Sarah A Dunlop

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc The effects of maternally administered methadone, buprenorphine and naltrexone on offspring: review of human and animal data
    W O Farid
    School of Animal Biology, The University of Western Australia, Nedlands, WA 6009, Australia
    Curr Neuropharmacol 6:125-50. 2008
  2. ncbi request reprint Failure to restore vision after optic nerve regeneration in reptiles: interspecies variation in response to axotomy
    Sarah A Dunlop
    School of Animal Biology, The University of Western Australia, Crawley 6009, Australia
    J Comp Neurol 478:292-305. 2004
  3. ncbi request reprint Failure to form a stable topographic map during optic nerve regeneration: abnormal activity-dependent mechanisms
    Sarah A Dunlop
    School of Animal Biology, The University of Western Australia, Hackett Drive, Nedlands 6907, Western Australia, Australia
    Exp Neurol 184:805-15. 2003
  4. ncbi request reprint Regenerating optic axons restore topography after incomplete optic nerve injury
    Sarah A Dunlop
    School of Animal Biology, University of Western Australia, Crawley, 6009, Australia
    J Comp Neurol 505:46-57. 2007
  5. ncbi request reprint Topographic order of retinofugal axons in a marsupial: implications for map formation in visual nuclei
    S A Dunlop
    Department of Zoology, The University of Western Australia, Nedlands 6907, Australia
    J Comp Neurol 428:33-44. 2000
  6. ncbi request reprint Development of visual projections follows an avian/mammalian-like sequence in the lizard Ctenophorus ornatus
    Sarah A Dunlop
    West Australian Institute for Medical Research, Crawley, Western Australia 6009, Australia
    J Comp Neurol 453:71-84. 2002
  7. ncbi request reprint Retinal projections throughout optic nerve regeneration in the ornate dragon lizard, Ctenophorus ornatus
    S A Dunlop
    Department of Zoology, The University of Western Australia, Nedlands 6907, Australia
    J Comp Neurol 416:188-200. 2000
  8. doi request reprint Activity-dependent plasticity: implications for recovery after spinal cord injury
    Sarah A Dunlop
    Experimental and Regenerative Neurosciences, School of Animal Biology M092, The University of Western Australia, Crawley, WA, Australia
    Trends Neurosci 31:410-8. 2008
  9. ncbi request reprint Extent of retinal ganglion cell death in the frog Litoria moorei after optic nerve regeneration induced by lesions of different sizes
    Sarah A Dunlop
    Department of Zoology, The University of Western Australia, Crawley, Western Australia 6009, Australia
    J Comp Neurol 446:276-87. 2002
  10. ncbi request reprint Axonal sprouting in the optic nerve is not a prerequisite for successful regeneration
    Sarah A Dunlop
    Neurobiology Laboratory, School of Animal Biology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Comp Neurol 465:319-34. 2003

Collaborators

Detail Information

Publications82

  1. pmc The effects of maternally administered methadone, buprenorphine and naltrexone on offspring: review of human and animal data
    W O Farid
    School of Animal Biology, The University of Western Australia, Nedlands, WA 6009, Australia
    Curr Neuropharmacol 6:125-50. 2008
    ..While each treatment is likely to have maternal advantages and disadvantages, studies are urgently required to determine which is optimal for offspring in the short and long term...
  2. ncbi request reprint Failure to restore vision after optic nerve regeneration in reptiles: interspecies variation in response to axotomy
    Sarah A Dunlop
    School of Animal Biology, The University of Western Australia, Crawley 6009, Australia
    J Comp Neurol 478:292-305. 2004
    ..stellatus RGC axons entered the opposite optic nerve; a limited ipsilateral projection was seen in G. variegata. Our results support a heterogeneous response to axotomy within the reptiles, each of which is nevertheless dysfunctional...
  3. ncbi request reprint Failure to form a stable topographic map during optic nerve regeneration: abnormal activity-dependent mechanisms
    Sarah A Dunlop
    School of Animal Biology, The University of Western Australia, Hackett Drive, Nedlands 6907, Western Australia, Australia
    Exp Neurol 184:805-15. 2003
    ..We suggest that the asynchronous activity reaching the optic tectum results in an inability to recapitulate the appropriate functional sequences of expression of NMDA and AMPA/kainate receptors necessary to refine the retinotectal map...
