Peter R Eastwood

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint The effects of learning on the ventilatory responses to inspiratory threshold loading
    P R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Am J Respir Crit Care Med 158:1190-6. 1998
  2. pmc Inhibition of inspiratory motor output by high-frequency low-pressure oscillations in the upper airway of sleeping dogs
    P R Eastwood
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison, WI 53705, USA
    J Physiol 517:259-71. 1999
  3. ncbi request reprint Hemodynamic effects of pressures applied to the upper airway during sleep
    P R Eastwood
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, Madison 53705, USA
    J Appl Physiol 89:537-48. 2000
  4. ncbi request reprint Inspiratory muscle performance in endurance athletes and sedentary subjects
    P R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Respirology 6:95-104. 2001
  5. ncbi request reprint Collapsibility of the upper airway during anesthesia with isoflurane
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Anesthesiology 97:786-93. 2002
  6. ncbi request reprint Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Australia 6009
    J Appl Physiol 94:1849-58. 2003
  7. doi request reprint Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    J Sleep Res 17:230-8. 2008
  8. pmc Effect of body posture on pharyngeal shape and size in adults with and without obstructive sleep apnea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Sleep 31:1543-9. 2008
  9. ncbi request reprint Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
    Robert A McLaughlin
    Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley, WA 6009, Australia
    Opt Express 16:17521-9. 2008
  10. pmc Influence of head extension, flexion, and rotation on collapsibility of the passive upper airway
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Sleep 31:1440-7. 2008

Detail Information

Publications42

  1. ncbi request reprint The effects of learning on the ventilatory responses to inspiratory threshold loading
    P R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Am J Respir Crit Care Med 158:1190-6. 1998
    ..Measurements from PTL should only be used to assess respiratory muscle performance after allowing time for learning...
  2. pmc Inhibition of inspiratory motor output by high-frequency low-pressure oscillations in the upper airway of sleeping dogs
    P R Eastwood
    John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison, WI 53705, USA
    J Physiol 517:259-71. 1999
    ..This reflex may help maintain UA patency by decreasing the collapsing pressure generated by the inspiratory pump muscles and transmitted to the UA...
  3. ncbi request reprint Hemodynamic effects of pressures applied to the upper airway during sleep
    P R Eastwood
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, Madison 53705, USA
    J Appl Physiol 89:537-48. 2000
    ..These findings suggest that activation of UA pressure-sensitive receptors does not contribute directly to the pressor response associated with sleep-disordered breathing events...
  4. ncbi request reprint Inspiratory muscle performance in endurance athletes and sedentary subjects
    P R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Respirology 6:95-104. 2001
    ..The aim of this study was to determine whether whole-body endurance training is associated with increased respiratory muscle strength and endurance...
  5. ncbi request reprint Collapsibility of the upper airway during anesthesia with isoflurane
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Anesthesiology 97:786-93. 2002
    ..The unprotected upper airway tends to obstruct during general anesthesia, yet its mechanical properties have not been studied in detail during this condition...
  6. ncbi request reprint Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Australia 6009
    J Appl Physiol 94:1849-58. 2003
    ..We hypothesize that regional differences in density and type of muscle fiber are the most likely sources of heterogeneity in these responses...
  7. doi request reprint Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    J Sleep Res 17:230-8. 2008
    ..These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA...
  8. pmc Effect of body posture on pharyngeal shape and size in adults with and without obstructive sleep apnea
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Sleep 31:1543-9. 2008
    ..This study compared the effect of body posture on upper airway shape and size in individuals with OSA with control subjects matched for age, BMI, and gender...
  9. ncbi request reprint Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway
    Robert A McLaughlin
    Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley, WA 6009, Australia
    Opt Express 16:17521-9. 2008
    ..The paper also illustrates the capability of the system to assess the real-time dynamic changes within the airway that occur during respiration...
  10. pmc Influence of head extension, flexion, and rotation on collapsibility of the passive upper airway
    Jennifer H Walsh
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Sleep 31:1440-7. 2008
    ..To determine the effect of head posture on upper airway collapsibility and site of collapse of the passive human upper airway...
  11. ncbi request reprint Relationship between upper airway and inspiratory pump muscle force in obstructive sleep apnea
    Kelly L Shepherd
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Chest 130:1757-64. 2006
    ..It is possible that the relative strengths of UA dilator and inspiratory pump muscles could be an important determinant of the susceptibility to UA collapse during sleep (ie, obstructive sleep apnea [OSA])...
  12. doi request reprint Evolution of changes in upper airway collapsibility during slow induction of anesthesia with propofol
    David R Hillman
    West Australian Sleep Disorders Research Institute, and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia 6009
    Anesthesiology 111:63-71. 2009
    ..This study assessed how this increase in collapsibility evolves during slow Propofol induction and how it relates to anesthesia-induced changes in upper airway muscle activity and conscious state...
