C Ding

Summary

Affiliation: University of Tasmania
Country: Australia

Publications

  1. pmc Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia
    Trials 13:131. 2012
  2. doi request reprint Body fat is associated with increased and lean mass with decreased knee cartilage loss in older adults: a prospective cohort study
    C Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Int J Obes (Lond) 37:822-7. 2013
  3. doi request reprint Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Rheumatology (Oxford) 52:1323-34. 2013
  4. ncbi request reprint Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study
    Oliver P Stannus
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 72:535-40. 2013
  5. doi request reprint The association between parity and knee cartilage in young women
    Shuying Wei
    Menzies Research Institute Tasmania, 17 Liverpool Street, Hobart, Tasmania 7001, Australia
    Rheumatology (Oxford) 51:2039-45. 2012
  6. pmc A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
    Arthritis Res Ther 14:R13. 2012
  7. pmc Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    BMC Musculoskelet Disord 6:10. 2005
  8. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
  9. pmc Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R223. 2010
  10. pmc The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study
    Oliver P Stannus
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Arthritis Res Ther 12:R95. 2010

Collaborators

Detail Information

Publications74

  1. pmc Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia
    Trials 13:131. 2012
    ....
  2. doi request reprint Body fat is associated with increased and lean mass with decreased knee cartilage loss in older adults: a prospective cohort study
    C Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Int J Obes (Lond) 37:822-7. 2013
    ..To determine the associations between body composition at baseline and knee cartilage loss over 2.9 years in older adults...
  3. doi request reprint Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Rheumatology (Oxford) 52:1323-34. 2013
    ..To systematically review the evidence for association between serum 25-hydroxyvitamin D (25-(OH)D) and OA and the effect of vitamin D therapy on OA...
  4. ncbi request reprint Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study
    Oliver P Stannus
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 72:535-40. 2013
    ..To determine the association between inflammatory markers and change in knee pain over 5 years...
  5. doi request reprint The association between parity and knee cartilage in young women
    Shuying Wei
    Menzies Research Institute Tasmania, 17 Liverpool Street, Hobart, Tasmania 7001, Australia
    Rheumatology (Oxford) 51:2039-45. 2012
    ..The aim of this study was to describe the association between parity, cartilage volume and cartilage defects in women aged 31-41 years...
  6. pmc A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
    Arthritis Res Ther 14:R13. 2012
    ..Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs...
  7. pmc Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    BMC Musculoskelet Disord 6:10. 2005
    ..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies...
  8. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
    ....
  9. pmc Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R223. 2010
    ....
  10. pmc The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study
    Oliver P Stannus
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Arthritis Res Ther 12:R95. 2010
    ..The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults...
  11. pmc Association between meniscal tears and the peak external knee adduction moment and foot rotation during level walking in postmenopausal women without knee osteoarthritis: a cross-sectional study
    Miranda L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, 89 Commercial Road, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Arthritis Res Ther 10:R58. 2008
    ..Joint loading mediated via gait parameters may be associated with meniscal tears, and determining whether such an association exists was the aim of this study...
  12. pmc Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
    Arthritis Res Ther 8:R137. 2006
    ..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI...
  13. doi request reprint Do NSAIDs affect longitudinal changes in knee cartilage volume and knee cartilage defects in older adults?
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Am J Med 122:836-42. 2009
    ..The aim of this longitudinal study was to determine the associations between use of NSAIDs and changes in knee cartilage volume and knee cartilage defects over 2.9 years in older adults...
  14. ncbi request reprint Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    Curr Opin Investig Drugs 7:1020-5. 2006
    ..In June 2005, a phase II clinical trial of VX-702 was initiated in rheumatoid arthritis. In July 2006, Vertex was planning to file an IND in the second half of 2006...
  15. ncbi request reprint Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Rheumatol 34:776-84. 2007
    ..To examine the associations between meniscal tear, knee structure, osteoarthritis (OA) risk factors, radiographic change, and symptoms in a largely non-osteoarthritic cohort...
  16. ncbi request reprint Smoking interacts with family history with regard to change in knee cartilage volume and cartilage defect development
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 56:1521-8. 2007
    ..To describe the effects of smoking on change in knee cartilage volume and increases in knee cartilage defects, and to test for interaction between smoking and family history of osteoarthritis (OA)...
  17. ncbi request reprint Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseases
    Changhai Ding
    Menzies Research Institute, Hobart, Tasmania, Australia
    Rev Recent Clin Trials 1:193-200. 2006
    ..Like other anti-cytokine immunotherapies, caution and close monitoring for the adverse events, especially infection, are necessary in subsequent clinical trials...
  18. ncbi request reprint Two-year prospective longitudinal study exploring the factors associated with change in femoral cartilage volume in a cohort largely without knee radiographic osteoarthritis
    C Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 16:443-9. 2008
    ..To identify factors associated with change in femoral cartilage volume over 2 years in a cohort largely without knee radiographic osteoarthritis...
  19. ncbi request reprint How important is MRI for detecting early osteoarthritis?
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Nat Clin Pract Rheumatol 4:4-5. 2008
  20. ncbi request reprint Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study
    C Ding
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 67:1256-61. 2008
    ..To describe the associations between leptin, body composition, sex and knee cartilage volume/defects in older adults...
  21. doi request reprint Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    J Clin Endocrinol Metab 93:1952-8. 2008
    ..IL-1, IL-6, and TNF-alpha play an important role in the pathogenesis of osteoporosis in animals; however, evidence that these play a similar role in bone loss in human studies is limited...
  22. ncbi request reprint ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases
    Changhai Ding
    University of Tasmania, Menzies Research Institute, 199 Macquarie Street, Hobart, Tasmania 7000, Australia
    Curr Opin Investig Drugs 9:515-22. 2008
    ..ABT-87 was previously being developed for the potential treatment of multiple sclerosis; however, by May 2007, development for this indication was discontinued...
  23. doi request reprint Not a simple fat-soluble vitamin: Changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adults
    C Ding
    Menzies Research Institute, University of Tasmania, Hobart, TAS, Australia
    J Intern Med 268:501-10. 2010
    ..To determine the associations between body adiposity and change in serum 25-(OH)D levels over 2.6 years, and if these associations are mediated by metabolic and inflammatory factors in older adults...
  24. ncbi request reprint B-cell-targeted therapy for systemic lupus erythematosus: an update
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    BioDrugs 22:239-49. 2008
    ..g. ocrelizumab) and agents that interrupt B-cell/T-cell interactions also have potential, and the efficacy of these, along with rituximab, belimumab and epratuzumab, needs to be determined by randomized controlled trials...
  25. ncbi request reprint Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases
    Changhai Ding
    University of Tasmania, Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Expert Opin Biol Ther 8:1805-14. 2008
    ..Belimumab (LymphoStat-B), a human monoclonal antibody that inhibits BlyS, was developed for the treatment of these diseases...
  26. doi request reprint Targeting IL-6 in the treatment of inflammatory and autoimmune diseases
    Changhai Ding
    Monash University, Central and Eastern Clinical School, Department of Epidemiology and Preventive Medicine, Commercial Road, Melbourne 3004, Australia
    Expert Opin Investig Drugs 18:1457-66. 2009
    ....
  27. doi request reprint Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania
    Arthritis Rheum 60:1381-9. 2009
    ..To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults...
  28. ncbi request reprint A longitudinal study of the effect of sex and age on rate of change in knee cartilage volume in adults
    Changhai Ding
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Rheumatology (Oxford) 46:273-9. 2007
    ..To describe the association between sex, age and rate of change in knee cartilage volume in adults...
  29. ncbi request reprint Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
    Curr Opin Investig Drugs 7:464-72. 2006
    ..By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year...
