C G Dos Remedios

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc A model selection approach to discover age-dependent gene expression patterns using quantile regression models
    Joshua W K Ho
    School of Information Technologies, The University of Sydney, NSW 2006, Australia
    BMC Genomics 10:S16. 2009
  2. ncbi request reprint Actin binding proteins: regulation of cytoskeletal microfilaments
    C G Dos Remedios
    Institute for Biomedical Research, Muscle Research Unit, Department of Anatomy and Histology, University of Sydney, Australia
    Physiol Rev 83:433-73. 2003
  3. pmc The regulation of muscle contraction: as in life, it keeps getting more complex
    C G Dos Remedios
    Muscle Research Unit, Bosch Institute, The University of Sydney, Sydney, Australia
    Biophys J 93:4097-8. 2007
  4. pmc Genomics, proteomics and bioinformatics of human heart failure
    C G Dos Remedios
    Muscle Research Unit, Institute for Biomedical Research, University of Sydney, Sydney 2006, Australia
    J Muscle Res Cell Motil 24:251-60. 2003
  5. ncbi request reprint Protein changes observed in pacing-induced heart failure using two-dimensional electrophoresis
    M Y Heinke
    Muscle Research Unit, Institute of Biomedical Research, The University of Sydney, NSW, Australia
    Electrophoresis 19:2021-30. 1998
  6. pmc Distance measurements near the myosin head-rod junction using fluorescence spectroscopy
    M Kekic
    Department of Anatomy and Histology, University of Sydney, Australia
    Biophys J 71:40-7. 1996
  7. ncbi request reprint Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: protein levels do not necessarily reflect mRNA levels
    C G Dos Remedios
    Muscle Research Unit, Department of Anatomy, The University of Sydney, Australia
    Electrophoresis 17:235-8. 1996
  8. ncbi request reprint The role of ATP, ADP and divalent cations in the formation of binary and ternary complexes of actin, cofilin and DNase I
    D Chhabra
    Department of Anatomy and Histology, Institute for Biomedical Research, The University of Sydney, Australia
    Electrophoresis 21:3863-9. 2000
  9. ncbi request reprint Two-dimensional gel electrophoresis of actin-binding proteins isolated by affinity chromatography from human skeletal muscle
    J V Coumans
    Institute for Biomedical Research, The University of Sydney, Australia
    Electrophoresis 18:1079-85. 1997
  10. ncbi request reprint The affinity of chick cofilin for actin increases when actin is complexed with DNase I: formation of a cofilin-actin-DNase I ternary complex
    N J Nosworthy
    Institute for Biomedical Research, Muscle Research Unit, Department of Anatomy and Histology, The University of Sydney, Sydney, Australia
    Proteomics 1:1513-8. 2001

Collaborators

  • Deepak Chhabra
  • M Yao
  • D Chang
  • Y Huang
  • J X Yan
  • R L Winslow
  • M J Dunn
  • L Jiang
  • J E Van Eyk
  • S L Hirsh
  • Bradley C Steel
  • Ian-R Mackay
  • R Martinez-Neira
  • M Kekic
  • J V Coumans
  • D A Berry
  • I V Dedova
  • N J Nosworthy
  • Joshua W K Ho
  • B K Gan
  • M Y Heinke
  • S V Avrova
  • T L Hazlett
  • Yu S Borovikov
  • A Keogh
  • N N Vikhoreva
  • L Belov
  • P D Moens
  • Maurizio Stefani
  • Michael A Charleston
  • R I Christopherson
  • M M M Bilek
  • D R McKenzie
  • C H Wheeler
  • R Einstein
  • D Nicolau
  • W Van der Meer
  • P G Vikhorev
  • L K Carter
  • R G Vikhorev
  • Iu S Borovikov
  • B W Van Der Meer
  • O de la Vega
  • S P Mulligan
  • V J Balcar
  • J A Barden
  • V Amin
  • A Drake-Holland
  • K Brennan
  • P Gunning
  • R K Seeto
  • E Hardeman
  • T Yeoh
  • I Humphery-Smith
  • W Huang
  • B D Hambly

Detail Information

Publications30

  1. pmc A model selection approach to discover age-dependent gene expression patterns using quantile regression models
    Joshua W K Ho
    School of Information Technologies, The University of Sydney, NSW 2006, Australia
    BMC Genomics 10:S16. 2009
    ..Clearly a more robust and flexible approach is needed to identify genes with various age-dependent gene expression patterns...
