M P Davenport

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc APOBEC3G and APOBEC3F rarely co-mutate the same HIV genome
    Diako Ebrahimi
    Centre for Vascular Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Retrovirology 9:113. 2012
  2. pmc The null oncogene hypothesis and protection from cancer
    M P Davenport
    Department of Pathology, University of New South Wales, Kensington, NSW 2052, Australia
    J Med Genet 39:12-4. 2002
  3. doi request reprint The race between infection and immunity: how do pathogens set the pace?
    Miles P Davenport
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    Trends Immunol 30:61-6. 2009
  4. ncbi request reprint Cell turnover and cell tropism in HIV-1 infection
    Miles P Davenport
    Dept of Pathology, Faculty of Medicine, University of New South Wales, NSW 2052, Kensington, Australia
    Trends Microbiol 10:275-8. 2002
  5. ncbi request reprint Understanding the mechanisms and limitations of immune control of HIV
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia
    Immunol Rev 216:164-75. 2007
  6. pmc National study of microphthalmia, anophthalmia, and coloboma (MAC) in Scotland: investigation of genetic aetiology
    D Morrison
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    J Med Genet 39:16-22. 2002
  7. ncbi request reprint Kinetics of major histocompatibility class I antigen presentation in acute infection
    Matthew D H Lay
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Immunol 182:902-11. 2009
  8. pmc Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood
    David van Bockel
    Centre for Immunology, St Vincent s Hospital, Sydney, NSW, Australia
    J Immunol Methods 326:127-38. 2007
  9. ncbi request reprint Methods for comparing the diversity of samples of the T cell receptor repertoire
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital and, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    J Immunol Methods 321:182-95. 2007
  10. ncbi request reprint Method for assessing the similarity between subsets of the T cell receptor repertoire
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital, Kensington NSW 2052, Australia
    J Immunol Methods 329:67-80. 2008

Collaborators

Detail Information

Publications58

  1. pmc APOBEC3G and APOBEC3F rarely co-mutate the same HIV genome
    Diako Ebrahimi
    Centre for Vascular Research, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Retrovirology 9:113. 2012
    ..We develop a method of identification based on the representation of hA3G and hA3F target and product motifs that does not require an alignment to a parental/consensus sequence...
  2. pmc The null oncogene hypothesis and protection from cancer
    M P Davenport
    Department of Pathology, University of New South Wales, Kensington, NSW 2052, Australia
    J Med Genet 39:12-4. 2002
    ..Germline deletion or inactivation of one copy of a proto-oncogene halves the risk of activation at this locus. We propose that studies of high risk cancer patients will show such "null oncogene" mutations...
  3. doi request reprint The race between infection and immunity: how do pathogens set the pace?
    Miles P Davenport
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    Trends Immunol 30:61-6. 2009
    ..Understanding the 'rules of the race' for slow growing pathogens has important implications for vaccine design and immune control of many chronic infections...
  4. ncbi request reprint Cell turnover and cell tropism in HIV-1 infection
    Miles P Davenport
    Dept of Pathology, Faculty of Medicine, University of New South Wales, NSW 2052, Kensington, Australia
    Trends Microbiol 10:275-8. 2002
    ..As the division rate of naive T cells increases with CD4+ depletion, X4 viruses come to dominate in late disease...
  5. ncbi request reprint Understanding the mechanisms and limitations of immune control of HIV
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia
    Immunol Rev 216:164-75. 2007
    ..However, important questions remain as to whether differences in pathogenesis in HIV will lead to different 'rules of engagement' for immune control of virus...
  6. pmc National study of microphthalmia, anophthalmia, and coloboma (MAC) in Scotland: investigation of genetic aetiology
    D Morrison
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    J Med Genet 39:16-22. 2002
    ..No pathogenic mutations were identified in the OFCD cases. A single PAX6 homeodomain missense mutation was identified in a subject with partial aniridia that had been initially misclassified as coloboma...
  7. ncbi request reprint Kinetics of major histocompatibility class I antigen presentation in acute infection
    Matthew D H Lay
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Immunol 182:902-11. 2009
    ..Understanding how such contrasting kinetics of Ag presentation impacts on the growth and size of developing protective T cell populations has important implications for the design of vaccines and immunotherapies...
  8. pmc Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood
    David van Bockel
    Centre for Immunology, St Vincent s Hospital, Sydney, NSW, Australia
    J Immunol Methods 326:127-38. 2007
    ....
