G A Donnan

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Stroke drug development: usually, but not always, animal models
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Australia
    Stroke 36:2326. 2005
  2. doi request reprint Stroke
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Melbourne, Victoria, Australia
    Lancet 371:1612-23. 2008
  3. pmc Where will the next generation of stroke treatments come from?
    D W Howells
    National Stroke Research Institute, Florey Neuroscience Institutes, University of Melbourne, Austin Health, Victoria, Australia
    PLoS Med 7:e1000224. 2010
  4. doi request reprint Moving beyond a single perfusion threshold to define penumbra: a novel probabilistic mismatch definition
    Yoshinari Nagakane
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Victoria 3053, Australia
    Stroke 43:1548-55. 2012
  5. doi request reprint Subacute ischemic stroke is associated with focal 11C PiB positron emission tomography retention but not with global neocortical Aβ deposition
    John V Ly
    University of Melbourne, Carlton South, Australia
    Stroke 43:1341-6. 2012
  6. pmc Family physician decisions following stroke symptom onset and delay times to ambulance call
    Ian Mosley
    National Stroke Research Institute, Melbourne, Australia
    BMC Fam Pract 12:82. 2011
  7. ncbi request reprint Stroke and nutrition: FOOD for thought
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Heidelberg West, Victoria 3081, Australia
    Lancet 365:729-30. 2005
  8. ncbi request reprint The 2007 Feinberg lecture: a new road map for neuroprotection
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Health, University of Melbourne, Waterdale Road, Heidelberg Heights, 3081, Australia
    Stroke 39:242. 2008
  9. ncbi request reprint Surgery for intracerebral hemorrhage: an evidence-poor zone
    Geoffrey A Donnan
    The National Stroke Research Institute, Austin and Repatriation Medical Centre, Level 1, Neuroscience Bldg, Banksia Street, Heidelberg VIC 3084 Australia
    Stroke 34:1569-70. 2003
  10. ncbi request reprint Stroke: prediction, prevention, and outcome
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg West, Victoria, Australia
    Lancet Neurol 3:9. 2004

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Stroke drug development: usually, but not always, animal models
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Australia
    Stroke 36:2326. 2005
  2. doi request reprint Stroke
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Melbourne, Victoria, Australia
    Lancet 371:1612-23. 2008
    ..These advances have exposed a worldwide shortage of stroke health-care workers, especially in developing countries...
  3. pmc Where will the next generation of stroke treatments come from?
    D W Howells
    National Stroke Research Institute, Florey Neuroscience Institutes, University of Melbourne, Austin Health, Victoria, Australia
    PLoS Med 7:e1000224. 2010
    ..Then, the physiological relevance of genetic abnormalities can be determined in in vitro and in vivo systems before candidate compounds are developed...
  4. doi request reprint Moving beyond a single perfusion threshold to define penumbra: a novel probabilistic mismatch definition
    Yoshinari Nagakane
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Victoria 3053, Australia
    Stroke 43:1548-55. 2012
    ....
  5. doi request reprint Subacute ischemic stroke is associated with focal 11C PiB positron emission tomography retention but not with global neocortical Aβ deposition
    John V Ly
    University of Melbourne, Carlton South, Australia
    Stroke 43:1341-6. 2012
    ..Specifically, we hypothesized that patients with recent ischemic stroke have higher local and neocortical PiB positron emission tomography retention and that this may be associated with major vascular risk factors...
  6. pmc Family physician decisions following stroke symptom onset and delay times to ambulance call
    Ian Mosley
    National Stroke Research Institute, Melbourne, Australia
    BMC Fam Pract 12:82. 2011
    ..Time to ambulance call will be longer when a family physician is first contacted.• Medical examination prior to the ambulance call will be associated with longer delay times...
  7. ncbi request reprint Stroke and nutrition: FOOD for thought
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Heidelberg West, Victoria 3081, Australia
    Lancet 365:729-30. 2005
  8. ncbi request reprint The 2007 Feinberg lecture: a new road map for neuroprotection
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Health, University of Melbourne, Waterdale Road, Heidelberg Heights, 3081, Australia
    Stroke 39:242. 2008
    ..The purpose of this article is to review how we reached this stage and make recommendations for a new approach to neuroprotection research...
  9. ncbi request reprint Surgery for intracerebral hemorrhage: an evidence-poor zone
    Geoffrey A Donnan
    The National Stroke Research Institute, Austin and Repatriation Medical Centre, Level 1, Neuroscience Bldg, Banksia Street, Heidelberg VIC 3084 Australia
    Stroke 34:1569-70. 2003
  10. ncbi request reprint Stroke: prediction, prevention, and outcome
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg West, Victoria, Australia
    Lancet Neurol 3:9. 2004
  11. doi request reprint How to make better use of thrombolytic therapy in acute ischemic stroke
    Geoffrey A Donnan
    Florey Neuroscience Institutes, University of Melbourne, Level 2, 161 Barry Street, Carlton South, VIC 3053, Australia
    Nat Rev Neurol 7:400-9. 2011
    ..Elimination of prehospital and in-hospital delays is an urgent priority...
