Peter R Ebeling
Affiliation: University of Melbourne
- Osteoporosis in men: its pathophysiology and the role of teriparatide in its treatmentClaudia Gagnon
Department of Medicine, The University of Melbourne, Western Hospital, Cnr Eleanor and Marion Streets, Footscray, VIC 3011, Australia
Clin Interv Aging 3:635-45. 2008..Furthermore, the evidence supporting the efficacy of teriparatide treatment in men with osteoporosis is reviewed and its current role in the management of osteoporosis in men is discussed...
- Osteoporosis in menPeter R Ebeling
Department of Endocrinology, Australian Institute of Musculoskeletal Science, North West Academic Centre, University of Melbourne, Western Health, Victoria, Australia
Curr Opin Rheumatol 25:542-52. 2013..Timely diagnosis and treatment of osteoporosis in men are therefore critical. Secondary causes for osteoporosis are common and need to be excluded. Absolute fracture risk assessment guides selection of men for anti-osteoporotic therapy...
- Efficacy and safety of vertebroplasty for treatment of painful osteoporotic vertebral fractures: a randomised controlled trial [ACTRN012605000079640]Rachelle Buchbinder
Monash Department of Clinical Epidemiology, Cabrini Hospital, 183 Wattletree Rd, Malvern Victoria, Australia
BMC Musculoskelet Disord 9:156. 2008....
- What is the clinical and ethical importance of incidental abnormalities found by knee MRI?Rebecca Grainger
Department of Medicine, Wellington School of Medicine, University of Otago, 23A Mein St, Newtown, Wellington South 6021, New Zealand
Arthritis Res Ther 10:R18. 2008..The prevalence of incidental, potentially clinically significant abnormalities identified by MRI and their clinical significance in a population undergoing knee MRI in research studies are unknown...
- Androgens and osteoporosisPeter R Ebeling
Department of Medicine RMH WH, The University of Melbourne, Western Hospital, Footscray, Victoria, Australia
Curr Opin Endocrinol Diabetes Obes 17:284-92. 2010..Osteoporosis in men is an important public health problem. An improved understanding of the role of androgens in the pathophysiology of bone loss will lead to new treatments...
- Clinical practice. Osteoporosis in menPeter R Ebeling
Department of Medicine, Royal Melbourne Hospital Western Hospital, and University of Melbourne, Western Hospital, Melbourne, Victoria, Australia
N Engl J Med 358:1474-82. 2008
- Transplantation osteoporosisPeter R Ebeling
Department of Medicine RMH WH, University of Melbourne, Western Hospital, Footscray Vic 3011, Australia
Curr Osteoporos Rep 5:29-37. 2007..Large, multicenter treatment trials with oral or parenteral bisphosphonates and calcitriol are recommended...
- Approach to the patient with transplantation-related bone lossPeter R Ebeling
Department of Medicine Royal Melbourne Hospital Western Hospital and Endocrinology, The University of Melbourne, Western Hospital, Gordon Street, Footscray 3011, Victoria, Australia
J Clin Endocrinol Metab 94:1483-90. 2009..Active vitamin D metabolites may have additional benefits in reducing hyperparathyroidism, particularly after kidney transplantation...
- Routine screening for vitamin D deficiency in early pregnancy: past its due date?Peter R Ebeling
Med J Aust 194:332-3. 2011
- Idiopathic or hypogonadal osteoporosis in men: current and future treatment optionsPeter R Ebeling
Department of Diabetes and Endocrinology, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Treat Endocrinol 3:381-91. 2004..In the future, selective androgen receptor modulating drugs may be useful in the prevention and treatment of osteoporosis, and in increasing lean body mass in men, without having adverse effects on prostate and breast tissue...
- Serum 25-hydroxyvitamin D deficiency and the 5-year incidence of CKDMatthew J Damasiewicz
Department of Nephrology, Monash Medical Centre, Melbourne, Australia
Am J Kidney Dis 62:58-66. 2013..Low serum 25-hydroxyvitamin D (25[OH]D) levels have been associated with chronic kidney disease in cross-sectional studies. However, this association has not been studied prospectively in a large general population-based cohort...
- 25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) studyMatthew J Damasiewicz
Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, 3168, Victoria, Australia
BMC Nephrol 13:55. 2012..We explored the relationship between 25(OH)D levels and prevalent chronic kidney disease (CKD), albuminuria and impaired GFR, in a national, population-based cohort of Australian adults (AusDiab Study)...
- Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based studyRobin M Daly
Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia
Clin Endocrinol (Oxf) 77:26-35. 2012..This study evaluated the vitamin D status of Australian adults aged ≥25 years and risk factors associated with vitamin D deficiency in this population. Design and..
