G C Farrell

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    A Enriquez
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biochem Biophys Res Commun 255:300-6. 1999
  2. ncbi request reprint Clinical potential of emerging new agents in hepatitis B
    G C Farrell
    Department of Medicine, University of Sydney at Westmead Hospital, New South Wales, Australia
    Drugs 60:701-10. 2000
  3. ncbi request reprint Drugs and steatohepatitis
    Geoffrey C Farrell
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Semin Liver Dis 22:185-94. 2002
  4. ncbi request reprint Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?
    Geoffrey C Farrell
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 18:124-38. 2003
  5. ncbi request reprint Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities
    L Zaluzny
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 5:256-63. 1990
  6. ncbi request reprint Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    G Robertson
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, New South Wales 2145, Australia
    Am J Physiol Gastrointest Liver Physiol 281:G1135-9. 2001
  7. ncbi request reprint Hepatitis C: an economic evaluation of extended treatment with interferon
    A Shiell
    Department of Public Health and Community Medicine, University of Sydney, NSW
    Med J Aust 171:189-93. 1999
  8. ncbi request reprint Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes
    C Liddle
    Department of Clinical Pharmacology, University of Sydney, Westmead Hospital, Australia
    J Clin Endocrinol Metab 83:2411-6. 1998
  9. ncbi request reprint Acute viral hepatitis
    G C Farrell
    Storr Liver Unit, Westmead Hospital, Sydney, NSW
    Med J Aust 168:565-70. 1998
  10. doi request reprint Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice
    K S Bell-Anderson
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
    Int J Obes (Lond) 35:1539-48. 2011

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    A Enriquez
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biochem Biophys Res Commun 255:300-6. 1999
    ..Further, they implicate leptin receptor signaling as a factor that may modulate expression of CYP gene products involved in fatty acid oxidation...
  2. ncbi request reprint Clinical potential of emerging new agents in hepatitis B
    G C Farrell
    Department of Medicine, University of Sydney at Westmead Hospital, New South Wales, Australia
    Drugs 60:701-10. 2000
    ....
  3. ncbi request reprint Drugs and steatohepatitis
    Geoffrey C Farrell
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Semin Liver Dis 22:185-94. 2002
    ..It follows that early recognition of hepatotoxicity is crucial to prevent the development of severer forms of liver disease and improve the clinical outcome...
  4. ncbi request reprint Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?
    Geoffrey C Farrell
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 18:124-38. 2003
    ..Some emerging concepts on pathogenesis will be mentioned briefly, but the emphasis will be on the potency of lifestyle adjustments (physical activity and diet) to prevent or reverse fatty liver disorders...
  5. ncbi request reprint Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities
    L Zaluzny
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 5:256-63. 1990
    ..46), P-450UT-F (rho = -0.65) and P-450j (rho = -0.71). Positive correlations of the same magnitude were also found between these mixed function oxidase activities and beta-hydroxybutyrate.(ABSTRACT TRUNCATED AT 250 WORDS)..
  6. ncbi request reprint Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    G Robertson
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, New South Wales 2145, Australia
    Am J Physiol Gastrointest Liver Physiol 281:G1135-9. 2001
    ....
  7. ncbi request reprint Hepatitis C: an economic evaluation of extended treatment with interferon
    A Shiell
    Department of Public Health and Community Medicine, University of Sydney, NSW
    Med J Aust 171:189-93. 1999
    ..To re-evaluate the cost effectiveness of treating hepatitis C virus (HCV) infection with interferon alfa (IF alpha) in Australia, taking into account changes in clinical practice...
  8. ncbi request reprint Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes
    C Liddle
    Department of Clinical Pharmacology, University of Sydney, Westmead Hospital, Australia
    J Clin Endocrinol Metab 83:2411-6. 1998
    ..Altered regulation of hepatic CYP3A4 is, therefore, likely to account for previous observations concerning the effects of endocrine diseases and hormonal treatments on human cytochrome P450-mediated drug and steroid metabolism...
  9. ncbi request reprint Acute viral hepatitis
    G C Farrell
    Storr Liver Unit, Westmead Hospital, Sydney, NSW
    Med J Aust 168:565-70. 1998
    ..Hepatitis A is a simple, enterically transmitted illness that does not cause chronic hepatitis. 95% of adults recover from acute hepatitis B, whereas infection with hepatitis B virus acquired in childhood usually becomes chronic...
