Darryl Eyles

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. doi request reprint Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
    Darryl W Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    Front Neuroendocrinol 34:47-64. 2013
  2. pmc The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Parasit Vectors 4:28. 2011
  3. doi request reprint Developmental vitamin D deficiency causes abnormal brain development
    D W Eyles
    Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia
    Psychoneuroendocrinology 34:S247-57. 2009
  4. doi request reprint A sensitive LC/MS/MS assay of 25OH vitamin D3 and 25OH vitamin D2 in dried blood spots
    Darryl Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Q4076, Australia
    Clin Chim Acta 403:145-51. 2009
  5. doi request reprint The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status
    Darryl W Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia
    Paediatr Perinat Epidemiol 24:303-8. 2010
  6. ncbi request reprint Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function
    Darryl W Eyles
    Queensland Centre for Mental Health Research, Wacol, The School of Biomedical Sciences, The University of Queensland, Brisbane, and Perinatal Research Centre, Royal Brisbane and Women s Hospital, Herston, Australia
    Psychoneuroendocrinology 31:958-64. 2006
  7. doi request reprint Vitamin D in fetal brain development
    Darryl Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia
    Semin Cell Dev Biol 22:629-36. 2011
  8. pmc The impact of nonlinear exposure-risk relationships on seasonal time-series data: modelling Danish neonatal birth anthropometric data
    John McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Q4076, Australia
    BMC Med Res Methodol 7:45. 2007
  9. ncbi request reprint Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera
    John McGrath
    Department of Psychiatry, Queensland Centre for Schizophrenia Research, University of Queensland, The Park Centre for Mental Health, Wacol Q4076, Australia
    Schizophr Res 63:73-8. 2003
  10. ncbi request reprint Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development
    Pauline Ko
    School of Biomedical Sciences, University of Queensland, QLD 4072, Brisbane, Australia
    Brain Res Dev Brain Res 153:61-8. 2004

