Research Topics
| L W DoyleSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Respiratory function at age 8-9 years in extremely low birthweight/very preterm children born in Victoria in 1991-1992Lex W Doyle
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
Pediatr Pulmonol 41:570-6. 2006..In conclusion, the abnormalities in respiratory function in ELBW/very preterm children compared with NBW subjects described in the presurfactant era persisted in the 1990s, especially in those who had BPD in the newborn period...
Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level Caroline A Crowther
Australian Research Centre for Health of Women and Babies ARCH, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Women s and Children s Hospital, Adelaide, Australia
Syst Rev 1:12. 2012..abstract:..
Antenatal magnesium sulfate and neuroprotectionLex W Doyle
Murdoch Childrens Research Institute, The Royal Women s Hospital, University of Melbourne, Melbourne, Victoria, Australia
Curr Opin Pediatr 24:154-9. 2012..Antenatal magnesium sulfate may reduce the excessive rates of cerebral palsy in survivors of very preterm birth...
Improving the outcome of infants born at <30 weeks' gestation--a randomized controlled trial of preventative care at homeAlicia J Spittle
Physiotherapy, School of Health Sciences, University of Melbourne, 200 Berkley Street, Parkville, Victoria 3052, Australia
BMC Pediatr 9:73. 2009..These interventions should be multi-faceted and include modules for caregivers given their high rates of mental health problems...
The burden of illness in perinatal and neonatal care: the epidemiologist's roleLex W Doyle
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, and University of Melbourne, Melbourne, Australia
Semin Fetal Neonatal Med 11:69-72. 2006....
Evaluation of neonatal intensive care for extremely-low-birth-weight infantsLex W Doyle
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, and University of Melbourne, Melbourne, Australia
Semin Fetal Neonatal Med 11:139-45. 2006..Neonatal intensive care should be re-evaluated at intervals in the future to ensure that its effectiveness, efficiency and availability are maintained...
Low-dose dexamethasone facilitates extubation among chronically ventilator-dependent infants: a multicenter, international, randomized, controlled trialLex W Doyle
Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
Pediatrics 117:75-83. 2006..Postnatal corticosteroid therapy is controversial. The aim of this study was to determine the short-term effects of low-dose dexamethasone treatment among chronically ventilator-dependent neonates...
Improved neurosensory outcome at 8 years of age of extremely low birthweight children born in Victoria over three distinct erasL W Doyle
The Royal Women s Hospital, 132 Grattan St, Carlton, Victoria, 3053, Australia
Arch Dis Child Fetal Neonatal Ed 90:F484-8. 2005..To determine neurosensory outcome at 8 years of age of extremely low birthweight (ELBW) children born in the 1990s, how it varies with birth weight, and how it compares with ELBW children born in the 1980s and 1970s...
Impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk for chronic lung diseaseLex W Doyle
Division of Paediatrics, Royal Women s Hospital, 132 Grattan St, Carlton 3053, Australia
Pediatrics 115:655-61. 2005..The objective of this study was to determine the effect of systemic postnatal corticosteroid treatment on death and CP and to assess any modification of effect arising from risk for CLD...
Neonatal intensive care at borderline viability--is it worth it?L W Doyle
The Royal Women s Hospital, Melbourne, Australia
Early Hum Dev 80:103-13. 2004....
Changing availability of neonatal intensive care for extremely low birthweight infants in Victoria over two decadesLex W Doyle
Department of Obstetrics and Gynaecology, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
Med J Aust 181:136-9. 2004..To determine the changes in availability of neonatal intensive care for extremely low birthweight (ELBW) infants, and the consequences of a lack of availability...
Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescenceLex W Doyle
Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia
Pediatrics 118:108-13. 2006....
Outcome at 2 years of age of infants from the DART study: a multicenter, international, randomized, controlled trial of low-dose dexamethasoneLex W Doyle
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
Pediatrics 119:716-21. 2007..Low-dose dexamethasone facilitates extubation in chronically ventilator-dependent infants with no obvious short-term complications. The objective of this study was to determine the long-term effects of low-dose dexamethasone...
