytokine expression after acute exercise
    Mark A Febbraio
    Am J Physiol Regul Integr Comp Physiol 282:R1253-7; author reply R1254-7. 2002
  64. ncbi request reprint Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
    Sarah M Turpin
    St Vincent s Institute of Medical Research, Fitzroy, Victoria 3064, Australia
    Am J Physiol Endocrinol Metab 291:E1341-50. 2006
    ..We conclude that lipoapoptosis occurs in skeletal muscle myotubes, at least partially via de novo ceramide accumulation, and that inhibiting downstream apoptotic signaling improves glucose uptake in vitro...
  65. ncbi request reprint IL-6 activates HSP72 gene expression in human skeletal muscle
    Mark A Febbraio
    Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    Biochem Biophys Res Commun 296:1264-6. 2002
    ..05) 2.5- and 2.3-fold, respectively after 30min of infusion and remained elevated (P<0.05) for 24h following infusion. These data demonstrate that IL-6 can rapidly induce HSP72 gene expression in human skeletal muscle...
  66. ncbi request reprint Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    Clinton R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Diabetes 52:2338-45. 2003
    ..The data provide new evidence that the pathogenesis of type 2 diabetes involves perturbations to the antioxidant defense mechanism within skeletal muscle...
  67. ncbi request reprint Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle
    Sarah J Lessard
    Exercise Metabolism Group, RMIT University School of Medical Sciences, Bundoora, Victoria, Australia
    Endocrinology 145:5665-70. 2004
    ..Our data suggest, therefore, that rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle...
  68. ncbi request reprint Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?
    Mark A Febbraio
    Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Australia
    Exerc Sport Sci Rev 33:114-9. 2005
    ..IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ...
  69. ncbi request reprint Regulation of glucose kinetics during intense exercise in humans: effects of alpha- and beta-adrenergic blockade
    Kirsten F Howlett
    Exercise, Muscle and Metabolism Unit, School of Health Sciences, Deakin University, Burwood, Australia
    Metabolism 52:1615-20. 2003
    ..05) in BLK. These findings demonstrate that adrenergic blockade during intense exercise results in a blunted plasma glucose response that is due to enhanced glucose uptake, with no significant change in glucose production...
  70. ncbi request reprint Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle
    Sarah J Lessard
    School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E251-7. 2006
    ..ACC phosphorylation was decreased with obesity (P < 0.05) but restored to the level of lean controls with RSG treatment. Our data demonstrate that RSG restores AMPK signaling in skeletal muscle of insulin-resistant obese Zucker rats...
  71. ncbi request reprint Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E500-8. 2006
    ..Taken together, these data indicate that HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle...
  72. ncbi request reprint PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
    FASEB J 19:2072-4. 2005
    ..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity...
  73. ncbi request reprint Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites
    Jong Sam Lee
    Department of Physical Therapy, College of Medicine, Eulji University, Young Du Dong, Jung Gu, Daejeon, Seoul, South Korea
    J Appl Physiol (1985) 100:1467-74. 2006
    ..Diets rich in n-6 PUFA appear to prevent insulin resistance by directing fat into TAG, rather than other lipid metabolites...
  74. ncbi request reprint Signaling pathways for IL-6 within skeletal muscle
    Mark A Febbraio
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Exerc Immunol Rev 9:34-9. 2003
    ..This review will briefly discuss the signaling pathways involved in IL-6 gene transcription...
  75. ncbi request reprint Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72
    Graeme I Lancaster
    The Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Division of Biosciences, Bundoora, Victoria, Australia
    Exerc Immunol Rev 11:46-52. 2005
    ....
  76. ncbi request reprint Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Endocrinology 147:2077-85. 2006
    ..These data support the use of CNTF as a potential therapeutic means to combat lipid-induced insulin resistance...
  77. ncbi request reprint CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia
    Nat Med 12:541-8. 2006
    ....
  78. ncbi request reprint Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans
    Christian P Fischer
    Centre of Inflammation and Metabolism, The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet and The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 100:1679-87. 2006
    ..The results indicate that gamma-tocopherol comprises a potent inhibitor of the exercise-induced increase of HSP72 in skeletal muscle as well as in the circulation...