  2. ncbi request reprint Actin binding proteins: regulation of cytoskeletal microfilaments
    C G Dos Remedios
    Institute for Biomedical Research, Muscle Research Unit, Department of Anatomy and Histology, University of Sydney, Australia
    Physiol Rev 83:433-73. 2003
    ..Some play crucial roles in human disorders, and for all of them, there are good reasons why investigations into their structures and functions should continue...
  3. pmc The regulation of muscle contraction: as in life, it keeps getting more complex
    C G Dos Remedios
    Muscle Research Unit, Bosch Institute, The University of Sydney, Sydney, Australia
    Biophys J 93:4097-8. 2007
  4. pmc Genomics, proteomics and bioinformatics of human heart failure
    C G Dos Remedios
    Muscle Research Unit, Institute for Biomedical Research, University of Sydney, Sydney 2006, Australia
    J Muscle Res Cell Motil 24:251-60. 2003
    ..Thus, we plan to provide meaningful molecular descriptions of a number of different conditions that result in terminal heart failure...
  5. ncbi request reprint Protein changes observed in pacing-induced heart failure using two-dimensional electrophoresis
    M Y Heinke
    Muscle Research Unit, Institute of Biomedical Research, The University of Sydney, NSW, Australia
    Electrophoresis 19:2021-30. 1998
    ..These results indicate that the development of heart failure in the paced dog involves alterations in mitochondrial energy production, the cytoskeleton and calcium activation...
  6. pmc Distance measurements near the myosin head-rod junction using fluorescence spectroscopy
    M Kekic
    Department of Anatomy and Histology, University of Sydney, Australia
    Biophys J 71:40-7. 1996
    ..This model suggests that the loci that bracket the head-rod junction will be useful for evaluating dynamic changes in this region...
  7. ncbi request reprint Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: protein levels do not necessarily reflect mRNA levels
    C G Dos Remedios
    Muscle Research Unit, Department of Anatomy, The University of Sydney, Australia
    Electrophoresis 17:235-8. 1996
    ..Zymograms of DCM and ND samples revealed a significant increase in DNase I activity in the DCM group compared to the ND samples. These data raise the possibility that end-stage failure may be associated with apoptosis...
  8. ncbi request reprint The role of ATP, ADP and divalent cations in the formation of binary and ternary complexes of actin, cofilin and DNase I
    D Chhabra
    Department of Anatomy and Histology, Institute for Biomedical Research, The University of Sydney, Australia
    Electrophoresis 21:3863-9. 2000
    ....
  9. ncbi request reprint Two-dimensional gel electrophoresis of actin-binding proteins isolated by affinity chromatography from human skeletal muscle
    J V Coumans
    Institute for Biomedical Research, The University of Sydney, Australia
    Electrophoresis 18:1079-85. 1997
    ..This strategy should detect ABPs which bind to sites other than the DNase I-binding site and some may prove to be novel...
  10. ncbi request reprint The affinity of chick cofilin for actin increases when actin is complexed with DNase I: formation of a cofilin-actin-DNase I ternary complex
    N J Nosworthy
    Institute for Biomedical Research, Muscle Research Unit, Department of Anatomy and Histology, The University of Sydney, Sydney, Australia
    Proteomics 1:1513-8. 2001
    ..The addition of cofilin to actin resulted in the polymerisation of actin at pH 6.8 whereas at alkaline pH a stable cofilin-actin binary complex could be formed. The biological implications are discussed...
