Tracey C Dickson

Summary

Affiliation: University of Tasmania
Country: Australia

Publications

  1. doi request reprint Focal demyelination in Alzheimer's disease and transgenic mouse models
    Stanislaw Mitew
    NeuroRepair Group, Wicking Dementia Research and Education Centre, Menzies Research Institute, University of Tasmania, Hobart, TAS 7000, Australia
    Acta Neuropathol 119:567-77. 2010
  2. ncbi request reprint Acute reactive and regenerative changes in mature cortical axons following injury
    Tracey C Dickson
    NeuroRepair Group, School of Medicine, University of Tasmania, Tasmania, Australia
    Neuroreport 18:283-8. 2007
  3. ncbi request reprint alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury
    Tracey C Dickson
    NeuroRepair Group, University of Tasmania, Hobart, Tasmania, 7000, Australia
    Neurobiol Dis 18:286-95. 2005
  4. doi request reprint Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease
    Adele Woodhouse
    Wicking Dementia Research and Education Centre and NeuroRepair Group, Menzies Research Institute, Private Bag 29, Hobart, TAS, 7001, Australia
    Acta Neuropathol 117:19-29. 2009
  5. doi request reprint Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice
    Yao Liu
    Wicking Dementia Research and Education Centre, Hobart, Tasmania 7001, Australia
    J Comp Neurol 521:1817-27. 2013
  6. ncbi request reprint Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro
    Matilda A Haas
    NeuroRepair Group, University of Tasmania, Hobart, Australia
    J Neurosci Res 85:34-46. 2007
  7. ncbi request reprint Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    J Neurotrauma 22:1081-91. 2005
  8. doi request reprint Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury
    Jerome A Staal
    NeuroRepair Group and Wicking Dementia Research and Education Centre, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    J Neurochem 112:1147-55. 2010
  9. ncbi request reprint Identification and characterization of a population of motile neurons in long-term cortical culture
    Matilda A Haas
    NeuroRepair Group, University of Tasmania, Hobart, Tasmania, Australia
    Cell Motil Cytoskeleton 64:274-87. 2007
  10. ncbi request reprint Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging
    Adele Woodhouse
    NeuroRepair Group, Menzies Research Institute, 43 Collins Street, Hobart, 7001 Tasmania, Australia
    Neurobiol Aging 30:864-74. 2009