  12. ncbi request reprint Can the time window for administration of thrombolytics in stroke be increased?
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, 300 Waterdale Road, West Heidelberg, Victoria 3081, Australia
    CNS Drugs 17:995-1011. 2003
    ..Should these means of extending the time window for thrombolysis prove successful, a more widespread use of this form of acute stroke therapy will be possible...
  13. ncbi request reprint Surgical decompression for malignant middle cerebral artery infarction: a challenge to conventional thinking
    Geoffrey A Donnan
    The National Stroke Research Institute, Austin and Repatriation Medical Centre, Level 1, Neuroscience Bldg, Banksia Street, Heidelberg VIC 3084
    Stroke 34:2307. 2003
  14. ncbi request reprint PROGRESS results: implementation in stroke guidelines
    Geoffrey A Donnan
    National Stroke Research Institute, West Heidelberg, Victoria, Australia
    J Hypertens Suppl 21:S25-8. 2003
    ..Hence, transfer of this information into clinical practice should put blood pressure lowering in place as the fourth major secondary prevention strategy for stroke...
  15. doi request reprint Neuroprotection: still achievable in humans
    Geoffrey A Donnan
    Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Stroke 39:525. 2008
  16. ncbi request reprint Stenting for middle cerebral artery stenosis: inevitable but when and how
    Geoffrey A Donnan
    National Stroke Research Institute, Heidelberg Heights, Victoria, Australia
    Stroke 38:1422. 2007
  17. doi request reprint Penumbral selection of patients for trials of acute stroke therapy
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Health, University of Melbourne, Australia
    Lancet Neurol 8:261-9. 2009
    ..Recent advances in penumbral imaging technology should enable a phase III alteplase trial to be done beyond 4.5 h by use of techniques to select patients with penumbral tissue...
  18. ncbi request reprint Extracranial arterial dissection: anticoagulation is the treatment of choice
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, 300 Waterdale Rd, Heidelberg Heights, VIC 3081, Australia
    Stroke 36:2043-4. 2005
  19. ncbi request reprint Controversy: the essence of medical debate
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Center and the University of Melbourne, Victoria, Australia
    Stroke 34:372-3. 2003
  20. ncbi request reprint The role of blood pressure lowering before and after stroke
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, West Heidelberg, and Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Curr Opin Neurol 16:81-6. 2003
    ..There have been a number of significant randomized controlled trials which may influence management in each of these three categories...
  21. ncbi request reprint MRI and stroke: why has it taken so long?
    Geoffrey A Donnan
    National Stroke Research Institute, Austin Hospital, University of Melbourne, Melbourne, Victoria 3081, Australia
    Lancet 369:252-4. 2007
  22. ncbi request reprint Warfarin for atrial fibrillation: the end of an era?
    Geoffrey A Donnan
    National Stroke Research Institute, Department of Neurology, Austin Health, Department of Medicine, University of Melbourne, Heidelberg Heights, Victoria, Australia
    Lancet Neurol 3:305-8. 2004
    ..Aspirin has also been used but is less effective...
  23. doi request reprint Baseline diabetic status and admission blood glucose were poor prognostic factors in the EPITHET trial
    D A De Silva
    The Royal Melbourne Hospital, Melbourne, Australia
    Cerebrovasc Dis 29:14-21. 2010
    ..Previous data have suggested that diabetes and hyperglycemia predict poor outcome following stroke. We studied the prognostic impact of diabetes and admission blood glucose in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  24. ncbi request reprint Topography and temporal evolution of hypoxic viable tissue identified by 18F-fluoromisonidazole positron emission tomography in humans after ischemic stroke
    R Markus
    Department of Medicine, University of Melbourne, Melbourne, Australia
    Stroke 34:2646-52. 2003
    ....
  25. ncbi request reprint Streptokinase increases luxury perfusion after stroke
    B Infeld
    Department of Neurology, Royal Melbourne Hospital, Victoria, Australia
    Stroke 27:1524-9. 1996
    ..We aimed to study the effect of streptokinase on the nature of reperfusion and the relation between reperfusion and clinical outcome...
  26. doi request reprint Ischemic diffusion lesion reversal is uncommon and rarely alters perfusion-diffusion mismatch
    T Chemmanam
    Department of Neurology, The Royal Melbourne Hospital, Grattan Street, Parkville VIC 3050, Australia
    Neurology 75:1040-7. 2010
    ..However, previous studies have not considered infarct involution. We investigated the prevalence of DWI lesion reversal in the EPITHET Trial...
