Kathryn A Ellis

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
    Kathryn A Ellis
    Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, St Vincent s Aged Psychiatry Service, St George s Hospital, Victoria, Australia
    Int Psychogeriatr 21:672-87. 2009
  2. ncbi request reprint Exploring the temporal dynamics of the spatial working memory n-back task using steady state visual evoked potentials (SSVEP)
    Kathryn A Ellis
    Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    Neuroimage 31:1741-51. 2006
  3. ncbi request reprint Tyrosine depletion alters cortical and limbic blood flow but does not modulate spatial working memory performance or task-related blood flow in humans
    Kathryn A Ellis
    Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    Hum Brain Mapp 28:1136-49. 2007
  4. ncbi request reprint A web-based normative data tool for assessing cognitive performance in healthy older Australians
    Simon J McBride
    Australian E Health Research Centre, CSIRO ICT Centre, Brisbane, QLD, Australia
    Med J Aust 194:S12-4. 2011
  5. doi request reprint Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative
    Kathryn A Ellis
    Department of Psychiatry, Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia
    Alzheimers Dement 6:291-6. 2010
  6. ncbi request reprint Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
    Yen Ying Lim
    1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
    Brain 137:221-31. 2014
  7. ncbi request reprint Decline in cognitive function over 18 months in healthy older adults with high amyloid-β
    Kathryn A Ellis
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 34:861-71. 2013
  8. doi request reprint BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Aging 34:2457-64. 2013
  9. doi request reprint Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing
    Christopher C Rowe
    Austin Health, Department of Nuclear Medicine and Centre for Positron Emission Tomography, Heidelberg, Victoria, Australia
    Ann Neurol 74:905-13. 2013
  10. doi request reprint Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS)
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Arch Clin Neuropsychol 28:320-30. 2013

Detail Information

Publications44

  1. ncbi request reprint The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
    Kathryn A Ellis
    Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, St Vincent s Aged Psychiatry Service, St George s Hospital, Victoria, Australia
    Int Psychogeriatr 21:672-87. 2009
    ..This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants...
  2. ncbi request reprint Exploring the temporal dynamics of the spatial working memory n-back task using steady state visual evoked potentials (SSVEP)
    Kathryn A Ellis
    Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    Neuroimage 31:1741-51. 2006
    ..The current findings may offer a framework in which to further investigate the temporal aspects of SWM...
  3. ncbi request reprint Tyrosine depletion alters cortical and limbic blood flow but does not modulate spatial working memory performance or task-related blood flow in humans
    Kathryn A Ellis
    Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    Hum Brain Mapp 28:1136-49. 2007
    ..These findings question the capacity of TPD to consistently modulate dopamine function and SWM neural networks in humans...
  4. ncbi request reprint A web-based normative data tool for assessing cognitive performance in healthy older Australians
    Simon J McBride
    Australian E Health Research Centre, CSIRO ICT Centre, Brisbane, QLD, Australia
    Med J Aust 194:S12-4. 2011
    ..A web-based calculator was developed to simplify the time-consuming process of comparing cognitive performance scores with these representative data...
  5. doi request reprint Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative
    Kathryn A Ellis
    Department of Psychiatry, Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia
    Alzheimers Dement 6:291-6. 2010
    ..Cross-sectional analysis of baseline data is revealing links between cognition, brain amyloid burden, structural brain changes, biomarkers, and lifestyle...
  6. ncbi request reprint Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
    Yen Ying Lim
    1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
    Brain 137:221-31. 2014
    ..Further, these results suggest that grouping amyloid data into at least two categories of abnormality may be useful in determining the disease risk level in non-demented individuals. ..
  7. ncbi request reprint Decline in cognitive function over 18 months in healthy older adults with high amyloid-β
    Kathryn A Ellis
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 34:861-71. 2013
    ....
  8. doi request reprint BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Aging 34:2457-64. 2013
    ..High Aβ levels coupled with Met carriage may be useful prognostic markers of accelerated cognitive decline and hippocampal degeneration in individuals in the preclinical stage of AD. ..
