Genevieve Evin

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville 3010, and The Mental Health Research Institute, Parkville 3052, Australia
    Biochemistry 44:4332-41. 2005
  2. pmc Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein
    Jiang Li Tan
    Department of Pathology, The University of Melbourne, Parkville, Australia
    PLoS ONE 8:e61246. 2013
  3. pmc Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
    Michael Ho
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Int J Alzheimers Dis 2011:950932. 2010
  4. ncbi request reprint BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville, Vic, 3010, Australia
    Drugs Aging 30:755-64. 2013
  5. ncbi request reprint BACE inhibitors as potential therapeutics for Alzheimer's disease
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville, Vic, Australia
    Recent Pat CNS Drug Discov 2:188-99. 2007
  6. ncbi request reprint Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
    Genevieve Evin
    Department of Pathology, University of Melbourne, Parkville, Australia
    J Neurosci Res 74:386-92. 2003
  7. ncbi request reprint Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
    Genevieve Evin
    Department of Pathology, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia
    Peptides 23:1285-97. 2002
  8. ncbi request reprint Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    CNS Drugs 20:351-72. 2006
  9. doi request reprint BACE: Therapeutic target and potential biomarker for Alzheimer's disease
    Genevieve Evin
    Department of Pathology, University of Melbourne, Parkville, Australia
    Int J Biochem Cell Biol 42:1923-6. 2010
  10. ncbi request reprint BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity
    Genevieve Evin
    Department of Pathology, and Mental Health Research Institute, The University of Melbourne, Parkville VIC, Australia
    Recent Pat CNS Drug Discov 6:91-106. 2011

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville 3010, and The Mental Health Research Institute, Parkville 3052, Australia
    Biochemistry 44:4332-41. 2005
    ..From these observations, we propose a model for the structure of active gamma-secretase that would consist of dimerization of 400-500 kDa subunits and be consistent with the apparent molecular mass of the complex...
  2. pmc Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein
    Jiang Li Tan
    Department of Pathology, The University of Melbourne, Parkville, Australia
    PLoS ONE 8:e61246. 2013
    ....
  3. pmc Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
    Michael Ho
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Int J Alzheimers Dis 2011:950932. 2010
    ..Mg(2+) stabilized a 1,000 kDa presenilin 1 complex through blue native gel electrophoresis and size-exclusion chromatography. Data suggest that Ca(2+) and Mg(2+) stabilize γ-secretase and enhance its activity...
  4. ncbi request reprint BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville, Vic, 3010, Australia
    Drugs Aging 30:755-64. 2013
    ....
  5. ncbi request reprint BACE inhibitors as potential therapeutics for Alzheimer's disease
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville, Vic, Australia
    Recent Pat CNS Drug Discov 2:188-99. 2007
    ..The beginning of Phase I clinical trials has been approved for one of them and we can expect that in the near future BACE inhibitors will provide novel effective therapeutics to treat AD...
  6. ncbi request reprint Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
    Genevieve Evin
    Department of Pathology, University of Melbourne, Parkville, Australia
    J Neurosci Res 74:386-92. 2003
    ..Finally, the finding of the same secretase products in platelets and neurons make platelets a potentially useful and easily accessible clinical tool to monitor effects of novel therapies based on inhibition of beta- or gamma-secretase...
  7. ncbi request reprint Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
    Genevieve Evin
    Department of Pathology, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia
    Peptides 23:1285-97. 2002
    ..Therapeutic approaches based on secretase inhibition or amyloid clearance are currently under development...
  8. ncbi request reprint Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    CNS Drugs 20:351-72. 2006
    ..The full understanding of gamma-secretase regulation may yet uncover new therapeutic leads...
  9. doi request reprint BACE: Therapeutic target and potential biomarker for Alzheimer's disease
    Genevieve Evin
    Department of Pathology, University of Melbourne, Parkville, Australia
    Int J Biochem Cell Biol 42:1923-6. 2010
    ..A full understanding of BACE biology in health and disease is needed to establish a safe AD therapy based on BACE inhibitors...
  10. ncbi request reprint BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity
    Genevieve Evin
    Department of Pathology, and Mental Health Research Institute, The University of Melbourne, Parkville VIC, Australia
    Recent Pat CNS Drug Discov 6:91-106. 2011
    ..In this review, we summarize and discuss the latest patents and publications describing BACE-1 inhibitors, principally focussing on their drug properties and performance in preclinical trials...
  11. ncbi request reprint Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
    G Evin
    Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biochemistry 40:8359-68. 2001
    ..Binding of pepstatin-biotin to PS1 from lymphocytes of a heterozygous carrier of pathologic exon 9 deletion was markedly decreased as compared to control lymphocytes, suggesting that this PS1 mutation altered the pepstatin binding site...
  12. ncbi request reprint Alternative transcripts of presenilin-1 associated with frontotemporal dementia
    Genevieve Evin
    Department of Pathology, The University of Melbourne, and Mental Health Research Institute, Parkville, Victoria 3010, Australia
    Neuroreport 13:917-21. 2002
    ..RT-PCR analysis using nested primers showed the presence of PS1 gene products with deletions within the exon 4-8 region. Our results suggest that alternative transcription of PS1 may be associated with FTD...
  13. ncbi request reprint Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
    Janetta G Culvenor
    Department of Pathology, The University of Melbourne, Australia
    Eur J Biochem 271:375-85. 2004
    ..Higher molecular mass presenilin 1-reactive species were detected in brain containing presenilin 1 exon 9 deletion mutation. This abnormality was confirmed using cells transfected with the same presenilin deletion mutation...
