J A Eisman

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Genetics of osteoporosis
    J A Eisman
    Bone and Mineral Research Program, St Vincent s Hospital, Sydney, New South Wales, Australia
    Endocr Rev 20:788-804. 1999
  2. ncbi request reprint Genetics, calcium intake and osteoporosis
    J A Eisman
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Proc Nutr Soc 57:187-93. 1998
  3. ncbi request reprint Pharmacogenetics of the vitamin D receptor and osteoporosis
    J A Eisman
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Drug Metab Dispos 29:505-12. 2001
  4. ncbi request reprint Cross-talk between 1,25-dihydroxyvitamin D3 and transforming growth factor-beta signaling requires binding of VDR and Smad3 proteins to their cognate DNA recognition elements
    N Subramaniam
    Bone and Mineral Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Biol Chem 276:15741-6. 2001
  5. ncbi request reprint Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes
    M A Brown
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Bone Miner Res 16:758-64. 2001
  6. doi request reprint Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria
    M Y Chan
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia
    Osteoporos Int 24:1015-22. 2013
  7. doi request reprint Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks
    N D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia
    Osteoporos Int 19:1431-44. 2008
  8. ncbi request reprint Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage
    E M Gardiner
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    FASEB J 14:1908-16. 2000
  9. ncbi request reprint Novel N-terminal variant of human VDR
    K L Sunn
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, 2010 Australia
    Mol Endocrinol 15:1599-609. 2001
  10. doi request reprint Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram
    S K Sandhu
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Osteoporos Int 21:863-71. 2010

Detail Information

Publications42

  1. ncbi request reprint Genetics of osteoporosis
    J A Eisman
    Bone and Mineral Research Program, St Vincent s Hospital, Sydney, New South Wales, Australia
    Endocr Rev 20:788-804. 1999
    ..Understanding the molecular physiology of such gene effects is likely to lead to more specific treatments and to allow the selection of more appropriate and effective treatment options...
  2. ncbi request reprint Genetics, calcium intake and osteoporosis
    J A Eisman
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Proc Nutr Soc 57:187-93. 1998
    ....
  3. ncbi request reprint Pharmacogenetics of the vitamin D receptor and osteoporosis
    J A Eisman
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Drug Metab Dispos 29:505-12. 2001
    ..Understanding the mechanisms underlying these allelic differences in relation to diet and lifestyle factors as well as response to therapy could aid selection of optimal therapy for osteoporosis prevention and treatment...
  4. ncbi request reprint Cross-talk between 1,25-dihydroxyvitamin D3 and transforming growth factor-beta signaling requires binding of VDR and Smad3 proteins to their cognate DNA recognition elements
    N Subramaniam
    Bone and Mineral Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Biol Chem 276:15741-6. 2001
    ..Thus the molecular mechanism, whereby Smad3 and VDR mediate cross-talk between the TGF-beta and vitamin D signaling pathways, requires both a VDRE and a SBE located in close proximity to the target promoter...
  5. ncbi request reprint Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes
    M A Brown
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Bone Miner Res 16:758-64. 2001
    ..These data support the involvement of COL1A1 in determination of bone density and the interaction of both COL1A1 and VDR with calcium intake in regulation of change of bone density over time...
  6. doi request reprint Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria
    M Y Chan
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia
    Osteoporos Int 24:1015-22. 2013
    ..e., BMD T-score > -2.5). We found that calcaneal QUS is an independent predictor of fracture risk in women with non-osteoporotic bone mineral density (BMD)...
  7. doi request reprint Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks
    N D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia
    Osteoporos Int 19:1431-44. 2008
    ..We have developed clinical nomograms for predicting 5-year and 10-year fracture risks for any elderly man or woman. The nomograms used age and information concerning fracture history, fall history, and BMD T-score or body weight...
  8. ncbi request reprint Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage
    E M Gardiner
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    FASEB J 14:1908-16. 2000
    ..A therapeutic approach that both stimulates cortical anabolic and inhibits trabecular resorptive pathways would be ideal for treatment of osteoporosis and other osteopenic disorders...
  9. ncbi request reprint Novel N-terminal variant of human VDR
    K L Sunn
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, 2010 Australia
    Mol Endocrinol 15:1599-609. 2001
    ..The intranuclear compartmentalization and altered functional activity of VDRB1 may mediate a specialized physiological role for this receptor isoform...
  10. doi request reprint Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram
    S K Sandhu
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Osteoporos Int 21:863-71. 2010
    ..These data emphasize the importance of external validation before widespread clinical implementation of prognostic tools in different cohorts...