Collaborators

Detail Information

Publications38

  1. doi request reprint Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
    Darryl W Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    Front Neuroendocrinol 34:47-64. 2013
    ..In this review we have attempted to integrate this clinical epidemiology with potential vitamin D-mediated basic mechanisms. Throughout the review we have highlighted areas where we think future research should focus...
  2. pmc The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Parasit Vectors 4:28. 2011
    ..Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced "bendy" and "shaky" phenotypes...
  3. doi request reprint Developmental vitamin D deficiency causes abnormal brain development
    D W Eyles
    Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia
    Psychoneuroendocrinology 34:S247-57. 2009
    ..Our conclusions from these data are that vitamin D is a plausible biological risk factor for neuropsychiatric disorders and that vitamin D acts as a neurosteroid with direct effects on brain development...
  4. doi request reprint A sensitive LC/MS/MS assay of 25OH vitamin D3 and 25OH vitamin D2 in dried blood spots
    Darryl Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Q4076, Australia
    Clin Chim Acta 403:145-51. 2009
    ..While a number of methods exist to measure 25OHD in sera, none have been specifically developed to examine dried blood spots (DBS)...
  5. doi request reprint The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status
    Darryl W Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia
    Paediatr Perinat Epidemiol 24:303-8. 2010
    ..They could be used for case-control studies investigating the association between perinatal vitamin D status and later health outcomes...
  6. ncbi request reprint Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function
    Darryl W Eyles
    Queensland Centre for Mental Health Research, Wacol, The School of Biomedical Sciences, The University of Queensland, Brisbane, and Perinatal Research Centre, Royal Brisbane and Women s Hospital, Herston, Australia
    Psychoneuroendocrinology 31:958-64. 2006
    ..We conclude that the behavioural alterations induced by DVD deficiency are due to some adverse event in brain development rather than via an alteration in stress response...
  7. doi request reprint Vitamin D in fetal brain development
    Darryl Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia
    Semin Cell Dev Biol 22:629-36. 2011
    ..Finally, we discuss the epidemiological data that suggests that vitamin D deficiency either in utero or in early life may have adverse neuropsychiatric implications...
  8. pmc The impact of nonlinear exposure-risk relationships on seasonal time-series data: modelling Danish neonatal birth anthropometric data
    John McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Q4076, Australia
    BMC Med Res Methodol 7:45. 2007
    ..The aims of this paper are twofold: (a) to explore seasonal patterns in a large, Danish Medical Birth Register, and (b) to explore models based on seasonal exposures and a non-linear exposure-risk relationship...
  9. ncbi request reprint Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera
    John McGrath
    Department of Psychiatry, Queensland Centre for Schizophrenia Research, University of Queensland, The Park Centre for Mental Health, Wacol Q4076, Australia
    Schizophr Res 63:73-8. 2003
    ..Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia...
  10. ncbi request reprint Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development
    Pauline Ko
    School of Biomedical Sciences, University of Queensland, QLD 4072, Brisbane, Australia
    Brain Res Dev Brain Res 153:61-8. 2004
    ....
  11. pmc Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency
    John McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Richlands, Australia
    PLoS ONE 3:e2383. 2008
    ..Because the nucleus accumbens has been implicated in neuropsychiatric disorders, in the current study we examined protein expression in this region in adult rats exposed to DVD deficiency..
  12. ncbi request reprint Schizophrenia, vitamin D, and brain development
    Alan Mackay-Sim
    School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
    Int Rev Neurobiol 59:351-80. 2004
    ..quot; We also discuss the possibility of a broader set of environmental and genetic factors interacting via the nuclear hormone receptors to affect the development of the brain leading to schizophrenia...
  13. ncbi request reprint Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain
    Darryl W Eyles
    Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    J Chem Neuroanat 29:21-30. 2005
    ..The widespread distribution of 1alpha-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain...
  14. ncbi request reprint The neurodevelopmental hypothesis of schizophrenia: a review of recent developments
    John J McGrath
    Queensland Centre for Schizophrenia Research, The Park Center for Mental Health, Wacol, QLD 4076, Australia
    Ann Med 35:86-93. 2003
    ..The NDH has provided great impetus to the schizophrenia research community. Recent versions of the hypothesis have encouraged more focused and testable hypotheses...
  15. doi request reprint A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
    John J McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Locked Bag 500, Richlands Q4077, Australia
    J Steroid Biochem Mol Biol 121:471-7. 2010
    ..Further research is required in order to clarify the genetic architecture underlying 25OHD serum concentrations, and to unravel the mechanisms of action responsible for these associations...
  16. pmc Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update
    John J McGrath
    Queensland Center for Mental Health Research, The Park Center for Mental Health, Wacol, Queensland 4076, Australia
    Schizophr Bull 36:1073-8. 2010
    ..This article provides a concise summary of the epidemiological and animal experimental research that has explored this hypothesis...
  17. ncbi request reprint Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia
    James P Kesby
    School of Biomedical Science, University of Queensland, Brisbane, Australia
    Biol Psychiatry 60:591-6. 2006
    ..The aim of this study was to examine the impact of selected psychotropic agents and one well-known antipsychotic agent on the behavioral phenotype of DVD deplete rats...
  18. doi request reprint Developmental vitamin D (DVD) deficiency alters pup-retrieval but not isolation-induced pup ultrasonic vocalizations in the rat
    Thomas H J Burne
    Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia
    Physiol Behav 102:201-4. 2011
    ..We speculate that the altered maternal-pup interactions identified in the DVD model may impact on early periods of brain development and behaviour...
  19. ncbi request reprint The association between birth weight, season of birth and latitude
    John J McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    Ann Hum Biol 32:547-59. 2005