  4. ncbi request reprint Regenerating optic axons restore topography after incomplete optic nerve injury
    Sarah A Dunlop
    School of Animal Biology, University of Western Australia, Crawley, 6009, Australia
    J Comp Neurol 505:46-57. 2007
    ....
  5. ncbi request reprint Topographic order of retinofugal axons in a marsupial: implications for map formation in visual nuclei
    S A Dunlop
    Department of Zoology, The University of Western Australia, Nedlands 6907, Australia
    J Comp Neurol 428:33-44. 2000
    ..R. Soc. Lond. B. 210:335-373)...
  6. ncbi request reprint Development of visual projections follows an avian/mammalian-like sequence in the lizard Ctenophorus ornatus
    Sarah A Dunlop
    West Australian Institute for Medical Research, Crawley, Western Australia 6009, Australia
    J Comp Neurol 453:71-84. 2002
    ..ornatus (Dunlop et al. [2000b] J. Comp. Neurol. 416:188-200), suggesting that axons recognise molecular signals associated with the initial exuberant innervation but not those associated with subsequent refinement...
  7. ncbi request reprint Retinal projections throughout optic nerve regeneration in the ornate dragon lizard, Ctenophorus ornatus
    S A Dunlop
    Department of Zoology, The University of Western Australia, Nedlands 6907, Australia
    J Comp Neurol 416:188-200. 2000
    ....
  8. doi request reprint Activity-dependent plasticity: implications for recovery after spinal cord injury
    Sarah A Dunlop
    Experimental and Regenerative Neurosciences, School of Animal Biology M092, The University of Western Australia, Crawley, WA, Australia
    Trends Neurosci 31:410-8. 2008
    ..Increased understanding of mechanisms driving activity-dependent plasticity will help develop rehabilitative strategies which optimise functional recovery...
  9. ncbi request reprint Extent of retinal ganglion cell death in the frog Litoria moorei after optic nerve regeneration induced by lesions of different sizes
    Sarah A Dunlop
    Department of Zoology, The University of Western Australia, Crawley, Western Australia 6009, Australia
    J Comp Neurol 446:276-87. 2002
    ..We suggest that delays in regeneration after an extensive lesion exacerbate ganglion cell death, indicating that conditions within the lesion are associated with the death of some ganglion cells...
  10. ncbi request reprint Axonal sprouting in the optic nerve is not a prerequisite for successful regeneration
    Sarah A Dunlop
    Neurobiology Laboratory, School of Animal Biology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Comp Neurol 465:319-34. 2003
    ..The data suggest that sprouting is not essential for either axon outgrowth or topographic map refinement...
  11. ncbi request reprint Repeated prenatal corticosteroids delay myelination in the ovine central nervous system
    S A Dunlop
    Department of Zoology, University of Western Australia, Nedlands
    J Matern Fetal Med 6:309-13. 1997
    ..Clinical practice should balance the known beneficial effects on lung maturation of a single course of corticosteroid against the potential damage to the CNS of repeated courses...
  12. ncbi request reprint Transient axonal side branches in the developing mammalian optic nerve
    S A Dunlop
    Neurobiology Laboratory, Department of Zoology, University of Western Australia, Nedlands 6009, Australia
    Cell Tissue Res 291:43-56. 1998
    ..Most side branches are lost by adulthood, indicating their transient nature. The absence of retrogradely-directed axons from adults suggests that cells with such axons are removed by naturally occurring cell death...
  13. ncbi request reprint Changing patterns of vasculature in the developing amphibian retina
    S A Dunlop
    Department of Zoology, University of Western Australia, Nedlands, Australia
    J Exp Biol 200:2479-92. 1997
    ..However, in post-metamorphic life, the topographies of the retinal vasculature and cells in the ganglion cell layer were closely related...
  14. ncbi request reprint Development of primary visual projections occurs entirely postnatally in the fat-tailed dunnart, a marsupial mouse, Sminthopsis crassicaudata
    S A Dunlop
    Department of Zoology, The University of Western Australia, Nedlands
    J Comp Neurol 384:26-40. 1997
    ....