  27. ncbi request reprint Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival
    R Markus
    FRACP, National Stroke Research Institute, 300 Waterdale Road, Heidelberg Heights, Victoria 3084, Australia
    Brain 127:1427-36. 2004
    ....
  28. ncbi request reprint Baseline blood pressure but not early computed tomography changes predicts major hemorrhage after streptokinase in acute ischemic stroke
    A K Gilligan
    National Stroke Research Institute and University of Melbourne Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia
    Stroke 33:2236-42. 2002
    ..Intracerebral hemorrhage is the most serious complication of thrombolytic therapy for stroke. We explored factors associated with this complication in the Australian Streptokinase Trial...
  29. ncbi request reprint Cost of stroke in Australia from a societal perspective: results from the North East Melbourne Stroke Incidence Study (NEMESIS)
    H M Dewey
    National Stroke Research Institute and the Neurology Department, Austin and Repatriation Medical Centre, Heidelberg, Australia
    Stroke 32:2409-16. 2001
    ..The purpose of this study was to determine the patterns of resource use among stroke patients and to estimate the total costs (direct service use and indirect production losses) of stroke (excluding SAH) in Australia for 1997...
  30. ncbi request reprint Three important subgroups of hypertensive persons at greater risk of intracerebral hemorrhage. Melbourne Risk Factor Study Group
    A G Thrift
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran, Victoria, Australia
    Hypertension 31:1223-9. 1998
    ....
  31. ncbi request reprint Incidence of the major stroke subtypes: initial findings from the North East Melbourne stroke incidence study (NEMESIS)
    A G Thrift
    National Stroke Research Institute, Austin and Repatriation Medical Centre, West Heidelberg, Australia. thrift@ austin.unimelb.edu.au
    Stroke 32:1732-8. 2001
    ..There may, however, be some differences in the incidence of subtypes within Australia...
  32. ncbi request reprint Stroke incidence on the east coast of Australia: the North East Melbourne Stroke Incidence Study (NEMESIS)
    A G Thrift
    National Stroke Research Institute, Austin and Repatriation Medical Center, West Heidelberg, Australia
    Stroke 31:2087-92. 2000
    ..The purpose of this study was to determine the incidence of stroke in a geographically defined region of Melbourne, Australia...
  33. ncbi request reprint White matter medullary infarcts: acute subcortical infarction in the centrum ovale
    S J Read
    Department of Neurology, Austin and Repatriation Medical Centre, Melbourne, Australia
    Cerebrovasc Dis 8:289-95. 1998
    ..More data are required to elucidate the mechanism of larger (> 1.5 cm) infarcts. Because of the potential overlap between white matter medullary infarcts and internal watershed infarcts, suggested criteria for each are presented...
  34. ncbi request reprint Increased risk of cognitive impairment 3 months after mild to moderate first-ever stroke: a Community-Based Prospective Study of Nonaphasic English-Speaking Survivors
    Velandai K Srikanth
    Epidemiology Division, National Stroke Research Institute, Austin and Repatriation Medical Center, Melbourne, Australia
    Stroke 34:1136-43. 2003
    ..There are no comprehensive data on this issue from prospective community-based studies comparing first-ever stroke patients with stroke-free subjects...
  35. ncbi request reprint Neuroprotection and thrombolysis: combination therapy in acute ischaemic stroke
    John V Ly
    National Stroke Research Institute, Level 1, Neurosciences Building, Austin Health, University of Melbourne, 300 Waterdale Road, Heidleberg Heights, Victoria 3081, Australia
    Expert Opin Pharmacother 7:1571-81. 2006
    ..Numerous studies in animal models support this view, but the concept has not, as yet, been rigorously tested in humans...
  36. ncbi request reprint Assessment of suitability of thrombolysis in middle cerebral artery infarction: a proof of concept study of a stereologically-based technique
    Thanh G Phan
    National Stroke Research Institute, Melbourne, Australia
    Cerebrovasc Dis 24:321-7. 2007
    ....
  37. doi request reprint Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Lancet Neurol 7:299-309. 2008
    ..We aimed to test whether alteplase given 3-6 h after stroke onset promotes reperfusion and attenuates infarct growth in patients who have a mismatch in perfusion-weighted MRI (PWI) and diffusion-weighted MRI (DWI)...
  38. ncbi request reprint Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke
    M R Macleod
    National Stroke Research Institute, Melbourne, Australia
    Cerebrovasc Dis 20:12-7. 2005
    ..While intra-arterial thrombolysis may be used in this context, no randomised controlled data exist to support its safety or efficacy...