  10. doi request reprint Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice
    K S Bell-Anderson
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
    Int J Obes (Lond) 35:1539-48. 2011
    ..The cannabinoid 1 receptor (CB1) antagonist SR141716 has been shown to improve obesity-associated metabolic complications in humans and rodent models. The aim of this study was to assess the effect of SR141716 in foz/foz mice...
  11. ncbi request reprint Drug-induced hepatic injury
    G C Farrell
    Storr Liver Unit, University of Sydney at Westmead Hospital, NSW, Australia
    J Gastroenterol Hepatol 12:S242-50. 1997
    ..Minocycline and diclofenac will be mentioned as two drugs for which drug hepatitis is an exceedingly rare complication. Finally, the evidence that Chinese herbal medicines can be hepatotoxic will be reviewed...
  12. ncbi request reprint Etiopathogenesis of nonalcoholic steatohepatitis
    S Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
    Semin Liver Dis 21:27-41. 2001
    ..In particular, the genetic, molecular, and cellular factors that ordain and moderate fibrosis in the context of steatohepatitis will be of greatest relevance to effective therapy and clinical outcome...
  13. ncbi request reprint Interferon suppresses the isoform-specific activities of hepatic cytochrome P450 in female rats
    P I Craig
    Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biochem Pharmacol 43:908-10. 1992
    ..Both hormone-dependent and hormone-independent isoforms are suppressed by IFN. The mechanism for this effect does not, however, appear to be mediated by changes in serum levels of sex steroids...
  14. ncbi request reprint Mechanism of azathioprine-induced injury to hepatocytes: roles of glutathione depletion and mitochondrial injury
    A U Lee
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, 2145, Westmead, NSW, Australia
    J Hepatol 35:756-64. 2001
    ..Cell death was prevented by potent antioxidants, glycine and blocking the mitochondrial permeability transition pore...
  15. pmc CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    I A Leclercq
    Storr Liver Unit, Department of Medicine and Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead NSW 2145, Australia
    J Clin Invest 105:1067-75. 2000
    ..We have now identified CYP4A enzymes as alternative initiators of oxidative stress in the liver...
  16. ncbi request reprint Drug-induced cholestasis
    S Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, New South Wales, Australia
    Semin Gastrointest Dis 12:113-24. 2001
    ..Nutritional support is essential for those with prolonged cholestasis, a subgroup who are at risk of developing biliary cirrhosis and liver failure. Timely referral for liver transplant assessment is crucial in these patients...
  17. ncbi request reprint Management of chronic hepatitis C virus infection: a new era of disease control
    N C Teoh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, New South Wales, Australia
    Intern Med J 34:324-37. 2004
    ..These latter factors favour fibrotic disease progression, complications of cirrhosis (such as hepatocellular carcinoma) and development of type 2 diabetes mellitus, as well as eroding the chances of SVR with antiviral therapy...
  18. ncbi request reprint Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice
    I A Leclercq
    Storr Liver Unit, University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    Biochem Biophys Res Commun 268:337-44. 2000
    ..This effect of leptin appears to be at least partly independent of the hypothalamic control of food intake...
  19. ncbi request reprint COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator
    Jun Yu
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    Hepatology 43:826-36. 2006
    ..COX-2 may therefore be a pro-inflammatory mediator in metabolic forms of steatohepatitis...
  20. ncbi request reprint Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    Geoffrey C Farrell
    The Storr Liver Unit, Westmead s Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Hepatology 43:S99-S112. 2006
    ..Future challenges are to approach NAFLD as a preventive public health initiative and to motivate affected persons to adopt a healthier lifestyle...
  21. ncbi request reprint Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats
    Michael K H Hsu
    Storr Liver Unit, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, NSW 2145, Australia
    J Hepatol 44:375-82. 2006
    ..Chronic ethanol consumption inhibits liver regeneration. We examined the effects of chronic ethanol consumption on two mitogen-activated protein kinases in relation to induction of cell cycle proteins after partial hepatectomy (PH)...
  22. ncbi request reprint Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice
    Isabelle A Leclercq
    Gastroenterology Unit, Universite Catholique de Louvain UCL, GAEN UCL 53 79, avenue E Mounier, 53, B 1200 Brussels, Belgium
    J Hepatol 41:926-34. 2004
    ..We analysed the role of NF-kappaB redox-sensitive signalling pathway of inflammatory recruitment in experimental steatohepatitis...
  23. ncbi request reprint Probing Prometheus: fat fueling the fire?