Collaborators

Detail Information

Publications30

  1. doi request reprint Focal demyelination in Alzheimer's disease and transgenic mouse models
    Stanislaw Mitew
    NeuroRepair Group, Wicking Dementia Research and Education Centre, Menzies Research Institute, University of Tasmania, Hobart, TAS 7000, Australia
    Acta Neuropathol 119:567-77. 2010
    ..We suggest that such plaque-associated focal demyelination of the cortical grey matter might impair cortical processing, and may also be associated with aberrant axonal sprouting that underlies dystrophic neurite formation...
  2. ncbi request reprint Acute reactive and regenerative changes in mature cortical axons following injury
    Tracey C Dickson
    NeuroRepair Group, School of Medicine, University of Tasmania, Tasmania, Australia
    Neuroreport 18:283-8. 2007
    ..These results indicate that damaged mature axons have an intrinsic capacity to react adaptively and attempt regeneration...
  3. ncbi request reprint alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury
    Tracey C Dickson
    NeuroRepair Group, University of Tasmania, Hobart, Tasmania, 7000, Australia
    Neurobiol Dis 18:286-95. 2005
    ..These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD...
  4. doi request reprint Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease
    Adele Woodhouse
    Wicking Dementia Research and Education Centre and NeuroRepair Group, Menzies Research Institute, Private Bag 29, Hobart, TAS, 7001, Australia
    Acta Neuropathol 117:19-29. 2009
    ..These differences in cytoskeletal pathology in PS1 cases suggest an accelerated rate of neuritic pathology development, potentially due to mutant PS1 influencing multiple pathogenic pathways...
  5. doi request reprint Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice
    Yao Liu
    Wicking Dementia Research and Education Centre, Hobart, Tasmania 7001, Australia
    J Comp Neurol 521:1817-27. 2013
    ..The data also indicate that changes in expression of other cytoskeletal proteins may compensate for decreased NFs...
  6. ncbi request reprint Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro
    Matilda A Haas
    NeuroRepair Group, University of Tasmania, Hobart, Australia
    J Neurosci Res 85:34-46. 2007
    ..Thus, Rho kinase is an important activator of ERMs in mediating specific neuronal functions...
  7. ncbi request reprint Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    J Neurotrauma 22:1081-91. 2005
    ..Hence, it is possible that the cytoskeletal characteristics that we have used in this study may be useful parameters for discriminating between mildly and severely injured axons following TBI...
  8. doi request reprint Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury
    Jerome A Staal
    NeuroRepair Group and Wicking Dementia Research and Education Centre, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    J Neurochem 112:1147-55. 2010
    ....
  9. ncbi request reprint Identification and characterization of a population of motile neurons in long-term cortical culture
    Matilda A Haas
    NeuroRepair Group, University of Tasmania, Hobart, Tasmania, Australia
    Cell Motil Cytoskeleton 64:274-87. 2007
    ..These studies provide new information on the structurally dynamic features of subsets of neurons...
  10. ncbi request reprint Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging
    Adele Woodhouse
    NeuroRepair Group, Menzies Research Institute, 43 Collins Street, Hobart, 7001 Tasmania, Australia
    Neurobiol Aging 30:864-74. 2009
    ..These results suggest that neuronal pathology in these mice represent an accurate and valuable model for understanding, and developing treatments for, the early brain changes of AD...
  11. ncbi request reprint Cytoplasmic cytochrome c immunolabelling in dystrophic neurites in Alzheimer's disease
    Adele Woodhouse
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 29, Hobart, TAS, 7001 Australia
    Acta Neuropathol 112:429-37. 2006
    ..Although cytochrome c release is indicative of the activation of the intrinsic apoptotic pathway, cytoplasmic cytochrome c may also indicate mitochondrial damage or dysfunction...
  12. doi request reprint Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity
    Catherine A Blizzard
    Wicking Dementia Research and Education Centre and NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 29, Hobart, Tasmania, Australia 7000
    Brain Res 1300:24-36. 2009
    ..These results may aid in defining the cellular basis of neuronal structural plasticity and defining the role of astrocyte reactivity in the response to trauma...
  13. doi request reprint Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and α-internexin immunoreactivity
    Anna E King
    Wicking Dementia Research and Education Centre and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania 7000, Australia
    Brain Res 1465:90-100. 2012
    ..These data suggest that white matter degeneration in this mouse model of ALS is widespread and involves a specific molecular signature, particularly the accumulation of NFL and alpha-internexin proteins...
  14. ncbi request reprint No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases
    Adele Woodhouse
    NeuroRepair Group, School of Medicine, Private Bag 29, University of Tasmania, Hobart, Tasmania 7001, Australia
    Neurobiol Dis 22:323-33. 2006
    ..Apoptosis may not play a major role in the pathogenesis of neuronal degeneration of AD...