  15. ncbi request reprint Compensatory and transneuronal plasticity after early collicular ablation
    Sarah A Dunlop
    School of Animal Biology, Western Australian Institute of Medical Research, The University of Western Australia, Crawley, Australia 6907
    J Comp Neurol 500:1117-26. 2007
    ..The implication is that the visual system acts in concert following unilateral injury to maintain set values for RGC terminal arbors as well as their cell bodies...
  16. doi request reprint Secondary retinal ganglion cell death and the neuroprotective effects of the calcium channel blocker lomerizine
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, School of Animal Biology and Western Australian Institute of Medical Research, University of Western Australia, Crawley, WA, Australia
    Invest Ophthalmol Vis Sci 50:5456-62. 2009
    ..Although the calcium channel blocker lomerizine reduces RGC death after partial ON injury, it is unknown whether this drug alleviates necrotic or apoptotic death...
  17. doi request reprint Near infrared light reduces oxidative stress and preserves function in CNS tissue vulnerable to secondary degeneration following partial transection of the optic nerve
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Western Australia, Australia
    J Neurotrauma 27:2107-19. 2010
    ..To our knowledge, this is the first demonstration that 670-nm NIR light can reduce oxidative stress and improve function in the CNS following traumatic injury in vivo...
  18. doi request reprint Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine
    Marion Selt
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, 6009 WA, Australia
    Brain Res Bull 81:467-71. 2010
    ..Importantly, none of the lomerizine treatment protocols resulted in full restoration of visual function, confirming the necessity of combining lomerizine with other treatment modalities...
  19. ncbi request reprint The balance of NMDA- and AMPA/kainate receptor-mediated activity in normal adult goldfish and during optic nerve regeneration
    Andrew L Taylor
    School of Animal Biology, The University of Western Australia, Crawley 6009, Australia
    Exp Neurol 195:391-9. 2005
    ..Furthermore, the normal operation of both receptors allows a response to injury in which the balance can be transiently reversed to restore topography and vision...
  20. doi request reprint rAAV.sFlt-1 gene therapy achieves lasting reversal of retinal neovascularization in the absence of a strong immune response to the viral vector
    Chooi May Lai
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Western Australia, Australia
    Invest Ophthalmol Vis Sci 50:4279-87. 2009
    ..sFlt-1-mediated gene therapy in a transgenic mouse model of retinal neovascularization (trVEGF029) and to assess whether rAAV.sFlt-1 administration generated any deleterious, long-lasting immune response that could affect efficacy...
  21. ncbi request reprint Myelin sheath decompaction, axon swelling, and functional loss during chronic secondary degeneration in rat optic nerve
    Sophie C Payne
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Western Australia, Australia
    Invest Ophthalmol Vis Sci 53:6093-101. 2012
    ..To examine chronic changes occurring at 6 months following partial optic nerve (ON) transection, assessing optic axons, myelin, and visual function...
  22. ncbi request reprint Characterisation of a model for retinal neovascularisation. VEGF model characterisation
    Pauline E van Eeden
    School of Animal Biology, The University of Western Australia, Nedlands, Western Australia
    Adv Exp Med Biol 572:163-8. 2006
  23. ncbi request reprint Optic nerve regeneration: molecular pre-requisites and the role of training. Restoring vision after optic nerve injury
    Lyn D Beazley
    School of Animal Biology, The University of Western Australia, Nedlands, Western Australia
    Adv Exp Med Biol 572:389-95. 2006
  24. doi request reprint Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, University of Western Australia, Crawley, WA, Australia
    Exp Neurol 216:219-30. 2009
    ..However such an approach may need to be combined with other treatments to ensure long-term maintenance of full visual function...
  25. ncbi request reprint Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection
    Carolyn E King
    School of Animal Biology, University of Western Australia, Nedlands, Western Australia
    Exp Neurol 205:48-55. 2007
    ....