  30. ncbi request reprint Licofelone (Merckle)
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, Hobart 7000, Tasmania, Australia
    IDrugs 6:802-8. 2003
    ..EuroAlliance (a consortium of Alfa Wassermann SpA, Lacer SA and Merckle GmbH) is developing licofelone, a dual cyclooxygenase and 5-lipoxygenase inhibitor for the potential treatment of inflammatory disorders including osteoarthritis...
  31. ncbi request reprint Technology evaluation: MRA, Chugai
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, 17 Liverpool Street, Hobart, 7000 TAS, Australia
    Curr Opin Mol Ther 5:64-9. 2003
    ..MRA is currently undergoing phase II clinical trials for these indications...
  32. ncbi request reprint Natural history of knee cartilage defects and factors affecting change
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart
    Arch Intern Med 166:651-8. 2006
    ..Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history...
  33. ncbi request reprint Bertilimumab Cambridge Antibody Technology Group
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
    Curr Opin Investig Drugs 5:1213-8. 2004
    ..By September 2003, CAT had released results from phase I/II trials, and was seeking to outlicense rights for bertilimumab...
  34. ncbi request reprint Knee and hip radiographic osteoarthritis predict total hip bone loss in older adults: a prospective study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Bone Miner Res 25:858-65. 2010
    ..In conclusion, older subjects with radiographic hip and knee OA have higher total hip bone loss over 2.6 years regardless of symptoms, suggesting that consideration should be given to the monitoring of bone mass in these subjects...
  35. ncbi request reprint Meniscal tear and increased tibial plateau bone area in healthy post-menopausal women
    M L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Osteoarthritis Cartilage 16:268-71. 2008
    ....
  36. ncbi request reprint The natural history of cartilage defects in people with knee osteoarthritis
    M L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
    Osteoarthritis Cartilage 16:337-42. 2008
    ..The aim of this study was to examine the progression of cartilage defects over 2 years in people with knee OA and to identify factors associated with progression...
  37. pmc Association between age and knee structural change: a cross sectional MRI based study
    C Ding
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 64:549-55. 2005
    ..To describe the associations between age, knee cartilage morphology, and bone size in adults...
  38. doi request reprint Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults
    O Stannus
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 18:1441-7. 2010
    ..We determined the associations between serum levels of interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), knee radiographic OA (ROA) and cartilage loss over 2.9 years in older adults...
  39. pmc Genetic mechanisms of knee osteoarthritis: a population based case-control study
    G Jones
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 63:1255-9. 2004
    ..To compare subjects who had at least one parent with a total knee replacement for severe primary knee osteoarthritis with age and sex matched controls who had no family history of knee osteoarthritis..
  40. doi request reprint Radiographic osteoarthritis and pain are independent predictors of knee cartilage loss: a prospective study
    J Saunders
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Intern Med J 42:274-80. 2012
    ..There is controversy about whether pain and radiographic osteoarthritis (ROA) predict subsequent cartilage loss. The aim of this study was to describe the relationship between ROA, pain and cartilage loss in the knee...
  41. ncbi request reprint Factors affecting progression of knee cartilage defects in normal subjects over 2 years
    Y Wang
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
    Rheumatology (Oxford) 45:79-84. 2006
    ..The aim of this study was to examine the change in cartilage defects over 2 yr and to identify factors associated with this change...
  42. doi request reprint A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia
    D Dore
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 16:1539-44. 2008
    ..To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density (sBMD)...
  43. ncbi request reprint Sex differences in knee cartilage volume in adults: role of body and bone size, age and physical activity
    C Ding
    Menzies Centre for Population Health Research, University of Tasmania Hobart, Australia
    Rheumatology (Oxford) 42:1317-23. 2003
    ..To test the hypothesis that sex differences in knee cartilage volume may be mediated through body and bone size, age and/or physical activity...
  44. doi request reprint Knee cartilage defects in a sample of older adults: natural history, clinical significance and factors influencing change over 2.9 years
    J Carnes
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 20:1541-7. 2012
    ..To describe the natural history of knee cartilage defects, and their relationship to cartilage volume loss and risk of knee replacement in a longitudinal study of older adults...
  45. ncbi request reprint Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis
    C Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 15:479-86. 2007
    ..Taken as a whole, these studies suggest that tibial subchondral bone expansion and cartilage defect development represent important targets for the prevention of cartilage loss and joint replacement...
  46. ncbi request reprint A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic population
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Rheumatol 34:181-6. 2007
    ..We investigated whether baseline malalignment of the knee predicts subsequent change in knee cartilage volume and chondral defects in subjects with and without radiographic knee osteoarthritis (OA)...
  47. ncbi request reprint The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Tasmania, Australia
    Arthritis Rheum 52:2830-4. 2005
    ..To estimate the heritability of longitudinal changes in knee cartilage volume, chondral defects, subchondral bone size, and lower limb muscle strength...
  48. doi request reprint The associations between parity, other reproductive factors and cartilage in women aged 50-80 years
    S Wei
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 19:1307-13. 2011
    ....
  49. ncbi request reprint Knee structural alteration and BMI: a cross-sectional study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Obes Res 13:350-61. 2005
    ..To describe the associations among BMI, knee cartilage morphology, and bone size in adults...
  50. ncbi request reprint Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study
    Flavia Cicuttini
    Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria, Australia
    Arthritis Rheum 52:2033-9. 2005
    ..The aim of this study was to examine the association between cartilage defects in the knee and cartilage volume both cross-sectionally and longitudinally in healthy, middle-age adults...
  51. ncbi request reprint Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal study
    Changhai Ding
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 52:3918-27. 2005
    ..To describe the association between prevalent and incident knee cartilage defects and loss of knee cartilage in male and female adults...
  52. ncbi request reprint The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studies
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    J Rheumatol 32:1937-42. 2005
    ....
  53. ncbi request reprint The clinical correlates of articular cartilage defects in symptomatic knee osteoarthritis: a prospective study
    A E Wluka
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
    Rheumatology (Oxford) 44:1311-6. 2005
    ..To determine whether articular cartilage defects are associated with cartilage loss and joint replacement in subjects with symptomatic knee osteoarthritis (OA)...
  54. doi request reprint Correlates of subchondral BMD: a cross-sectional study
    Dawn Dore
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Bone Miner Res 24:2007-15. 2009
    ..10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality...
  55. pmc Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume
    Changhai Ding
    Menzies Research Institute, University of Tasmania, 199 Macquarie Street, Hobart 7000, Australia
    Arthritis Res Ther 9:R21. 2007
    ....
  56. ncbi request reprint Physical activity and knee structural change: a longitudinal study using MRI
    Stella Foley
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Med Sci Sports Exerc 39:426-34. 2007
    ..Exercise therapy is effective in improving symptoms of knee osteoarthritis, but its effect on structural change remains unclear...
  57. ncbi request reprint Knee articular cartilage development in children: a longitudinal study of the effect of sex, growth, body composition, and physical activity
    Graeme Jones
    Menzies Centre for Population Health Research, GPO Box 252 23, Hobart, Tasmania, Australia 7000
    Pediatr Res 54:230-6. 2003
    ..These results provide novel data on articular cartilage development in humans. The long-term significance of these results with regard to osteoarthritis of the knee in later life remains hypothetical...
  58. pmc Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Arthritis Res Ther 8:R8. 2006
    ..Importantly, the cartilage changes are largely dependent on baseline differences in cartilage volume, tibial bone area, BMI and knee pain, suggesting that these factors might have a role in their initiation...
  59. ncbi request reprint Factors associated with hip cartilage volume measured by magnetic resonance imaging: the Tasmanian Older Adult Cohort Study
    Guangju Zhai
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 52:1069-76. 2005
    ....
  60. ncbi request reprint Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females
    G Jones
    Menzies Centre for Population Health Research, GPO Box 252 23, Tasmania 7000, Hobart, Australia
    Osteoarthritis Cartilage 12:169-74. 2004
    ..To describe the association between early radiographic osteoarthritis of the knee (ROA), knee cartilage volume and tibial bone surface area...
  61. ncbi request reprint The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair study
    Guangju Zhai
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 50:805-10. 2004
    ..To estimate the heritability of muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis (ROA), and to assess whether heritability of the knee structural components is independent of ROA...
  62. doi request reprint A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults
    David Scott
    Menzies Research Institute, University of Tasmania, Hobart School of Human Life Sciences, University of Tasmania, Launceston, TAS, Australia
    Clin Endocrinol (Oxf) 73:581-7. 2010
    ..Our objective was to describe prospective associations between 25OHD, muscle parameters, and PA in community-dwelling older adults...
  63. ncbi request reprint What can we learn about osteoarthritis by studying a healthy person against a person with early onset of disease?
    Changhai Ding
    Department of Epidemiology and Preventive Medicine, Monash University Medical School, Melbourne, Australia
    Curr Opin Rheumatol 22:520-7. 2010
    ..This review aims to examine the recent epidemiological and clinical evidences of early knee structural changes in the younger populations with relatively healthy knees...
  64. doi request reprint Subchondral bone and cartilage damage: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 62:1967-73. 2010
    ..The aim of this study was to describe the association between baseline tibial bone area and tibial subchondral bone mineral density (BMD) with tibial cartilage defect development and cartilage volume loss...
  65. ncbi request reprint Do NSAIDs affect the progression of osteoarthritis?
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, Australia
    Inflammation 26:139-42. 2002
    ..Therefore, it is necessary and valuable to clarify the effects of these NSAIDs on cartilage in patients with OA using validated non-invasive methods such as MRI...
  66. ncbi request reprint Static knee alignment is associated with the risk of unicompartmental knee cartilage defects
    Neela Janakiramanan
    Department of Epidemiology and Preventative Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
    J Orthop Res 26:225-30. 2008
    ....
  67. ncbi request reprint Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 13:198-205. 2005
    ..To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults...
  68. ncbi request reprint Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    Arthritis Rheum 55:264-71. 2006
    ..To describe the association between chondral defects, bone marrow lesions, knee and hip radiographic osteoarthritis (OA), and knee pain...
  69. ncbi request reprint Correlates of knee pain in younger subjects
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
    Clin Rheumatol 26:75-80. 2007
    ..MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects...
  70. doi request reprint Association of baseline knee bone size, cartilage volume, and body mass index with knee cartilage loss over time: a longitudinal study in younger or middle-aged adults
    Benny Antony
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    J Rheumatol 38:1973-80. 2011
    ..To determine the association of knee bone size, cartilage volume, and body mass index (BMI) at baseline with knee cartilage loss over 2 years in younger or middle-aged adults...
  71. ncbi request reprint Predictors of clinical response to intraarticular Hylan injections -- a prospective study using synovial fluid measures, clinical outcomes, and magnetic resonance imaging
    Ananthila Anandacoomarasamy
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    J Rheumatol 35:685-90. 2008
    ..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections...
  72. ncbi request reprint Does diclofenac induce accelerated progression of hip and knee radiographic osteoarthritis? Comment on the article by Reijman et al
    Changhai Ding
    Arthritis Rheum 54:1027; author reply 1028. 2006
  73. ncbi request reprint Association of ACE gene polymorphism with genetic susceptibility to systemic lupus erythematosus in a Chinese population: a family-based association study
    Jianhua Xu
    Department of Rheumatology, First Affiliated Hospital, Hefei, China
    J Rheumatol 34:2408-11. 2007
    ..Family-based association analysis was performed to investigate whether the angiotensin-converting enzyme (ACE)-G261T and ACE-A592G polymorphisms are risk factors for systemic lupus erythematosus (SLE) in a Chinese population...
  74. ncbi request reprint Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial
    Chunde Bao
    Department of Clinical Immunology, Shanghai Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Chin Med J (Engl) 116:1228-34. 2003
    ..To evaluate the efficacy and safety of leflunomide in comparison with methotrexate (MTX) on patients with rheumatoid arthritis (RA) in China...