  11. ncbi request reprint Electrophoretic monitoring of pollutants: effect of cations and organic compounds on protein interactions monitored by native gel electrophoresis
    M Kekic
    Department of Anatomy and Histology, Institute for Biomedical Research, The University of Sydney, Australia
    Electrophoresis 20:2053-8. 1999
    ..We suggest that if this molecular assay is sensitive to a wide range of environmental pollutants, it could be used as a rapid and convenient assay of the environment in combination with currently available tests...
  12. doi request reprint A comparison of covalent immobilization and physical adsorption of a cellulase enzyme mixture
    S L Hirsh
    Applied and Plasma Physics, School of Physics A28, The University of Sydney, Sydney, NSW 2006, Australia
    Langmuir 26:14380-8. 2010
    ..A model for the attachment process of a protein mixture that includes the adsorption kinetics for both surfaces is presented...
  13. ncbi request reprint A conformational change in F-actin when myosin binds: fluorescence resonance energy transfer detects an increase in the radial coordinate of Cys-374
    P D Moens
    Department of Anatomy and Histology, Institute for Biomedical Research, The University of Sydney, Australia
    Biochemistry 36:7353-60. 1997
    ..S-1 increases the radial position of Cys-374 either by direct interaction or via an allosteric conformational change associated with its binding...
  14. ncbi request reprint Changes in myocardial protein expression in pacing-induced canine heart failure
    M Y Heinke
    Institute for Biomedical Research, The University of Sydney, NSW, Australia
    Electrophoresis 20:2086-93. 1999
    ..These results strongly support the notion that energy production is impaired and mitochondrial dysfunction is involved in the development of heart failure in the paced dog...
  15. ncbi request reprint Determination of P2X1alpha-sarcoglycan (adhalin) expression levels in failing human dilated cardiomyopathic left ventricles
    D A Berry
    Protein Laboratory Sutherland Center of Immunology, Sutherland Hospital, Caringbah, NSW, Australia
    Electrophoresis 21:3857-62. 2000
    ..We found no evidence for upregulation of P2X1 receptors nor was the expression of alpha-sarcoglycan significantly altered...
  16. ncbi request reprint A novel biosensor for mercuric ions based on motor proteins
    R Martinez-Neira
    Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, Anderson Stuart Bldg F 13, Sydney NSW2006, Australia
    Biosens Bioelectron 20:1428-32. 2005
    ..Thus, we have demonstrated the biochemical, biophysical and nanotechnological basis of what may prove to be a useful nano-device...
  17. ncbi request reprint Nuclear membrane proteins in failing human dilated cardiomyopathy
    D A Berry
    Protein Laboratory Sutherland Centre of Immunology, Sutherland Hospital, Caringbah, NSW, Australia
    Proteomics 1:1507-12. 2001
    ..Subcellular Biochem. 1998, 31, 587-610). Preliminary data show that both lamin isoforms and emerin are present...
  18. ncbi request reprint Apparatus for exposing cell membranes to rapid temperature transients
    B Steel
    School of Physics, University of Sydney, 2006 NSW, Australia
    Eur Biophys J 33:117-20. 2004
    ..We refer to this device as a nanosecond hotplate...
  19. ncbi request reprint Cardiomyocyte apoptosis is associated with increased wall stress in chronic failing left ventricle
    L Jiang
    Department of Cardiology, Cardiac Technology Centre, Royal North Shore Hospital, St Leonards, NSW, Australia
    Eur Heart J 24:742-51. 2003
    ..We examined cardiomyocyte apoptosis in chronic heart failure (HF) and its possible link to elevated wall stress...
  20. ncbi request reprint Elevated DNase activity and caspase expression in association with apoptosis in failing ischemic sheep left ventricles
    L Jiang
    Cooperative Research Centre for Cardiac Technology, Royal North Shore Hospital, St Leonards, NSW, Australia
    Electrophoresis 20:2046-52. 1999
    ..There was a 2.2-fold increased expression of caspase-2 p < 0.001 = and a 2.6-fold increased expression of caspase-3 p < 0.001) in failing left ventricles compared to normal samples...