    Geoffrey C Farrell
    Hepatology 40:1252-5. 2004
  24. ncbi request reprint Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice
    Robert S McCuskey
    Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, AZ 85724 5044, USA
    Hepatology 40:386-93. 2004
    ..In conclusion, these results are consistent with a dysfunctional hepatic microvasculature. Thus, microvascular changes may contribute to progressive liver injury in metabolic and toxic forms of steatohepatitis...
  25. ncbi request reprint Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, and Department of Gastroenterology and Hepatology, Westmead Hospital, NSW, Australia
    Hepatology 40:46-54. 2004
    ..Reduced adiponectin level is associated with more extensive necroinflammation and may contribute to the development of necroinflammatory forms of NAFLD...
  26. ncbi request reprint Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis
    Jun Yu
    Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Biochem Biophys Res Commun 356:53-9. 2007
    ..These findings indicate that NO-1886 is a potential therapeutic agent for steatohepatitis...
  27. ncbi request reprint The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    ..By applying this model, a liver biopsy would have been avoided in 549 (75%) of the 733 patients, with correct prediction in 496 (90%)...
  28. ncbi request reprint TNF-alpha as therapeutic target in NASH: tried, but not yet proven
    Shivakumar Chitturi
    J Gastroenterol Hepatol 22:613-4. 2007
  29. ncbi request reprint NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis
    Aileen Dela Pena
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
    J Hepatol 46:304-13. 2007
    ..g., gp91phox) renders NADPH oxidase inactive. We tested whether activated inflammatory cells contribute to oxidant stress in steatohepatitis...
  30. doi request reprint VAT fat is bad for the liver, SAT fat is not!
    Jian Gao Fan
    J Gastroenterol Hepatol 23:829-32. 2008
  31. doi request reprint Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways
    Claire Z Larter
    Department of Gastroenterology and Hepatology, ANU Medical School, Australian National University at The Canberra Hospital, ACT, Australia
    J Hepatol 48:638-47. 2008
    ..We determined the effects of dietary lipid composition on steatohepatitis development with particular attention to the nature of lipid molecules that accumulate in the liver and pathways of hepatic triglyceride synthesis...
  32. ncbi request reprint Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation
    Claire Z Larter
    Australian National University Medical School at The Canberra Hospital, Canberra, Australian Capital Territory, Australia
    J Gastroenterol Hepatol 23:267-75. 2008
    ..n-3 polyunsaturated fatty acids (PUFA), such as those found in fish oil (FO), are naturally occurring PPARalpha ligands which also suppress lipid synthesis...
  33. ncbi request reprint Diannexin, a novel annexin V homodimer, provides prolonged protection against hepatic ischemia-reperfusion injury in mice
    Narci C Teoh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Gastroenterology 133:632-46. 2007
    ..Sinusoidal endothelial cells (SECs), damaged during reperfusion, activate and recruit inflammatory cells and platelets. We hypothesized that a recombinant human annexin V homodimer, Diannexin, would protect SECs from reperfusion injury...
  34. ncbi request reprint Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines
    Ian Homer Y Cua
    Storr Liver Unit, Westmead Millennium Institute and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Hepatology 46:66-73. 2007
    ..HCV-associated IR is most likely an adipocytokine-independent effect of the virus to modulate insulin sensitivity...
  35. ncbi request reprint How should we manage patients with non-alcoholic fatty liver disease in 2007?
    Henry L Y Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Gastroenterol Hepatol 22:801-8. 2007
    ..Lifestyle changes are the first line and mainstay of management...
  36. ncbi request reprint Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines
    Shivakumar Chitturi
    Gastroenterology and Hepatology Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Garran, Australia
    J Gastroenterol Hepatol 22:778-87. 2007
    ..The present document reviews the reasoning and evidence behind the APWP-NAFLD proposals for definition, assessment, and management of NAFLD in the Asia-Pacific region...
  37. ncbi request reprint Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary
    Geoffrey C Farrell
    Gastroenterology and Hepatology Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Garran, Australia
    J Gastroenterol Hepatol 22:775-7. 2007
  38. ncbi request reprint Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury
    Michael J Tapner
    Storr Liver Unit, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    J Hepatol 40:454-63. 2004
    ..To study effects of pharmacologic concentrations of azathioprine and 6-mercaptopurine (6-MP) on rat hepatocytes...