Cardiopulmonary outcomes of extreme prematurityLex W Doyle
The Royal Women s Hospital, University of Melbourne, Murdoch Childrens Research Institute, Melbourne, Australia
Semin Perinatol 32:28-34. 2008..The contribution of these cardiopulmonary problems in early adulthood to morbidity in middle and old ages needs to be determined...
Changing long-term outcomes for infants 500-999 g birth weight in Victoria, 1979-2005L W Doyle
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia
Arch Dis Child Fetal Neonatal Ed 96:F443-7. 2011....
Caffeine and brain development in very preterm infantsLex W Doyle
Royal Women s Hospital, University of Melbourne, Parkville, Victoria, Australia
Ann Neurol 68:734-42. 2010..The objective of this study was to assess whether caffeine influenced brain macro- or microstructural development in preterm infants...
Adult outcome of extremely preterm infantsLex W Doyle
Department of Obstetrics and Gynaecology, Royal Women s Hospital, Parkville, Victoria, Australia
Pediatrics 126:342-51. 2010..Pediatricians can aid the transition to adult health care by being aware of the nutritional, cardiovascular, respiratory, motor, cognitive, psychiatric, and functional outcomes into adulthood of survivors of extreme prematurity...
Pulmonary and neurological follow-up of extremely preterm infantsLex W Doyle
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, University of Melbourne, and Murdoch Children s Research Institute, Parkville, Vic, Australia
Neonatology 97:388-94. 2010..At school age other cognitive impairments including learning disabilities and behavioural problems occur more frequently. Despite these difficulties, most EP survivors escape without major long-term pulmonary or neurological problems...
Dexamethasone treatment in the first week of life for preventing bronchopulmonary dysplasia in preterm infants: a systematic reviewLex W Doyle
Department of Obstetrics and Gynaecology, University of Melbourne, The Royal Women s Hospital, Melbourne, Victoria, Australia
Neonatology 98:217-24. 2010..Dexamethasone treatment started soon after birth is controversial...
Postnatal hydrocortisone for preventing or treating bronchopulmonary dysplasia in preterm infants: a systematic reviewLex W Doyle
Department of Obstetrics and Gynaecology, University of Melbourne, The Royal Women s Hospital, and Murdoch Children s Research Institute, Parkville, Vic, Australia
Neonatology 98:111-7. 2010..Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose...
Outcomes at age 2 years of infants < 28 weeks' gestational age born in Victoria in 2005Lex W Doyle
Newborn Services, Royal Women s Hospital, Melbourne, Australia
J Pediatr 156:49-53.e1. 2010..To determine the survival rates and neurosensory outcomes of infants born at gestational age 22-27 weeks in the state of Victoria in 2005 and compare theses data with those for similar infants born in the 1990s...
Antenatal magnesium sulfate and neurologic outcome in preterm infants: a systematic reviewLex W Doyle
Royal Women s Hospital, Parkville, Victoria, Australia
Obstet Gynecol 113:1327-33. 2009..To systematically review rates of neurologic outcomes reported in childhood for the preterm fetus exposed to antenatal magnesium sulfate...
Extremely low birth weight and body size in early adulthoodL W Doyle
The Division of Newborn Services, The Royal Women s Hospital, Melbourne, Australia
Arch Dis Child 89:347-50. 2004..To determine the body size of extremely low birth weight (ELBW, birth weight 500-999 g) subjects in early adulthood...
Evaluation of neonatal intensive care for extremely low birth weight infants in Victoria over two decades: II. EfficiencyLex W Doyle
Department of Obstetrics and Gynaecology, Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, Australia
Pediatrics 113:510-4. 2004....
Outcome at 14 years of extremely low birthweight infants: a regional studyL W Doyle
The Royal Women s Hospital, Melbourne, Australia
Arch Dis Child Fetal Neonatal Ed 85:F159-64. 2001....