  39. ncbi request reprint The use of PWI and DWI measures in the design of "proof-of-concept" stroke trials
    P Alan Barber
    Department of Neurology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    J Neuroimaging 14:123-32. 2004
    ..The authors used serial magnetic resonance perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) to determine whether major reperfusion and the attenuation of infarct expansion are associated with improved stroke outcome...
  40. ncbi request reprint Stroke units, tissue plasminogen activator, aspirin and neuroprotection: which stroke intervention could provide the greatest community benefit?
    Amanda K Gilligan
    Department of Neurology, Austin and Repatriation Medical Center, Heidelberg, Australia
    Cerebrovasc Dis 20:239-44. 2005
    ..Although a number of acute stroke interventions are of proven efficacy, there is uncertainty about their community benefits. We aimed to assess this within a defined population...
  41. ncbi request reprint Dextran reduces embolic signals after carotid endarterectomy
    C R Levi
    Department of Neurology, John Hunter Hospital, Newcastle, Australia
    Ann Neurol 50:544-7. 2001
    ..040). We conclude that dextran reduces embolic signals within 3 hours of CEA...
  42. doi request reprint Improvements in the quality of care and health outcomes with new stroke care units following implementation of a clinician-led, health system redesign programme in New South Wales, Australia
    D A Cadilhac
    National Stroke Research Institute, Austin Health, Heidelberg Heights, Victoria, Australia
    Qual Saf Health Care 17:329-33. 2008
    ..Our objective was to determine the effects of this initiative for improving: (i) access to SCUs and care quality and (ii) health outcomes...
  43. ncbi request reprint The functional neuroanatomy and long-term reproducibility of brain activation associated with a simple finger tapping task in older healthy volunteers: a serial PET study
    L M Carey
    National Stroke Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Victoria, 3084
    Neuroimage 11:124-44. 2000
    ..Evidence of individual differences in extent of activation over time highlights the need for caution when interpreting similar changes in patient studies...
  44. ncbi request reprint Risk of ischemic stroke among users of the oral contraceptive pill: The Melbourne Risk Factor Study (MERFS) Group
    Sasitorn Siritho
    National Stroke Research Institute, Austin and Repatriation Medical Centre, West Heidelberg, Australia
    Stroke 34:1575-80. 2003
    ..Use of oral contraceptives has increased, and there is uncertainty about the stroke risk associated with their use. Our aim was to investigate this issue...
  45. doi request reprint The benefits of intravenous thrombolysis relate to the site of baseline arterial occlusion in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)
    Deidre A De Silva
    Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
    Stroke 41:295-9. 2010
    ..We studied the influence of site and degree of arterial obstruction patients enrolled in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)...
  46. ncbi request reprint Long-term outcome in the North East Melbourne Stroke Incidence Study: predictors of quality of life at 5 years after stroke
    Seana L Paul
    National Stroke Research Institute, Heidelberg Heights, Victoria, Australia
    Stroke 36:2082-6. 2005
    ..For these reasons, we aimed to examine these aspects of HRQoL in an unselected population of stroke patients...
  47. doi request reprint Multidisciplinary approach to carotid stenting
    C S Mak
    National Stroke Research Institute, Australia
    Intern Med J 41:789-94. 2011
    ..The aims of this study were to describe our organisational model and to determine whether 30-day complications and early outcomes were similar to those of major trials...
  48. ncbi request reprint Timing of clinically significant microembolism after carotid endarterectomy
    A L Abbott
    National Stroke Research Institute, Melbourne, Australia
    Cerebrovasc Dis 23:362-7. 2007
    ..The aims here were to quantify this risk and determine the most efficient monitoring protocol...
  49. ncbi request reprint Long-term cognitive transitions, rates of cognitive change, and predictors of incident dementia in a population-based first-ever stroke cohort
    Velandai K Srikanth
    National Stroke Research Institute, Heidelberg Heights, Melbourne, Australia
    Stroke 37:2479-83. 2006
    ..We aimed to study long-term cognitive transitions, rates of cognitive change, and factors associated with incident dementia and cognitive impairment-no dementia (CIND) 2 years after first-ever stroke...
  50. doi request reprint Paracentral strip infarcts of the middle cerebral artery: borderzone ischaemia or cortical artery occlusion?
    Takeshi Iwanaga
    National Stroke Research Institute, Austin Health, Vic, Australia
    Cerebrovasc Dis 27:215-22. 2009
    ..To clarify these issues we retrospectively and prospectively identified these patients in our own stroke unit population...
  51. doi request reprint Hypertension and TIA
    W W Zhang
    National Stroke Research Institute, part of Florey Neuroscience Institutes, Victoria, Australia
    Int J Stroke 4:206-14. 2009
    ..Diurnal blood pressure patterns may influence subsequent stroke risk after transient ischemic attack and more evidence is needed to inform clinical practice to improve blood pressure management for transient ischemic attack patients...