  9. doi request reprint Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing
    Christopher C Rowe
    Austin Health, Department of Nuclear Medicine and Centre for Positron Emission Tomography, Heidelberg, Victoria, Australia
    Ann Neurol 74:905-13. 2013
    ..We aimed to determine the prognostic value of β-amyloid imaging, alone and in combination with memory performance, hippocampal atrophy, and apolipoprotein E ε4 status in nondemented, older individuals...
  10. doi request reprint Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS)
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Arch Clin Neuropsychol 28:320-30. 2013
    ..This may potentially be used to inform future estimates of cognitive change in clinical trials...
  11. doi request reprint Aβ amyloid, cognition, and APOE genotype in healthy older adults
    Yen Ying Lim
    Department of Psychiatry, University of Melbourne, Parkville, Australia
    Alzheimers Dement 9:538-45. 2013
    ..Further, when demographic variables were controlled, the influence of APOE ε4 on the relationship between cerebral Aβ and cognition dissipated...
  12. doi request reprint Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study
    Yen Ying Lim
    Department of Psychiatry, University of Melbourne, Parkville, Vic, Australia
    J Clin Exp Neuropsychol 34:345-58. 2012
    ..These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes...
  13. doi request reprint Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neuropsychology 27:322-32. 2013
    ..We aimed to determine the extent to which high Aβ amyloid influenced cognitive function in healthy older adults and adults with MCI...
  14. doi request reprint Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: prodromal Alzheimer's disease?
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 33:1167-76. 2013
    ....
  15. doi request reprint Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Australia
    Neurology 79:1645-52. 2012
    ..Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear...
  16. doi request reprint Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
    Christopher C Rowe
    Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia
    Neurobiol Aging 31:1275-83. 2010
    ....
  17. ncbi request reprint Incidence of cerebral microbleeds in preclinical Alzheimer disease
    Paul A Yates
    From the Department of Nuclear Medicine and Centre for PET P A Y, V L V, C C R, Austin Health, Heidelberg The University of Melbourne P A Y, P M D, C S, C C R, Parkville Department of Radiology P M D, P M P, C S, Royal Melbourne Hospital, Parkville National Ageing Research Institute D A, Parkville CSIRO Preventative Health Flagship O S, Parkville Florey Institute of Neuroscience and Mental Health K A E, C L M, V L V, The University of Melbourne, Parkville Academic Unit for Psychiatry of Old Age K A E, D A, Department of Psychiatry, The University of Melbourne, Kew, Victoria Centre of Excellence for Alzheimer s Disease Research and Care R N M, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Australia
    Neurology 82:1266-73. 2014
    ..We sought to determine the incidence and associations of lobar microbleeds (LMBs) in a longitudinal cohort with (11)C-Pittsburgh compound B (PiB) PET imaging...
  18. doi request reprint Rapid decline in episodic memory in healthy older adults with high amyloid-β
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 33:675-9. 2013
    ..High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults...
  19. ncbi request reprint Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease
    Alan Rembach
    The Mental Health Research Institute, The University of Melbourne, Vic, Australia
    J Alzheimers Dis 34:171-82. 2013
    ..The aim of this study was to determine the diagnostic value of serum copper, CP, and non-CP copper levels in a large cohort of AD subjects...
  20. doi request reprint Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, VIC 3084, Australia
    Lancet Neurol 12:357-67. 2013
    ..We aimed to use longitudinal data to calculate the rates of amyloid β (Aβ) deposition, cerebral atrophy, and cognitive decline...
  21. ncbi request reprint Advances in structural and molecular neuroimaging in Alzheimer's disease
    Kathryn A Ellis
    Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 194:S20-3. 2011
    ....
  22. ncbi request reprint The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI
    Karra D Harrington
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Int Psychogeriatr 25:1667-77. 2013
    ..This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia...
  23. doi request reprint Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study
    Yen Ying Lim
    Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 9:e86498. 2014
    ..We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ...
