Research Topics
Species | Changhai DingSummaryAffiliation: University of Tasmania Country: Australia Publications
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Publications
Do NSAIDs affect the progression of osteoarthritis?Changhai Ding
Menzies Centre for Population Health Research, University of Tasmania, Australia
Inflammation 26:139-42. 2002..Therefore, it is necessary and valuable to clarify the effects of these NSAIDs on cartilage in patients with OA using validated non-invasive methods such as MRI...
Genetic mechanisms of knee osteoarthritis: a population-based longitudinal studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
Arthritis Res Ther 8:R8. 2006..Importantly, the cartilage changes are largely dependent on baseline differences in cartilage volume, tibial bone area, BMI and knee pain, suggesting that these factors might have a role in their initiation...- Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volumeChanghai Ding
Menzies Research Institute, University of Tasmania, 199 Macquarie Street, Hobart 7000, Australia
Arthritis Res Ther 9:R21. 2007.... - Oral administration of type II collagen suppresses pro-inflammatory mediator production by synoviocytes in rats with adjuvant arthritisC H Ding
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China
Clin Exp Immunol 132:416-23. 2003..Bystander active suppression may be the main mechanism of oral CII in the suppression of synoviocyte function... - Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Rheumatol 34:776-84. 2007..To examine the associations between meniscal tear, knee structure, osteoarthritis (OA) risk factors, radiographic change, and symptoms in a largely non-osteoarthritic cohort... - Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair studyGuangju Zhai
Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
Arthritis Res Ther 8:R137. 2006..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI... 
Subchondral bone and cartilage damage: a prospective study in older adultsDawn Dore
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 62:1967-73. 2010..The aim of this study was to describe the association between baseline tibial bone area and tibial subchondral bone mineral density (BMD) with tibial cartilage defect development and cartilage volume loss...- Correlates of knee pain in younger subjectsGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
Clin Rheumatol 26:75-80. 2007..MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects... - The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studiesChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
J Rheumatol 32:1937-42. 2005..CONCLUSION: Knee cartilage defects are common, have a genetic component that is linked to the genetic contribution to knee pain and bone size, and may have a role in the genetic pathogenesis of knee OA... - The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional studyOliver P Stannus
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Arthritis Res Ther 12:R95. 2010..The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults... - Natural history of knee cartilage defects and factors affecting changeChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart
Arch Intern Med 166:651-8. 2006..Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history... - A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic populationGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Rheumatol 34:181-6. 2007..We investigated whether baseline malalignment of the knee predicts subsequent change in knee cartilage volume and chondral defects in subjects with and without radiographic knee osteoarthritis (OA)... - Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adultsDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
Arthritis Res Ther 12:R222. 2010.... - Knee structural alteration and BMI: a cross-sectional studyChanghai Ding
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Obes Res 13:350-61. 2005..Preventing these changes may prevent knee osteoarthritis in overweight and obese subjects... - The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair studyGuangju Zhai
Menzies Research Institute, University of Tasmania, Tasmania, Australia
Arthritis Rheum 52:2830-4. 2005.... - Smoking interacts with family history with regard to change in knee cartilage volume and cartilage defect developmentChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 56:1521-8. 2007..To describe the effects of smoking on change in knee cartilage volume and increases in knee cartilage defects, and to test for interaction between smoking and family history of osteoarthritis (OA)... - Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adultsDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
Arthritis Res Ther 12:R223. 2010.... - Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdownChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 13:198-205. 2005..Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA... - Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania
Arthritis Rheum 60:1381-9. 2009..To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults... - Knee and hip radiographic osteoarthritis predict total hip bone loss in older adults: a prospective studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Bone Miner Res 25:858-65. 2010..In conclusion, older subjects with radiographic hip and knee OA have higher total hip bone loss over 2.6 years regardless of symptoms, suggesting that consideration should be given to the monitoring of bone mass in these subjects... - Correlates of knee pain in older adults: Tasmanian Older Adult Cohort StudyGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
Arthritis Rheum 55:264-71. 2006..The association between radiographic hip OA and knee pain indicates that referred pain from the hip needs to be considered in unexplained knee pain... - Do NSAIDs affect longitudinal changes in knee cartilage volume and knee cartilage defects in older adults?Changhai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Am J Med 122:836-42. 2009..The aim of this longitudinal study was to determine the associations between use of NSAIDs and changes in knee cartilage volume and knee cartilage defects over 2.9 years in older adults... - A longitudinal study of the effect of sex and age on rate of change in knee cartilage volume in adultsChanghai Ding
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Rheumatology (Oxford) 46:273-9. 2007..To describe the association between sex, age and rate of change in knee cartilage volume in adults... - Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal studyChanghai Ding
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 52:3918-27. 2005..Both increases and decreases in knee cartilage defects are associated with changes in knee cartilage volume, which implies a potential for reversal of knee cartilage loss... - Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studiesGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Australia
BMC Musculoskelet Disord 6:10. 2005..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies... - Physical activity and knee structural change: a longitudinal study using MRIStella Foley
Menzies Research Institute, University of Tasmania, Hobart, Australia
Med Sci Sports Exerc 39:426-34. 2007..Exercise therapy is effective in improving symptoms of knee osteoarthritis, but its effect on structural change remains unclear... - A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the kneeDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
Arthritis Res Ther 14:R13. 2012..Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs... - Association of baseline knee bone size, cartilage volume, and body mass index with knee cartilage loss over time: a longitudinal study in younger or middle-aged adultsBenny Antony
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
J Rheumatol 38:1973-80. 2011..To determine the association of knee bone size, cartilage volume, and body mass index (BMI) at baseline with knee cartilage loss over 2 years in younger or middle-aged adults... - Factors associated with hip cartilage volume measured by magnetic resonance imaging: the Tasmanian Older Adult Cohort StudyGuangju Zhai
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 52:1069-76. 2005..Furthermore, the generally stronger associations with volume compared with radiographic OA suggest that MRI may be superior at identifying risk factors for hip OA... - The association between parity and knee cartilage in young womenShuying Wei
Menzies Research Institute Tasmania, 17 Liverpool Street, Hobart, Tasmania 7001, Australia
Rheumatology (Oxford) 51:2039-45. 2012..This association was more apparent with increasing number of live births, suggesting a possible adverse effect of parity on knee cartilage... - The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair studyGuangju Zhai
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 50:805-10. 2004..Cartilage volume, bone size, and muscle strength all have the potential to be studied in quantitative trait linkage analyses, but their exact relevance with regard to OA remains uncertain at this time... - Correlates of subchondral BMD: a cross-sectional studyDawn Dore
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Bone Miner Res 24:2007-15. 2009..10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality... - Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseasesChanghai Ding
Menzies Research Institute, Hobart, Tasmania, Australia
Rev Recent Clin Trials 1:193-200. 2006..Like other anti-cytokine immunotherapies, caution and close monitoring for the adverse events, especially infection, are necessary in subsequent clinical trials... - ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseasesChanghai Ding
University of Tasmania, Menzies Research Institute, 199 Macquarie Street, Hobart, Tasmania 7000, Australia
Curr Opin Investig Drugs 9:515-22. 2008..ABT-87 was previously being developed for the potential treatment of multiple sclerosis; however, by May 2007, development for this indication was discontinued... - Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndromeChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
Curr Opin Investig Drugs 7:1020-5. 2006..In June 2005, a phase II clinical trial of VX-702 was initiated in rheumatoid arthritis. In July 2006, Vertex was planning to file an IND in the second half of 2006... - A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adultsDavid Scott
Menzies Research Institute, University of Tasmania, Hobart School of Human Life Sciences, University of Tasmania, Launceston, TAS, Australia
Clin Endocrinol (Oxf) 73:581-7. 2010..Our objective was to describe prospective associations between 25OHD, muscle parameters, and PA in community-dwelling older adults... - Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort studyOliver P Stannus
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Ann Rheum Dis 72:535-40. 2013..To determine the association between inflammatory markers and change in knee pain over 5 years... - Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
J Clin Endocrinol Metab 93:1952-8. 2008..IL-1, IL-6, and TNF-alpha play an important role in the pathogenesis of osteoporosis in animals; however, evidence that these play a similar role in bone loss in human studies is limited... - B-cell-targeted therapy for systemic lupus erythematosus: an updateChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
BioDrugs 22:239-49. 2008..g. ocrelizumab) and agents that interrupt B-cell/T-cell interactions also have potential, and the efficacy of these, along with rituximab, belimumab and epratuzumab, needs to be determined by randomized controlled trials... - Knee articular cartilage development in children: a longitudinal study of the effect of sex, growth, body composition, and physical activityGraeme Jones
Menzies Centre for Population Health Research, GPO Box 252 23, Hobart, Tasmania, Australia 7000
Pediatr Res 54:230-6. 2003..These results provide novel data on articular cartilage development in humans. The long-term significance of these results with regard to osteoarthritis of the knee in later life remains hypothetical... - How important is MRI for detecting early osteoarthritis?Changhai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Nat Clin Pract Rheumatol 4:4-5. 2008 - Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and femalesG Jones
Menzies Centre for Population Health Research, GPO Box 252 23, Tasmania 7000, Hobart, Australia
Osteoarthritis Cartilage 12:169-74. 2004..To describe the association between early radiographic osteoarthritis of the knee (ROA), knee cartilage volume and tibial bone surface area... - Technology evaluation: MRA, ChugaiChanghai Ding
Menzies Centre for Population Health Research, University of Tasmania, 17 Liverpool Street, Hobart, 7000 TAS, Australia
Curr Opin Mol Ther 5:64-9. 2003..MRA is currently undergoing phase II clinical trials for these indications... - Targeting IL-6 in the treatment of inflammatory and autoimmune diseasesChanghai Ding
Monash University, Central and Eastern Clinical School, Department of Epidemiology and Preventive Medicine, Commercial Road, Melbourne 3004, Australia
Expert Opin Investig Drugs 18:1457-66. 2009.... - The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 yearsShuying Wei
Menzies Research Institute, University of Tasmania, Hobart, TAS 7001, Australia
Contraception 84:357-62. 2011..The associations between oral contraceptive (OC) use, bone mineral density (BMD) and the risk of fractures remain controversial... - Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trialYuelong Cao
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia
Trials 13:131. 2012.... - Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKlineChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
Curr Opin Investig Drugs 7:464-72. 2006..By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year... - Licofelone (Merckle)Changhai Ding
Menzies Centre for Population Health Research, University of Tasmania, Hobart 7000, Tasmania, Australia
IDrugs 6:802-8. 2003..EuroAlliance (a consortium of Alfa Wassermann SpA, Lacer SA and Merckle GmbH) is developing licofelone, a dual cyclooxygenase and 5-lipoxygenase inhibitor for the potential treatment of inflammatory disorders including osteoarthritis... - Bertilimumab Cambridge Antibody Technology GroupChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
Curr Opin Investig Drugs 5:1213-8. 2004..By September 2003, CAT had released results from phase I/II trials, and was seeking to outlicense rights for bertilimumab... - Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseasesChanghai Ding
University of Tasmania, Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Expert Opin Biol Ther 8:1805-14. 2008..Belimumab (LymphoStat-B), a human monoclonal antibody that inhibits BlyS, was developed for the treatment of these diseases... - Association of ACE gene polymorphism with genetic susceptibility to systemic lupus erythematosus in a Chinese population: a family-based association studyJianhua Xu
Department of Rheumatology, First Affiliated Hospital, Hefei, China
J Rheumatol 34:2408-11. 2007..Family-based association analysis was performed to investigate whether the angiotensin-converting enzyme (ACE)-G261T and ACE-A592G polymorphisms are risk factors for systemic lupus erythematosus (SLE) in a Chinese population... - Tocilizumab: a review of its safety and efficacy in rheumatoid arthritisGraeme Jones
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
Clin Med Insights Arthritis Musculoskelet Disord 3:81-9. 2010..In summary, there is sufficient evidence to make TCZ a first line biologic therapy for rheumatoid arthritis especially for those who are unable to take methotrexate or who fail anti-TNF therapy... - Does diclofenac induce accelerated progression of hip and knee radiographic osteoarthritis? Comment on the article by Reijman et alChanghai Ding
Arthritis Rheum 54:1027; author reply 1028. 2006 - Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective studyFlavia Cicuttini
Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria, Australia
Arthritis Rheum 52:2033-9. 2005..The aim of this study was to examine the association between cartilage defects in the knee and cartilage volume both cross-sectionally and longitudinally in healthy, middle-age adults... - Static knee alignment is associated with the risk of unicompartmental knee cartilage defectsNeela Janakiramanan
Department of Epidemiology and Preventative Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
J Orthop Res 26:225-30. 2008.... - Predictors of clinical response to intraarticular Hylan injections -- a prospective study using synovial fluid measures, clinical outcomes, and magnetic resonance imagingAnanthila Anandacoomarasamy
Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
J Rheumatol 35:685-90. 2008..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections... - Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trialChunde Bao
Department of Clinical Immunology, Shanghai Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Chin Med J (Engl) 116:1228-34. 2003..To evaluate the efficacy and safety of leflunomide in comparison with methotrexate (MTX) on patients with rheumatoid arthritis (RA) in China...