  21. ncbi request reprint Analysis of the binding of deoxyribonuclease I to G-actin by capillary electrophoresis
    L K Carter
    Institute for Biomedical Research, and Department of Anatomy and Histology, The University of Sydney, New South Wales, Australia
    Electrophoresis 18:1054-8. 1997
    ..Subsequent determination of K(d) values for other actin-binding proteins should provide information on interactions between the binding sites on actin for these proteins and their spatial relationship...
  22. ncbi request reprint Heart failure and apoptosis: electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics
    L Jiang
    Institute for Biomedical Research, Department of Anatomy and Histology, University of Sydney, NSW, Australia
    Proteomics 1:1481-8. 2001
    ..Similar principles will apply to other tissues and cells...
  23. ncbi request reprint Variations in the relative mRNA levels of actins and myosin heavy chains do not produce corresponding differences in their proteins in the adult human heart
    J V Coumans
    Department of Anatomy and Histology, University of Sydney, Australia
    J Mol Cell Cardiol 29:895-905. 1997
    ..We conclude that the human ventricle can accommodate a substantial imbalance between sarcomeric MHC and actin mRNA levels while maintaining a constant ratio of their corresponding proteins...
  24. ncbi request reprint Actin-binding proteins in mouse C2 myoblasts and myotubes: a combination of affinity chromatography and two-dimensional gel electrophoresis
    J V Coumans
    Institute for Biomedical Research, Department of Anatomy and Histology, The University of Sydney, Australia
    Electrophoresis 19:826-33. 1998
    ..These findings are discussed in relation to reports in which the myoblast-myotube transformation was associated with the up-regulation or de novo synthesis of more than ten proteins...
  25. ncbi request reprint Plasma immersion ion implantation treatment of polyethylene for enhanced binding of active horseradish peroxidase
    B K Gan
    Applied and Plasma Physics, School of Physics A28, The University of Sydney, New South Wales 2006, Australia
    J Biomed Mater Res A 85:605-10. 2008
    ..We propose that the treatment produces new binding sites on the surface and that the function of the HRP is retained because the treated surface is substantially more hydrophilic...
  26. doi request reprint An actin-myosin functional assay for analysis of smooth muscle (anti-microfilament) autoantibodies in human plasma
    R Martinez-Neira
    School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney NSW 2006, Australia
    J Immunol Methods 338:63-6. 2008
    ..The data from these functional assays provide new insights into the significance of anti-microfilament assays in the diagnosis, and perhaps also pathogenesis, of AIH-1...
  27. ncbi request reprint Immunophenotyping of leukemias using a cluster of differentiation antibody microarray
    L Belov
    Department of Biochemistry, Institute for Biomedical Research, University of Sydney, NSW 2006, Australia
    Cancer Res 61:4483-9. 2001
    ..The microarray enables extensive immunophenotyping, and the intact cells captured on antibody dots can be further characterized using soluble, fluorescently labeled antibodies...
  28. pmc Cofilin, actin and their complex observed in vivo using fluorescence resonance energy transfer
    D Chhabra
    Muscle Research Unit, School of Medical Sciences, Institute for Biomedical Research, University of Sydney, Sydney, New South Wales, Australia
    Biophys J 89:1902-8. 2005
    ..Our data suggest there is significantly more cofilin-G-actin complex and less free cofilin in the nucleus than in the cytoplasm...
  29. pmc Fluorescence depolarization of actin filaments in reconstructed myofibers: the effect of S1 or pPDM-S1 on movements of distinct areas of actin
    Yu S Borovikov
    Institute of Cytology, Russian Academy of Science, St Petersburg 194064, Russia
    Biophys J 86:3020-9. 2004
    ..These altered probe orientations suggest that myosin binding alters the conformation of F-actin. Strong binding by myosin heads produces changes in probe orientation that are opposite to those observed during weak binding...
  30. ncbi request reprint [Conformational changes of actin induced by strong or weak myosin subfragment-1 binding]
    I V Dedova
    Tsitologiia 46:719-34. 2004
    ..Presumably, these alterations in F-actin conformation play an important role in muscle contraction...