Evaluation of neonatal intensive care for extremely low birth weight infants in Victoria over two decades: I. EffectivenessLex W Doyle
Department of Obstetrics and Gynaecology, Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, Australia
Pediatrics 113:505-9. 2004..Although individual components of neonatal intensive care have proven efficacy, doubts remain about its overall effectiveness...
Health and hospitalistions after discharge in extremely low birth weight infantsLex W Doyle
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
Semin Neonatol 8:137-45. 2003..ELBW survivors require closer surveillance after discharge, not only for adverse neurosensory outcome, but also for other general health problems in early childhood...
Adverse effects of smoking on respiratory function in young adults born weighing less than 1000 gramsLex W Doyle
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
Pediatrics 112:565-9. 2003..To determine whether active smoking has an adverse impact on respiratory function of young adults of extremely low birth weight (ELBW; birth weight <1000 g)...
Blood pressure in late adolescence and very low birth weightLex W Doyle
Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia
Pediatrics 111:252-7. 2003....
Changes in neurodevelopmental outcome at age eight in geographic cohorts of children born at 22-27 weeks' gestational age during the 1990sG Roberts
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 20 Flemington Road, Parkville 3052, Australia
Arch Dis Child Fetal Neonatal Ed 95:F90-4. 2010..The aims of this study were to determine the outcomes at age eight for a regional cohort of children born at 22-27 weeks during 1997, and to compare their rates of disability with a cohort of the same gestational age born in 1991-1992...
The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997G Roberts
Department of Obstetrics and Gynaecology, The Royal Women s Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia
Arch Dis Child 95:786-90. 2010....
Methylxanthines and sensorineural outcome at 14 years in children < 1501 g birthweightP G Davis
Department of Obstetrics and Gynaecology, University of Melbourne, Australia
J Paediatr Child Health 36:47-50. 2000..The aim of this study was to determine the relationship between theophylline therapy and outcome at 14 years of age in surviving preterm children of birthweight < 1501 g...
Neonatal resuscitation 2: an evaluation of manual ventilation devices and face masksC P F O'Donnell
Royal Women s Hospital Melbourne, Victoria 3053, Australia
Arch Dis Child Fetal Neonatal Ed 90:F392-6. 2005..The expiratory tidal volume measured at the mask (V(TE(mask))) is a good estimate of the tidal volume delivered during simulated neonatal resuscitation...
Growth and respiratory health in adolescence of the extremely low-birth weight survivorL W Doyle
Division of Newborn Services, Royal Women s Hospital, Victoria, Australia
Clin Perinatol 27:421-32. 2000..The effects of cigarette smoke, both passive and active, and of newer therapies, such as exogenous surfactant and postnatal corticosteroids, on respiratory health in adulthood remain to be determined...
Survival, cranial ultrasound and cerebral palsy in very low birthweight infants: 1980s versus 1990sL W Doyle
Division of Newborn Services, Royal Women s Hospital, Victoria, Australia
J Paediatr Child Health 36:7-12. 2000..To determine the changes in the rates of survival, cranial ultrasound abnormalities and cerebral palsy in very low birthweight (VLBW) (birthweight 500-1499 g) infants between the early 1980s and the early 1990s...
Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm childrenL W Doyle
Department of Obstetrics and Gynaecology and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
Clin Sci (Lond) 98:137-42. 2000..It is concluded that antenatal corticosteroid therapy is associated with higher systolic and diastolic blood pressures in adolescence, and might lead to clinical hypertension in survivors well beyond birth...
Changing mortality and causes of death in infants 23-27 weeks' gestational ageL W Doyle
Division of Paediatrics, Royal Women s Hospital, Carlton, Victoria, Australia
J Paediatr Child Health 35:255-9. 1999....
Birth weight <1501 g and respiratory health at age 14L W Doyle
Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, 3052, Australia Doyle
Arch Dis Child 84:40-44. 2001..To determine the respiratory health in adolescence of children of birth weight <1501 g, and to compare the results with normal birthweight controls...