- Frequent walking, but not total physical activity, is associated with increased fracture incidence: a 5-year follow-up of an Australian population-based prospective study (AusDiab)Riku Nikander
Department of Medicine, NorthWest Academic Centre, University of Melbourne, Western Hospital, Melbourne, Australia
J Bone Miner Res 26:1638-47. 2011..In conclusion, older adults who adhered to the current PA guidelines were not protected against fragility fractures, but more frequent walking was associated with an increased fracture risk...
- The relative effect of endogenous estradiol and androgens on menopausal bone loss: a longitudinal studyJanet R Guthrie
Office for Gender and Health, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Charles Connibere Building, Melbourne, Victoria, Australia
Osteoporos Int 15:881-6. 2004..The aim of this study was to assess the relative strength of the association of endogenous estradiol and androgens with bone loss at the lumbar spine and femoral neck during the menopausal transition...
- Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: a community-based randomized controlled trialJenny Gianoudis
NorthWest Academic Centre, University of Melbourne, Western Health, Melbourne, Australia Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia
J Bone Miner Res 29:182-91. 2014..Although this did not translate into a reduction in the rate of falls, further large-scale trials are needed to evaluate the efficacy of this multimodal approach on reducing falls and fracture...
- Environmental, personal, and genetic determinants of response to vitamin d supplementation in older adultsMary Waterhouse
Population Health Division M W, B T, C B, C H, P M W, D C W, R E N, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia Centre for Research Excellence in Sun and Health B T, P R E, M G K, D C W, R E N, Kelvin Grove, Queensland 4059, Australia Sydney School of Public Health, The University of Sydney B K A, Sydney, New South Wales 2006, Australia Northwest Academic Centre, The University of Melbourne P R E, St Albans, Victoria 3021, Australia Melbourne School of Population and Global Health D R E, The University of Melbourne, Melbourne, Victoria 3010, Australia Cancer Epidemiology Centre D R E, Cancer Council Victoria, Melbourne, Victoria 3004, Australia National Health and Medical Research Council Clinical Trials Centre V G, Sydney Medical School, The University of Sydney, Sweden
J Clin Endocrinol Metab 99:E1332-40. 2014....
- Vitamin D and health in adults in Australia and New Zealand: a position statementCaryl A Nowson
Centre for Physical Activity and Nutrition Research, Deakin University, Melbourne, Vic
Med J Aust 196:686-7. 2012..People in high-risk groups may require higher doses. There is good evidence that vitamin D plus calcium supplementation effectively reduces fractures and falls in older men and women...
- Secondary causes of low bone mass in patients with breast cancer: a need for greater vigilanceG Bruce Mann
Royal Women s Hospital, Parkville, Victoria, 3052, Australia
J Clin Oncol 27:3605-10. 2009..An observational study to assess the prevalence of secondary causes of low bone density in patients with breast cancer...
- Undercarboxylated osteocalcin, muscle strength and indices of bone health in older womenItamar Levinger
Institute of Sport, Exercise and Active Living ISEAL, College of Sport and Exercise Science, Victoria University, Melbourne, Australia Australian Institute of Musculoskeletal Science, NorthWest Academic Centre, The University of Melbourne, Western Health, St Albans, Australia Electronic address
Bone 64:8-12. 2014..These data support a role for ucOC in musculoskeletal interactions in humans. Whilst tOC is associated with bone health, ucOC% and ucOC may also be linked to falls and fracture risk by influencing muscle function...
- Decreased spinal and femoral neck volumetric bone mineral density (BMD) in men with primary osteoporosis and their first-degree male relatives: familial effect on BMD in menBircan Erbas
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Parkville, Australia
Clin Endocrinol (Oxf) 66:78-84. 2007..The purpose of this study was to examine differences in bone volume and volumetric bone mineral density (vBMD) in men with primary osteoporosis and their first-degree male relatives (FDMR)...
- Osteo-cise: strong bones for life: protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fracturesJenny Gianoudis
NorthWest Academic Centre, Department of Medicine, University of Melbourne, Western Health, Melbourne, Australia
BMC Musculoskelet Disord 13:78. 2012..Thus, there is a need to develop evidence-based, safe and acceptable prevention strategies at the population level that target multiple risk factors for fragility fractures to reduce the health and economic burden of the condition...
- Is high dose vitamin D harmful?Kerrie M Sanders
Department of Medicine, Western Health, NorthWest Academic Centre, University of Melbourne, PO Box 294, St Albans, Vic, 3021, Australia
Calcif Tissue Int 92:191-206. 2013..The current dilemma of defining vitamin D insufficiency and identifying safe and efficacious repletion regimens needs to be resolved...