  15. ncbi request reprint Binding partners L1 cell adhesion molecule and the ezrin-radixin-moesin (ERM) proteins are involved in development and the regenerative response to injury of hippocampal and cortical neurons
    Matilda A Haas
    NeuroRepair Group, University of Tasmania, 43 Collins Street, Hobart, Tasmania, 7000, Australia
    Eur J Neurosci 20:1436-44. 2004
    ..We have demonstrated that L1 and the ERM proteins are involved in the neuronal response to injury, and that neurons derived from the hippocampus and cortex may have different post-injury regenerative neurite sprouting abilities...
  16. doi request reprint Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy
    Jerome A Staal
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Neurotrauma 26:781-8. 2009
    ..Protein ubiquitination in the axon may therefore have a protective role relative to the diffuse axonal changes that follow traumatic brain injury...
  17. doi request reprint Altered synapses and gliotransmission in Alzheimer's disease and AD model mice
    Stanislaw Mitew
    Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia
    Neurobiol Aging 34:2341-51. 2013
    ..Using tissue fractionation, this increased activity was localized to glial synaptosomes, suggesting that Aβ plaques stimulate increased astrocyte GABA synthesis. ..
  18. ncbi request reprint Does beta-amyloid plaque formation cause structural injury to neuronal processes?
    Adele Woodhouse
    NeuroRepair Group, School of Medicine, University of Tasmania, Australia
    Neurotox Res 7:5-15. 2005
    ..Identification of the key neuronal alterations underlying the pathology of Alzheimer's disease may provide new avenues for therapeutic intervention...
  19. doi request reprint Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit
    Katherine A Southam
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania 7000, Australia
    J Neurosci Methods 218:164-9. 2013
    ....
  20. doi request reprint Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system
    James C Vickers
    NeuroRepair Group and Wicking Dementia Research and Education Centre, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Brain Res Bull 80:217-23. 2009
    ..The identification of a degenerative process initiated in the axon may provide new therapeutic targets for early intervention to inhibit the grim outcomes related to the progression of these diseases...
  21. ncbi request reprint Vaccination strategies for Alzheimer's disease: A new hope?
    Adele Woodhouse
    School of Medicine, NeuroRepair Group, University of Tasmania, Hobart, Tasmania, Australia
    Drugs Aging 24:107-19. 2007
    ..The vigour of international research on immunotherapy for AD provides significant hope for a strong therapeutic lead for the escalating number of individuals who will develop this otherwise incurable condition...
  22. ncbi request reprint Intrinsic regenerative ability of mature CNS neurons
    Jyoti A Chuckowree
    University of Tasmania, Hobart, Tasmania, Australia
    Neuroscientist 10:280-5. 2004
    ....
  23. doi request reprint α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway
    Ruth E J Musgrove
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia
    Neurotox Res 23:358-69. 2013
    ..The current data suggest that α-synuclein prevents cytochrome c release and apoptosis through inhibition of the MAPK signalling pathway...
  24. ncbi request reprint Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease
    James C Vickers
    Discipline of Pathology, School of Medicine, University of Tasmania, 43 Collins St, GPO Box 252 29, Tasmania Hobart 7001, Australia
    Brain Res 971:135-7. 2003
    ..Thus, most neocortical tangles in Alzheimer's disease are intracellular and may not be the principal cause of neocortical cell loss...
  25. ncbi request reprint Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer' s disease
    Oiivier Bibari
    Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia
    Curr Alzheimer Res 10:688-96. 2013
    ..In summary, our results show that Aβ plaque deposition in the central nervous system can be modified transsynaptically by deafferentation. ..
  26. doi request reprint Stainless steel pinholes for fast fabrication of high-performance microchip electrophoresis devices by CO2 laser ablation
    Yiing C Yap
    School of Pharmacy, University of Tasmania, Private Bag 26, Hobart, Tasmania, 7001, Australia
    Anal Chem 85:10051-6. 2013
    ....
  27. ncbi request reprint ERMs colocalize transiently with L1 during neocortical axon outgrowth
    C David Mintz
    Fishberg Research Center for Neurobiology, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 464:438-48. 2003
    ..Furthermore, these data suggest that there is a developmentally regulated switch in MCL function in the developing brain...
  28. pmc ERM proteins regulate growth cone responses to Sema3A
    C David Mintz
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Comp Neurol 510:351-66. 2008
    ..Our data support a model in which ERMs can coordinate membrane and actin dynamics in response to Sema3A...
  29. pmc Functional binding interaction identified between the axonal CAM L1 and members of the ERM family
    Tracey C Dickson
    Fishberg Research Center for Neurobiology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 157:1105-12. 2002
    ..Together, our data indicate that L1 binds directly to members of the ERM family and suggest this association may coordinate aspects of axonal morphogenesis...