  9. ncbi request reprint Methods for comparing the diversity of samples of the T cell receptor repertoire
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital and, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    J Immunol Methods 321:182-95. 2007
    ..One example involves a comparison between the central and effector memory T cell subsets, defined on the basis of CD62L expression, and the other examines changes in the TCR repertoire over time...
  10. ncbi request reprint Method for assessing the similarity between subsets of the T cell receptor repertoire
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital, Kensington NSW 2052, Australia
    J Immunol Methods 329:67-80. 2008
    ....
  11. doi request reprint Division-linked differentiation can account for CD8+ T-cell phenotype in vivo
    Timothy E Schlub
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia
    Eur J Immunol 39:67-77. 2009
    ..Comparison of model results with experimental data suggests that division-linked differentiation provides a simple mechanism to explain the relationship between clone size and phenotype of CD8(+) T cells during acute infection...
  12. pmc Vaccine-induced T cells control reversion of AIDS virus immune escape mutants
    Caroline S Fernandez
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, and Department of Haematology, Prince of Wales Hospital, Kensington, NSW, Australia
    J Virol 81:4137-44. 2007
    ..These findings have important implications for the further development of T-cell-based HIV vaccines where exposure to escape mutant viruses is common...
  13. pmc Is the gut the major source of virus in early simian immunodeficiency virus infection?
    Matthew D H Lay
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    J Virol 83:7517-23. 2009
    ....
  14. pmc Predicting CD62L expression during the CD8+ T-cell response in vivo
    Timothy E Schlub
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, New South Wales, Australia
    Immunol Cell Biol 88:157-64. 2010
    ..We calculate that approximately 20% of CD62L(high) cells convert to CD62L(low) during each division...
  15. doi request reprint Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response
    David J van Bockel
    St Vincent s Centre for Applied Medical Research, University of New South Wales, Sydney, New South Wales, Australia
    J Immunol 186:359-71. 2011
    ....
  16. ncbi request reprint Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty
    John M Murray
    School of Mathematics, University of NSW, Sydney, Australia
    Immunol Cell Biol 81:487-95. 2003
    ..7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export...
  17. pmc Kinetics of virus-specific CD8+ T cells and the control of human immunodeficiency virus infection
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital, Kensington, New South Wales, Australia
    J Virol 78:10096-103. 2004
    ..However, this response is too little too late to prevent establishment of persistent infection...
  18. pmc High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Virol 79:10059-62. 2005
    ..Nevertheless, higher initial CD8(+) T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4(+) T-cell depletion...
  19. ncbi request reprint Influence of peak viral load on the extent of CD4+ T-cell depletion in simian HIV infection
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales, Australia
    J Acquir Immune Defic Syndr 41:259-65. 2006
    ..Whether such a simple relation also holds for HIV or simian immunodeficiency virus infections remains to be determined, particularly in the gut and other anatomic sites in which most early T-cell depletion occurs...
  20. doi request reprint Rates of HIV immune escape and reversion: implications for vaccination
    Miles P Davenport
    Centre for Vascular Research, University of NSW, Kensington, NSW 2052, Australia
    Trends Microbiol 16:561-6. 2008
    ..We predict that inducing synchronous, broad CTL by vaccination should limit the likelihood of viral escape from immune control...
  21. doi request reprint Does cytolysis by CD8+ T cells drive immune escape in HIV infection?
    Mehala Balamurali
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    J Immunol 185:5093-101. 2010
    ..These dynamics are consistent with an epitope-specific, MHC class I-restricted, noncytolytic mechanism of CD8(+) T cell control of SHIV that specifically inhibits the growth of WT virus in vivo...
  22. pmc Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination
    Lei Zhang
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia
    J Virol 78:5520-2. 2004
    ..By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control...
  23. pmc CD4+ target cell availability determines the dynamics of immune escape and reversion in vivo
    Janka Petravic
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, NSW 2052, Australia
    J Virol 82:4091-101. 2008
    ..This has important implications for comparative studies of immune escape and reversion in different infections and for identifying epitopes with high fitness cost for use as vaccine targets...
  24. ncbi request reprint The role of production frequency in the sharing of simian immunodeficiency virus-specific CD8+ TCRs between macaques
    Vanessa Venturi
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Immunol 181:2597-609. 2008
    ..Thus, convergent recombination is a major determinant of the extent of TCRbeta sharing...
  25. pmc Estimating the impact of vaccination on acute simian-human immunodeficiency virus/simian immunodeficiency virus infections
    Janka Petravic
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales 2052, New South Wales, Australia
    J Virol 82:11589-98. 2008
    ..3- and 2-fold, respectively. This method allows the comparison of vaccination efficacies among different viral strains and animal models in vivo...
