G Duque

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Once-yearly zoledronic acid in hip fracture prevention
    Oddom Demontiero
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia
    Clin Interv Aging 4:153-64. 2009
  2. pmc Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem Cells
    Daniel Rivas
    Lady Davis, Institute for Medical Research, Montreal, Quebec, Canada QC H3T 1E2
    PPAR Res 2007:81654. 2007
  3. doi Age-related bone loss in the LOU/c rat model of healthy ageing
    Gustavo Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Nepean Hospital, NSW, Australia
    Exp Gerontol 44:183-9. 2009
  4. ncbi Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention
    Gustavo Duque
    Ageing Bone Research Program, Sydney Medical School Nepean Campus, University of Sydney, Sydney, NSW, Australia
    Med J Aust 193:173-9. 2010
  5. doi Effects of risedronate on bone marrow adipocytes in postmenopausal women
    G Duque
    Aging Bone Research Program, Sydney Medical School Nepean Campus, The University of Sydney, Penrith, NSW, Australia
    Osteoporos Int 22:1547-53. 2011
  6. doi Bone and fat connection in aging bone
    Gustavo Duque
    Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    Curr Opin Rheumatol 20:429-34. 2008
  7. doi Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome
    Gustavo Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    J Am Geriatr Soc 56:935-41. 2008
  8. ncbi Vitamin D status in relation to postural stability in the elderly
    D Boersma
    Department of Geriatric Medicine, Nepean Hospital, Penrith, NSW, Australia 2751
    J Nutr Health Aging 16:270-5. 2012
  9. ncbi Prevention and treatment of senile osteoporosis and hip fractures
    G Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia
    Minerva Med 100:79-94. 2009
  10. pmc Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors
    G Duque
    Ageing Bone Research Program, Sydney Medical School Nepean Campus, The University of Sydney, Penrith, NSW, Australia
    Br J Pharmacol 162:1109-18. 2011