Antenatal corticosteroids and outcome at 14 years of age in children with birth weight less than 1501 gramsL W Doyle
Division of Newborn Services, Royal Women s Hospital, Melbourne, Australia
Pediatrics 106:E2. 2000..To determine whether exposure to antenatal corticosteroid therapy was associated with adverse effects on growth, sensorineural outcome, or lung function of children of birth weight <1501 g at 14 years of age...
Auditory function at 14 years of age of very-low-birthweightN M Davis
Division of Newborn Services, Royal Women's Hospital, Carlton, Australia
Dev Med Child Neurol 43:191-6. 2001..VLBW children had higher rates of some central auditory processing problems, which in turn were associated with poorer intellectual, academic, and behavioural progress...
Outcome at 5 years of age of children 23 to 27 weeks' gestation: refining the prognosisL W Doyle
Department of Obstetrics and Gynaecology, Royal Women s Hospital, Carlton, Australia
Pediatrics 108:134-41. 2001..To determine the changes with postnatal age for survival, with and without major sensorineural disability, to 5 years of age in very preterm infants and to contrast their prognosis with normal birth weight (NBW) control participants...
Sepsis in neonatal intensive care in the late 1990sS S Mehr
Division of Newborn Services, Royal Women's Hospital, Carlton, Australia
J Paediatr Child Health 38:246-51. 2002..Coagulase-negative staphylococci were the commonest cause of LOS. The mortality rate from sepsis in the LOS group was 11% (5/45). CONCLUSIONS: EOS and LOS are significant problems in ventilated NICU infants in the late 1990s...
Cognition, academic progress, behavior and self-concept at 14 years of very low birth weight childrenA L Rickards
Division of Newborn Services, The Royal Women's Hospital, Carlton, Victoria, Australia
J Dev Behav Pediatr 22:11-8. 2001..VLBW children had significantly reduced self-esteem. VLBW children had more cognitive, academic, and behavioral problems and lower self-esteem at 14 years of age than NBW control subjects...
Nasal CPAP or intubation at birth for very preterm infantsColin J Morley
Neonatal Services, Royal Women s Hospital, Melbourne, Australia
N Engl J Med 358:700-8. 2008....
Longitudinal predictors of psychiatric disorders in very low birth weight adultsE M Westrupp
The University of Melbourne, Melbourne, Australia
Child Psychiatry Hum Dev 43:113-23. 2012..11, p = 0.05) and the adult social environment (high rates of negative life event stress at the time of assessment: OR = 1.39, CI = 1.10, 1.76, p = 0.02), contributed significantly to adult psychiatric outcomes...
Developmental coordination disorder at 8 years of age in a regional cohort of extremely-low-birthweight or very preterm infantsN M Davis
Department of Obstetrics and Gynaecology, Royal Women s Hospital, Carlton, Victoria, Australia
Dev Med Child Neurol 49:325-30. 2007..DCD is more common in ELBW/very preterm children, has few perinatal correlates, and is associated with poor cognitive and academic performance as well as increased behaviour problems...
Why do preterm infants die in the 1990s?L W Doyle
Division of Paediatrics, Royal Women s Hospital, Melbourne, Vic
Med J Aust 170:528-32. 1999..To describe the mortality rate for preterm infants (born 23-36 completed weeks' gestational age) and to determine the causes of death, focusing on avoidable causes...
Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990sPeter Anderson
Royal Women's Hospital, Murdoch Childrens Research Institute, Melbourne, Australia
JAMA 289:3264-72. 2003..CONCLUSION: School-aged ELBW or very preterm children born in the 1990s continue to display cognitive, educational, and behavioral impairments...
Abnormal white matter signal on MR imaging is related to abnormal tissue microstructureJ L Y Cheong
Victorian Infant Brain Studies, Murdoch Children s Research Institute, Parkville, Australia
AJNR Am J Neuroradiol 30:623-8. 2009..This study aimed to relate regional DTI measures with severity of WMSA in very preterm infants...
Early sensitivity training for parents of preterm infants: impact on the developing brainJeannette Milgrom
Department of Clinical and Health Psychology, Austin Health, Victoria, Australia
Pediatr Res 67:330-5. 2010..Thus, sensitivity training for parents in the NICU is associated with improved cerebral white matter micro-structural development in preterm infants...
Neurodevelopmental sequelae of intraventricular haemorrhage at 8 years of age in a regional cohort of ELBW/very preterm infantsR L Sherlock
Royal Women's Hospital, Melbourne, Australia
Early Hum Dev 81:909-16. 2005..CONCLUSIONS: Neurodevelopmental dysfunction at school age in ELBW/very preterm survivors varies little with increasing severity of IVH, with the exception of grade 4 IVH...
Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trialSusan E Jacobs
Neonatal Services, Royal Women s Hospital, corner Grattan Street and Flemington Road, Parkville, Victoria 3052, Australia
Arch Pediatr Adolesc Med 165:692-700. 2011..To determine the effectiveness and safety of moderate whole-body hypothermia in newborns with hypoxic-ischemic encephalopathy born in hospitals with and without newborn intensive care facilities or complicated hypothermia equipment...
8: Non-parametric methods for continuous or ordered dataJ B Carlin
Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, University of Melbourne, Parkville, Victoria 3010, Australia
J Paediatr Child Health 39:309-11. 2003
Perinatal risk factors altering regional brain structure in the preterm infantDeanne K Thompson
Howard Florey Institute, University of Melbourne, Melbourne, Australia
Brain 130:667-77. 2007..These findings add to our understanding of the potential pathways leading to altered brain structure and outcome in the preterm infant...
Early emergence of behavior and social-emotional problems in very preterm infantsAlicia J Spittle
Victorian Infant Brain Studies VIBeS team, Murdoch Childrens Research Institute, Australia
J Am Acad Child Adolesc Psychiatry 48:909-18. 2009..In addition, the relation between perinatal variables and early behavior problems was also examined to help identify those very preterm children most at risk...
Evaluating "old" definitions for the "new" bronchopulmonary dysplasiaPeter G Davis
Department of Paediatrics, Royal Women's Hospital, Melbourne, Victoria, Australia
J Pediatr 140:555-60. 2002..CONCLUSIONS: Poor pulmonary outcome and poor neurosensory outcome are common late adverse outcomes in this population. BPD as defined by duration of oxygen therapy is a less accurate surrogate currently than in previous eras...
Cognitive and educational deficits in children born extremely pretermPeter J Anderson
Department of Psychology, The University of Melbourne, The Royal Women s Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
Semin Perinatol 32:51-8. 2008....
Preterm infant hippocampal volumes correlate with later working memory deficitsMiriam H Beauchamp
Murdoch Childrens Research Institute, The University of Melbourne, Melbourne, Vic, Australia
Brain 131:2986-94. 2008..Preterm children appear to have altered hippocampal volumes by discharge from hospital which may have a lasting impact on working memory function...
Preventive care at home for very preterm infants improves infant and caregiver outcomes at 2 yearsAlicia J Spittle
Murdoch Childrens Research Institute, Victoria Infant Brain Studies, Melbourne, Australia
Pediatrics 126:e171-8. 2010..The objective of this study was to determine the effects of preventive care at home on child development and primary caregiver mental health at 2 years of age...
Rates of early intervention services in very preterm children with developmental disabilities at age 2 yearsGehan Roberts
Victorian Infant Brain Study Group, Murdoch Children s Research Institute, University of Melbourne, Melbourne, Victoria, Australia
J Paediatr Child Health 44:276-80. 2008..This study explores the association of levels of disability at age 2 years with EI services and social risk in a large cohort of very preterm children...
Reduced cerebellar diameter in very preterm infants with abnormal general movementsAlicia J Spittle
Murdoch Childrens Research Institute, Victoria, Australia
Early Hum Dev 86:1-5. 2010..However, other structural correlates of abnormal GMs have not been defined...
Executive functioning in school-aged children who were born very preterm or with extremely low birth weight in the 1990sPeter J Anderson
Royal Women s Hospital, Melbourne, Australia
Pediatrics 114:50-7. 2004....
Underestimation of developmental delay by the new Bayley-III ScalePeter J Anderson
Murdoch Childrens Research Institute, Melbourne, Australia
Arch Pediatr Adolesc Med 164:352-6. 2010..To assess the ability of the third edition of the Bayley Scales of Infant and Toddler Development (Bayley-III) to detect developmental delay in 2-year-old children who were extremely preterm and those carried to term...
Caffeine for Apnea of Prematurity trial: benefits may vary in subgroupsPeter G Davis
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
J Pediatr 156:382-7. 2010..To determine whether the benefits of caffeine vary in three subgroups of 2006 participants in the Caffeine for Apnea of Prematurity (CAP) trial...
Parental mental health and early social-emotional development of children born very pretermKarli Treyvaud
Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria, 3052, Australia
J Pediatr Psychol 35:768-77. 2010..The aims of this study were to describe the mental health of parents of children born very preterm and examine relations between parental mental health and early social-emotional development in very preterm and term born children...
Interleukin-6 and interleukin-8 in newborn bacterial infectionS S Mehr
Division of Newborn Services, The Royal Women's Hospital, Carlton, Australia
Am J Perinatol 18:313-24. 2001..IL-6 and IL-8 had little diagnostic accuracy in infants with probable infection. IL-6 and IL-8 concentrations increase early in newborn infants with definite infection...
Long-term outcomes of bronchopulmonary dysplasiaLex W Doyle
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
Semin Fetal Neonatal Med 14:391-5. 2009..The importance of these neurological and respiratory problems later into adult life needs to be determined...
Neurobehavior at term and white and gray matter abnormalities in very preterm infantsNisha C Brown
Victorian Infant Brain Studies, Murdoch Children s Research Institute, Melbourne, Australia
J Pediatr 155:32-8, 38.e1. 2009..To examine the relationship between very preterm infant neurobehavior at term and concurrent magnetic resonance-defined cerebral abnormalities...
Predicting motor development in very preterm infants at 12 months' corrected age: the role of qualitative magnetic resonance imaging and general movements assessmentsAlicia J Spittle
Victorian Infant Brain Studies, Murdoch Children s Research Institute, 2nd Floor, Royal Children s Hospital, Flemington Road, Parkville 3052, Melbourne, Australia
Pediatrics 123:512-7. 2009....
Quality of general movements is related to white matter pathology in very preterm infantsAlicia J Spittle
Victorian Infant Brain Studies, Murdoch Childrens Research Institute, 2nd Floor, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Australia 3052
Pediatrics 121:e1184-9. 2008..The objective of this study was to determine the association between MRI-defined cerebral abnormalities and general movements at 1 and 3 months' corrected age in infants who were born very preterm...
Newer approaches to the diagnosis of early onset neonatal sepsisU K Mishra
Newborn Services, Royal Women's Hospital, Victoria, Australia
Arch Dis Child Fetal Neonatal Ed 91:F208-12. 2006..In the future, molecular biology techniques offer the prospect of rapid identification of both pathogens and antimicrobial resistance markers...
Sample sizeJ B Carlin
Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia
J Paediatr Child Health 38:300-4. 2002
Neonatal resuscitation 3: manometer use in a model of face mask ventilationC P F O'Donnell
Royal Women s Hospital Melbourne, Victoria 3053, Australia
Arch Dis Child Fetal Neonatal Ed 90:F397-400. 2005..These devices may be used with a manometer to measure airway pressures delivered. The expiratory tidal volume measured at the mask (V(TE(mask))) is a good estimate of the tidal volume delivered during simulated neonatal resuscitation...
Adverse reactions to immunization with newer vaccines in the very preterm infantVanessa J Ellison
Division of Newborn Services, The Royal Women s Hospital, Victoria, Australia
J Paediatr Child Health 41:441-3. 2005..To study the frequency and types of adverse reactions to currently available vaccines in very preterm infants...
A systematic review of the clinimetric properties of neuromotor assessments for preterm infants during the first year of lifeAlicia J Spittle
Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Parkville, Melbourne, Australia
Dev Med Child Neurol 50:254-66. 2008..85). Selection of motor assessment tools during the first year of life for infants born preterm will depend on the intended purpose of their use for discrimination, prediction, and/or evaluation...
Neurosensory disabilities at school age in geographic cohorts of extremely low birth weight children born between the 1970s and the 1990sGehan Roberts
Premature Infant Follow up Program, The Royal Women s Hospital, Parkville, Australia
J Pediatr 154:829-34.e1. 2009....
Neurodevelopmental outcome of bronchopulmonary dysplasiaPeter J Anderson
The Murdoch Childrens Research Institute, Melbourne, Australia
Semin Perinatol 30:227-32. 2006..BPD does not appear to be associated with a specific neuropsychological impairment but rather a global impairment...
Single versus bihemispheric amplitude-integrated electroencephalography in relation to cerebral injury and outcome in the term encephalopathic infantShelly Lavery
Victorian Infant Brain Study Group, and Murdoch Childrens Research Institute, The Royal Children s Hospital Melbourne, Victoria, Australia
J Paediatr Child Health 44:285-90. 2008..New bedside aEEG devices with more channels are entering the neonatal environment. Little data are available to compare the utility of two channels (B-aEEG) with that of an S-aEEG recording...
Head growth in preterm infants: correlation with magnetic resonance imaging and neurodevelopmental outcomeJeanie L Y Cheong
Royal Women s Hospital, Department of Neonatal Services, 132 Grattan St, Carlton 3053, Melbourne, Australia
Pediatrics 121:e1534-40. 2008..The purpose of this work was to establish the relationship between head circumference with brain MRI at term-equivalent age and to relate head circumference with neurodevelopmental outcome at 2 years...
Parenting behavior is associated with the early neurobehavioral development of very preterm childrenKarli Treyvaud
Critical Care and Neurosciences, Murdoch Childrens Research Institute, Victoria, Australia
Pediatrics 123:555-61. 2009..The aim of this study was to assess the relationship between parenting behavior, parent-child synchrony, and neurobehavioral development in very preterm children at 24 months of age...
Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcomeDeanne K Thompson
Howard Florey Institute, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia
Ann Neurol 63:642-51. 2008..To compare preterm (PT) and full-term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome...
MR-determined hippocampal asymmetry in full-term and preterm neonatesDeanne K Thompson
Neuroimaging and Neuroinformatics, Howard Florey Institute, University of Melbourne, Victoria, Australia
Hippocampus 19:118-23. 2009..This study may suggest that hippocampal asymmetry develops in utero and is maintained into adulthood in infants with a normal neurological course...
Compliance with alarm limits for pulse oximetry in very preterm infantsLuisa Clucas
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
Pediatrics 119:1056-60. 2007..The objective of this study was to determine the rate of compliance with hospital guidelines for alarm limits for pulse oximetry in preterm infants on oxygen therapy...
Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathyTerrie E Inder
Division of Newborn Services, Royal Women s Hospital, Neonatal Neurology, Royal Children s Hospital, Melbourne, Australia
J Pediatr 145:835-7. 2004..036), which may indicate differing regional benefit from systemic hypothermia...
Alterations in neurobehavior at term reflect differing perinatal exposures in very preterm infantsNisha C Brown
Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Parkville, Australia
Pediatrics 118:2461-71. 2006..We hypothesized that neurobehavior at term would be different in very preterm infants compared with term infants and that perinatal exposures would be associated with these alterations in neurobehavior...
Monitoring the neonatal brain: a survey of current practice among Australian and New Zealand neonatologistsPeter M Filan
Victorian Infant Brain Study Group, Murdoch Children s Research Institute, Melbourne, Victoria, Australia
J Paediatr Child Health 43:557-9. 2007..The aims of this study were (i) to document the current practice among Australian and New Zealand neonatologists; and (ii) to identify the factors that influence local practice...
Prematurity and later cognitive outcomesLex W Doyle
JAMA 288:2542-3; author reply 2543. 2002
Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trialCaroline A Crowther
Department of Obstetrics and Gynaecology, The University of Adelaide, Women s and Children s Hospital, King William Road, North Adelaide, South Australia, 5006 Australia
JAMA 290:2669-76. 2003..Prenatal magnesium sulfate may reduce the risk of cerebral palsy or death in very preterm infants...
The association of growth impairment with neurodevelopmental outcome at eight years of age in very preterm childrenErick Kan
Department of Obstetrics and Gynaecology at The University of Melbourne, Australia
Early Hum Dev 84:409-16. 2008..The relative contributions of poor growth before and after birth in very preterm infants to subsequent outcomes at school-age are not certain...
Regionalized long-term follow-upVictor Y H Yu
Department of Paediatrics and Ritchie Centre for Baby Health Research, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
Semin Neonatol 9:135-44. 2004..Regionalized long-term follow-up provides unique information that is not available from institution-based studies, which is vital to the regional organization of perinatal-neonatal care...
Caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont, Canada
N Engl J Med 354:2112-21. 2006..It is uncertain whether methylxanthines have other short- and long-term benefits or risks in infants with very low birth weight...
Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trialCaroline A Crowther
Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia 5006, Australia
Lancet 367:1913-9. 2006..The efficacy and safety of repeat doses of prenatal corticosteroids remains uncertain. Our aim was to establish whether repeat prenatal corticosteroids given to women at risk of preterm birth can reduce neonatal morbidity without harm...
Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in PretermsNandkishor S Kabra
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
J Pediatr 150:229-34, 234.e1. 2007....
Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at termDivyen K Shah
Department of Pediatrics, Washington University, St Louis, MO 63105, USA
J Pediatr 153:170-5, 175.e1. 2008..To test the hypothesis that the impact of postnatal sepsis/necrotizing enterocolitis (NEC) on neurodevelopment may be mediated by white matter abnormality (WMA), which can be demonstrated with magnetic resonance imaging (MRI)...
An overview of mortality and sequelae of preterm birth from infancy to adulthoodSaroj Saigal
Department of Paediatrics, McMaster University, Hamilton, ON, Canada
Lancet 371:261-9. 2008..In addition, follow-up to middle age and beyond is warranted to identify the risks, especially for cardiovascular and metabolic disorders that are likely to be experienced by preterm survivors...
Long-term effects of caffeine therapy for apnea of prematurityBarbara Schmidt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
N Engl J Med 357:1893-902. 2007..Methylxanthine therapy is commonly used for apnea of prematurity but in the absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines have long-term effects on neurodevelopment and growth...
Evaluation of the Ages and Stages Questionnaires in identifying children with neurosensory disability in the Magpie Trial follow-up studyLy Mee Yu
Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
Acta Paediatr 96:1803-8. 2007..To evaluate performance of the Ages and Stages Questionnaires (full ASQ), and a shortened version (short ASQ), in detecting children with severe neurosensory disability in the Magpie Trial follow-up study...
Outcomes at 2 years of age after repeat doses of antenatal corticosteroidsCaroline A Crowther
Disciplines of Obstetrics and Gynaecology, University of Adelaide, Women s and Children s Hospital, Adelaide, Australia
N Engl J Med 357:1179-89. 2007..However, data have not been available regarding longer-term effects of this treatment...
Antenatal magnesium sulphate neuroprotection in the preterm infantStephane Marret
Department of Neonatal Medicine, University Hospital, 1, rue de Germont, 76031, Rouen Cedex, France
Semin Fetal Neonatal Med 12:311-7. 2007..The role for antenatal magnesium sulphate therapy as a neuroprotective agent for the preterm fetus is not yet established...