  11. ncbi request reprint Species-divergent regulation of human and mouse osteocalcin genes by calciotropic hormones
    G P Thomas
    Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW, 2010, Australia
    Exp Cell Res 258:395-402. 2000
    ..Elucidation of this unique aspect of bone physiology will provide valuable insights into the still incompletely understood roles of osteocalcin and 1, 25-(OH)(2)D(3) in bone...
  12. ncbi request reprint Femoral neck axis length, height loss and risk of hip fracture in males and females
    J R Center
    Bone and Mineral Research Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Osteoporos Int 8:75-81. 1998
    ..Moreover, FNAL appears to have limited utility in the prediction of hip fracture risk and any role of HAL in the prediction of hip fracture does not relate to its major component of femoral neck length...
  13. ncbi request reprint Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts
    G P Thomas
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Endocrinol 170:451-60. 2001
    ....
  14. ncbi request reprint Association between breast cancer and bone mineral density: the Dubbo Osteoporosis Epidemiology Study
    T V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research St Vincent s Hospital, NSW 2010, Sydney, Australia
    Maturitas 36:27-34. 2000
    ..D.) years, as part of the Dubbo Osteoporosis Epidemiology Study (Australia)...
  15. ncbi request reprint Risk factors for proximal humerus, forearm, and wrist fractures in elderly men and women: the Dubbo Osteoporosis Epidemiology Study
    T V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Am J Epidemiol 153:587-95. 2001
    ..0, 3.6) and a history of falls (women: RR = 1.9, 95% CI: 1.4, 2.6) were also significant. These data suggest that elderly men and women largely share common risk factors for upper limb fractures and that FNBMD is the primary risk factor...
  16. ncbi request reprint Genetic and environmental correlations between bone formation and bone mineral density: a twin study
    M Harris
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Bone 22:141-5. 1998
    ..These findings indicate that BSAP and BMD are heritable and negatively correlated. However, the genetic loci influencing BSAP and BMD appear to be largely independent as are any environmental factors...
  17. ncbi request reprint Mortality after all major types of osteoporotic fracture in men and women: an observational study
    J R Center
    Bone and Mineral Research Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Lancet 353:878-82. 1999
    ..Mortality increases after hip fractures in women and more so in men. Little is known, however, about mortality after other fractures. We investigated the mortality associated with all fracture types in elderly women and men...
  18. ncbi request reprint Molecular mechanism of vitamin D receptor action
    L L Issa
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Inflamm Res 47:451-75. 1998
    ....
  19. ncbi request reprint Hormonal and biochemical parameters in the determination of osteoporosis in elderly men
    J R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales
    J Clin Endocrinol Metab 84:3626-35. 1999
    ....
  20. doi request reprint Neuropeptide Y mediates the short-term hypometabolic effect of estrogen deficiency in mice
    A Zengin
    Osteoporosis and Bone Biology, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Int J Obes (Lond) 37:390-8. 2013
    ..Hypothalamic neuropeptide Y (NPY) expression is altered by estrogen deficiency in rodents, but the long-term consequences on energy homeostasis are unknown...
  21. doi request reprint Bariatric surgery, bone loss, obesity and possible mechanisms
    M M Brzozowska
    Osteoporosis and Bone Biology Division, Garvan Institute of Medical Research, Sydney, Australia
    Obes Rev 14:52-67. 2013
    ....
  22. ncbi request reprint Discordance of longitudinal changes in bone density between densitometers
    S A Frost
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Bone 41:690-7. 2007
    ..Even though a high concordance between the densitometers was observed on a single measurement occasion, a significant discordance in longitudinal changes in BMD was observed...
  23. ncbi request reprint Osteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy
    A Carr
    HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent s Hospital, Sydney, Australia
    AIDS 15:703-9. 2001
    ..Osteopenia has been associated with antiretroviral therapy, particularly with protease inhibitors. Osteopenia in HIV-uninfected men is associated with mitochondrial defects...
  24. ncbi request reprint Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription
    G M Leong
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Biol Chem 276:18243-8. 2001
    ..Thus, SKIP appears to modulate both TGF-beta and nuclear hormone receptor signaling pathways...
  25. ncbi request reprint Quality of life in osteoporosis: reliability, consistency, and validity of the Osteoporosis Assessment Questionnaire
    A G Randell
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    J Rheumatol 25:1171-9. 1998
    ..To determine the reliability, consistency, and clinical utility of the Osteoporosis Assessment Questionnaire (OPAQ), an AIMS2 based self-assessment questionnaire...
  26. ncbi request reprint Development of a nomogram for individualizing hip fracture risk in men and women
    N D Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Osteoporos Int 18:1109-17. 2007
    ..We have developed a nomogram for predicting the absolute risk of hip fracture for any individual by using clinical factors, including age, prior fracture and fall, in addition to BMD that was based on a 15-year follow-up cohort study...