  26. ncbi request reprint Pathological heterogeneity of vasoproliferative retinopathy in transgenic mice overexpressing vascular endothelial growth factor in photoreceptors
    Wei Yong Shen
    Department of Molecular Ophthalmology, Lions Eye Institute, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Adv Exp Med Biol 572:187-93. 2006
  27. doi request reprint In vivo imaging and biodistribution of multimodal polymeric nanoparticles delivered to the optic nerve
    James Harrison
    Centre for Strategic Nanofabrication, School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia
    Small 8:1579-89. 2012
    ..Multifunctional nanoparticles may be a useful mechanism to deliver therapeutic agents to the injury site and somata of injured CNS neurons and thus may be of therapeutic value following brain or spinal cord trauma...
  28. doi request reprint Functional topography and integration of the contralateral and ipsilateral retinocollicular projections of ephrin-A-/- mice
    Daniel J Haustead
    School of Animal Biology, Faculty of Medicine and Dentistry, University of Western Australia, Crawley, WA 6009, Australia
    J Neurosci 28:7376-86. 2008
    ..Moreover, the misalignment of ipsilateral and contralateral visual information in ephrin-A2/A5(-/-) mice suggests a role for ephrin-As in integrating convergent visual inputs...
  29. ncbi request reprint Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish
    Carolyn E King
    Neurobiology Laboratory, Department of Zoology, The University of Western Australia, 6907, Western, Nedlands, Australia
    Exp Neurol 183:593-9. 2003
    ..The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information...
  30. pmc Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract
    Sophie C Payne
    Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Crawley, Western Australia, Australia
    PLoS ONE 8:e65710. 2013
    ..Taken together, chronic OPC decreases may contribute to the persistent myelin abnormalities and functional loss seen in ON during secondary degeneration...
  31. doi request reprint Chronic swelling and abnormal myelination during secondary degeneration after partial injury to a central nervous system tract
    Sophie C Payne
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, WA, Australia
    J Neurotrauma 28:1077-88. 2011
    ..05). Chronic axon swelling and myelin sheath compaction defects are features of secondary degeneration, and may contribute to the reported loss of ON function following partial transection...
  32. doi request reprint Early events of secondary degeneration after partial optic nerve transection: an immunohistochemical study
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, School of Animal Biology, Western Australian Institute of Medical Research, 6009, Western Australia, Australia
    J Neurotrauma 27:439-52. 2010
    ....
  33. ncbi request reprint Neurite responses to ephrin-A5 modulated by BDNF: evidence for TrkB-EphA interactions
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, School of Animal Biology, University of Western Australia, Hackett Drive, Crawley 6009, WA, Australia
    Biochem Biophys Res Commun 374:625-30. 2008
    ..Our results suggest that the conversion of growth cone responses from collapse to stabilisation as topography refines, occurs as a result of interactions between EphA and TrkB receptors...
  34. pmc Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm
    Nadia Cummins
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley 6009, WA, Australia
    BMC Neurosci 14:98. 2013
    ....
  35. doi request reprint Burn injury has a systemic effect on reinnervation of skin and restoration of nociceptive function
    Natalie M Morellini
    Telstra Burn Outcome Centre, The McComb Research Foundation, Perth, Western Australia, Australia
    Wound Repair Regen 20:367-77. 2012
    ..We conclude that burn injury compromises nociceptive function and nerve regeneration both at the injury site and systemically; thus, therapies in addition to Zn(7) -MT-IIA should be explored to return normal sensory function...
  36. doi request reprint Early in vivo changes in calcium ions, oxidative stress markers, and ion channel immunoreactivity following partial injury to the optic nerve
    Jonathan Wells
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Western Australia, Australia
    J Neurosci Res 90:606-18. 2012
    ....
  37. doi request reprint Multimodal analysis of PEI-mediated endocytosis of nanoparticles in neural cells
    Cameron W Evans
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia
    ACS Nano 5:8640-8. 2011
    ..This fundamental knowledge may also assist in the preparation of next-generation nonviral vectors...
  38. ncbi request reprint Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularization
    Pauline E van Eeden
    School of Animal Biology, The University of Western Australia, Crawley, Australia
    Invest Ophthalmol Vis Sci 47:4638-45. 2006
    ....