- Lack of sustained response to teriparatide in a patient with adult hypophosphatasiaClaudia Gagnon
Department of Medicine, University of Melbourne, Western Hospital, Footscray Vic 3011, Australia
J Clin Endocrinol Metab 95:1007-12. 2010..In contrast to the two previously reported cases, biochemical response to teriparatide was unsustained, suggesting that response may be variable depending on the TNSALP gene mutation...
- Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: a systematic reviewSharon L Brennan
Department of Medicine, NorthWest Academic Centre, The University of Melbourne, Sunshine Hospital, St Albans, Victoria, Australia
J Clin Densitom 15:165-75. 2012....
- Efficacy and safety of oral continuous low-dose versus short-term high-dose vitamin D: a prospective randomised trial conducted in a clinical settingKathryn L Hackman
Department of Medicine, University of Melbourne, Melbourne, Vic, Australia
Med J Aust 192:686-9. 2010..The primary end points were the change in serum 25-hydroxyvitamin D (25(OH)D) concentrations at 3 months and the development of hypercalcaemia and hypercalciuria...
- When continuity of care breaks down: a systems failure in identification of osteoporosis risk in older patients treated for minimal trauma fracturesAnne Maree Kelly
Joseph Epstein Centre for Emergency Medicine Research, Western Health, Melbourne, Vic
Med J Aust 188:389-91. 2008..Our aim was to determine the proportion of patients who underwent bone density testing for osteoporosis of those with a minimal trauma wrist fracture treated in the emergency department (ED)...
- A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urineJohn R Sheedy
Department of Medicine, Royal Melbourne and Western Hospitals, University of Melbourne, Footscray, Victoria 3011, Australia
Anal Biochem 398:263-5. 2010..The efficacy of this protocol was tested using a bovine serum albumin/metabolite mix and human serum samples. This sample preparation method can be readily applied to any protein-containing biofluid for (1)H NMR studies...
- Effect of vitamin D supplementation on antibiotic use: a randomized controlled trialBich Tran
Population Health Department, Queensland Institute of Medical Research, Brisbane, Queensland, Australia BT, DCW, PMW, and REN the Centre for Research Excellence in Sun and Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia BT, MGK, DCW, and REN the School of Population Health, University of Queensland, Brisbane, Queensland, Australia JCvdP the Sydney School of Public Health BKA and the National Health and Medical Research Council of Australia Clinical Trials Centre, Sydney Medical School VG, University of Sydney, Camperdown, New South Wales, Australia Northwest Academic Centre, University of Melbourne, and Western Health, Melbourne, Victoria, Australia PRE the School of Population Health, University of Melbourne, Parkville, Victoria, Australia DRE the AusSun Research Laboratory, Queensland University of Technology, Kelvin Grove, Queensland, Australia MGK and the Menzies Research Institute Tasmania, Hobart, Tasmania, Australia AV
Am J Clin Nutr 99:156-61. 2014..Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent...
- Suburban clustering of vitamin D deficiency in Melbourne, AustraliaBircan Erbas
Centre for Molecular Environmental Genetic Analytic Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria, Australia
Asia Pac J Clin Nutr 17:63-7. 2008..Vitamin D status of women with differ-ing age and ethnic distributions residing in other suburbs is unknown...
- Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adultsDavid Scott
NorthWest Academic Centre, The University of Melbourne and Western Health, St Albans, Victoria, Australia Australian Institute of Musculoskeletal Science, St Albans, Victoria, Australia
Obesity (Silver Spring) 22:1568-74. 2014..To determine whether obesity concurrent with sarcopenia (low muscle mass) or dynapenia (low muscle strength) is associated with increased falls risk in middle-aged and older adults...
- Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fractureDavid Scott
NorthWest Academic Centre, The University of Melbourne, Western Health, St Albans, Victoria, Australia Electronic address
Arch Gerontol Geriatr 58:308-13. 2014..Quadriceps strength tests may be an acceptable alternative to gait speed for geriatric assessments of falls risk...
- Is excess calcium harmful to health?Robin M Daly
Department of Medicine, The University of Melbourne, Western Hospital, Melbourne 3011, Australia
Nutrients 2:505-22. 2010....
- Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study)Claudia Gagnon
Department of Medicine, NorthWest Academic Centre, The University of Melbourne, Western Hospital, Melbourne, Australia
Diabetes Care 34:1133-8. 2011..To examine whether serum 25-hydroxyvitamin D (25OHD) and dietary calcium predict incident type 2 diabetes and insulin sensitivity...
- A randomized trial of vertebroplasty for painful osteoporotic vertebral fracturesRachelle Buchbinder
Monash Department of Clinical Epidemiology, Cabrini Hospital, and Monash University, Malvern, Vic, Australia
N Engl J Med 361:557-68. 2009..Vertebroplasty has become a common treatment for painful osteoporotic vertebral fractures, but there is limited evidence to support its use...
