Research Topics
Genomes and GenesSpecies | Mohamed DiraniSummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Association of retinal vessel calibre with diabetic retinopathy in an urban Australian indigenous populationMohamed Dirani
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, NSW, Australia
Clin Experiment Ophthalmol 38:577-82. 2010..To assess the relationship of retinal vessel diameter and diabetic retinopathy (DR) in a subgroup of participants recruited through the Darwin Region Urban Indigenous Diabetes study...- Outdoor activity and myopia in Singapore teenage childrenM Dirani
Singapore Eye Research Institute, and Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597
Br J Ophthalmol 93:997-1000. 2009..To investigate the relationship of outdoor activities and myopia in Singapore teenage children... - Evidence of shared genes in refraction and axial length: the Genes in Myopia (GEM) twin studyMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 49:4336-9. 2008..However, no study has attempted to determine whether the correlation between axial length and refraction is explained by shared genetic or environmental factors... - Prevalence of refractive error in Singaporean Chinese children: the strabismus, amblyopia, and refractive error in young Singaporean Children (STARS) studyMohamed Dirani
Singapore Eye Research Institute, Singapore
Invest Ophthalmol Vis Sci 51:1348-55. 2010..To determine the prevalence of refractive error types in Singaporean Chinese children aged 6 to 72 months... - Long-term refractive outcomes and stability after excimer laser surgery for myopiaMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
J Cataract Refract Surg 36:1709-17. 2010..To evaluate the long-term refractive outcomes of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for myopia... - The role of vision in academic school performanceMohamed Dirani
Singapore Eye Research Institute, Singapore, Community Occupational and Family Medicine, National University of Singapore
Ophthalmic Epidemiol 17:18-24. 2010..To determine whether presenting distance visual acuity is related to subsequent academic school performance in Singaporean children between 9 to 10 years of age... - Prevalence and causes of decreased visual acuity in Singaporean Chinese preschoolersM Dirani
Singapore Eye Research Institute, Singapore, Singapore
Br J Ophthalmol 94:1561-5. 2010..To describe the prevalence and causes of decreased visual acuity (VA) in Singaporean Chinese children... 
Evaluation of accuracy in proband-reported family history and its determinants: the Genes in Myopia family studyPam Garoufalis
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Optom Vis Sci 84:481-6. 2007..This study aims to determine the accuracy of proband-reported family history of myopia and to assess whether demographic or clinical factors are predictive of an accurate history...- Assessment of TGIF as a candidate gene for myopiaKelly K Pertile
Centre for Eye Research Australia, Department of Ophthalmology University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 49:49-54. 2008..This is the first study conducted to investigate the association of TGIF with refraction and ocular biometric measurements... - Testability of vision and refraction in preschoolers: the strabismus, amblyopia, and refractive error study in singaporean childrenMichelle J Trager
Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Republic of Singapore
Am J Ophthalmol 148:235-241.e6. 2009..To determine the testability of several vision and refraction tests in preschool-aged children... - Heritability of refractive error and ocular biometrics: the Genes in Myopia (GEM) twin studyMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne 3002, Australia
Invest Ophthalmol Vis Sci 47:4756-61. 2006..A classic twin study was undertaken to assess the contribution of genes and environment to the development of refractive errors and ocular biometrics in a twin population... - Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool childrenWilson Low
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive MD3, Singapore 117597
Br J Ophthalmol 94:1012-6. 2010..To investigate the risk factors for myopia, including near work and outdoor activity, in Singapore Chinese preschool children... - Methodology and early findings of the Diabetes Management Project: a cohort study investigating the barriers to optimal diabetes care in diabetic patients with and without diabetic retinopathyEcosse Luc Lamoureux
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 40:73-82. 2012..The Diabetes Management Project is investigating the clinical, behavioural and psychosocial barriers to optimal diabetes care in individuals with and without diabetic retinopathy... - The role of educational attainment in refraction: the Genes in Myopia (GEM) twin studyMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 49:534-8. 2008.... - Role of the hepatocyte growth factor gene in refractive errorSundar Veerappan
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia
Ophthalmology 117:239-45.e1-2. 2010..Several genetic loci have been associated with myopia but none to date have been reported for hypermetropia. We investigated the hepatocyte growth factor (HGF) as a candidate gene influencing these 2 refractive error states... - Vision-related quality of life comparison for emmetropes, myopes after refractive surgery, and myopes wearing spectacles or contact lensesChristine Y Chen
Ocular Genetics Unit, Centre for Eye Research Australia, University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia
J Refract Surg 23:752-9. 2007..To compare the vision-related quality of life among emmetropes, myopes who had refractive surgery, and myopes who wore spectacles and/or contact lenses... - Mirror image congenital esotropia and concordant hypermetropia in identical twinsMohamed Dirani
Centre for Eye Research Australia University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
Eur J Ophthalmol 19:1073-5. 2009..To report the occurrence of mirror image congenital esotropia and concordant hypermetropia in a pair of monozygotic twins... - Gene-environment interactions and aging visual function: a classical twin studyRuth E Hogg
Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia
Ophthalmology 116:263-9. 2009..To elucidate the contribution of environmental versus genetic factors to the significant losses in visual function associated with normal aging... - Body stature and myopia-The Genes in Myopia (GEM) twin studyMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Australia
Ophthalmic Epidemiol 15:135-9. 2008..We wished to explore the relationship of body stature and myopia using a large Australian twin cohort [The Genes in Myopia (GEM) twin study]... - Dominant genetic effects on corneal astigmatism: the genes in myopia (GEM) twin studyMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 49:1339-44. 2008..This study was conducted to assess the relative influence of genetics and environment on corneal astigmatism and corneal curvature in a large sample of twins... - Peripheral refraction and refractive error in singapore chinese childrenChelvin C A Sng
Singapore Eye Research Institute, Singapore
Invest Ophthalmol Vis Sci 52:1181-90. 2011..Peripheral hyperopia was hypothesized to stimulate axial elongation. This study describes peripheral refraction and its associations with central refractive error in young Singapore Chinese children... - The longitudinal impact of macular telangiectasia (MacTel) type 2 on vision-related quality of lifeEcosse L Lamoureux
Centre for Eye Research Australia, The University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 52:2520-4. 2011..To determine the longitudinal impact of idiopathic macular telangiectasia (MacTel) type 2 on vision-specific quality of life (QoL)... - Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management projectMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
Invest Ophthalmol Vis Sci 52:4416-21. 2011..To investigate the relationship between anthropometric parameters and diabetic retinopathy (DR) in adults with diabetes... 
Fine mapping linkage analysis identifies a novel susceptibility locus for myopia on chromosome 2q37 adjacent to but not overlapping MYP12Maria Schache
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
Mol Vis 15:722-30. 2009..The purpose of this study was to perform fine mapping of this region and identify single nucleotide polymorphisms (SNPs) associated with myopia...- Adult-onset myopia: the Genes in Myopia (GEM) twin studyMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 49:3324-7. 2008.... - Myopia and personality: the genes in myopia (GEM) personality studyRobert van de Berg
Centre for Eye Research Australia, The University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 49:882-6. 2008..However, existing research on this question is flawed, and its findings are inconsistent. The authors therefore aimed to determine whether myopia and personality are associated... - Refractive errors in twin studiesMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Australia Vision Cooperative Research Centre, Sydney, Australia
Twin Res Hum Genet 9:566-72. 2006..5 to .9. This article will review those twin studies that have investigated refractive error, particularly myopia, as well as biometric measures linked to refractive error, to compare heritability estimates and methodology designs... - Genetic mapping of myopia susceptibility lociMaria Schache
Centre for Eye Research Australia, The University of Melbourne, East Melbourne, Vic, Australia
Invest Ophthalmol Vis Sci 48:4924-9. 2007..In an independent yet ethnically and phenotypically similar twin cohort, linkage to these chromosomal regions was sought... - The impact of diabetic retinopathy on quality of life: qualitative findings from an item bank development projectEva K Fenwick
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia
Qual Life Res 21:1771-82. 2012..We are developing a DR-specific quality of life (QoL) item bank, and we report here on the qualitative results from the first phase of this project... - Social and emotional impact of diabetic retinopathy: a reviewEva Fenwick
Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 40:27-38. 2012.... - Differential association of serum lipids with diabetic retinopathy and diabetic macular edemaRehab Benarous
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 52:7464-9. 2011..To assess the association of serum lipids with diabetic retinopathy (DR), diabetic macular edema (DME), and macular thickness in adults with diabetes... - The GEnes in Myopia (GEM) study in understanding the aetiology of refractive errorsPaul N Baird
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
Prog Retin Eye Res 29:520-42. 2010.... - Economic impact of primary open-angle glaucoma in AustraliaMohamed Dirani
Centre for Eye Research Australia, University of Melbourne Royal Victorian Eye and Ear Hospital, Melbourne, Victoria Access Economics Pty Limited, Canberra, ACT, Australia
Clin Experiment Ophthalmol 39:623-32. 2011..Glaucoma is the World's leading cause of irreversible blindness, and poses serious public health and economic concerns... - Vision-specific distress and depressive symptoms in people with vision impairmentGwyneth Rees
Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Vic, Australia
Invest Ophthalmol Vis Sci 51:2891-6. 2010..To determine the unique contribution of vision-specific distress in predicting depressive symptoms in people with vision impairment attending a tertiary eye care clinic... - Outcomes of laser refractive surgery for myopiaEng K Ang
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
J Cataract Refract Surg 35:921-33. 2009..Studies with a minimum follow-up of 1 year with at least 2 of the 3 major outcome measures--efficacy, stability, and safety--were reviewed, and how the findings were affected by differences in ethnicity was assessed... - Mirror-image congenital esotropia in monozygotic twinsMohamed Dirani
Centre for Eye Research Australia, University of Melbourne, Australia
J Pediatr Ophthalmol Strabismus 43:170-1. 2006..One had right congenital esotropia surgically corrected during childhood, and the other had left congenital esotropia surgically corrected at 3 and 6 years old... - Is the pediatric quality of life inventory valid for use in preschool children with refractive errors?Ecosse L Lamoureux
Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Australia
Optom Vis Sci 87:813-22. 2010..To determine the psychometric validity of the pediatric quality of life inventory (PedsQL 4.0) in assessing the impact of refractive errors on health-related quality of life (HRQoL) in preschool children in Singapore... - Heritability of macular thickness determined by optical coherence tomographyMatthew D Chamberlain
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Invest Ophthalmol Vis Sci 47:336-40. 2006..To examine whether genetic factors significantly influence macular thickness in healthy older subjects... - The relationship between visual function, duration and main causes of vision loss and falls in older people with low visionEcosse Lamoureux
Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia
Graefes Arch Clin Exp Ophthalmol 248:527-33. 2010..The aim of this study, therefore, was to determine the relationship between visual function, duration, and main causes of visual impairment, and falls in individuals with low vision... - Methodology and recruitment of probands and their families for the Genes in Myopia (GEM) StudyPam Garoufalis
Centre for Eye Research Australia, University of Melbourne, Australia
Ophthalmic Epidemiol 12:383-92. 2005..In addition, the participation rate in the study appears to vary reflecting a proband's perception of disease severity... - Linkage replication of the MYP12 locus in common myopiaChristine Y Chen
Eye Research Australia, Australia
Invest Ophthalmol Vis Sci 48:4433-9. 2007..This study reports the successful replication of MYP12 in three large, multigenerational families with autosomal dominant (AD) common myopia (spherical equivalent [SphE] </= -0.50 D)... - Heritability and shared environment estimates for myopia and associated ocular biometric traits: the Genes in Myopia (GEM) family studyChristine Yi Chin Chen
Ocular Genetics Unit, Eye Research Australia, The University of Melbourne, 32 Gisborne Street, East Melbourne, Vic, 3002, Australia
Hum Genet 121:511-20. 2007..These traits therefore all represent candidates for quantitative trait linkage analyses... - Concordant bilateral Duane's Retraction Syndrome (type 1) in female monozygotic twinsMohamed Dirani
Clin Experiment Ophthalmol 34:495-7. 2006..To our knowledge this is the first case to report concordant bilateral DRS (type 1) in female MZ twins. The concordance for the presence of DRS and associated clinical signs observed in this MZ twin pair supports a genetic origin to DRS...