  24. doi request reprint Short term stability of verbal memory impairment in mild cognitive impairment and Alzheimer's disease measured using the International Shopping List Test
    Yen Ying Lim
    Department of Psychiatry, University of Melbourne, Parkville, Australia
    J Clin Exp Neuropsychol 34:853-63. 2012
    ..There was no difference between groups on within-subject variability. These data suggest that in English-speaking samples, the ISLT is sensitive to MCI and can be given repeatedly in order to assess change in memory...
  25. ncbi request reprint Combined D1/D2 receptor stimulation under conditions of dopamine depletion impairs spatial working memory performance in humans
    Kathryn A Ellis
    Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
    Psychopharmacology (Berl) 181:771-80. 2005
    ....
  26. ncbi request reprint Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)
    Kathryn A Ellis
    Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne St Vincent s Aged Psychiatry Service, St George s Hospital, Kew, Victoria, Australia
    Int Psychogeriatr 26:543-54. 2014
    ..The first aim was to compute rates of transition from HC to MCI, and MCI to AD. The second aim was to characterize the cognitive profiles of individuals who transitioned to a more severe disease stage compared with those who did not...
  27. ncbi request reprint Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
    Robert H Pietrzak
    Robert H Pietrzak, PhD, MPH, J Cobb Scott, PhD, United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven and Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA Alexander Neumeister, MD, Departments of Psychiatry and Radiology, New York University School of Medicine, New York, USA Yen Ying Lim, PhD, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia David Ames, MD, Academic Unit for Psychiatry of Old Age, St Vincent s Health, Department of Psychiatry, The University of Melbourne, Kew and National Ageing Research Institute, Parkville, Victoria, Australia Kathryn A Ellis, PhD, The Florey Institute of Neuroscience and Mental Health, Parkville, Academic Unit for Psychiatry of Old Age, St Vincent s Health, Department of Psychiatry, The University of Melbourne, Kew and National Ageing Research Institute, Parkville, Victoria, Pest Infestation Laboratory
    Br J Psychiatry 204:400-1. 2014
    ..These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid. ..
  28. doi request reprint Plasma amyloid-β levels are significantly associated with a transition toward Alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden
    Alan Rembach
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Vic, Australia
    J Alzheimers Dis 40:95-104. 2014
    ..We evaluated the utility of longitudinal measures of plasma amyloid-β (Aβ) as a means to identify pre-symptomatic cognitive decline in Alzheimer's disease (AD) when coupled to neuroimaging and neuropsychological parameters...
  29. doi request reprint Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
    Alan Rembach
    The Mental Health Research Institute, The University of Melbourne, Victoria, Australia Electronic address
    Alzheimers Dement 10:53-61. 2014
    ..A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD)...
  30. doi request reprint Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease
    Vincent Dore
    CSIRO Preventative Health National Research Flagship ICTC, the Australian e Health Research Centre BioMedical, Royal Brisbane and Women s Hospital, Herston, Queensland, Australia
    JAMA Neurol 70:903-11. 2013
    ..We aimed to further characterize the cross-sectional and longitudinal relationship between Aβ deposition, gray matter atrophy, and cognitive impairment...
  31. doi request reprint Appearance modeling of 11C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
    Jurgen Fripp
    Australian e Health Research Center, CSIRO ICT Centre, Brisbane, Australia
    Neuroimage 43:430-9. 2008
    ....
  32. ncbi request reprint The cognitive effects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls
    Colin Palmer
    Behavioural Neuroscience Laboratory, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Victoria, Australia
    Hum Psychopharmacol 23:151-9. 2008
    ....
  33. ncbi request reprint Personal memory function in mild cognitive impairment and subjective memory complaints: results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) Study of Ageing
    Rachel F Buckley
    Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Vic, Australia The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Vic, Australia
    J Alzheimers Dis 40:551-61. 2014
    ..Mild cognitive impairment (MCI) is routinely diagnosed with the aid of neuropsychological tests, which do not tap the ABM and PSM domains...
  34. pmc Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial
    Elizabeth V Cyarto
    National Ageing Research Institute, Melbourne, Australia
    BMC Psychiatry 12:167. 2012
    ..The aim of AIBL Active is to determine whether a 24-month physical activity program can delay the progression of white matter changes on magnetic resonance imaging (MRI)...
  35. doi request reprint Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study
    Noel G Faux
    The Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 27:909-22. 2011
    ..These findings underscore the association of plasma homocysteine with cognitive deterioration, although not unique to AD, and identified an unexpected abnormality of red cell folate...
  36. doi request reprint Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement: A randomized controlled trial
    Helen Macpherson
    Centre for Human Psychopharmacology, NICM Collaborative Centre for Neurocognition, Swinburne University of Technology, 427 451 Burwood Road, Hawthorn, Melbourne, Vic, 3122, Australia
    Psychopharmacology (Berl) 220:351-65. 2012
    ..This randomized, double-blind, placebo-controlled trial was conducted to investigate the effects of 16 weeks multivitamin supplementation (Swisse Women's 50+ Ultivite ®) on cognition in elderly women...
  37. pmc Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia
    Ann Neurol 69:181-92. 2011
    ..Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression...
  38. ncbi request reprint Physical activity program preferences and perspectives of older adults with and without cognitive impairment
    Terence W H Chong
    Melbourne Health North Western Aged Persons Mental Health Program, Bundoora Extended Care Centre, Melbourne, Australia Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Asia Pac Psychiatry 6:179-90. 2014
    ..This paper describes (i) the attitudes, beliefs and barriers towards physical activity of older adults with and without cognitive impairment and (ii) their opinion of the attributes of the ideal physical activity program...
  39. ncbi request reprint Disclosing a dementia diagnosis: what do patients and family consider important?
    Maree Mastwyk
    Florey Institute of Neuroscience and Mental Health, 155 Oak Street, Parkville 3052, Victoria, Australia
    Int Psychogeriatr 26:1263-72. 2014
    ..They want the support of a family member or friend when they are told of their diagnosis and they would like a written summary to refer to afterwards. ..
  40. ncbi request reprint Among Vitamin B12 Deficient Older People, High Folate Levels are Associated with Worse Cognitive Function: Combined Data from Three Cohorts
    Eileen M Moore
    Department of Psychiatry, The University of Melbourne, Parkville, Vic, Australia Barwon Health, Geelong, Vic, Australia
    J Alzheimers Dis 39:661-8. 2014
    ..This topic is of global significance due to the wide distribution of food fortification programs, so prospective studies should be a high priority. ..
  41. ncbi request reprint Enabling a multidisciplinary approach to the study of ageing and Alzheimer's disease: an update from the Australian Imaging Biomarkers and Lifestyle (AIBL) study
    Kathryn A Ellis
    Academic Unit for Psychiatry of Old Age, University of Melbourne Department of Psychiatry, St Vincent s Aged Psychiatry Service, St George s Hospital, Kew, Victoria, Australia
    Int Rev Psychiatry 25:699-710. 2013
    ..In this paper, we present key findings from the AIBL study and discuss how they contribute to our understanding of AD pathogenesis and diagnosis...
  42. ncbi request reprint Muscarinic and nicotinic receptor modulation of object and spatial n-back working memory in humans
    Amity Green
    Behavioural Neuroscience Laboratory, Department of Physiology, Monash Centre for Brain and Behaviour, PO Box 13F, Monash University, Melbourne, VIC 3800, Australia
    Pharmacol Biochem Behav 81:575-84. 2005
    ....
  43. doi request reprint Health professionals' and students' perceptions of elder abuse
    Briony Dow
    National Ageing Research Institute, Melbourne, Victoria, Australia
    Australas J Ageing 32:48-51. 2013
    ..This study aimed to compare perceptions about elder abuse among health professionals and students in the same health disciplines...
  44. ncbi request reprint Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans
    Julia R Ellis
    Behavioural Neuroscience Laboratory, Department of Physiology, Monash Centre for Brain and Behaviour, Monash University, Melbourne Australia
    Int J Neuropsychopharmacol 9:175-89. 2006
    ....