- Serum selenium status in Graves' disease with and without orbitopathy: a case-control studyJwu Jin Khong
NorthWest Academic Centre, The University of Melbourne, Western Health, St Albans, Australia Orbital Plastics and Lacrimal Unit, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
Clin Endocrinol (Oxf) 80:905-10. 2014..The study aims to determine whether serum selenium levels are reduced in patients with Graves' disease with orbitopathy (GO) compared with without orbitopathy (GD)...
- Vitamin D deficiency and its role in muscle-bone interactions in the elderlyKerrie M Sanders
NorthWest Academic Centre, The University of Melbourne, St Albans, Victoria, Australia, 3021
Curr Osteoporos Rep 12:74-81. 2014....
- Central abdominal fat and endogenous hormones during the menopausal transitionJanet R Guthrie
Office for Gender and Health, Royal Melbourne Hospital, Victoria, Australia
Fertil Steril 79:1335-40. 2003..To investigate the effect of endogenous hormone levels on central abdominal fat during the menopausal transition in a population-based cohort of Australian-born women...
- Cord blood-derived macrophage-lineage cells rapidly stimulate osteoblastic maturation in mesenchymal stem cells in a glycoprotein-130 dependent mannerTania J Fernandes
NorthWest Academic Centre, Department of Medicine, The University of Melbourne, Victoria, Australia Barwon Biomedical Research, The Geelong Hospital, Geelong, Victoria, Australia
PLoS ONE 8:e73266. 2013..This supports the notion that eliciting gp130-dependent signals in human MSC would be a useful approach to increase bone formation. ..
- Oral health risk factors for bisphosphonate-associated jaw osteonecrosisClaudine Tsao
Oral Health CRC and Melbourne Dental School, University of Melbourne, Melbourne, Australia
J Oral Maxillofac Surg 71:1360-6. 2013..To investigate the role of oral health, including periodontitis, as a risk factor for bisphosphonate-associated jaw osteonecrosis (ONJ)...
- An atypical subtrochanteric femoral fracture from pycnodysostosis: a lesson from natureChristopher J Yates
Endocrinology Unit, University of Melbourne, Western Hospital, Footscray, Victoria, Australia
J Bone Miner Res 26:1377-9. 2011..Therefore, there should be vigilant monitoring for the development of long-term complications noted to occur in diseases of reduced osteoclast function, including pycnodysostosis, in patients receiving these novel antiresorptive agents...
- Relationship between bone markers and knee cartilage volume in healthy menYuanyuan Wang
Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Australia
J Rheumatol 32:2200-4. 2005..To determine the relationship between biochemical bone markers and knee cartilage volume and cartilage loss over 2 years; and to investigate whether bone markers are useful to predict the cartilage loss in healthy men...
- The relationship between body composition and knee cartilage volume in healthy, middle-aged subjectsFlavia M Cicuttini
Monash University Medical School, Alfred Hospital, Prahran, Australia
Arthritis Rheum 52:461-7. 2005..This study examined the effect of measures of body composition on the longitudinal change in tibial cartilage volume...
- Defective osteoblast function may be responsible for bone loss from the proximal femur despite pamidronate therapyPeter R Ebeling
J Clin Endocrinol Metab 90:4414-6. 2005
- Editorial: inhibin in bone--new tricks for an old dogPeter R Ebeling
J Clin Endocrinol Metab 91:1669-70. 2006
- Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatmentSundeep Khosla
J Oral Maxillofac Surg 66:1320-1; author reply 1321-2. 2008
- Preventing osteoporosis: outcomes of the Australian Fracture Prevention SummitPhilip N Sambrook
Med J Aust 176:S1-16. 2002
- Randomized controlled trial of the effects of calcium with or without vitamin D on bone structure and bone-related chemistry in elderly women with vitamin D insufficiencyKun Zhu
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
J Bone Miner Res 23:1343-8. 2008..Vitamin D supplementation adds no extra short-term skeletal benefit to calcium citrate supplementation even in women with vitamin D insufficiency...
- Megadose therapy for vitamin D deficiencyPeter R Ebeling
Med J Aust 183:4-5. 2005
- The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal womenFabien S Dalais
Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Hospital, Prahran, Australia
Clin Endocrinol (Oxf) 58:704-9. 2003..To assess the effect of a dietary soy protein supplement containing isoflavones on lipids and indices of bone resorption in postmenopausal women...
- Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral ResearchSundeep Khosla
J Bone Miner Res 22:1479-91. 2007..This report summarizes the findings and recommendations of the task force...
- Positive effects of intravenous zoledronic acid on bone remodeling and structure: are different effects on osteoblast activity to other oral bisphosphonates responsible?Peter R Ebeling
J Bone Miner Res 23:2-5. 2008