  14. ncbi request reprint Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
    Margaret J Smith
    Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Grattan St, Parkville, Victoria 3010, Australia
    Brain Res Mol Brain Res 127:128-35. 2004
    ..Our findings support previous evidence for increased expression of this variant PS2 isoform in sporadic AD and suggest this isoform may contribute to neurodegeneration...
  15. ncbi request reprint Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage
    M Fleur Sernee
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Biochem 270:495-506. 2003
    ..The single aspartate mutations showed a concomitant reduction in Abeta secretion, whereas the D257A/D385A and DeltaE9 mutations had no effect on Abeta secretion...
  16. pmc Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease
    Ya Hui Hung
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    J Biol Chem 284:21899-907. 2009
    ..copper complexes are more likely to form. This explains the paradoxical hypermetallation of Abeta with copper under tissue copper deficiency conditions in AD...
  17. ncbi request reprint APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease
    Amee J George
    Department of Pathology, The University of Melbourne, Victoria, Australia
    Neurobiol Dis 16:124-32. 2004
    ..AICD has a proposed role in signal transduction and apoptosis, hence modulation of AICD production could be an alternative mechanism by which cholesterol contributes to AD pathogenesis...
  18. ncbi request reprint Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
    Anthony R White
    Department of Pathology, University of Melbourne, Cnr Grattan Street and Royal Parade, Victoria 3010, Australia
    J Biol Chem 281:17670-80. 2006
    ..Our findings identify an alternative mechanism of action for CQ in the reduction of Abeta deposition in the brains of CQ-treated animals and potentially in Alzheimer disease patients...
  19. ncbi request reprint Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
    Nancy T Ilaya
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 91:230-7. 2004
    ..These findings suggest a function for nicastrin in muscle other than participation in the gamma-secretase complex...
  20. pmc Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity
    Mark A Greenough
    Mental Health Research Institute, Parkville, Victoria 3052, Australia
    J Biol Chem 286:9776-86. 2011
    ..These data indicate that presenilins are important for cellular copper and zinc turnover, influencing SOD1 activity, and having the potential to indirectly impact β-amyloid aggregation through metal ion clearance...
  21. doi request reprint Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
    Claudia Santosa
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Dis 43:176-83. 2011
    ..These data suggest that altered compartmentalization of BACE in AD promotes the amyloidogenic processing of APP...
  22. ncbi request reprint Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
    R M Damian Holsinger
    Department of Pathology, Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
    Ann Neurol 51:783-6. 2002
    ..Similarly, we found the levels of the amyloid precursor protein C-terminal fragment produced by beta-secretase to be increased by nearly twofold in Alzheimer's disease cortex...
  23. doi request reprint Investigation of matrix metalloproteinases, MMP-2 and MMP-9, in plasma reveals a decrease of MMP-2 in Alzheimer's disease
    Nastasia K H Lim
    Department of Pathology, The University of Melbourne, Parkville VIC, Australia
    J Alzheimers Dis 26:779-86. 2011
    ..16, p < 0.05), but there was no association with PiB. This is the first report of a change in MMP-2 activity in AD plasma and these findings may provide some insight into AD pathogenesis...
  24. ncbi request reprint The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
    J Nunan
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Biochem 268:5329-36. 2001
    ..These results raise the possibility that defective proteasome function could lead to an increase in Abeta production in the AD brain...
  25. doi request reprint A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease
    Victoria M Perreau
    Neuroproteomics and Neurogenomics Platform, National Neurosciences Facility, The University of Melbourne, Parkville, Vic, Australia
    Proteomics 10:2377-95. 2010
    ..Gene ontology and network analysis were used to identify potentially novel functional relationships among interacting proteins...
  26. pmc Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues
    Hongyun Li
    Illawarra Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Clin Sci (Lond) 122:409-19. 2012
    ....
  27. doi request reprint Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis
    Jiangli Tan
    Department of Pathology, and Mental Health Research Institute, The University of Melbourne, Parkville, Australia
    J Neurochem 120:869-80. 2012
    ..Decreased levels of GGA3 also impair BACE1 degradation. Further understanding of BACE1 trafficking and its regulation may offer new therapeutic approaches for the treatment of Alzheimer's disease...
  28. ncbi request reprint Alternative transcripts of presenilin-1 associated with frontotemporal dementia
    Genevieve Evin
    Department of Pathology, The University of Melbourne, and Mental Health Research Institute, Parkville, Victoria 3010, Australia
    Neuroreport 13:719-23. 2002
    ..RT-PCR analysis using nested primers showed the presence of PS1 gene products with deletions within the exon 4-8 region. Our results suggest that alternative transcription of PS1 may be associated with FTD...
  29. ncbi request reprint Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells
    J G Culvenor
    Department of Pathology, University of Melbourne, Parkville, Victoria, 3052, Australia
    Exp Cell Res 255:192-206. 2000
    ..The differential expression of PS1 and PS2 within the P19 cells following retinoic acid treatment indicates different utilization or temporal requirements for these proteins during neuronal differentiation...
  30. ncbi request reprint Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system
    J G Culvenor
    Department of Pathology, University of Melbourne, Victoria, Australia
    Amyloid 5:79-89. 1998
    ..These studies demonstrate clear differences in the expression properties of different A beta PP polypeptides...
  31. ncbi request reprint Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment
    J G Culvenor
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    J Neurosci Res 49:719-31. 1997
    ..These results indicate that PS1 is a resident protein of the ERGIC and could be involved in trafficking of proteins, including APP, between the ER and Golgi compartments...
  32. doi request reprint Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia
    Adel Barakat
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Schizophr Res 124:200-7. 2010
    ..671, p<0.001) but not in the schizophrenic groups. These data suggest that the proteolytic processing of NRG1 is impaired in schizophrenia...