Lindsay M Edwards

Summary

Affiliation: University of Tasmania
Country: Australia

Publications

  1. pmc The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS ONE 5:e10681. 2010
  2. doi Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men
    Lindsay M Edwards
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK
    FASEB J 25:1088-96. 2011
  3. doi In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration
    Lindsay M Edwards
    School of Medicine, University of Tasmania, Private Bag 34, Medical Sciences Building One, Hobart, Tasmania 7000, Australia
    Mol Biosyst 7:3335-42. 2011
  4. pmc Endurance exercise training blunts the deleterious effect of high-fat feeding on whole body efficiency
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 301:R320-6. 2011
  5. doi A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects
    Cameron J Holloway
    Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
    Am J Clin Nutr 93:748-55. 2011
  6. pmc The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e37237. 2012
  7. doi Critical role of complex III in the early metabolic changes following myocardial infarction
    Lisa C Heather
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Cardiovasc Res 85:127-36. 2010
  8. ncbi Mitochondria and heart failure
    Andrew J Murray
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK corrected
    Curr Opin Clin Nutr Metab Care 10:704-11. 2007
  9. pmc Regulation of human metabolism by hypoxia-inducible factor
    Federico Formenti
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 107:12722-7. 2010
  10. doi A comparison of visual and quantitative assessment of left ventricular ejection fraction by cardiac magnetic resonance
    Cameron J Holloway
    Department of Physiology, University of Oxford, Oxford, UK
    Int J Cardiovasc Imaging 27:563-9. 2011

Detail Information

Publications11

  1. pmc The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS ONE 5:e10681. 2010
    ..7+/-0.2 vs. POST: 4.5+/-0.2 cm(2), p<0.05), yet exercising metabolites were unchanged. These results suggest that, in response to high altitude hypoxia, skeletal muscle function is maintained in humans, despite significant atrophy...
  2. doi Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men
    Lindsay M Edwards
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK
    FASEB J 25:1088-96. 2011
    ..01) and decreased power of attention (P<0.01). Thus, we have shown that a high-fat diet blunts whole-body efficiency and cognition in sedentary men. We suggest that this effect may be due to increased respiratory uncoupling...
  3. doi In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration
    Lindsay M Edwards
    School of Medicine, University of Tasmania, Private Bag 34, Medical Sciences Building One, Hobart, Tasmania 7000, Australia
    Mol Biosyst 7:3335-42. 2011
    ....
  4. pmc Endurance exercise training blunts the deleterious effect of high-fat feeding on whole body efficiency
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 301:R320-6. 2011
    ..Neither diet led to changes in citrate synthase, ATP synthase, or mitochondrial uncoupling protein 3. We conclude that prior exercise training blunts the deleterious effect of short-term, high-fat feeding on whole body efficiency...
  5. doi A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects
    Cameron J Holloway
    Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
    Am J Clin Nutr 93:748-55. 2011
    ..High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations...
  6. pmc The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e37237. 2012
    ..Thus, the aim of this study was to assess the reproducibility of (31)P-MRS in trained skeletal muscle...
  7. doi Critical role of complex III in the early metabolic changes following myocardial infarction
    Lisa C Heather
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Cardiovasc Res 85:127-36. 2010
    ..Therefore, we investigated cardiac mitochondrial metabolism shortly after infarction...
  8. ncbi Mitochondria and heart failure
    Andrew J Murray
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK corrected
    Curr Opin Clin Nutr Metab Care 10:704-11. 2007
    ..Therefore, it is crucial to elucidate the causes of mitochondrial myopathy, in order to improve cardiac and skeletal muscle function, and hence quality of life, in heart failure patients...
  9. pmc Regulation of human metabolism by hypoxia-inducible factor
    Federico Formenti
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 107:12722-7. 2010
    ..These findings have significant implications for the development of therapeutic approaches targeting the HIF pathway...
  10. doi A comparison of visual and quantitative assessment of left ventricular ejection fraction by cardiac magnetic resonance
    Cameron J Holloway
    Department of Physiology, University of Oxford, Oxford, UK
    Int J Cardiovasc Imaging 27:563-9. 2011
    ..4% on average, with particular inaccuracy in those with mild dysfunction. Given the important clinical information provided by LV assessment, quantitative analysis is recommended for accurate assessment...
  11. pmc Integrating muscle cell biochemistry and whole-body physiology in humans:(31)P-MRS data from the InSight trial
    Lindsay M Edwards
    School of Biological Sciences, University of Essex, Colchester, UK
    Sci Rep 3:1182. 2013
    ..Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable...