Peter R Dodd

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    Heather L Scott
    Departments of Biochemistry and Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia, 4072
    J Neurosci 22:RC206. 2002
  2. ncbi request reprint Genes and gene expression in the brains of human alcoholics
    Peter R Dodd
    School of Molecular and Microbial Science, University of Queensland, Brisbane 4072, Australia
    Ann N Y Acad Sci 1074:104-15. 2006
  3. ncbi request reprint Genes and gene expression in the brain of the alcoholic
    Peter R Dodd
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    Addict Behav 29:1295-309. 2004
  4. ncbi request reprint Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Brain Res Brain Res Protoc 11:67-79. 2003
  5. ncbi request reprint GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype
    S Tracey Buckley
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    Neurochem Int 49:557-67. 2006
  6. doi request reprint The expression of NMDA receptor subunit mRNA in human chronic alcoholics
    Justin P Ridge
    SMMS, University of Queensland, Brisbane, Queensland, Australia
    Ann N Y Acad Sci 1139:10-9. 2008
  7. doi request reprint Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
    Heather A Scott
    School of Chemistry and Molecular Biosciences, University of Queensland, Queensland, Australia
    Neurobiol Aging 32:553.e1-11. 2011
  8. ncbi request reprint Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia
    Cell Tissue Res 320:379-92. 2005
  9. ncbi request reprint Quantitation of alternatively spliced NMDA receptor NR1 isoform mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Brain Res Brain Res Protoc 11:52-66. 2003
  10. doi request reprint Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology
    Dustin T Proctor
    School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia
    J Alzheimers Dis 21:795-811. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    Heather L Scott
    Departments of Biochemistry and Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia, 4072
    J Neurosci 22:RC206. 2002
    ..This study implicates aberrant glutamate transporter expression as a mechanism involved in neurodegeneration in Alzheimer's disease...
  2. ncbi request reprint Genes and gene expression in the brains of human alcoholics
    Peter R Dodd
    School of Molecular and Microbial Science, University of Queensland, Brisbane 4072, Australia
    Ann N Y Acad Sci 1074:104-15. 2006
    ..Most genotypes did not divide alcoholics and controls on glutamate-NMDA receptor pharmacology, although gender and cirrhosis did. Genotype may affect amino acid transmission locally to influence neuronal vulnerability...
  3. ncbi request reprint Genes and gene expression in the brain of the alcoholic
    Peter R Dodd
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    Addict Behav 29:1295-309. 2004
    ..Genotype may modulate amino acid transmission locally so as to mediate neuronal vulnerability. This has implications for the effectiveness of pharmacological interventions aimed at ameliorating brain damage and, possibly, dependence...
  4. ncbi request reprint Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Brain Res Brain Res Protoc 11:67-79. 2003
    ..Used in conjunction with a method for the quantitation of hNR1 transcripts [Brain Res. Protoc., in press], a complete analysis of NMDA receptor mRNA expression can be obtained...
  5. ncbi request reprint GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype
    S Tracey Buckley
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    Neurochem Int 49:557-67. 2006
    ..DRD2A and SLC6A4 genotypes were without significant effect. A restricted set of genotypes may influence subunit expression in this group of high-consumption alcoholics...
  6. doi request reprint The expression of NMDA receptor subunit mRNA in human chronic alcoholics
    Justin P Ridge
    SMMS, University of Queensland, Brisbane, Queensland, Australia
    Ann N Y Acad Sci 1139:10-9. 2008
    ..Thus, polymorphisms in one gene can have a significant effect on the expression of a second, unrelated, gene. The expression of the N-methyl-d-aspartate glutamate receptor complex is under multifactorial control...
  7. doi request reprint Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease
    Heather A Scott
    School of Chemistry and Molecular Biosciences, University of Queensland, Queensland, Australia
    Neurobiol Aging 32:553.e1-11. 2011
    ..These results have implications for the treatment of AD as modulators of EAAT2 splicing and/or glutamate uptake would augment current therapies aimed at blocking glutamate receptors...
  8. ncbi request reprint Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia
    Cell Tissue Res 320:379-92. 2005
    ..We suggest that differences in GAT distribution, especially the expression of GAT-3 by oligodendrocytes in humans, must be accommodated in extrapolating rodent models of GABA homeostasis to humans...
  9. ncbi request reprint Quantitation of alternatively spliced NMDA receptor NR1 isoform mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Brain Res Brain Res Protoc 11:52-66. 2003
    ..Neurochem. 78 (2001) 175]. Furthermore, alterations in hNR1 mRNA expression may be reflected at the translational level, resulting in functional changes in the NMDA receptor...
  10. doi request reprint Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology
    Dustin T Proctor
    School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia
    J Alzheimers Dis 21:795-811. 2010
    ..This is the first study to investigate SAP-102 in the aging human brain and suggest a possible mechanism for NMDA receptor expression aberrations in AD...
  11. ncbi request reprint Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease
    Matthew R Hynd
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 90:913-9. 2004
    ..The results suggest that NR2 subunit composition may modulate NMDA receptor-mediated excitotoxicity. NMDA receptor dysfunction might give rise to the regionally selective pattern of neuronal loss that is characteristic of AD...
  12. ncbi request reprint Analysis of multiple exon-skipping mRNA splice variants using SYBR Green real-time RT-PCR
    Heather S Walton
    School of Molecular and Microbial Sciences, University of Queensland, Australia
    J Neurosci Methods 160:294-301. 2007
    ..Standard curves are stable and produce accurate absolute copy number data. We report that exon-skipping transcripts, EAAT2Delta7 and EAAT2Delta9, account for 5.8% of EAAT2 mRNA in autopsy human neocortex...
  13. ncbi request reprint GABAA receptor beta subunit mRNA expression in the human alcoholic brain
    S Tracey Buckley
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    Neurochem Int 45:1011-20. 2004
    ..Age at death and post-mortem delay (PMD) had no significant effect on beta mRNA expression in either case group in either region. A beta(1) signal could not be detected in the RT-PCR assay...
  14. ncbi request reprint Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Neurochem Int 45:583-95. 2004
    ..This review discusses mechanisms for the involvement of the NMDA receptor complex and its interaction with polyamines in the pathogenesis of AD. NMDA receptor antagonists have potential for the therapeutic amelioration of AD...
  15. ncbi request reprint Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Australia
    J Neurochem 89:240-7. 2004
    ..Cells that express NR1 subunits with the N-terminal cassette may be selectively vulnerable to toxicity in AD...
  16. ncbi request reprint Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE varepsilon4
    Rudi K Tannenberg
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Queensland, Australia
    Neurochem Int 49:631-9. 2006
    ....
  17. pmc Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2
    Florian M Gebhardt
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Australia
    J Biol Chem 285:31313-24. 2010
    ..This could allow glutamate to accumulate extracellularly and promote excitotoxicity...
  18. ncbi request reprint Quantitation of human brain GABAA receptor beta isoforms by competitive RT-PCR
    S Tracey Buckley
    Neuroscience Unit, Department of Biochemistry, University of Queensland, Brisbane, Australia
    Brain Res Brain Res Protoc 11:19-26. 2003
    ..This method is suitable for the quantitation of beta(1), beta(2) and beta(3) isoforms of the GABA(A) receptor in human alcoholic and control brain...
  19. pmc Sex differences in NMDA receptor expression in human alcoholics
    Justin P Ridge
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, Australia
    Alcohol Alcohol 44:594-601. 2009
    ..The aim of this study was to assess whether chronic alcohol misuse affects N-methyl-d-aspartate (NMDA) receptor subunit concentrations in human cases, and whether male and female subjects respond differently...
  20. doi request reprint Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease
    Dustin T Proctor
    School of Chemistry and Molecular Biosciences, Molecular Biosciences Building 76, Coopers Road, St Lucia Campus, University of Queensland, Brisbane 4072, Australia
    Prog Neurobiol 93:509-21. 2011
    ..In this review we discuss disruptions to excitatory neurotransmission at the level of glutamate receptor-post-synaptic scaffolding protein interactions that may contribute to synaptic dysfunction in AD...
  21. doi request reprint Cortical NMDA receptor expression in human chronic alcoholism: influence of the TaqIA allele of ANKK1
    Justin P Ridge
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Building 76, Brisbane, QLD 4072, Australia
    Neurochem Res 34:1775-82. 2009
    ..Using PCR, ANKK1 mRNA transcript was detected in inferior temporal, occipital, superior frontal and primary motor cortex of control human brain. ANKK1 expression may mediate the influence of the TaqIA polymorphism on phenotype...
  22. ncbi request reprint Glutamate-glutamine cycling in Alzheimer's disease
    Heather Scott Walton
    School of Molecular and Microbial Science, University of Queensland, Australia
    Neurochem Int 50:1052-66. 2007
    ..This review encompasses those aspects of glutamate-glutamine cycling that are altered in AD...
  23. doi request reprint Housekeepers for accurate transcript expression analysis in Alzheimer's disease autopsy brain tissue
    Florian M Gebhardt
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Alzheimers Dement 6:465-74. 2010
    ..Alzheimer's disease (AD) alters brain metabolism. The stability of housekeeper transcript expression must be carefully validated...
  24. ncbi request reprint Glial glutamate transporter expression patterns in brains from multiple mammalian species
    Susan M Williams
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Glia 49:520-41. 2005
    ..Collectively our data suggest that assumptions as to the roles of glutamate transporters in any species may need to be tested empirically...
  25. ncbi request reprint GABA(A) receptor sites in the developing human foetus
    Danielle L Andersen
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Brain Res Dev Brain Res 139:107-19. 2002
    ..The results strongly suggest that the subunit composition of cortical GABA(A) sites changes significantly during this important developmental stage...
  26. ncbi request reprint Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer's disease
    Smriti Agarwal
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    J Alzheimers Dis 14:313-21. 2008
    ..A major splice variant of gephyrin was detected in all cases and in all three brain areas. This is the first study of gephyrin expression in AD...
  27. ncbi request reprint Excited to death: different ways to lose your neurones
    Peter R Dodd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Biogerontology 3:51-6. 2002
    ..Thus the excitotoxicity is indirect. A variety of such mechanisms is possible, which may combine in different ways...
  28. ncbi request reprint The identification and characterization of excitotoxic nerve-endings in Alzheimer disease
    Rudi K Tannenberg
    Department of Biochemistry, University of Queensland, Australia
    Curr Alzheimer Res 1:11-25. 2004
    ..We discuss experimental methods to quantitate synapses, which are crucial for deciding between the various possibilities...
  29. pmc Electrically evoked synaptosomal amino acid transmitter release in human brain in alcohol misuse
    Sheng Wen Kuo
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia
    Neurosignals 19:117-27. 2011
    ..Neither age nor postmortem interval was a significant confounder. The released transmitters may differentially alter receptor profiles on postsynaptic cells...
  30. ncbi request reprint Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex
    Lotten Ragnarsson
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    J Neurochem 81:765-79. 2002
    ..Modified conantokins are useful for identifying the NMDA receptors involved, and may have potential as protective agents...
  31. ncbi request reprint The application of proteomics to the human alcoholic brain
    Joanne M Lewohl
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Ann N Y Acad Sci 1025:14-26. 2004
    ..The finding that the expression level of differentially expressed proteins is preponderantly lower in the alcoholic brain is supported by recent results from parallel studies using microarray mRNA transcript...
  32. ncbi request reprint Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study
    Nancy E Liyou
    School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia
    J Histochem Cytochem 51:1655-64. 2003
    ..The findings from this study may assist in determining the physiological role of this SULT isoform...
  33. ncbi request reprint Nucleic Acid aptamers as novel class of therapeutics to mitigate Alzheimer's disease pathology
    Rudi K Tannenberg
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia 4072
    Curr Alzheimer Res 10:442-8. 2013
    ..Herein, we review the aptamers that bind to the various forms of Aβ peptides for use in diagnosis and to inhibit plaque formation...
  34. ncbi request reprint Biochemical and molecular studies using human autopsy brain tissue
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    J Neurochem 85:543-62. 2003
    ..We conclude that valid and practical measures of a variety of parameters may be made in human brain tissue, provided that specific factors are controlled...
  35. ncbi request reprint Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurochem 90:1050-8. 2004
    ..Importantly, hierarchical clustering of differentially expressed genes accurately distinguished between control and alcoholic cases, particularly in the frontal cortex...
  36. doi request reprint Upregulation of beta-catenin levels in superior frontal cortex of chronic alcoholics
    Ali M Al-Housseini
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 32:1080-90. 2008
    ..Thus, novel techniques that allow a comprehensive assessment of this complexity will enable the simultaneous assessment of changes across a group of proteins in the relevant neural circuitry...
  37. ncbi request reprint Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 31:1460-6. 2007
    ..Heavy alcohol use results in brain damage that is generally more severe in cirrhotic compared with noncirrhotic alcoholics. We examined, at the cellular level, gene expression in the frontal cortex of cirrhotic alcoholics...
  38. ncbi request reprint Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Neuropsychopharmacology 31:1574-82. 2006
    ..These results revealed a consistent re-programming of gene expression in alcohol abusers that reliably discriminates alcoholic from non-alcoholic individuals...
  39. ncbi request reprint Alcoholic neurobiology: changes in dependence and recovery
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 29:1504-13. 2005
    ....
  40. ncbi request reprint Methods for the identification of differentially expressed genes in human post-mortem brain
    R Dayne Mayfield
    Department of Psychology, Waggoner Center for Alcohol and Addiction Research, Molecular Biology Building 1 124, University of Texas at Austin, Austin, TX 78712, USA
    Methods 31:301-5. 2003
    ..This technical report describes the basic methodology and analyses used to identify such genes in human post-mortem brain tissue...
  41. ncbi request reprint Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics
    R Dayne Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    J Neurochem 81:802-13. 2002
    ..These results suggest that multiple pathways may be important for neuropathology and altered neuronal function observed in alcoholism...
  42. ncbi request reprint The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease
    Vicky W W Tsai
    School of Molecular and Microbial Sciences and Institute for Molecular Bioscience, University of Queensland, Brisbane 4072 Australia
    Neurotox Res 7:125-41. 2005
    ..They represent a pharmacological path to a relatively subtle amelioration of neurotoxicity because they serve a modulatory rather than a direct role in excitatory glutamatergic transmission...
  43. ncbi request reprint Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain
    Joanne M Lewohl
    Genomics Research Centre, School of Medical Sciences, Griffith University, Gold Coast, Australia
    Alcohol Clin Exp Res 29:1698-705. 2005
    ..Chronic alcohol misuse also results in alterations in the expression of a number of genes, including a selective reprogramming of myelin gene expression in the frontal cortex...