  52. ncbi request reprint Prediction of the final infarct volume within 6 h of stroke using single photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime
    T Hirano
    Department of Neurology, Austin and Repatriation Medical Centre, Melbourne, Australia
    Cerebrovasc Dis 11:119-27. 2001
    ..CONCLUSIONS: If no significant early reperfusion or clinical recovery occurs, a CBF threshold value of 63.7% on (99m)Tc-HMPAO SPECT performed within 6 h of stroke onset will reliably predict the final infarct size...
  53. ncbi request reprint Using mismatch on MRI to select thrombolytic responders: an attractive hypothesis awaiting confirmation
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, and University of Melbourne, Parkville, Australia
    Stroke 36:1106-7. 2005
  54. ncbi request reprint The existence and evolution of diffusion-perfusion mismatched tissue in white and gray matter after acute stroke
    Masatoshi Koga
    National Stroke Research Institute, Melbourne, Australia
    Stroke 36:2132-7. 2005
    ..To explore these issues further, we examined the differential effects of ischemia on gray and white matter using magnetic resonance (MR) perfusion-diffusion mismatch after acute stroke...
  55. ncbi request reprint CT screening for thrombolysis: uncertainties remain
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital and the University of Melbourne, Parkville Victoria 3050, Australia
    Stroke 34:822-3. 2003
  56. doi request reprint Fragmentation of the classical magnetic resonance mismatch "penumbral" pattern with time
    Henry Ma
    National Stroke Research Institute, Austin Health, University of Melbourne, 300 Waterdale Rd, Heidelberg West, VIC 3081, Australia
    Stroke 40:3752-7. 2009
    ..Because of variable rates of tissue salvage, we hypothesized that this pattern may fragment over time and may be influenced by vessel patency, mismatch volume, and infarct core location...
  57. ncbi request reprint Blood pressure reduction and ACE inhibition in secondary stroke prevention: mechanism uncertain
    Stephen M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 34:1335-6. 2003
  58. ncbi request reprint Possible determinants of early microembolism after carotid endarterectomy
    Jacinda L Stork
    National Stroke Research Institute, Austin and Repatriation Medical Centre, West Heidelberg, Victoria 3081, Australia
    Stroke 33:2082-5. 2002
    ..High numbers of microembolic signals (MES) have been associated with increased risk of postoperative stroke after carotid endarterectomy (CEA). We sought to identify factors predictive of postoperative MES...
  59. ncbi request reprint Lifetime cost of stroke subtypes in Australia: findings from the North East Melbourne Stroke Incidence Study (NEMESIS)
    Helen M Dewey
    National Stroke Research Institute, Level 1, Neurosciences Bldg, Repatriation Campus, Austin and Repatriation Medical Centre, 300 Waterdale Rd, Heidelberg Heights, Victoria 3081, Australia au
    Stroke 34:2502-7. 2003
    ..The purpose of this study was to describe the patterns of resource use and to estimate the first-year and lifetime costs for stroke subtypes...
  60. ncbi request reprint Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke
    Mark W Parsons
    Royal Melbourne Hospital Echoplanar Imaging Stroke Study Group, Melbourne, Australia
    Ann Neurol 51:28-37. 2002
    ..This has implications for the use of diffusion- and perfusion-weighted imaging in selecting and monitoring patients for thrombolytic therapy...
  61. ncbi request reprint Lacunar stroke: transoesophageal echocardiographic factors influencing long-term prognosis
    S Kazui
    The National Stroke Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Vic, Australia
    Cerebrovasc Dis 12:325-30. 2001
    ..002). CONCLUSIONS: Until the mechanism of lacunar stroke is better understood, it is reasonable to suggest that its investigation and prevention should be directed at all potential causes of future strokes including cardioembolism...
  62. pmc Ischemic stroke risk and passive exposure to spouses' cigarette smoking. Melbourne Stroke Risk Factor Study (MERFS) Group
    R X You
    National Stroke Research Institute, Austin, Australia
    Am J Public Health 89:572-5. 1999
    ..This study investigated the association between ischemic stroke risk and passive exposure to cigarette smoking...
  63. ncbi request reprint Risk factors for stroke due to cerebral infarction in young adults
    R X You
    Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Vic, Australia
    Stroke 28:1913-8. 1997
    ..Given the importance of risk factor assessment in primary prevention, we aimed to assess this using case-control methodology in a hospital-based series and community-based control subjects...
  64. ncbi request reprint Interrater reliability of the National Institutes of Health Stroke Scale: rating by neurologists and nurses in a community-based stroke incidence study
    H M Dewey
    National Stroke Research Institute, Austin and Repatriation Medical Centre, Melbourne, Australia
    Cerebrovasc Dis 9:323-7. 1999
    ..This ability could be used to advantage in large community-based trials and epidemiological studies...
  65. pmc Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: case-control study
    A G Thrift
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran 3181, Australia
    BMJ 318:759-64. 1999
    ..To examine the association between use of aspirin or other non-steroidal anti-inflammatory drugs and intracerebral haemorrhage...
  66. ncbi request reprint The risk of intracerebral haemorrhage with smoking. The Melbourne Risk Factor Study Group
    A G Thrift
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Vic, Australia
    Cerebrovasc Dis 9:34-9. 1999
    ..13, 95% CI 2.0432.42). This interaction is a new finding, but the post-hoc nature of this analysis requires that it be further tested, preferably in a large prospective study...
  67. ncbi request reprint Risk factors for cerebral hemorrhage in the era of well-controlled hypertension. Melbourne Risk Factor Study (MERFS) Group
    A G Thrift
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran, Australia
    Stroke 27:2020-5. 1996
    ....
  68. ncbi request reprint Individuals with first-ever clinical presentation of a lacunar infarction syndrome: Is there an increased likelihood of developing mild cognitive impairment in the first 12 months after stroke?
    Jacqueline F I Anderson
    Department of Psychology, The University of Melbourne, Melbourne, Australia
    J Neuropsychol 2:373-85. 2008
    ..It was concluded that a clinically diagnosed first ever stroke event, presenting as a lacunar syndrome, was not associated with an elevated risk of developing mild cognitive impairment 12 months post-stroke...
  69. ncbi request reprint Improving access to evidence-based acute stroke services: development and evaluation of a health systems model to address equity of access issues
    Dominique A Cadilhac
    National Stroke Research Institute, Level 1 Neurosciences Building, Repatriation Hospital, 300 Waterdale Road, Melbourne, and the University of Melbourne, Vic, Australia
    Aust Health Rev 30:109-18. 2006
    ..The development process and initial evaluation of the model are described. Use of the model to increase capacity within the health care system to treat stroke is discussed...
  70. doi request reprint Chronic information-processing changes in individuals with a first-ever clinical lacunar syndrome
    Jacqueline F I Anderson
    Department of Psychology, School of Behavioural Science, The University of Melbourne, Victoria, Australia
    Cogn Behav Neurol 21:236-41. 2008
    ..The aim of this study was to examine whether chronic cognitive changes occur after a first-ever single clinical lacunar syndrome...
  71. doi request reprint Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial
    Toby B Cumming
    Florey Neuroscience Institute, Australia
    Stroke 42:153-8. 2011
    ..We hypothesized that introducing earlier and more intensive out-of-bed activity after stroke would reduce time to unassisted walking and improve independence in activities of daily living...
  72. ncbi request reprint Greater incidence of both fatal and nonfatal strokes in disadvantaged areas: the Northeast Melbourne Stroke Incidence Study
    Amanda G Thrift
    National Stroke Research Institute, Austin Health, Heidelberg Heights, Victoria, Australia
    Stroke 37:877-82. 2006
    ..Greater stroke mortality has been reported among lower socioeconomic groups. We aimed to determine whether fatal, nonfatal, and overall stroke incidence varied by socioeconomic status...
  73. ncbi request reprint Multicenter comparison of processes of care between Stroke Units and conventional care wards in Australia
    Dominique A Cadilhac
    National Stroke Research Institute, Level 1 Neurosciences Building, Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria, Australia 3081
    Stroke 35:1035-40. 2004
    ..Reasons may include greater adherence to processes of care (PoC). The primary hypothesis was that adherence to selected PoC is greater in SUs than in other acute care models...
  74. ncbi request reprint Neuroimaging, the ischaemic penumbra, and selection of patients for acute stroke therapy
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, West Heidelberg, Victoria, Australia
    Lancet Neurol 1:417-25. 2002
    ..Future developments in imaging technologies may provide other opportunities for surrogate outcome studies...
  75. ncbi request reprint 'Out of pocket' costs to stroke patients during the first year after stroke - results from the North East Melbourne Stroke Incidence Study
    Helen M Dewey
    National Stroke Research Institute, Austin, USA
    J Clin Neurosci 11:134-7. 2004
    ..The majority of 'out of pocket' costs relate to post-acute care aimed at minimising disability and handicap rather than to 'acute' healthcare...
  76. ncbi request reprint Recommendations for the relationship between sponsors and investigators in the design and conduct of clinical stroke trials
    Geoffrey A Donnan
    National Stroke Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, West Heidelberg, Victoria, Australia
    Stroke 34:1041-5. 2003
    ..Both parties need benchmarks or recommendations to act as a reference point when trials are initiated and conducted. These recommendations are designed to fulfill this role...
  77. ncbi request reprint Trial application of a Model of Resource Utilization, Costs, and Outcomes for Stroke (MORUCOS) to assist priority setting in stroke
    Marjory L Moodie
    National Stroke Research Institute, Health, Heidelberg Heights, Australia
    Stroke 35:1041-6. 2004
    ..The aim of this study was to trial the use of the intervention module of the economic model, a Model of Resource Utilization, Costs, and Outcomes for Stroke (MORUCOS) to facilitate evaluation and ranking of the options...
  78. ncbi request reprint Heparin in stroke: not for most, but the controversy lingers
    Geoffrey A Donnan
    National Stroke Research Institute, Austin and Repatriation Medical Center and the University of Melbourne, Australia
    Stroke 34:232-3. 2003
  79. ncbi request reprint Pooling of animal experimental data reveals influence of study design and publication bias
    Malcolm R Macleod
    National Stroke Research Institute, Melbourne, Australia
    Stroke 35:1203-8. 2004
    ..To our knowledge, such assessments have not been made. Nicotinamide is a candidate neuroprotective drug with efficacy in experimental stroke, but the limits to and characteristics of that efficacy have not been fully described...
  80. ncbi request reprint Incidence and outcome of subtypes of ischaemic stroke: initial results from the north East melbourne stroke incidence study (NEMESIS)
    Helen M Dewey
    National Stroke Research Institute and Department of Neurology, Austin and Repatriation Medical Centre, Melbourne, Australia
    Cerebrovasc Dis 15:133-9. 2003
    ..TACI had the poorest functional outcome at 3 and 12 months. These findings are similar to those of two previous studies conducted in the northern hemisphere...
  81. ncbi request reprint Brief comprehensive quality of life assessment after stroke: the assessment of quality of life instrument in the north East melbourne stroke incidence study (NEMESIS)
    Jonathan W Sturm
    National Stroke Research Institute, Department of Neurology, Austin, Australia
    Stroke 33:2888-94. 2002
    ..The aim of this study was to validate the Assessment of Quality of Life (AQoL) instrument in a stroke population...
  82. ncbi request reprint Handicap after stroke: how does it relate to disability, perception of recovery, and stroke subtype?: the north North East Melbourne Stroke Incidence Study (NEMESIS)
    Jonathan W Sturm
    National Stroke Research Institute and Department of Neurology, Austin and Repatriation Medical Centre, West Heidelberg, Victoria 3081, Australia
    Stroke 33:762-8. 2002
    ..The aim of this study was to assess handicap 3 and 12 months after first-ever stroke in a community-based study...
  83. ncbi request reprint 1,026 experimental treatments in acute stroke
    Victoria E O'Collins
    Neuroscience Lab, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
    Ann Neurol 59:467-77. 2006
    ..Therefore, we endeavored to contrast experimental efficacy and scope of testing of drugs used clinically and those tested only experimentally...
  84. ncbi request reprint Development and application of Model of Resource Utilization, Costs, and Outcomes for Stroke (MORUCOS): an Australian economic model for stroke
    Catherine Mihalopoulos
    The University of Melbourne, 4 207 Bouverie Street, Melbourne, 3010 Victoria, Australia
    Int J Technol Assess Health Care 21:499-505. 2005
    ..To outline the development, structure, data assumptions, and application of an Australian economic model for stroke (Model of Resource Utilization, Costs, and Outcomes for Stroke [MORUCOS])...
  85. ncbi request reprint Aspirin therapy should be first line: probably, but watch this space
    Geoffrey A Donnan
    National Stroke Research Institute, University of Melbourne, Heidelberg West, Victoria, Australia
    Stroke 33:2139-40. 2002
  86. ncbi request reprint Reduced risk of intracerebral hemorrhage with dynamic recreational exercise but not with heavy work activity
    Amanda G Thrift
    National Stroke Research Institute, Austin and Repatriation Medical Centre, West Heidelberg, Victoria, Australia
    Stroke 33:559-64. 2002
    ..It is unclear whether intracerebral hemorrhage (ICH) is associated with dynamic or static exercise. Our aim was to assess whether such an association exists...
  87. doi request reprint History of animal models of stroke
    Victoria E O'Collins
    Department of Medicine, University of Melbourne, Heidelberg, Vic, Australia
    Int J Stroke 6:77-8. 2011
    ....
  88. ncbi request reprint Newer antiplatelet therapies in stroke prevention
    S M Davis
    Department of Neurology, Royal Melbourne Hospital, and the University of Melbourne, Victoria
    Aust Fam Physician 30:129-34. 2001
    ..Other novel approaches, such as oral platelet Gp IIb/IIIa antagonists are also being evaluated...
  89. ncbi request reprint Access to stroke care units in Australian public hospitals: facts and temporal progress
    D A Cadilhac
    National Stroke Research Institute, Repatriation Hospital, Heidelberg Heights, Victoria, Australia
    Intern Med J 36:700-4. 2006
    ....