Collaborators

Detail Information

Publications26

  1. pmc Once-yearly zoledronic acid in hip fracture prevention
    Oddom Demontiero
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia
    Clin Interv Aging 4:153-64. 2009
    ..In this review, we report the current evidence on the use of ZOL for the prevention of hip fractures in the elderly. We also report the pharmacological characteristics and the advantages and disadvantages of ZOL in this particular group...
  2. pmc Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem Cells
    Daniel Rivas
    Lady Davis, Institute for Medical Research, Montreal, Quebec, Canada QC H3T 1E2
    PPAR Res 2007:81654. 2007
    ..In summary, inhibition of protein farnesylation arrests the adipogenic differentiation of MSCs and affects PPARgamma expression and activity...
  3. doi Age-related bone loss in the LOU/c rat model of healthy ageing
    Gustavo Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Nepean Hospital, NSW, Australia
    Exp Gerontol 44:183-9. 2009
    ..In summary, aged LOU rats exhibit low-turnover bone loss and marrow fat infiltration, which are the hallmarks of senile osteoporosis, and thus represent a novel model in which to study the molecular mechanisms leading to this disorder...
  4. ncbi Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention
    Gustavo Duque
    Ageing Bone Research Program, Sydney Medical School Nepean Campus, University of Sydney, Sydney, NSW, Australia
    Med J Aust 193:173-9. 2010
    ..In general, teriparatide should not be considered as a first-line treatment for fracture prevention, particularly for people in RACFs...
  5. doi Effects of risedronate on bone marrow adipocytes in postmenopausal women
    G Duque
    Aging Bone Research Program, Sydney Medical School Nepean Campus, The University of Sydney, Penrith, NSW, Australia
    Osteoporos Int 22:1547-53. 2011
    ..Their effect on adipogenesis in vivo remains unknown. In this study, we demonstrate that risedronate prevents marrow fat infiltration in postmenopausal women after 3 years of treatment...
  6. doi Bone and fat connection in aging bone
    Gustavo Duque
    Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    Curr Opin Rheumatol 20:429-34. 2008
    ..Additionally, bone marrow fat will be considered as a diagnostic and therapeutic approach to osteoporosis...
  7. doi Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome
    Gustavo Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    J Am Geriatr Soc 56:935-41. 2008
    ..New potential treatments are also considered, including therapeutic approaches to osteoporosis in elderly people that focus on the pathophysiology and potential reversal of the adipogenic shift in bone...
  8. ncbi Vitamin D status in relation to postural stability in the elderly
    D Boersma
    Department of Geriatric Medicine, Nepean Hospital, Penrith, NSW, Australia 2751
    J Nutr Health Aging 16:270-5. 2012
    ..In this study, we investigated the impact of vitamin D deficiency on PI in a sample of community dwelling older subjects. Our objective was to determine the potential association between vitamin D deficiency and PI in older fallers...
  9. ncbi Prevention and treatment of senile osteoporosis and hip fractures
    G Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia
    Minerva Med 100:79-94. 2009
    ..The choice of therapy should be determined by the patient's calculated fracture risk and efficacy of the potential treatment, including long term compliance associated with the agent of choice...
  10. pmc Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors
    G Duque
    Ageing Bone Research Program, Sydney Medical School Nepean Campus, The University of Sydney, Penrith, NSW, Australia
    Br J Pharmacol 162:1109-18. 2011
    ..However, its role in osteoblast differentiation and function remains unknown. In this study, we assessed the role of protein isoprenylation in osteoblastogenesis in a model of mesenchymal stem cells (MSC) differentiation...
  11. ncbi Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells
    Gustavo Duque
    Division of Geriatric Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 22:1603-11. 2007
    ..ALN inhibited adipogenesis while promoting osteoblast differentiation and activity. Our results reveal a new anabolic effect of ALN in differentiating bone marrow cells...
  12. ncbi Age-related bone loss: old bone, new facts
    George K Chan
    Division of Geriatric Medicine, McGill University, Montreal, Que, Canada
    Gerontology 48:62-71. 2002
    ..We also consider the mechanism of programmed cell death, apoptosis, as being an important determinant of aging in bone as well as describe possible future interventions to prolong the life span of osteoblasts...
  13. ncbi Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, 3755, Cote Sainte Catherine, Montreal, QC, Canada H3T 1E2
    Biogerontology 5:421-9. 2004
    ..In summary, this study illustrates the anti-adipogenic effect of 1,25(OH)2D3 in bone cells and identifies some of the possible key signals involved in bone cell plasticity...
  14. ncbi Will reducing adopogenesis in bone increase bone mass?: PPARgamma2 as a key target in the treatment of age-related bone loss
    Gustavo Duque
    Division of Geriatric Medicine McGill University, Jewish General Hospital, 3599 Cote Sainte Catherine, Montreal, Quebec, Canada
    Drug News Perspect 16:341-6. 2003
    ....
  15. ncbi 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2)
    Gustavo Duque
    Division of Geriatric Medicine, Department of Medicine, 3755, Cote Sainte Catherine, Montreal, Que, Canada H3T 1E2
    Exp Gerontol 39:333-8. 2004
    ..01) In summary, this study shows that the administration of 1,25(OH)(2)D(3) in an in vivo model of senile osteoporosis is associated with reduction in PPARgamma2 a key transcription factor for the adipose differentiation of MSC...
  16. ncbi 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6)
    Gustavo Duque
    Calcium Research Laboratories, Department of Medicine, McGill University Health Centre, Quebec, Canada
    Am J Physiol Endocrinol Metab 288:E723-30. 2005
    ..Taken together, these findings demonstrate that 1,25(OH)2D3 acts simultaneously on bone formation and resorption to prevent the development of senile osteoporosis...
  17. ncbi Severe bone changes in a case of Hutchinson-Gilford syndrome
    Giselle Helena de Paula Rodrigues
    Division on Aging, Sorocaba Medical School, Pontifícia Universidade Católica de São Paulo, Brazil
    Ann Genet 45:151-5. 2002
    ..In summary, we report the case of an 8-year-old girl who meets the diagnostic criteria for HGPS with severe involvement of her bones and joints with a review of the current literature and a possible therapeutic approach...
  18. ncbi Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation
    Gustavo Duque
    Calcium Research Laboratory, Department of Medicine, McGill University, Que, Montreal, Canada
    Biochem Biophys Res Commun 299:446-54. 2002
    ..002). In summary, our results demonstrate that E(2) increases VDR expression in bone in vivo and potentiate the bioresponse of VDR in osteoblasts in vitro...
  19. ncbi [Osteoporosis in the elderly]
    Frederique Retornaz
    Division de gériatrie, Universite McGill, Hôpital général juif, Montreal, Quebec, Canada
    Presse Med 35:1547-56. 2006
    ..Strontium ranelate is a promising treatment in this population. Fall prevention is a major part of osteoporosis management. The potential benefit of hip protectors is questionable, even in institutionalized patients...
  20. ncbi Taking musculoskeletal aging out of the bench: do we finally understand frailty?
    Gustavo Duque
    Jewish General Hospital, Division of Geriatric Medicine, McGill University, 3755, chemin de la Côte, Sainte Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Aspects Med 26:141-3. 2005
  21. ncbi Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk
    Cherian Joseph
    UConn Center on Aging, University of Connecticut Health Center, MC 5215, 263 Farmington Ave, Farmington, CT 06030 5215, United States
    Mol Aspects Med 26:181-201. 2005
    ....
  22. ncbi Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone
    Manuel Montero-Odasso
    Geriatric Medicine Program, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    Mol Aspects Med 26:203-19. 2005
    ....
  23. ncbi Age-related changes in lamin A/C expression in the osteoarticular system: laminopathies as a potential new aging mechanism
    Gustavo Duque
    Division of Geriatric Medicine, Jewish General Hospital 3755, McGill University, Chemin de la Cote Sainte Catherine Montreal, Que, Canada H3T 1E2
    Mech Ageing Dev 127:378-83. 2006
    ..In this study we hypothesize that the expression of lamin A/C may play a role in the pathogenesis of age-related diseases in the osteoarticular system...
  24. ncbi Age-related changes in lamin A/C expression in cardiomyocytes
    Jonathan Afilalo
    Division of Internal Medicine, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 293:H1451-6. 2007
    ..This is the first study to show that normal aging is associated with reduced expression and altered distribution of lamin A/C in nuclei of cardiomyocytes...
  25. ncbi To treat or not to treat, that is the question: proceedings of the Quebec Symposium for the Treatment of Osteoporosis in Long-term Care Institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, Quebec, Canada
    J Am Med Dir Assoc 7:435-41. 2006
    ..Management strategies include both nonpharmacological and pharmacological interventions for the prevention and treatment of osteoporotic fractures in very frail older subjects...
  26. ncbi To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada
    J Am Med Dir Assoc 8:e67-73. 2007
    ..Management strategies include both nonpharmacological and pharmacological interventions for the prevention and treatment of osteoporotic fractures in very frail older subjects...