  39. ncbi request reprint NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia
    Hepatology 35:373-9. 2002
    ..IR is present in mild as well as advanced cases of NASH but is unusual in chronic HCV of similar fibrotic severity...
  40. ncbi request reprint Liver regeneration in obese mice with fatty livers: does the impairment have relevance for other types of fatty liver disease?
    Geoffrey C Farrell
    Hepatology 35:731-2. 2002
  41. ncbi request reprint HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, New South Wales 2145, Australia
    Hepatology 36:142-9. 2002
    ..In conclusion, hepatic iron is not a factor linked to hepatic fibrogenesis in patients with NASH. HFE mutations do not confer an additional risk of hepatic fibrosis in this disorder...
  42. ncbi request reprint Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    Isabelle A Leclercq
    Storr Liver Unit, Department of Medicine and Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW 2145, Australia
    J Hepatol 37:206-13. 2002
    ..The correlation between increased leptin, obesity and hepatic fibrosis prompted us to hypothesise that leptin has profibrogenic effects on the liver...
  43. ncbi request reprint Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Department of Anatomical Pathology, New South Wales, Australia
    J Gastroenterol Hepatol 17:873-81. 2002
    ..In the present prospective study, we examined metabolic factors associated with non-alcoholic fatty liver and viral genotype as predictors of steatosis and fibrosis in chronic hepatitis C infection...
  44. ncbi request reprint Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury
    Isabelle A Leclercq
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
    Gastroenterology 124:1451-64. 2003
    ..Our aim was to establish whether defective liver regeneration in ob/ob mice is a direct consequence of leptin-dependent, intracellular signaling mechanisms controlling cell-cycle regulation in hepatocytes...
  45. ncbi request reprint Changes in antipyrine clearance and platelet count, but not conventional liver tests, correlate with fibrotic change in chronic hepatitis C: value for predicting fibrotic progression
    Shirley A Coverdale
    The Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, NSW, Australia
    Am J Gastroenterol 98:1384-90. 2003
    ..We tested whether fibrotic progression in chronic hepatitis C could be predicted by liver tests, antipyrine clearance, or platelet count...
  46. ncbi request reprint Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    Emilia Ip
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    Hepatology 38:123-32. 2003
    ....
  47. ncbi request reprint Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection
    Narci C Teoh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    J Gastroenterol Hepatol 18:891-902. 2003
    ..A better understanding of preconditioning mechanisms will lead to novel approaches to improve outcomes of liver surgery...
  48. ncbi request reprint Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, and Department of Gastroenterology and Hepatology, Westmead Hospital, University of Sydney, NSW, Australia
    Hepatology 38:420-7. 2003
    ..In conclusion, liver failure is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis, except that HCC appears less common...
  49. ncbi request reprint Non-alcoholic steatohepatitis in the Asia-Pacific region: future shock?
    Shivakumar Chitturi
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    J Gastroenterol Hepatol 19:368-74. 2004
    ..Pharmacotherapy may play a role in selected individuals. A regional agenda for case definition, future study and public health initiatives is urgently required...
  50. ncbi request reprint Improved prediction of fibrosis in chronic hepatitis C using measures of insulin resistance in a probability index
    Archana Sud
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia
    Hepatology 39:1239-47. 2004
    ..Such an index should prove useful to guide decision making regarding the need for liver biopsy, and potentially for avoiding or deferring biopsy in a large proportion of patients with mild liver disease...
  51. ncbi request reprint Clear messages from sonographic shadows? Links between metabolic disorders and liver disease, and what to do about them
    Jason M Hui
    J Gastroenterol Hepatol 18:1115-7. 2003
  52. ncbi request reprint Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Insitute, and Department of Gastroenterology and Hepatology, University of Sydney at Westmead Hospital, New South Wales, Australia
    Gastroenterology 125:1695-704. 2003
    ..Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection...
  53. ncbi request reprint Emerging leaders of gastroenterology and hepatology in the Asia-Pacific region
    Geoffrey C Farrell
    J Gastroenterol Hepatol 22:961-2. 2007
  54. ncbi request reprint Fatty liver now, diabetes and heart attack later? The liver as a barometer of metabolic health
    Shivakumar Chitturi
    J Gastroenterol Hepatol 22:967-9. 2007
  55. ncbi request reprint Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
    Claire Z Larter
    The Storr Liver Unit, Westmead s Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia
    J Hepatol 44:253-61. 2006
  56. ncbi request reprint Drugs and the liver updated, 2002
    Geoffrey C Farrell
    Semin Liver Dis 22:109-13. 2002
  57. ncbi request reprint Changes in serum albumin during treatment of chronic hepatitis B with lamivudine: effects of response and emergence of drug resistance
    Jason M Hui
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia
    Am J Gastroenterol 97:1003-9. 2002
    ..The aim of the present study was to assess the effect of lamivudine therapy on hepatic synthetic function in patients with moderately severe chronic hepatitis B and, particularly, to determine the effect of drug resistance...
  58. doi request reprint Primary biliary cirrhosis in Asians: less common than in Europeans, but just as depressing
    Geoffrey C Farrell
    J Gastroenterol Hepatol 23:508-11. 2008
  59. ncbi request reprint Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
    Dinesh Kumar
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Australia
    Hepatology 36:1266-72. 2002
    ..7-481, P =.007). In conclusion, these data provide strong support for a direct causal association between HCV genotype 3 infection and hepatic steatosis...
  60. ncbi request reprint Expanding horizons for the Journal: The role of the Journal of Gastroenterology and Hepatology Foundation
    Geoffrey C Farrell
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 18:235-6. 2003
  61. ncbi request reprint Hepatotoxicity associated with non-steroidal anti-inflammatory drugs
    Narci C Teoh
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Darcy Road, PO Box 412, Westmead, New South Wales 2145, Australia
    Clin Liver Dis 7:401-13. 2003
    ..Better outcomes require people taking NSAIDs to be aware of possible drug reactions involving the liver, and prescribers should be vigilant for early symptoms of hepatotoxicity so that incriminated agents are discontinued promptly...
  62. ncbi request reprint Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice
    Todor Arsov
    John Curtin School of Medical Research, The Australian National University ANU, Canberra, ACT, Australia
    Biochem Biophys Res Commun 342:1152-9. 2006
    ..In this model of metabolic syndrome, transition of steatosis to steatohepatitis was associated with hypoadiponectinemia, a mediator of hepatic fatty acid disposal pathways...
  63. ncbi request reprint MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma
    Alexander D Guminski
    Department of Gynaecological Oncology, Westmead Hospital, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Gynecol Oncol 100:239-46. 2006
    ..The aim of this study was to determine the role of MRP2 in modulating cisplatin cytotoxicity in normal cells as well as the relationship between MRP2 expression and clinical response to platinum-based agents in ovarian cancer...
  64. ncbi request reprint The maturation of the Journal of Gastroenterology and Hepatology ( JGH) and the JGH Foundation
    Geoffrey C Farrell
    J Gastroenterol Hepatol 21:1-2. 2006
  65. ncbi request reprint Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C
    Dinesh Kumar
    Storr Liver Unit, Westmead Millennium Institute, Westmead, New South Wales, Australia
    J Gastroenterol Hepatol 20:1395-400. 2005
    ..Obesity associated hepatic steatosis has been suggested to have a premalignant potential. We determined whether hepatic steatosis predisposes to liver cancer in persons with chronic hepatitis C virus (HCV) infection...
  66. ncbi request reprint Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C
    Priyanka Bandara
    Storr Liver Unit, Westmead Millennium Institute, Sydney, Australia
    Liver Int 25:518-26. 2005
    ..We then determined whether regular antioxidant supplementation influenced these antioxidant levels or disease severity...
  67. ncbi request reprint Drug-induced cholestasis
    Lakshumanan S Velayudham
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, NSW, Australia
    Expert Opin Drug Saf 2:287-304. 2003
    ..This review considers diagnosis, pathogenesis, prevention and management of drug-induced cholestasis, with particular reference to frequently- and newly-described causes...
  68. ncbi request reprint New hepatitis C guidelines for the Asia-Pacific region: APASL consensus statements on the diagnosis, management and treatment of hepatitis C virus infection
    Geoffrey C Farrell
    J Gastroenterol Hepatol 22:607-10. 2007
  69. ncbi request reprint How reversible is hepatic functional impairment in autoimmune hepatitis?
    Shirley A Coverdale
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Australia
    J Gastroenterol Hepatol 18:371-5. 2003
    ..We quantifed the short-term effects of immunosuppressive therapy on hepatic metabolic function in autoimmune hepatitis to establish how long it takes to achieve maximum functional improvement...
  70. ncbi request reprint High sensitivity C-reactive protein values do not reliably predict the severity of histological changes in NAFLD
    Jason M Hui
    Hepatology 39:1458-9. 2004