  39. ncbi request reprint EphA5 and ephrin-A2 expression during optic nerve regeneration: a 'two-edged sword'
    A C E Symonds
    School of Animal Biology M092, The University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, Western Australia
    Eur J Neurosci 25:744-52. 2007
    ..The repulsive ephrin-A2 environment offers at least a partial explanation for the observation that only a limited number of RGC axons can exit the graft to enter target central nervous system tissue...
  40. ncbi request reprint PSA-NCAM is up-regulated during optic nerve regeneration in lizard but not in goldfish
    A M Harman
    Department of Psychology, University of Western Australia, Nedlands, Western Australia, Australia
    Exp Neurol 182:180-5. 2003
    ..The lack of sialylation in goldfish presumably reflects the permissive nature of the substrate allowing axon regeneration and the successful reestablishment of a topographic map...
  41. ncbi request reprint Effects of immunosuppression on regrowth of adult rat retinal ganglion cell axons into peripheral nerve allografts
    Russell S Gillon
    School of Anatomy and Human Biology, The Western Australian Institute for Medical Research, The University of Western Australia, Crawley, Perth, Australia
    J Neurosci Res 74:524-32. 2003
    ..This study demonstrates that PN allografts can support axonal regrowth in immunosuppressed adult hosts, and points to possible clinical use in CNS repair...
  42. ncbi request reprint Reinnervation of the superior colliculus delays down-regulation of ephrin A2 in neonatal rat
    A C Symonds
    Department of Zoology, University of Western Australia, Crawley, Western Australia, 6009, Australia
    Exp Neurol 170:364-70. 2001
    ..Following unilateral enucleation at P2, levels are not significantly different from normal. Our results show that innervation but not denervation triggers increased ephrin A2 expression after a brachial lesion...
  43. ncbi request reprint Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep
    W L Huang
    Neurobiology Laboratory, Department of Zoology, The University of Western Australia, 6009, Crawley, Australia
    Int J Dev Neurosci 19:415-25. 2001
    ..68 vs. 0.94 and 0.11 vs. 0.14 microm, P<0.05). Our data suggest that repeated prenatal corticosteroid administration delays myelination of the corpus callosum and that further safety data are needed to evaluate clinical practice...
  44. doi request reprint Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
    Melinda Fitzgerald
    School of Animal Biology, The University of Western Australia, Crawley, Australia
    Rev Neurosci 24:205-26. 2013
    ....
  45. doi request reprint Transcranial pulsed magnetic field stimulation facilitates reorganization of abnormal neural circuits and corrects behavioral deficits without disrupting normal connectivity
    Jennifer Rodger
    Experimental and Regenerative Neuroscience, School of Animal Biology M317, The University of Western Australia, Crawley, WA 6009, Australia
    FASEB J 26:1593-606. 2012
    ..Thus, PMF-induced biochemical changes are congruent with its capacity to facilitate beneficial reorganization of abnormal neural circuits without disrupting normal connectivity and function...
  46. ncbi request reprint Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model
    W Y Shen
    Centre of Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Perth, WA, Australia
    Diabetologia 49:1690-701. 2006
    ..We investigated whether transgenic mice with moderate VEGF expression in photoreceptors (trVEGF029) developed changes similar to diabetic retinopathy and whether retinopathy progressed with time...
  47. ncbi request reprint Repeated ultrasound guided fetal injections of corticosteroid alter nervous system maturation in the ovine fetus
    J A Quinlivan
    University Department of Obstetrics and Gynecology, University of Western Australia, Australia
    J Perinat Med 29:112-27. 2001
    ..We have evaluated the effect of repeated fetal administration of betamethasone on nervous system maturation in an ovine model...
  48. doi request reprint VEGF-induced choroidal damage in a murine model of retinal neovascularisation
    L B G Tee
    School of Animal Biology, The University of Western Australia, Perth, Australia
    Br J Ophthalmol 92:832-8. 2008
    ..Here we have determined whether the choroidal vasculature is also affected in Kimba...
  49. ncbi request reprint Changes in subtypes of Ca microdomains following partial injury to the central nervous system
    Ivan Lozić
    BioNano, School of Chemistry and Biochemistry, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
    Metallomics 6:455-64. 2014
    ..NanoSIMS analyses of Ca microdomains allow quantitative and novel insights into Ca dynamics, applicable to a range of normal, as well as diseased or injured mammalian systems. ..
