Timothy W Failes

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat
    Timothy W Failes
    Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia
    J Inorg Biochem 101:396-403. 2007
  2. doi request reprint Cellular uptake and distribution of cobalt complexes of fluorescent ligands
    Natsuho Yamamoto
    Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
    J Biol Inorg Chem 13:861-71. 2008
  3. ncbi request reprint Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug
    Timothy W Failes
    Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia
    Chemistry 13:2974-82. 2007
  4. doi request reprint Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: the importance of pKa matching
    Timothy W Failes
    School of Chemistry, The University of Sydney, NSW, 2006, Australia
    J Inorg Biochem 115:220-5. 2012
  5. ncbi request reprint Structural investigations of palladium(II) and platinum(II) complexes of salicylhydroxamic acid
    Matthew D Hall
    Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, New South Wales 2006, Australia
    Inorg Chem 41:1223-8. 2002

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat
    Timothy W Failes
    Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia
    J Inorg Biochem 101:396-403. 2007
    ..Furthermore, biological testing of the marimastat complex established that these carriers are stable in non-reducing biological environments and would serve to deliver MMP inhibitors to tumour sites intact...
  2. doi request reprint Cellular uptake and distribution of cobalt complexes of fluorescent ligands
    Natsuho Yamamoto
    Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
    J Biol Inorg Chem 13:861-71. 2008
    ..The results also reveal that the cytotoxicity of such agents correlates with their uptake and distribution patterns and that these are influenced by the types of ligands attached to the complex...
  3. ncbi request reprint Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug
    Timothy W Failes
    Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia
    Chemistry 13:2974-82. 2007
    ..Both free marimastat and and its Co(III) complex increased metastasis in the model used, with the complex significantly more active...
  4. doi request reprint Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: the importance of pKa matching
    Timothy W Failes
    School of Chemistry, The University of Sydney, NSW, 2006, Australia
    J Inorg Biochem 115:220-5. 2012
    ....
  5. ncbi request reprint Structural investigations of palladium(II) and platinum(II) complexes of salicylhydroxamic acid
    Matthew D Hall
    Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, New South Wales 2006, Australia
    Inorg Chem 41:1223-8. 2002
    ..It was found that the [N,O'] mode gave the more stable complex, in accord with experimental observations. Stabilization of hydroxamate binding to platinum is evidently afforded by soft ligands lying trans to them...