  90. ncbi request reprint The Avoid Stroke as Soon as Possible (ASAP) general practice stroke audit
    Jonathan W Sturm
    National Stroke Research Institute and Department of Neurology, Austin and Repatriation Medical Centre, West Heidelberg, Vic
    Med J Aust 176:312-6. 2002
    ..To determine the prevalence of stroke risk factors in a general practice population and to identify pharmacotherapies currently used in management of stroke risk factors...
  91. pmc Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis
    Mark W Parsons
    Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia
    J Cereb Blood Flow Metab 30:1214-25. 2010
    ..Clinical responsiveness to IV-tPA, and stroke outcome, depends more on baseline DWI and PWI lesion volumes than the extent of perfusion-diffusion mismatch...
  92. doi request reprint Expediting MRI-based proof-of-concept stroke trials using an earlier imaging end point
    Martin Ebinger
    Department of Neurology, The Royal Melbourne Hospital, Grattan Street, Parkville, Australia
    Stroke 40:1353-8. 2009
    ..These trials could be expedited if subacute diffusion-weighted imaging lesion volume replaced late T2-weighted lesion volume as the primary end point...
  93. doi request reprint Patterns of stroke recurrence according to subtype of first stroke event: the North East Melbourne Stroke Incidence Study (NEMESIS)
    Mahmoud Reza Azarpazhooh
    National Stroke Research Institute, Austin Health, Heidelberg, Victoria, Australia
    Int J Stroke 3:158-64. 2008
    ..We aimed to determine whether stroke recurrence rates, the pattern of subtype recurrence, and prescription of secondary prevention agents differed according to initial stroke subtype...
  94. ncbi request reprint Motor impairment and recovery in the upper limb after stroke: behavioral and neuroanatomical correlates
    Leeanne M Carey
    National Stroke Research Institute, Austin Health, Level 2, Neurosciences Building, Banksia St, Heidelberg West, Victoria, Australia 3081
    Stroke 36:625-9. 2005
    ..We therefore aimed to characterize the relationship between motor impairment, motor recovery, and task-related changes in regional cerebral blood flow (DeltarCBF) longitudinally...
  95. ncbi request reprint Inflammation following stroke
    M Nilupul Perera
    National Stroke Research Institute, Austin Health, University of Melbourne, Level 1, Neurosciences Building, 300 Waterdale Road, Heidelberg Heights, Victoria 3081, Australia
    J Clin Neurosci 13:1-8. 2006
    ..However, because of the potential for broader applicability across all aspects of stroke, a better understanding of anti-inflammatory mechanisms is important...
  96. ncbi request reprint The resistance to ischemia of white and gray matter after stroke
    Antonio L E Falcao
    National Stroke Research Institute, Heidelberg Heights, Melbourne, Australia
    Ann Neurol 56:695-701. 2004
    ..For the latter possibility, alternative therapeutic strategies may be required for its salvage...
  97. ncbi request reprint Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge
    P E Batchelor
    Departments of Medicine, Neurology, The University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, 3084, Australia
    Mol Cell Neurosci 21:436-53. 2002
    ..Once at the wound edge, sprouting ceases over macrophages at the point of maximal neurotrophic factor expression and further axonal growth into the relatively poor trophic environment of the wound core fails to occur...
  98. doi request reprint 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage
    J V Ly
    National Stroke Research Institute, Level 1, Neurosciences Building, Austin Health, University of Melbourne, 300 Waterdale Rd, Heidelberg Heights, Victoria 3081, Australia
    Neurology 74:487-93. 2010
    ..We hypothesized that patients with a clinical diagnosis of CAA-related hemorrhage (CAAH) have increased (11)C-PIB uptake and that the pattern differs from Alzheimer disease (AD)...
  99. doi request reprint Imaging the penumbra - strategies to detect tissue at risk after ischemic stroke
    M Ebinger
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050, Australia
    J Clin Neurosci 16:178-87. 2009
    ..We comment on concepts of clinical-imaging mismatch models and we explore the implications for clinical trials...
  100. ncbi request reprint An unusual disease presenting at an unusual age: Susac's syndrome
    C Plummer
    Austin and Repatriation Medical Centre, Studley Road, Heidelberg, Australia
    J Clin Neurosci 12:99-100. 2005
    ..We present the case of a 55-year-old female, the oldest patient yet described with the condition, and highlight the syndrome's clinical features...
  101. doi request reprint Penumbral mismatch is underestimated using standard volumetric methods and this is exacerbated with time
    H Ma
    National Stroke Research Institute, Austin Health, University of Melbourne, 300 Waterdale Rd, Heidelberg West, VIC 3081, Australia
    J Neurol Neurosurg Psychiatry 80:991-6. 2009
    ..That there are differences in the mismatch volume analysed by each method and that these are time dependent was hypothesised...