  50. doi request reprint Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems
    Eliza James
    Centre for Strategic Nano Fabrication, The University of Western Australia, 35 Stirling Hwy, Crawley 6009, Australia
    Org Biomol Chem 11:6108-12. 2013
    ..The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery. ..
  51. doi request reprint Multifunctional nanoadditives for the thermodynamic and kinetic stabilization of enzymes
    Tristan D Clemons
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia
    Nanoscale 3:4085-7. 2011
    ..Here, we describe the kinetic and thermodynamic stabilization of a variety of enzymes in the presence of cationic multifunctional polymeric nanoparticles...
  52. ncbi request reprint Visual system in a diurnal marsupial, the numbat (Myrmecobius fasciatus): retinal organization, visual acuity and visual fields
    C Arrese
    Department of Zoology, University of Western Australia, Nedlands, Australia
    Brain Behav Evol 55:163-75. 2000
    ..Monitoring of pupillary responses with an infrared video camera showed that the numbat possesses a remarkably wide, static pupil. Our results are discussed in relation to the ecology of the species and its phylogeny...
  53. ncbi request reprint Impaired vision for binocular tasks after unilateral optic nerve regeneration in the frog Litoria moorei
    S A Dunlop
    Department of Zoology, University of Western Australia, Perth
    Behav Brain Res 84:195-201. 1997
    ..We suggest that the poor visual performance for frogs with one regenerated and one intact optic nerve for tasks presented in the binocular field is related to the integration of a degraded and a normal image within the visual centres...
  54. ncbi request reprint Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration
    M R Ziman
    Department of Zoology, University of Western Australia, Nedlands, Australia
    Histol Histopathol 16:239-49. 2001
    ..We predict that such information will provide valuable insights for the induction of successful regeneration of the optic nerve and of other regions of the central nervous system in mammals including man...
  55. ncbi request reprint Evidence that regenerating optic axons maintain long-term growth in the lizard Ctenophorus ornatus: growth-associated protein-43 and gefiltin expression
    J Rodger
    Department of Zoology, The University of Western Australia, WA 6907, Nedlands, Australia
    Neuroscience 102:647-54. 2001
    ....
  56. ncbi request reprint Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat
    J Rodger
    Department of Zoology, The University of Western Australia, Nedlands 6907, Western Australia
    Eur J Neurosci 14:1929-36. 2001
    ..By 1 month, expression was decreased in far temporal retina, resulting in a uniform expression across the naso-temporal axis. We suggest that denervation-induced plastic changes within the SC modify expression of these molecules...
  57. ncbi request reprint Training on a visual task improves the outcome of optic nerve regeneration
    L D Beazley
    School of Animal Biology and Western Australian Institute of Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
    J Neurotrauma 20:1263-70. 2003
    ..The results suggest that for successful central nerve regeneration to occur in mammals, it may be necessary to introduce training to complement procedures stimulating axon regeneration...
  58. ncbi request reprint Effect of corticosteroids on brain growth in fetal sheep
    W L Huang
    Department of Zoology, The University of Western Australia, Nedlands, Australia
    Obstet Gynecol 94:213-8. 1999
    ..To compare the effects of single and repeated courses of corticosteroids on brain growth in fetal sheep...
  59. pmc Generation of transgenic mice with mild and severe retinal neovascularisation
    C M Lai
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Australia
    Br J Ophthalmol 89:911-6. 2005
    ..To generate a mouse model for slow progressive retinal neovascularisation through vascular endothelial growth factor (VEGF) upregulation...
  60. ncbi request reprint Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus
    J Rodger
    School of Animal Biology Zoology, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia
    Eur J Neurosci 22:1840-52. 2005
    ..Bilateral increases in retinal EphA5 expression demonstrate that signals for up-regulation operate interocularly. The study demonstrates that signals regulating guidance cue expression are both localized and relayed transneuronally...
  61. ncbi request reprint Changing Pax6 expression correlates with axon outgrowth and restoration of topography during optic nerve regeneration
    J Rodger
    School of Animal Biology M092, University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia, Australia
    Neuroscience 142:1043-54. 2006
    ..The results suggest that decreased Pax6 expression is permissive for axon regeneration and extensive searching, while higher levels of Pax6 are associated with restoration of topography...
  62. ncbi request reprint EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression
    J Rodger
    School of Animal Biology, The University of Western Australia, Crawley 6009, Western Australia, Australia
    Mol Cell Neurosci 25:56-68. 2004
    ..The findings, supported by in vitro studies, implicate EphA/ephrin-A interactions in restoring precise topography and in regulating ephrin-A2 expression during regeneration...
  63. ncbi request reprint An in vitro technique for electrophysiological mapping of reptilian retinotectal projections
    R V Stirling
    Department of Zoology, University of Western Australia, Nedlands, Australia
    J Neurosci Methods 81:85-9. 1998
    ..The technique offers opportunities to introduce pharmacological agents via the perfusate or to conduct anatomical tracing studies coincident with electrophysiological recording...
  64. ncbi request reprint Effect of exogenous corticosteroids on the developing central nervous system: a review
    W L Huang
    Department of Zoology, University of Western Australia, Nedlands, Australia
    Obstet Gynecol Surv 54:336-42. 1999
    ..Studies using large animal models and with long-term follow-up should be undertaken to establish the relative risks and benefits of the repeated application of exogenous corticosteroids...
  65. ncbi request reprint The development and mature organisation of the end-artery retinal vasculature in a marsupial, the dunnart Sminthopsis crassicaudata
    J Rodger
    Department of Zoology, University of Western Australia, Nedlands, WA 6907, Australia
    Vision Res 41:13-21. 2001
    ..A retinal end-artery system may have evolved in marsupials because their precocity requires a vasculature that is functional from early stages of development...
  66. ncbi request reprint Electrophysiological evidence for transient topographic organization of retinotectal projections during optic nerve regeneration in the lizard, Ctenophorus ornatus
    R V Stirling
    Department of Zoology, University of Western Australia, Nedlands, Australia
    Vis Neurosci 16:681-93. 1999
    ..Presumably in lizard map-making cues fade with time and/or the mechanisms are lacking to stabilize and refine the ephemeral map. Moreover, the transient retinotopy is insufficient for useful visual function...
  67. doi request reprint Short-term low intensity PMF does not improve functional or histological outcomes in a rat model of transient focal cerebral ischemia
    Kristyn A Bates
    Experimental and Regenerative Neurosciences, School of Animal Biology, University of Western Australia, Crawley Western Australia, 6009, Australia
    Brain Res 1458:76-85. 2012
    ..No detrimental side-effects of PMF were observed, indicating that low-intensity PMF may have limited safety concerns for future human and animal studies...
  68. doi request reprint Exogenous metallothionein-IIA promotes accelerated healing after a burn wound
    Natalie M Morellini
    School of Animal Biology, University of Western Australia, Crawley, WA 6009, Australia
    Wound Repair Regen 16:682-90. 2008
    ..PBS: 101+/-19 microm, p<0.05) compared with controls. Our data suggest that exogenous Zn(7)-MT-IIA may prove a valuable therapeutic for patients with burns and other skin injuries...
  69. ncbi request reprint Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection
    R S Beaver
    Department of Zoology, The University of Western Australia, Western Australia 6907, Nedlands, Australia
    Vision Res 41:1765-70. 2001
    ....
  70. ncbi request reprint Repeated prenatal corticosteroid administration delays astrocyte and capillary tight junction maturation in fetal sheep
    W L Huang
    Neurobiology Laboratory, Department of Zoology, University of Western Australia, WA 6009, Crawley, Australia
    Int J Dev Neurosci 19:487-93. 2001
    ..65%, P<0.05). Our data suggest that repeated corticosteroids delay both astrocyte and capillary tight junction maturation. The implications for clinical practice are as yet unknown...
  71. doi request reprint The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures
    Dominic Ho
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia
    Nanoscale 3:907-10. 2011
    ..Importantly, we report that the final nanoscale fiber architecture is an important factor to consider in designing scaffolds to promote regeneration in the central nervous system...