  26. pmc Predicting the impact of a nonsterilizing vaccine against human immunodeficiency virus
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia
    J Virol 78:11340-51. 2004
    ....
  27. pmc Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut
    David P Wilson
    Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, New South Wales, Australia
    J Virol 81:8025-9. 2007
    ..6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo...
  28. doi request reprint Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG
    Simon X Liang
    St George Clinical School, University of New South Wales, Sydney, Australia
    Blood 116:1958-60. 2010
    ..Our results suggest that the NOD/SCID mouse model is useful for investigating the efficacy of current and future DITP therapies, an area in which there is little experimental evidence to guide treatment...
  29. ncbi request reprint TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV
    Vanessa Venturi
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Immunol 181:7853-62. 2008
    ..These results suggest that TCRbeta production frequency plays an important role in the interindividual sharing of TCRbeta sequences within CD8(+) T cell responses specific for CMV and EBV...
  30. ncbi request reprint The T cell repertoire in infection and vaccination: implications for control of persistent viruses
    Miles P Davenport
    Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington NSW, Australia
    Curr Opin Immunol 19:294-300. 2007
    ..Recent advances have increased our understanding of the interactions between persistent viruses and the available T cell repertoire, and will guide approaches to the generation and maintenance of an 'ideal' T cell response...
  31. pmc Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination
    Vanessa Venturi
    Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    Proc Natl Acad Sci U S A 103:18691-6. 2006
    ....
  32. pmc APOBEC3 has not left an evolutionary footprint on the HIV-1 genome
    Diako Ebrahimi
    Centre for Vascular Research, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia
    J Virol 85:9139-46. 2011
    ..We therefore find no evidence of an evolutionary footprint of hA3G/F. We postulate several mechanisms to explain why the HIV-1 genome does not contain the hA3G/F footprint...
  33. doi request reprint The molecular basis for public T-cell responses?
    Vanessa Venturi
    Complex Systems Biology Group, Centre for Vascular Research, University of New South Wales, Kensington New South Wales 2052, Australia
    Nat Rev Immunol 8:231-8. 2008
    ....
  34. pmc Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes
    Hui Yee Greenaway
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, New South Wales, Australia
    Immunol Cell Biol 87:546-53. 2009
    ..This primary description of the rhesus macaque TRB genes will provide a standardized nomenclature and enable better characterization of TCR usage in studies that use this species...
  35. ncbi request reprint A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation
    Yishay Orr
    Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, School of Medical Sciences, The University of New South Wales, Anzac Parade, Kensington, NSW, Australia
    Am J Physiol Regul Integr Comp Physiol 292:R1707-16. 2007
    ..4 h of maturation...
  36. pmc Accurately measuring recombination between closely related HIV-1 genomes
    Timothy E Schlub
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Comput Biol 6:e1000766. 2010
    ..We demonstrate that this system is applicable to other studies to accurately measure the recombination rate and show that recombination does not occur randomly within the HIV genome...
  37. pmc The effects of thymic selection on the range of T cell cross-reactivity
    Dennis L Chao
    Fred Hutchinson Cancer Research Center, Seattle, USA
    Eur J Immunol 35:3452-9. 2005
    ....
  38. ncbi request reprint Partial treatment interruption of protease inhibitors augments HIV-specific immune responses in vertically infected pediatric patients
    Fatema A Legrand
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158 2261, USA
    AIDS 19:1575-85. 2005
    ..Protease inhibitor (PI) based therapy has been hypothesized to depress cell-mediated immune responses by reducing antigen presentation...
  39. ncbi request reprint The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion
    Miranda Z Smith
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    J Med Primatol 34:282-93. 2005
    ..Mane-A*10(+) animals have lower set point SIV levels than Mane-A*10(-) animals, suggesting a significant fitness cost of escape. These studies pave the way for a more robust understanding of HIV vaccines in pigtail macaques...
  40. pmc Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 102:11432-7. 2005
    ..Thus, whereas TCR sequence (or affinity) appears to contribute substantially to the avidity profile of diverse virus-specific CD8+ populations, other mechanisms may be prominent where the TCR spectrum is more limited...
  41. pmc Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Virol 80:802-9. 2006
    ..We also investigate the effects of different antiviral strategies. Surprisingly, these results suggest that both conventional antiretroviral regimens and CCR5 receptor-blocking drugs will promote R5 virus over X4 virus...
  42. ncbi request reprint Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity
    Stephen J Kent
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    Trends Microbiol 13:243-6. 2005
    ..A virus crippled by immune escape mutations would result in reduced viral load and delayed disease. Such knowledge could be used to rationally design more effective vaccines...
  43. ncbi request reprint A stochastic model of cytotoxic T cell responses
    Dennis L Chao
    Department of Computer Science, University of New Mexico, Albuquerque, NM 87131, USA
    J Theor Biol 228:227-40. 2004
    ..We compare the model to experimental data on the cytotoxic T cell response to lymphocytic choriomeningitis virus infections...
  44. pmc Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 103:9184-9. 2006
    ..Hence, our analysis suggests that early establishment of influenza-specific memory within the CD8(+)CD62L(hi) subset preserves clonal diversity and prevents "overdominance" by a few public, or shared, clones...
  45. pmc Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques
    Robert De Rose
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    J Virol 81:292-300. 2007
    ..These studies suggest priming of T-cell immunity to prevent AIDS in humans is possible, but differences in the immunogenicity of various subtype vaccines and broad cross-subtype protection are substantial hurdles...
  46. pmc Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 181:2556-62. 2008
    ..The key finding is thus that the role of TdT in ensuring enhanced diversity and the selection of private TCR repertoires promotes optimal CD8(+) T cell immunity, both within individuals and across the species as a whole...
  47. ncbi request reprint Homogenization of TCR repertoires within secondary CD62Lhigh and CD62Llow virus-specific CD8+ T cell populations
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    J Immunol 180:7938-47. 2008
    ..A better understanding of TCR selection and maintenance has implications for improved vaccine and immunotherapy protocols...
  48. ncbi request reprint Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:6484-9. 2008
    ..We therefore conclude that the correlation in Vbeta expression patterns between CD4(+) and CD8(+) T cells can be explained predominantly by germline TCR-beta locus factors and not TCR-beta allelic or HLA effects...
  49. ncbi request reprint Clonal selection, clonal senescence, and clonal succession: the evolution of the T cell response to infection with a persistent virus
    Miles P Davenport
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Immunol 168:3309-17. 2002
    ..Comparison of the model output with the experimental results obtained from primary and persistent EBV infection suggests that there is indeed a role for cellular senescence in shaping the immune response to persistent infection...
  50. pmc In vivo fitness costs of different Gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques
    Liyen Loh
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    J Virol 81:5418-22. 2007
    ..The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia...
  51. ncbi request reprint Contemporaneous fluctuations in T cell responses to persistent herpes virus infections
    Tania Crough
    Tumour Immunology Laboratory and Co Operative Centre for Vaccine Technology, Queensland Institute of Medical Research, Department of Molecular and Cellular Pathology, University of Queensland, Brisbane 4006, Australia
    Eur J Immunol 35:139-49. 2005
    ..This study demonstrates that the dynamic process of T cell expansion and contractions in persistent viral infections is not limited to the acute phase of infection, but also continues during the latent phase of infection...
  52. ncbi request reprint Modelling the impact of antigen kinetics on T-cell activation and response
    Dennis L Chao
    Department of Computer Science, University of New Mexico, Albuquerque, NM 87131, USA
    Immunol Cell Biol 82:55-61. 2004
    ..These findings may provide insight into how different vaccination strategies can quantitatively and qualitatively affect the outcome of the immune response...
  53. pmc Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:6341-6. 2007
    ..The ability of the memory T cells to remove antigen-presenting cells provides a negative-feedback loop to directly limit the duration of antigen presentation in vivo...
  54. ncbi request reprint Stochastic stage-structured modeling of the adaptive immune system
    Dennis L Chao
    Department of Computer Science, University of New Mexico, Albuquerque, 87131, USA
    Proc IEEE Comput Soc Bioinform Conf 2:124-31. 2003
    ..Our model can provide insights into the effect infections have on the CTL repertoire and the response to subsequent infections...
  55. pmc Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge
    Miranda Z Smith
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Australia
    J Virol 82:7357-68. 2008
    ..These findings have implications for future AIDS virus vaccine studies, which should consider the "fitness" of vaccine-induced T cells in order to generate robust responses in the face of virus exposure...
  56. pmc Vaccination and timing influence SIV immune escape viral dynamics in vivo
    Liyen Loh
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS Pathog 4:e12. 2008
    ....
  57. pmc Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response
    Tania Crough
    Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
    J Virol 81:11538-42. 2007
    ..These studies suggest that a strong functional T-cell response plays a crucial role in defining the clinical outcome of acute viral recrudescence...
  58. pmc Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class I decay rates
    Brian D Rudd
    Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85718, USA
    J Immunol 181:5199-203. 2008
    ..Rather, DCs pretreated with TLR ligands exhibited increased stability of cognate pMHCs, enabling extended TCR triggering. These findings are of potential importance to T cell vaccination...