  27. ncbi request reprint Pharmacogenomics of osteoporosis: opportunities and challenges
    T V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Musculoskelet Neuronal Interact 6:62-72. 2006
    ....
  28. doi request reprint Association between hypertension and fragility fracture: a longitudinal study
    S Yang
    Division of Musculoskeletal Diseases, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, New South Wales, 2010, Australia
    Osteoporos Int 25:97-103. 2014
    ..Hypertension is an independent risk factor for osteoporosis and osteoporotic fracture in postmenopausal women...
  29. ncbi request reprint Expression of rat homeobox gene, rHOX, in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone morphogenetic protein 2 and parathyroid hormone-related protein
    Y S Hu
    Department of Medicine, The University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Mol Endocrinol 12:1721-32. 1998
    ..Furthermore, down-regulation of rHox mRNA by bone morphogenetic protein 2 and its up-regulation by PTHrP support a role of the homeodomain protein, rHox, in osteoblast differentiation...
  30. doi request reprint Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis
    K Ganda
    Department of Endocrinology and Metabolism, Bone Research Program, ANZAC Research Institute, The University of Sydney, Concord, NSW, 2139, Australia
    Osteoporos Int 24:393-406. 2013
    ..Fully coordinated, intensive models of care for secondary fracture prevention are more effective in improving patient outcomes than approaches involving alerts and/or education only...
  31. ncbi request reprint A randomized study of two different information-based interventions on the management of osteoporosis in minimal and moderate trauma fractures
    D Bliuc
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
    Osteoporos Int 17:1309-17. 2006
    ..A secondary aim was to define participant- and doctor-related barriers to osteoporosis management...
  32. ncbi request reprint Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk
    L L Issa
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Endocrinology 142:1606-15. 2001
    ..These data suggest different coactivators regulate VDR function via distinct mechanisms and support the hypothesis that the VDR recruits different coactivators depending on specific gene and cellular contexts...
  33. ncbi request reprint Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo
    N A Sims
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Mol Endocrinol 11:1695-708. 1997
    ..Increased understanding of these murine-human differences in osteocalcin regulation may shed light on the function of osteocalcin and its regulation by vitamin D in bone physiology...
  34. ncbi request reprint A polymorphism in the human GALR3 galanin receptor gene (GALNR3)
    N M Lapsys
    The Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Sydney, NSW 2010, Australia
    Mol Cell Probes 13:325-7. 1999
  35. ncbi request reprint Upper gastrointestinal and overall tolerability of alendronate once weekly in patients with osteoporosis: results of a randomized, double-blind, placebo-controlled study
    J A Eisman
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Curr Med Res Opin 20:699-705. 2004
    ..Subjects were randomized to alendronate 70 mg once weekly or matching placebo in a 1:1 ratio...
  36. ncbi request reprint Targeted overexpression of vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals
    B M Misof
    Ludwig Boltzmann Institute of Osteology, 4th Med Dept, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Calcif Tissue Int 73:251-7. 2003
    ....
  37. ncbi request reprint The use of multiple sites for the diagnosis of osteoporosis
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, S10 2RX Sheffield, UK
    Osteoporos Int 17:527-34. 2006
    ..It has been suggested that bone mineral density (BMD) measurements should be made at multiple sites, and that the lowest T-score should be taken for the purpose of diagnosing osteoporosis...
  38. ncbi request reprint Smoking and fracture risk: a meta-analysis
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 16:155-62. 2005
    ..Its validation on an international basis permits the use of this risk factor in case finding strategies...
  39. ncbi request reprint A family history of fracture and fracture risk: a meta-analysis
    J A Kanis
    Centre for Metabolic Bone Diseases WHO Collaborating Centre, University of Sheffield Medical School, Sheffield, UK
    Bone 35:1029-37. 2004
    ..Its identification on an international basis supports the use of this risk factor in case-finding strategies...
  40. ncbi request reprint rHox: a homeobox gene expressed in osteoblastic cells
    Y Hu
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    J Cell Biochem 59:486-97. 1995
    ..These data suggest that rHox is a potent negative regulator of gene expression, although the specific role of rHox in bone gene regulation remains to be determined...
  41. ncbi request reprint Body mass index as a predictor of fracture risk: a meta-analysis
    C de Laet
    Scientific Institute of Public Health, Brussels, Belgium
    Osteoporos Int 16:1330-8. 2005
    ..The significance of BMI as a risk factor varies according to the level of BMI. Its validation on an international basis permits the use of this risk factor in case-finding strategies...
  42. ncbi request reprint The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 18:1033-46. 2007
    ..The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. INTRODUCTION AND HYPOTHESES: To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD...