James W Denham

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. pmc Risk Stratification after Biochemical Failure following Curative Treatment of Locally Advanced Prostate Cancer: Data from the TROG 96.01 Trial
    Allison Steigler
    School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Prostate Cancer 2012:814724. 2012
  2. doi request reprint Picking the optimal duration of hormonal therapy in men with high-risk and locally advanced prostate cancer treated with radiotherapy
    James W Denham
    Prostate Cancer Trials Group, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
    Semin Radiat Oncol 23:206-14. 2013
  3. doi request reprint Paradoxical metastatic progression following 3 months of neo-adjuvant androgen suppression in the TROG 96.01 trial for men with locally advanced prostate cancer
    James W Denham
    School of Medicine and Public Health, The University of Newcastle, Australia
    Radiother Oncol 107:123-8. 2013
  4. doi request reprint Rectal and urinary dysfunction in the TROG 03.04 RADAR trial for locally advanced prostate cancer
    James W Denham
    University of Newcastle, Australia
    Radiother Oncol 105:184-92. 2012
  5. doi request reprint Quality of life in men with locally advanced prostate cancer treated with leuprorelin and radiotherapy with or without zoledronic acid (TROG 03.04 RADAR): secondary endpoints from a randomised phase 3 factorial trial
    James W Denham
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Lancet Oncol 13:1260-70. 2012
  6. pmc Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial
    Daniel A Galvão
    Edith Cowan University Health and Wellness Institute and School of Exercise and Health Sciences, Edith Cowan University, Joondalup, Australia
    BMC Cancer 11:517. 2011
  7. pmc A randomized controlled trial of an exercise intervention targeting cardiovascular and metabolic risk factors for prostate cancer patients from the RADAR trial
    Daniel A Galvão
    Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
    BMC Cancer 9:419. 2009
  8. doi request reprint PSA response signatures - a powerful new prognostic indicator after radiation for prostate cancer?
    James W Denham
    University of Newcastle, NSW, Australia
    Radiother Oncol 90:382-8. 2009
  9. doi request reprint Short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-year data from the TROG 96.01 randomised trial
    James W Denham
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Lancet Oncol 12:451-9. 2011
  10. doi request reprint Recognizing false biochemical failure calls after radiation with or without neo-adjuvant androgen deprivation for prostate cancer
    James W Denham
    University of Newcastle, New South Wales, Australia
    Int J Radiat Oncol Biol Phys 74:404-11. 2009

Collaborators

Detail Information

Publications26

  1. pmc Risk Stratification after Biochemical Failure following Curative Treatment of Locally Advanced Prostate Cancer: Data from the TROG 96.01 Trial
    Allison Steigler
    School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Prostate Cancer 2012:814724. 2012
    ..External validation, particularly in long-term AST and radiotherapy datasets, is necessary...
  2. doi request reprint Picking the optimal duration of hormonal therapy in men with high-risk and locally advanced prostate cancer treated with radiotherapy
    James W Denham
    Prostate Cancer Trials Group, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
    Semin Radiat Oncol 23:206-14. 2013
    ..Trials are also ongoing to determine whether radiation dose escalation and/or nonhormonal agents, such as zoledronic acid and docetaxel, will reduce the need for supplementary androgen suppression therapy...
  3. doi request reprint Paradoxical metastatic progression following 3 months of neo-adjuvant androgen suppression in the TROG 96.01 trial for men with locally advanced prostate cancer
    James W Denham
    School of Medicine and Public Health, The University of Newcastle, Australia
    Radiother Oncol 107:123-8. 2013
    ..In the TROG 96.01 trial 6 month neo-adjuvant androgen suppression (NAS) and radiotherapy (RT) for locally advanced prostate cancer prevented distant progressions (DPs) when compared to RT alone, but 3 months did not. We ask why?..
  4. doi request reprint Rectal and urinary dysfunction in the TROG 03.04 RADAR trial for locally advanced prostate cancer
    James W Denham
    University of Newcastle, Australia
    Radiother Oncol 105:184-92. 2012
    ..This study examines whether these measures increase rectal and urinary dysfunction and are secondary trial endpoints...
  5. doi request reprint Quality of life in men with locally advanced prostate cancer treated with leuprorelin and radiotherapy with or without zoledronic acid (TROG 03.04 RADAR): secondary endpoints from a randomised phase 3 factorial trial
    James W Denham
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Lancet Oncol 13:1260-70. 2012
    ..In this study, we investigated whether these treatments had a detrimental effect on patient-reported-outcome (PRO) scores...
  6. pmc Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial
    Daniel A Galvão
    Edith Cowan University Health and Wellness Institute and School of Exercise and Health Sciences, Edith Cowan University, Joondalup, Australia
    BMC Cancer 11:517. 2011
    ..The aim of this study is to determine the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases...
  7. pmc A randomized controlled trial of an exercise intervention targeting cardiovascular and metabolic risk factors for prostate cancer patients from the RADAR trial
    Daniel A Galvão
    Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
    BMC Cancer 9:419. 2009
    ..Our primary outcomes are cardiorespiratory capacity, abdominal obesity, and lipid and glycemic control, while secondary outcomes include self-reported physical activity, quality of life and psychological distress...
  8. doi request reprint PSA response signatures - a powerful new prognostic indicator after radiation for prostate cancer?
    James W Denham
    University of Newcastle, NSW, Australia
    Radiother Oncol 90:382-8. 2009
    ..We sought to determine whether inter-patient variations in pattern of PSA changes after radiation exist and, if so, are they prognostically significant...
  9. doi request reprint Short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-year data from the TROG 96.01 randomised trial
    James W Denham
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Lancet Oncol 12:451-9. 2011
    ..Here we report the 10-year results...
  10. doi request reprint Recognizing false biochemical failure calls after radiation with or without neo-adjuvant androgen deprivation for prostate cancer
    James W Denham
    University of Newcastle, New South Wales, Australia
    Int J Radiat Oncol Biol Phys 74:404-11. 2009
    ..We studied prostate-specific antigen (PSA) changes after radiation with or without neoadjuvant androgen deprivation to determine posttreatment PSA scenarios in which false-positive biochemical failures (FPBF) are most likely to occur...
  11. doi request reprint Measuring time to biochemical failure in the TROG 96.01 trial: when should the clock start ticking?
    James W Denham
    School of Medicine and Public Health, University of Newcastle, New South Wales, Australia
    Int J Radiat Oncol Biol Phys 75:1008-12. 2009
    ..We sought to determine whether short-term neoadjuvant androgen deprivation (STAD) duration influences the optimal time point from which Phoenix fail (time to biochemical failure; TTBF) should be measured...
  12. doi request reprint Why are pretreatment prostate-specific antigen levels and biochemical recurrence poor predictors of prostate cancer survival?
    James W Denham
    School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia
    Cancer 115:4477-87. 2009
    ..The authors sought to determine why using randomized trial data with 7-year minimum follow-up...
  13. ncbi request reprint It's time to depolarise the unhelpful PSA-testing debate and put into practice lessons from the two major international screening trials
    James W Denham
    Prostate Cancer Trials Group, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 192:393-6. 2010
    ..Active surveillance" programs (whereby men with early-stage cancers are monitored regularly by PSA testing and digital rectal examinations) and development of counselling services should be encouraged...
  14. ncbi request reprint Short-term androgen deprivation and radiotherapy for locally advanced prostate cancer: results from the Trans-Tasman Radiation Oncology Group 96.01 randomised controlled trial
    James W Denham
    Newcastle Mater Hospital, Newcastle, New South Wales, Australia
    Lancet Oncol 6:841-50. 2005
    ..We did a large randomised controlled trial to determine whether 3 months or 6 months of androgen deprivation given before and during radiotherapy improves outcomes for patients with locally advanced prostate cancer...
  15. doi request reprint Time to biochemical failure and prostate-specific antigen doubling time as surrogates for prostate cancer-specific mortality: evidence from the TROG 96.01 randomised controlled trial
    James W Denham
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Lancet Oncol 9:1058-68. 2008
    ..We sought to assess time to biochemical failure (TTBF) and prostate-specific antigen doubling time (PSADT) after failure of curative treatment as candidates for this endpoint...
  16. doi request reprint Treatment-related morbidity in prostate cancer: a comparison of 3-dimensional conformal radiation therapy with and without image guidance using implanted fiducial markers
    Jasmeet Singh
    Calvary Mater Newcastle, Newcastle, Australia
    Int J Radiat Oncol Biol Phys 85:1018-23. 2013
    ..To estimate the prevalence of rectal and urinary dysfunctional symptoms using image guided radiation therapy (IGRT) with fiducials and magnetic resonance planning for prostate cancer...
  17. doi request reprint Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial
    Anne Capp
    Calvary Mater Newcastle, NSW, Australia
    Radiother Oncol 90:400-7. 2009
    ..We sought to categorize longitudinal radiation-induced rectal toxicity data obtained from men participating in a randomised controlled trial for locally advanced prostate cancer...
  18. ncbi request reprint Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer
    Peter C O'Brien
    Department of Radiation Oncology, Newcastle Mater Hospital, Waratah, NSW, Australia
    Int J Radiat Oncol Biol Phys 58:75-80. 2004
    ..To describe the natural history of mucosal changes, in particular the development of telangiectases in the rectum, after radiotherapy (RT) for prostate cancer...
  19. doi request reprint Androgen deprivation therapy for prostate cancer does not increase cardiovascular mortality in the long term
    Chantelle Wilcox
    School of Medicine and Public Health, The University of Newcastle, Callaghan, N S W, Australia
    Oncology 82:56-8. 2012
    ..To determine if 6 months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality...
  20. ncbi request reprint A magnetic resonance imaging-based workflow for planning radiation therapy for prostate cancer
    Peter B Greer
    Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    Med J Aust 194:S24-7. 2011
    ..MRI-based radiotherapy planning can also be used for tumours in other locations, such as head and neck, and breast cancers...
  21. ncbi request reprint Breast edema in patients undergoing breast-conserving treatment for breast cancer: assessment via high frequency ultrasound
    Christopher R Wratten
    Radiation Oncology, Newcastle Mater Hospital, Waratah, NSW, Australia
    Breast J 13:266-73. 2007
    ..HFUS appears to be a useful in the research setting in quantifying the effect of techniques that aim to reduce complications such as edema...
  22. doi request reprint Thrombin generation as a predictor of radiotherapy induced skin erythema
    Lisa F Lincz
    Department of Haematology, Calvary Mater Newcastle, NSW, Australia
    Radiother Oncol 90:136-40. 2009
    ..Based on the recent findings in patients suffering from chronic urticaria, we sought to determine if similar mechanisms of hypercoagulation contributed to comparable skin reactions during radiotherapy...
  23. ncbi request reprint Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial--Trans-Tasman Radiation Oncology Group
    Peter C O'Brien
    Department of Radiation Oncology, Newcastle Mater Hospital, Newcastle, NSW, Australia
    Int J Radiat Oncol Biol Phys 54:442-9. 2002
    ....
  24. doi request reprint MRI-guided prostate radiation therapy planning: Investigation of dosimetric accuracy of MRI-based dose planning
    Jonathan Lambert
    School of Mathematical and Physical Sciences, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Radiother Oncol 98:330-4. 2011
    ..This study compares the accuracy of MR-alone based dose calculations with bulk electron density assignment to CT-based dose calculations for prostate radiotherapy...
  25. ncbi request reprint 'When measurements mean action' decision models for portal image review to eliminate systematic set-up errors
    Christopher R Wratten
    Radiation Oncology, Newcastle Mater Hospital, Newcastle, New South Wales, Australia
    Australas Radiol 48:272-9. 2004
    ..When combined with the potential for rapid diagnosis of larger (>4 mm) systematic errors using one-dimensional decision models, HEP can eliminate the majority of systematic errors during the first 2 treatment weeks...
  26. ncbi request reprint The radiotherapeutic injury--a complex 'wound'
    James W Denham
    Department of Radiation Oncology, Newcastle Mater Misericordiae Hospital, Newcastle University, Locked Bag 7, Hunter Region Mail Centre, NSW 2310, Newcastle, Australia
    Radiother Oncol 63:129-45. 2002
    ..Important clinical implications relevant to these processes are also discussed...