    ..Birth weight is known to fluctuate with month of birth and with latitude; however the mechanisms underlying these gradients remain unclear...
  20. ncbi request reprint Vitamin D3-implications for brain development
    John J McGrath
    Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, Australia
    J Steroid Biochem Mol Biol 89:557-60. 2004
    ..It remains to be seen if these processes are of clinical relevance in humans, but in light of the high rates of hypovitaminosis D in pregnant women and neonates, this area warrants further scrutiny...
  21. ncbi request reprint Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint
    Thomas H J Burne
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland 4076, Australia
    Behav Brain Res 174:119-24. 2006
    ..The time spent in the centre was not altered by prenatal diet or acute restraint. Thus, transient prenatal vitamin D deficiency induces a transient spontaneous hyperlocomotion in adulthood that is modulated by acute restraint stress...
  22. ncbi request reprint No association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III
    John McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
    Neuroepidemiology 29:49-54. 2007
    ..We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D(3) [25(OH)D] levels and performance on various cognitive tasks, based on a large, representative community sample...
  23. ncbi request reprint Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice
    Lauren R Harms
    School of Biomedical Sciences, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland 4072, Australia
    Behav Brain Res 187:343-50. 2008
    ....
  24. ncbi request reprint Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats
    Thomas H J Burne
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
    Behav Brain Res 154:549-55. 2004
    ..Thus, transient prenatal Vitamin D deficiency induces hyperlocomotion in adulthood, without severe motor abnormalities...
  25. doi request reprint Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats
    James P Kesby
    School of Biomedical Science, University of Queensland, Brisbane, QLD, 4072, Australia
    Psychopharmacology (Berl) 208:159-68. 2010
    ..DVD-deficient adult rats show novelty-induced hyperlocomotion and an enhanced locomotor response to MK-801, which can be ameliorated by pretreatment with the antipsychotic drug haloperidol...
  26. ncbi request reprint Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring
    Darryl W Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    Psychoneuroendocrinology 32:227-34. 2007
    ..These findings suggest there may be a therapeutic window for maternal dietary intervention in the DVD model of psychosis...
  27. doi request reprint Neonatal vitamin D status and childhood peanut allergy: a pilot study
    Raymond James Mullins
    John James Medical Centre, Deakin, Australia, Medical School, Canberra, Australia
    Ann Allergy Asthma Immunol 109:324-8. 2012
    ..Although a number of factors have been proposed to explain the increase in food allergy during the last decade, the possibility that vitamin D status may play a pathogenic role has received recent attention...
  28. ncbi request reprint Maternal vitamin D depletion alters neurogenesis in the developing rat brain
    Xiaoying Cui
    School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia
    Int J Dev Neurosci 25:227-32. 2007
    ..These results show that vitamin D can regulate cell proliferation in the developing brain. Further studies are warranted to examine the underlying mechanisms for these findings...
  29. doi request reprint Developmental vitamin D3 deficiency induces alterations in immune organ morphology and function in adult offspring
    Louise Harvey
    School of Biomedical Sciences, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Steroid Biochem Mol Biol 121:239-42. 2010
    ..Given an increased incidence of vitamin D3 deficiency in women of child-bearing age these findings may be highly relevant for autoimmune disorders with a developmental basis...
  30. ncbi request reprint Behavioural characterization of vitamin D receptor knockout mice
    Thomas H J Burne
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
    Behav Brain Res 157:299-308. 2005
    ..Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety...
  31. doi request reprint Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study
    John J McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
    Arch Gen Psychiatry 67:889-94. 2010
    ..Clues from the epidemiology of schizophrenia suggest that low levels of developmental vitamin D may be associated with increased risk of schizophrenia...
  32. ncbi request reprint Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle
    Thomas H J Burne
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Queensland 4111, Australia
    Physiol Behav 81:651-5. 2004
    ..We conclude that combined prenatal and chronic postnatal hypovitaminosis D, but not early life hypovitaminosis D, alters PPI...
  33. ncbi request reprint 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
    Jillanne Brown
    School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Neurosci Lett 343:139-43. 2003
    ..The role of vitamin D(3) during brain development warrants closer scrutiny...
  34. doi request reprint Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6J mice
    Claire J Foldi
    Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia
    Eur J Neurosci 31:556-64. 2010
    ..Male APA mice had thinner cortices at birth and increased cortical volume as adults. This animal model may assist in exploring the mechanism of action linking APA with disorders such as schizophrenia and autism...
  35. doi request reprint Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain
    James P Kesby
    School of Biomedical Science, University of Queensland, QLD 4072, Australia
    Neurosci Lett 461:155-8. 2009
    ..Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development...
  36. pmc Seasonal variation in birth weight
    John J McGrath
    CMAJ 173:733; author reply 733-4. 2005
  37. ncbi request reprint Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats
    Axel Becker
    O v Guericke University, Faculty of Medicine, Institute of Pharmacology and Toxicology, Leipziger Str 44, 39120 Magdeburg, Germany
    Behav Brain Res 161:306-12. 2005
    ..The behavioural phenotype associated with this animal model may provide insights into the neurobiological correlates of the cognitive impairments of schizophrenia...
  38. ncbi request reprint Hyperserotonaemia and reduced brain serotonin levels in NaS1 sulphate transporter null mice
    SooHyun Lee
    School of Biomedical Sciences, University of Queensland, St Lucia, Australia
    Neuroreport 18:1981-5. 2007
    ..Our data indicate that decreased circulating SO4 concentrations modulate 5-HT neurotransmitter and receptor levels, in a manner consistent with the behavioural phenotypes of Nas1 mice...