  13. doi request reprint Estimating maximum work rate during incremental cycle ergometry testing from six-minute walk distance in patients with chronic obstructive pulmonary disease
    Kylie Hill
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Arch Phys Med Rehabil 89:1782-7. 2008
    ....
  14. ncbi request reprint Modulation of upper and lower esophageal sphincter tone during sleep
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia
    Sleep Med 8:135-43. 2007
    ..This study sought to describe the effects of sleep, respiration and posture on the function of the UES and the LES and the pressure differentials developed across them...
  15. doi request reprint Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea
    Kelly L Shepherd
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia
    J Sleep Res 20:241-9. 2011
    ..This association is independent of other risk factors including age, gender and body mass index, suggesting a causal relationship between OSA and nocturnal reflux...
  16. doi request reprint Variability of human upper airway collapsibility during sleep and the influence of body posture and sleep stage
    Jeremy S L Ong
    Centre for Sleep Science, School of Anatomy and Human Biology, University of Western Australia, Australia
    J Sleep Res 20:533-7. 2011
    ..When within-subject variability is accounted for, change in body posture from supine to lateral significantly decreases passive pharyngeal collapsibility...
  17. ncbi request reprint Anaerobic metabolism of inspiratory muscles in COPD
    Peter R Eastwood
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Respirology 11:32-40. 2006
    ....
  18. ncbi request reprint Respiratory gating of anatomical optical coherence tomography images of the human airway
    Robert A McLaughlin
    Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley WA 6009, Australia
    Opt Express 17:6568-77. 2009
    ..It is shown that respiratory gating can substantially improve the quality of aOCT images and reveal events and features that are otherwise obscured by blurring...
  19. doi request reprint Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography
    Jonathan P Williamson
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, Australia
    Am J Respir Crit Care Med 183:612-9. 2011
    ..Such knowledge could help elucidate mechanisms of excessive airway narrowing...
  20. ncbi request reprint Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three tests
    Sian E Turner
    Physiotherapy Department, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia
    Chest 126:766-73. 2004
    ..To investigate cardiorespiratory and dyspnea responses to incremental and self-paced exercise tests in patients with COPD...
  21. ncbi request reprint Collapsibility of the upper airway at different concentrations of propofol anesthesia
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, and School of Anatomy and Human Biology, University of Western Australia
    Anesthesiology 103:470-7. 2005
    ..This study investigated the effect of varying concentrations of propofol on upper airway collapsibility and the mechanisms responsible for it...
  22. ncbi request reprint Dyspnoea in COPD: can inspiratory muscle training help?
    Kylie Hill
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Aust J Physiother 50:169-80. 2004
    ..This paper describes the origin of dyspnoea in COPD, with particular attention given to the role of inspiratory muscle dysfunction in its genesis and its possible amelioration through inspiratory muscle training...
  23. ncbi request reprint The effect of learning on ventilatory responses to inspiratory threshold loading in COPD
    Gavin A Sturdy
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Respir Med 98:1-8. 2004
    ..This study sought to determine whether a similar "learning effect" is evident in patients with COPD, and what the mechanism of any such effect may be...
  24. doi request reprint The effect of diaphragm contraction on upper airway collapsibility
    David R Hillman
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia
    J Appl Physiol 115:337-45. 2013
    ..The effect appears primarily mediated by changes in lung volume rather than mediastinal traction from diaphragm descent. The study provides a rationale for use of continuous phrenic stimulation to treat obstructive sleep apnea. ..
  25. doi request reprint Using optical coherence tomography to improve diagnostic and therapeutic bronchoscopy
    Jonathan P Williamson
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA 6009, Australia
    Chest 136:272-6. 2009
    ..The severity of newly diagnosed tracheomalacia was able to be quantified using aOCT imaging (subject 3). aOCT imaging during bronchoscopy allows accurate real-time airway measurements and may assist bronchoscopic assessment...
  26. doi request reprint Anesthesia, sleep, and upper airway collapsibility
    David R Hillman
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth, Australia
    Anesthesiol Clin 28:443-55. 2010
    ..Specific follow-up of suspected cases is needed to ensure that the sleep-related component of the problem receives appropriate care...
  27. ncbi request reprint Six-minute walk distance in healthy Singaporean adults cannot be predicted using reference equations derived from Caucasian populations
    Hermione Poh
    School of Physiotherapy, Curtin University of Technology, Perth, Western Australia, Australia
    Respirology 11:211-6. 2006
    ..The aim of this study was to determine 6MWD in healthy Singaporeans and identify contributors to 6MWD in this population. We also compared measured 6MWD with predicted 6MWD from two regression equations derived in Caucasian subjects...
  28. ncbi request reprint Obstructive sleep apnoea and anaesthesia
    David R Hillman
    West Australian Sleep Disorders Research Institute and Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Sleep Med Rev 8:459-71. 2004
    ..On the other hand difficulty with airway maintenance during anaesthesia should prompt further investigation for the possibility of OSA...