  72. ncbi request reprint Retinal characteristics of the ornate dragon lizard, Ctenophorus ornatus
    Helen R Barbour
    Department of Zoology, University of Western Australia, Crawley WA 6009, Australia
    J Comp Neurol 450:334-44. 2002
    ..The presence of a fovea containing slender cone photoreceptors and three visual pigments suggests that the lizard has high acuity and the potential for color vision...
  73. ncbi request reprint Classification of retinal ganglion cells in the southern hemisphere lamprey Geotria australis (Cyclostomata)
    Lee Norman Fletcher
    School of Animal Biology, The University of Western Australia, Crawley, Western Australia, 6009, Australia Oceans Institute, The University of Western Australia, Crawley, Western Australia, 6009, Australia
    J Comp Neurol 522:750-71. 2014
    ..These findings, together with the results of previous studies, indicate that the visual system of the lamprey G. australis represents the upper limit of visual complexity in extant agnathans...
  74. pmc Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood
    Waleed O Farid
    Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e52812. 2012
    ..Collectively, these data show pronounced effects of developmental naltrexone exposure, some of which persist into adulthood, highlighting the need for follow up of humans that were exposed to naltrexone in utero...
  75. ncbi request reprint Culture conditions affect proliferative responsiveness of olfactory ensheathing glia to neuregulins
    T R de Mello
    Red s Spinal Cord Research Laboratory, School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
    Glia 55:734-45. 2007
    ..The long-term stimulation of OEG proliferation by initial culture conditions raises the possibility of manipulating OEG before therapeutic transplantation...
  76. doi request reprint Manually-stimulated recovery of motor function after facial nerve injury requires intact sensory input
    Stoyan P Pavlov
    Department of Anatomy, Histology, Embryology, Medical University Varna, Bulgaria
    Exp Neurol 211:292-300. 2008
    ..When afferent inputs are abolished, these effects are eliminated or even reversed. We conclude that rehabilitation strategies must be carefully designed to take into account the extent of motor and/or sensory damage...
  77. ncbi request reprint Lateralized predatory responses in the ornate dragon lizard (Ctenophorus ornatus)
    Andrew Robins
    School of Biological Sciences, University of Southern Queensland, Toowoomba 4350, Australia
    Neuroreport 16:849-52. 2005
    ....
  78. ncbi request reprint Manual stimulation of facial muscles improves functional recovery after hypoglossal-facial anastomosis and interpositional nerve grafting of the facial nerve in adult rats
    Orlando Guntinas-Lichius
    Department of Otorhinolaryngology, Friedrich Schiller University Jena, D 07740 Jena, Germany
    Neurobiol Dis 28:101-12. 2007
    ..Our data show that a simple approach leading to improved quality of muscle fiber reinnervation is functionally beneficial after different types of clinically relevant surgical interventions...
  79. doi request reprint Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
    Maria Grosheva
    Department of Otorhinolaryngology, University of Cologne, Cologne, Germany
    Biol Chem 389:873-88. 2008
    ..Furthermore, such deleterious effects cannot be overridden by manual stimulation. We conclude that entubulation with BM-MSCs is not beneficial for facial nerve repair...
  80. pmc Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury
    Roger S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Biol Chem 283:15349-58. 2008
    ..This unsuspected action of MT represents a novel paradigm of astrocyte-neuronal interaction after injury and may have implications for the development of MT-based therapeutic agents...
  81. ncbi request reprint Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking
    Doychin N Angelov
    Anatomical Institute I, University of Cologne, Germany
    Neurobiol Dis 26:229-42. 2007
    ..Our findings indicate the potential of use-specific training to enhance appropriate functional outcome after peripheral nerve injury and may be useful in a clinical rehabilitation setting...
  82. ncbi request reprint Repeated prenatal corticosteroids reduce glial fibrillary acidic protein in the ovine central nervous system
    Julie A Quinlivan
    Department of Obstetrics and Gynecology, Melbourne University, Victoria, Australia
    J Perinat Med 30:209-19. 2002
    ..We have evaluated the effect of prenatal corticosteroid upon ovine GFAP...