  29. doi request reprint Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients
    Kelly L Shepherd
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Respirology 13:1045-52. 2008
    ..This study investigated the relationship between nocturnal GOR, OSA and BOS in a group of lung transplant patients...
  30. ncbi request reprint The impact of continuous positive airway pressure on the lower esophageal sphincter
    Kelly L Shepherd
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G1200-5. 2007
    ..The findings suggest CPAP may make the LES less susceptible to reflux by increasing Pb and decreasing the duration of LES relaxation...
  31. pmc Treating obstructive sleep apnea with hypoglossal nerve stimulation
    Peter R Eastwood
    Sir Charles Gairdner Hospital, Perth, Australia
    Sleep 34:1479-86. 2011
    ..Reduced upper airway muscle activity during sleep is fundamental to obstructive sleep apnea (OSA) pathogenesis. Hypoglossal nerve stimulation (HGNS) counteracts this problem, with potential to reduce OSA severity...
  32. ncbi request reprint Six minute walk distance in healthy subjects aged 55-75 years
    Bernadine Camarri
    School of Physiotherapy, Curtin University of Technology, Perth, Western Australia, Australia
    Respir Med 100:658-65. 2006
    ..This study was undertaken to determine 6MWD in a population-based sample of healthy subjects and to identify predictors of 6MWD in this group...
  33. ncbi request reprint Function of the lower esophageal sphincter during and after high-intensity exercise
    Kathleen J Maddison
    Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands, Australia
    Med Sci Sports Exerc 37:1728-33. 2005
    ..The aim of this study was to determine the influence of exercise with and without ingestion of fluid on the LES barrier pressure in asymptomatic individuals...
  34. pmc Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography
    Peter B Noble
    Division of Clinical Sciences, Telethon Institute for Child Health Research, Roberts Road, Perth, 6008, Australia
    Respir Res 11:9. 2010
    ..Whilst heterogeneity has been detected by previous experimental approaches, its spatial relationship either within or between airways is unknown...
  35. doi request reprint Airway narrowing assessed by anatomical optical coherence tomography in vitro: dynamic airway wall morphology and function
    Peter B Noble
    Div of Clinical Sciences, Telethon Institute for Child Health Research, PO Box 855, West Perth, WA, Australia 6872
    J Appl Physiol 108:401-11. 2010
    ..Findings suggest that aOCT can be used to relate changes in airway caliber to dynamic events in the wall of airways...
  36. ncbi request reprint Quantitative upper airway imaging with anatomic optical coherence tomography
    Julian J Armstrong
    Optical Biomedical Engineering Laboratory, School of Electrical, Electronic, and Computer Engineering, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009
    Am J Respir Crit Care Med 173:226-33. 2006
    ..We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that provides quantitative real-time imaging of the internal anatomy of the human upper airway...
  37. doi request reprint Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions
    Peter R Eastwood
    West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
    Respirology 15:587-95. 2010
    ....
  38. doi request reprint Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis
    Liam G Johnson
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia
    J Clin Neuromuscul Dis 10:178-84. 2009
    ..The study aimed to investigate the effects of a combined functional and aerobic exercise program on aerobic capacity, muscle strength, and functional mobility in a group of patients with sporadic inclusion body myositis (IBM)...
  39. doi request reprint Anatomical optical coherence tomography for long-term, portable, quantitative endoscopy
    Matthew S Leigh
    Optical Biomedical Engineering Laboratory OBEL, School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley, W A 6009, Australia
    IEEE Trans Biomed Eng 55:1438-46. 2008
    ..Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record dynamic changes in airway size and shape...
  40. ncbi request reprint The effect of interstate travel on the sleep patterns and performance of elite Australian Rules footballers
    Louise K Richmond
    School of Human Movement and Exercise Science, University of Western Australia, Australia
    J Sci Med Sport 10:252-8. 2007
    ..05). All other measures of performance were similar at home and away. These results show that prior interstate travel has minimal effect on sleep quality and game performance in elite footballers...
  41. ncbi request reprint Effect of surface tension of mucosal lining liquid on upper airway mechanics in anesthetized humans
    Jason P Kirkness
    Ludwig Engel Centre for Respiratory Research, Westmead Hospital and University of Sydney, Westmead, New South Wales, 2145, Australia
    J Appl Physiol 95:357-63. 2003
    ..Instillation of exogenous surfactant into the UA lowers the gamma of UAL, thus increasing UA patency and augmenting reopening of the collapsed airway...
  42. ncbi request reprint Comparison of upper airway collapse during general anaesthesia and sleep
    Peter R Eastwood
    Lancet 359:1207-9. 2002
    ..Our findings suggest that sleep-disordered breathing should be considered in all patients with a pronounced tendency for upper airway obstruction during anaesthesia or during recovery from it...